scholarly journals Multiwalled Carbon Nanotubes as Nanomaterial Tool in the Management of Prostate Cancer: A Possible Nanoformulation Approach

2021 ◽  
Author(s):  
Raja Murugesan ◽  
Raman Sureshkumar ◽  
Arun Radhakrishnan ◽  
Srikanth Jupudi ◽  
Manisha Chennu
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Kinase Inhibitor ◽  
Prostate Gland ◽  
Chemical Properties ◽  
Binding Mode ◽  
Multiwalled Carbon ◽  
Over Expression ◽  
Multi Walled Carbon Nanotubes ◽  
Fluorescent Agent

Prostate cancer (PCa) is one of the leading diseases in men all over the world caused due to over-expression of PSMA (Prostate Specific Membrane Antigen). Currently, the detection and targeting of PCa is one of the major challenges in prostate gland. Therefore, Bruton Tyrosine Kinase Inhibitor molecules like Ibrutinib (Ibr) loaded with nanomaterials like Multi walled Carbon nanotubes (MWCNTs), which has good physico-chemical properties may be a best regimen to treat PCa. In this strategy, the chemically modified MWCNTs which have excellent ‘Biosensing’ properties therefore makes easy for detecting PCa without fluorescent agent and thus targets particular site of PCa. In the present study, Ibr/MWCNTs conjugated with T30 oligonucleotide may target and inhibit PSMA thereby reduce the over-expression in PCa. Hence, the proposed formulation design can extensively reduce the dosage regimen without any toxic effect. Additionally, the present hypothesis also revealed the binding mode of Ibr in catalytic pocket of PSMA by in silico method. Therefore, we presume that if this hypothesis proves correct, it becomes an additional novel tool and one of the conceivable therapeutic options in treating PCa.

Aqueous Deposition of Metals on Multiwalled Carbon Nanotubes to be Used as Electrocatalyst for Polymer Exchange Membrane Fuel Cells

2006 ◽  
Vol 4 (2) ◽  
pp. 130-133 ◽  
Author(s):  
Y. Verde ◽  
A. Keer ◽  
M. Miki-Yoshida ◽  
F. Paraguay-Delgado ◽  
G. Alonso-Nuñez ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Fuel Cell ◽  
Chemical Properties ◽  
Precursor Solution ◽  
Pd Nanoparticles ◽  
Multiwalled Carbon ◽  
O2 Reduction ◽  
Direct Methanol ◽  
Multi Walled Carbon Nanotubes ◽  
Exchange Membrane

The polymer exchange membrane fuel cell (PEMFC) is considered the new power source technology for portable applications. Pt and Pt–alloy nanoparticles supported on carbon black have been used traditionally to make electrodes due to their high activity for H2 oxidation and O2 reduction under PEMFC conditions. Recently, ammonium hexachloroplatinate (IV) ((NH4)2PtCl6) has been shown to be a good precursor of metallic Pt by thermal decomposition. In addition, multi-walled carbon nanotubes (MWCNTs) present convenient physical and chemical properties to be employed as a support for electrocatalysts. MWCNTs were synthesized by spray pyrolysis using a precursor solution of ferrocene dissolved in benzene or toluene. Ammonium hexachloroplatinate, ammonium hexachlororhutenate, and ammonium hexachloropaladate were used as the Pt, Ru, and Pd precursors, respectively. Aqueous solution reaction, followed by a two stage thermal process, was utilized to support separately Pt, Ru, and Pd nanoparticles on the MWCNT. The results suggest that the deposition takes place on anchored sites formed during the aqueous reaction, due to the in situ oxidation of the external wall of the nanotube. Very good dispersion and particle size between 3nm and 12nm were obtained for each metal. Such characteristics are advantageous for the use of CNT supported electrocatalyst in PEMFC and direct methanol fuel cell (DMFC) electrodes.

Recent trends in carbon nanotubes based prostate cancer therapy: A biomedical hybrid for diagnosis and treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
High Capacity ◽  
Chemical Properties ◽  
Diagnosis And Treatment ◽  
High Level

: At present treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to annoy the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug loading by in circulating modification with bio-molecules, project them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs which have excellent 'Biosensing' properties therefore makes it easy for detecting PCa without fluorescent agent and thus targets the particular site of PCa and also, Drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focussed on the diagnosis and treatment of PCa. Here, we detailly reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.

