5FU-loaded PCL/Chitosan/Fe3O4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System

Purpose: 5FU and Fe3O4 nanoparticles were encapsulated in core-shell Polycaprolactone/Chitosan nanofibers as a multi-mode anticancer system to study drug release sustainability. The structure of the core-shell drug delivery system was also optimized according to drug release behavior by artificial intelligence. Methods: The core-shell nanofibers were electrospun by a coaxial syringe. ANN was used for function approximation to estimate release parameters. A genetic algorithm was then used for optimizing the structure. Chemical assay of the optimized sample was performed by FTIR, XRD, and EDX. VSM test was conducted to measure the real amount of loaded magnetic nanoparticles. HepG2 cell cytotoxicity was studied and the results for the optimized samples with and without Fe3O4 after 72hrs were reported. Results: Feeding ratio of sheath to core and the amount of CS, Fe3O4, and 5FU had a statistical effect on nanofibers diameters, which were 300-450nm. The drug loading efficiency of these nanofibers was 65-86%. ANN estimated the release parameters with an error of 10%. The temperature increased about 5.6°C in the AMF of 216kA.m-1~300kHz and 4.8°C in the AMF of 154kA.m-1~400kHz after 20min. HepG2 cell cytotoxicity for the optimized samples with and without Fe3O4 after 72hrs were 39.7% and 38.8%, respectively. Conclusion: Since this core-shell drug release system was more sustainable compared to the blend structure despite the low half-life of 5FU, it is suggested to utilize it as post-surgical implants for various cancer treatments such as liver or colorectal cancer in the future. This system is capable of providing chemotherapy and hyperthermia simultaneously.

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ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽

10.1039/d1ra03899k ◽

2021 ◽

Vol 11 (48) ◽

pp. 29986-29996

Author(s):

Xiuxiu Qi ◽

Hongmei Yan ◽

Yingxue Li

Keyword(s):

Controlled Release ◽

Drug Release ◽

Self Assembly ◽

Drug Loading ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Core Shell ◽

Assembly Process ◽

Block Polymer ◽

Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

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Core–shell noble-metal@zeolitic-imidazolate-framework nanocarriers with high cancer treatment efficiency in vitro

Journal of Materials Chemistry B ◽

10.1039/c8tb03318h ◽

2019 ◽

Vol 7 (7) ◽

pp. 1050-1055 ◽

Cited By ~ 5

Author(s):

Liangcan He ◽

Kanglei Pang ◽

Wenwen Liu ◽

Yue Tian ◽

Lin Chang ◽

...

Keyword(s):

Drug Release ◽

Cancer Treatment ◽

Drug Loading ◽

Controlled Drug Release ◽

Core Shell ◽

Treatment Efficiency ◽

Zeolitic Imidazolate Framework ◽

High Drug ◽

High Drug Loading

Core–shell Au@zeolitic-imidazolate-framework nanocarriers with high drug-loading, controlled drug release properties, and high cancer treatment efficiency.

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Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Open Physics ◽

10.1515/phys-2017-0125 ◽

2017 ◽

Vol 15 (1) ◽

pp. 1004-1014 ◽

Cited By ~ 2

Author(s):

Ting-Yun Kuo ◽

Cuei-Fang Jhang ◽

Che-Min Lin ◽

Tzu-Yang Hsien ◽

Hsyue-Jen Hsieh

Keyword(s):

Drug Release ◽

Polyvinyl Alcohol ◽

Gum Arabic ◽

Release Time ◽

Core Shell ◽

The Core ◽

Chitosan Nanofiber ◽

Application Potential ◽

Nanofiber Membranes ◽

Model Drug

AbstractIt is difficult to fabricate chitosan-wrapped coaxial nanofibers, because highly viscous chitosan solutions might hinder the manufacturing process. To overcome this difficulty, our newly developed method, which included the addition of a small amount of gum arabic, was utilized to prepare much less viscous chitosan solutions. In this way, coaxial polyvinyl alcohol (PVA)/chitosan (as core/shell) nanofiber membranes were fabricated successfully by coaxial electrospinning. The core/shell structures were confirmed by TEM, and the existence of PVA and chitosan was also verified using FT-IR and TGA. The tensile strength of the nanofiber membranes was increased from 0.6-0.7 MPa to 0.8-0.9 MPa after being crosslinked with glutaraldehyde. The application potential of the PVA/chitosan nanofiber membranes was tested in drug release experiments by loading the core (PVA) with theophylline as a model drug. The use of the coaxial PVA/chitosan nanofiber membranes in drug release extended the release time of theophylline from 5 minutes to 24 hours. Further, the release mechanisms could be described by the Korsmeyer-Peppas model. In summary, by combining the advantages of PVA and chitosan (good mechanical strength and good biocompatibility respectively), the coaxial PVA/chitosan nanofiber membranes are potential biomaterials for various biomedical applications.