Characterization of Mechanical and Viscoelastic Properties of SC-15 Epoxy Nanocomposites Reinforced With Multi-Walled Carbon Nanotubes, Nanoclay and Binary Nanoparticles

2014 ◽  
Author(s):  
Tanjheel H. Mahdi ◽  
Mohammad E. Islam ◽  
Mahesh V. Hosur ◽  
Alfred Tcherbi-Narteh ◽  
S. Jeelani
Keyword(s):  
Carbon Nanotubes ◽  
Epoxy Resin ◽  
Viscoelastic Properties ◽  
Flexural Modulus ◽  
Epoxy Nanocomposites ◽  
Multiwalled Carbon ◽  
Epoxy Resin System ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Binary Nanoparticles

Mechanical and viscoelastic properties of polymer nanocomposites reinforced with carboxyl functionalized multiwalled carbon nanotubes (COOH-MWCNT), montmorillonite nanoclays (MMT) and MWCNT/MMT binary nanoparticle were investigated. In this study, 0.3 wt. % of COOH-MWCNT, 2 wt. % of MMT and 0.1 wt. % COOH-MWCNT/2 wt. % MMT binary nanoparticles by weight of epoxy were incorporated to modify SC-15 epoxy resin system. The nanocomposites were subjected to flexure test, dynamic mechanical and thermomechanical analyses. Morphological study was conducted with scanning electron microscope. Addition of each of the nanoparticles in epoxy showed significant improvement in mechanical and viscoelastic properties compared to those of control ones. But, best results were obtained for addition of 0.1% MWCNT/2% MMT binary nanoparticles in epoxy. Nanocomposites modified with binary nanoparticles exhibited about 20% increase in storage modulus as well as 25° C increase in glass transition temperature. Flexural modulus for binary nanoparticle modified composites depicted about 30% improvement compared to control ones. Thus, improvement of mechanical and viscoelastic properties was achieved by incorporating binary nanoparticles to epoxy nanocomposites. The increase in properties was attributed to synergistic effect of MWCNTs and nanoclay in chemically interacting with each other and epoxy resin as well as in arresting and delaying the crack growth once initiated.

scholarly journals Enhancement photocatalytic activity of spinel oxide (Co, Ni)3O4 by combination with carbon nanotubes

2017 ◽  
Vol 19 (3) ◽  
pp. 61-67 ◽  
Author(s):  
Bashaer J. Kahdum ◽  
Abbas J. Lafta ◽  
Amir M. Johdh
Keyword(s):  
Carbon Nanotubes ◽  
Photocatalytic Activity ◽  
Diffuse Reflectance Spectroscopy ◽  
X Rays ◽  
Spinel Oxide ◽  
Reaction Conditions ◽  
Multiwalled Carbon ◽  
Radiation Sources ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

Abstract In this study, some types of composites consisting of multi-walled carbon nanotubes (MWCNTs) and spinel oxide (Co, Ni)3O4 were synthesized by simple evaporation method. These composites were characterized by UV–Vis diffuse reflectance spectroscopy, X-rays diffraction(XRD), Scanning electron microscopy (SEM) and specific surface area(SBET). The photocatalytic activity of the prepared composites was investigated by the following removal of Bismarck brown G (BBG) dye from its aqueous solutions. The obtained results showed that using MWCNTs in combination with spinel oxide to produced composites (spinel/MWCNTs) which succeeded in increasing the activity of spinel oxide and exhibited higher photocatalytic activity than spinel oxide alone. Also it was found that, multiwalled carbon nanotubes were successful in increasing the adsorption and improving the activity of photocatalytic degradation of Bismarck brown G dye(BBG). The obtained results showed that spinel/MWCNTs was more active in dye removal in comparison with each of spinel oxide and MWCNTs alone under the same reaction conditions. Also band gap energies for the prepared composites showed lower values in comparison with neat spinel. This point represents a promising observation as these composites can be excited using a lower energy radiation sources.

Tribological Properties of Stearic Acid Modified Multi-Walled Carbon Nanotubes in Water

2012 ◽  
Vol 135 (1) ◽  
Author(s):  
Yitian Peng ◽  
Zhonghua Ni
Keyword(s):  
Electron Microscopy ◽  
Carbon Nanotubes ◽  
Stearic Acid ◽  
Tribological Properties ◽  
Friction Reduction ◽  
Multiwalled Carbon ◽  
Transmission Electron ◽  
Multi Walled Carbon Nanotubes ◽  
Lubricant Application ◽  
Walled Carbon Nanotubes

The oxidized multiwalled carbon nanotubes (MWCNTs) were modified with stearic acid (SA) molecules. The SA-modified MWCNTs were characterized with scanning electron microscopy, transmission electron microscopy, and Fourier transform-infrared spectroscopy. The tribological properties of the oxidized and SA-modified MWCNTs as additives in water were comparatively investigated with a four-ball tester. The results showed the SA-modified MWCNTs in water have better tribological properties including friction reduction and antiwear than oxidized MWCNTs. The possible mechanism of SA-modified MWCNT as an additive in water was discussed. This research provides the opportunity for the lubricant application of MWCNTs.