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Functional responsive superparamagnetic core/shell nanoparticles and their drug release properties

RSC Advances ◽

10.1039/c7ra02437a ◽

2017 ◽

Vol 7 (42) ◽

pp. 26243-26249 ◽

Cited By ~ 9

Author(s):

Zied Ferjaoui ◽

Raphaël Schneider ◽

Abdelaziz Meftah ◽

Eric Gaffet ◽

Halima Alem

Keyword(s):

Folic Acid ◽

Iron Oxide ◽

Drug Release ◽

Drug Loading ◽

Superparamagnetic Iron Oxide ◽

Cancer Drug ◽

Oxide Nanoparticles ◽

Core Shell ◽

Shell Nanoparticles ◽

Core Shell Nanoparticles

Folic acid functionalized responsive core/shell superparamagnetic iron oxide nanoparticles were successfully synthesized for further application in cancer therapy. Their cancer drug loading and release performances were demonstrated.

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In-Vitro Cytotoxicity and Anticancer Drug Release Behavior of Methionine - Coated Magnetite Nanoparticles As Carriers.

10.21203/rs.3.rs-1128844/v1 ◽

2021 ◽

Author(s):

Faten Eshrati Yeganeh ◽

Amir Eshrati Yeganeh ◽

Bahareh Farasati Far ◽

Iman Akbarzadeh ◽

Sameer Quazi ◽

...

Keyword(s):

Drug Delivery ◽

Amino Acid ◽

Drug Release ◽

Drug Loading ◽

Average Particle Size ◽

Mcf10a Cell ◽

Core Shell ◽

Average Particle ◽

Release Behavior

Abstract An innovative and customized drug delivery system for in vitro cancer treatment has been developed successfully by a simple one-step method. A CoFe2O4@Methionine core-shell nanoparticle was prepared by the reflux assay, in which amino acid on the surface makes the ferrite biocompatible, enhances the chemical stability of the compound, and increases the drug loading capacity. The synthesized nanoparticles were evaluated using SEM, TEM, FTIR, and VSM, while XRD and TGA analysis verified the presence of a coating amino acid on the surface of CoFe2O4. The appearance of a new peak for C≡N in the FTIR spectrum validates the synthesis of a letrozole-loaded carrier. Both uncoated CoFe2O4 and methionine-coated CoFe2O4 nanoparticles behave super-paramagnetically at room temperature, with saturation values of 46 emu/g and 16.8 emu/g, respectively. SEM and TEM were used to characterize the morphology and size of samples, revealing that the average particle size was around 28–29 nm. The loading of Letrozole and the effect of pH (5, 7.4) on the release behavior of the carrier were studied. The result of the drug release in pH (5) was about 88% higher than pH (7.4). Also, the preparation has been evaluated for determining its cytotoxicity using MCF-7, MDA-MB-231, and MCF10A cell lines as an in vitro model, and the results of in vitro experiments showed that CoFe2O4@Methionine could significantly reduce cancer in the cell model. These results demonstrate that core-shell nanoparticles were prepared that are biocompatible and have potential use as drug delivery.

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In Vitro Drug Release Activity from Core/Shell Electrospun MATS of sPLA-cPEG/GS and sPLA/CA-cPEG/GS

Materials Science Forum ◽

10.4028/www.scientific.net/msf.714.263 ◽

2012 ◽

Vol 714 ◽

pp. 263-270 ◽

Cited By ~ 1

Author(s):

Koravee Vichitchote ◽

Poonsub Threepopnatkul ◽

Supakij Suttiruengwong ◽

Chanin Kulsetthanchalee

Keyword(s):

Drug Release ◽

Core Shell ◽

Immersion Method ◽

Electrospinning Technique ◽

The Core ◽

Buffer Solutions ◽

Initial Release ◽

Total Immersion ◽

Core Section

In this research, the core-shell structured fiber was fabricated by coaxial electrospinning technique. A set of biodegradable polymers namely polylactic acid (PLA) and cellulose acetate (CA) were used as the shell material. Gentamicin sulfate (GS) as antimicrobial drug with polyethylene glycol (PEG) was used as the core structure. PEG formed the core section of the coreshell fibers for GS encapsulation.In-vitrodrug release activity of the core-shell fibers was determined by total immersion method in pH 7.4 phosphate buffer solutions (PBS). It was found that core-shell fibers sPLA-cPEG/GS exhibit higher initial release compared to that of core-shell fibers sPLA/CA-cPEG/GS.