Effects of hydroxyl-functionalized multiwalled carbon nanotubes on sperm health and testes of Wistar rats

2017 ◽  
Vol 33 (6) ◽  
pp. 519-529 ◽  
Author(s):  
NK Nirmal ◽  
KK Awasthi ◽  
PJ John
Keyword(s):  
Carbon Nanotubes ◽  
Wistar Rats ◽  
Chemical Properties ◽  
Control Group ◽  
Dependent Manner ◽  
Multiwalled Carbon ◽  
Treatment Groups ◽  
Significant Impairment ◽  
Functionalized Multiwalled Carbon Nanotubes ◽  
Male Reproductive Health

Carbon nanotubes (CNTs) are promising candidates for various applications including biomedical purposes. Owing to their remarkable physical, mechanical, electrical and chemical properties, CNTs have become an area of intense research and industrial activity in recent years. Therefore, toxicity and risk assessment studies are becoming increasingly important. The present study was designed to assess the effects of hydroxyl-functionalized multiwalled CNTs (OH-f MWCNTs) on sperm health and testes of adult Wistar rats. Animals were treated with different doses of OH-f MWCNTs (0.4, 2.0 and 10.0 mg/kg) along with a control group receiving only vehicle. Assessments after 15 alternate intraperitoneal doses revealed dose-related adverse effects on many endpoints tested. Results of the study showed significant impairment of sperm health at 2.0 and 10.0 mg/kg. Histology of testes demonstrated degeneration of germinal epithelium and loss of germ cells in the treatment groups. The exposure resulted in increased oxidative stress in testes in a dose-dependent manner. The findings of the study demonstrate that CNTs are potentially harmful for male reproductive health.

Highly dispersed palladium nanoparticles on poly(N1,N3-dimethylbenzimidazolium)iodide-functionalized multiwalled carbon nanotubes for ethanol oxidation in alkaline solution

RSC Advances ◽  
2016 ◽  
Vol 6 (104) ◽  
pp. 102582-102594 ◽  
Author(s):  
Yan Lin ◽  
Qi Liu ◽  
Jinchen Fan ◽  
Kexuan Liao ◽  
Jiawei Xie ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
High Performance ◽  
Ethanol Oxidation ◽  
Multiwalled Carbon ◽  
Composite Catalysts ◽  
Multi Walled Carbon Nanotubes ◽  
High Performance Composite ◽  
Functionalized Multiwalled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Supporting Materials

Multi-walled carbon nanotubes (MWCNTs) have been considered as good catalyst supporting materials, and their dispersion and functionalization are important, challenging problems for high-performance composite catalysts.

Electrodeposited multi-walled carbon nanotubes on Ag-loaded TiO2 nanotubes/Ti plates as a new photocatalyst for dye degradation

RSC Advances ◽  
2015 ◽  
Vol 5 (56) ◽  
pp. 44840-44846 ◽  
Author(s):  
Neda Mohaghegh ◽  
Masoud Faraji ◽  
Fereydoon Gobal ◽  
Mohammad Reza Gholami
Keyword(s):  
Carbon Nanotubes ◽  
Electrochemical Reduction ◽  
Multiwalled Carbon Nanotubes ◽  
Tio2 Nanotubes ◽  
Dye Degradation ◽  
Multiwalled Carbon ◽  
Multi Walled Carbon Nanotubes ◽  
Functionalized Multiwalled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

MWCNTs/Ag/TiO2NTs plates were synthesized via electrochemical reduction of functionalized multiwalled carbon nanotubes (MWCNTs) on Ag/TiO2NTs.

Inelastic Deformations in Multi-Walled Carbon Nanotubes

1999 ◽  
Vol 593 ◽  
Author(s):  
D. Tekleab ◽  
R. Czerw ◽  
A. Rubio ◽  
P.M. Ajayan ◽  
D.L. Carroll
Keyword(s):  
Mechanical Properties ◽  
Carbon Nanotubes ◽  
Multiwalled Carbon Nanotubes ◽  
High Power ◽  
Multiwalled Carbon ◽  
Ultrasonic Agitation ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Insight Into

ABSTRACTWe report the use of high power ultrasonic agitation to create inelastic deformations in multiwalled carbon nanotubes. Using STM coupled with TEM we show that this damage can range from kinking to breaking of continuous tube walls into segments. Such deformed tubes provide an insight into the role of re-hybridization in the electrical and mechanical properties of tubes.

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