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Itraconazole Coated Super Paramagnetic Iron Oxide Nanoparticles for Antimicrobial Studies

Biointerface Research in Applied Chemistry ◽

10.33263/briac105.62186225 ◽

2020 ◽

Vol 10 (5) ◽

pp. 6218-6225 ◽

Cited By ~ 1

Keyword(s):

Iron Oxide ◽

Drug Release ◽

Iron Oxide Nanoparticles ◽

Release Kinetics ◽

Diffusion Method ◽

Oxide Nanoparticles ◽

Core Shell ◽

Drug Release Profile ◽

The Core ◽

Antimicrobial Studies

In this present study, Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were produced using FeCl3 and FeCl2 which were reduced to iron oxides using NaOH and ammonia solution (chemical co-precipitation). These naked SPIONs were further fabricated to form drug laden core-shell for controlled drug release and delivery. The fabrication was achieved by subjugating the naked SPIONs for oleic acid functionalization, drug tagging (Itraconazole) and finally encapsulated with a microbial derived polyester namely Polyhydroxybutyrate (PHB). Every stage of fabrication was characterized by scanning electron microscopy (SEM). The core-shell produced was checked for drug release kinetics, antibacterial and antifungal activities. These synthesized core-shells were carrying the drug and showed a slow drug release profile. The antimicrobial studies against bacteria - Pseudomonas aeruginosa & Brevibacillus brevis and fungi - Candida albicans by diffusion method proved that the core-shells inhibited bacterial and fungal activity. Furthermore, the naked SPIONs was found to be a good contrasting agent in X-ray imaging.

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Synthesys and Characterization of PLA-CNC Matrix for Antidiabetic Drug Release Applications

Materials Science Forum ◽

10.4028/www.scientific.net/msf.988.169 ◽

2020 ◽

Vol 988 ◽

pp. 169-174

Author(s):

Nufus Kanani ◽

Yenny Meliana ◽

Endarto Yudo Wardhono ◽

Rahmayetty ◽

Sri Agustina ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Loading ◽

Study Drug ◽

The Body ◽

Raw Material ◽

Poly Lactic Acid ◽

Burst Release ◽

Antidiabetic Drug

Recently, drug nanoparticles formulation using Poly Lactic Acid-Cellulose nanocrystal (PLA-CNC) have been introduced. PLA-CNC were prepared by emulsion method for antidiabetic drug delivery applications. PLA is one of polymer which potentially used as raw material of drug delivery because it has the ability to bind and carry drugs into cell target, but the hydrophilic character of PLA can cause the degradation of PLA in the body run slowly, so it is necessary combining PLA with CNC to improve its property. In this study, special attention has been given to the modification of PLA-CNC as a drug delivery matrix to obtain the optimum drug release of antidiabetic drugs. In this study drug release analysis was conducted at 35-39 °C and pH range 3 to 9 with varied of time dissolution 0 to 180 min. PLA-CNC matrixs were characterized using FTIR and SEM, its drug loading capacity, encapsulation efficiency and in vitro drug release behavior was determined by using UV spectrophotometer. It gave the initial burst release at the first hour at 37 °C pH 3.

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Preparation and characterization of PGS/PLLA@PNIPAM core-shell nanofiber membrane by electrospinning and surface ATRP grafting

Journal of Engineered Fibers and Fabrics ◽

10.1177/1558925021988967 ◽

2021 ◽

Vol 16 ◽

pp. 155892502198896

Author(s):

Qijian Niu ◽

Lili Ma ◽

Junxia Guo ◽

Xiaoping Yang

Keyword(s):

Drug Release ◽

Surface Morphology ◽

Core Layer ◽

Core Shell ◽

Shell Layer ◽

Nanofiber Membrane ◽

H Nmr ◽

Temperature Responsive ◽

The Core

In this study, a temperature responsive PGS/PLLA@PNIPAM core-shell nanofiber membrane was prepared by combining electrospinning with surface ATRP grafting polymer technology, in which the core layer of PGS/PLLA nanofiber was prepared by electrospinning, and then the shell layer of temperature responsive PNIPAM polymer was grafted on the nanofiber surface by ATRP reaction. In the experiment, a macromolecule-initiator PGS-Br was prepared and characterized by FTIR and 1H NMR. The surface morphology, composition, element of the core-shell nanofiber membrane were characterized by SEM, FTIR, and XPS. In addition, it is worth noting that the core-shell nanofiber membrane can respond to temperature in drug release tests.

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Monodisperse Fe3O4/SiO2 and Fe3O4/SiO2/PPy Core-Shell Composite Nanospheres for IBU Loading and Release

Materials ◽

10.3390/ma12050828 ◽

2019 ◽

Vol 12 (5) ◽

pp. 828 ◽

Cited By ~ 1

Author(s):

Lazhen Shen ◽

Bei Li ◽

Yongsheng Qiao ◽

Jinping Song

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Fe3o4 Nanoparticles ◽

Shell Structure ◽

Solvothermal Method ◽

Drug Loading ◽

Core Shell ◽

Prepared Nanoparticles ◽

Sio2 Shell ◽

Core Shell Structure

The magnetic targeting drug delivery system is an effective way of targeting therapy. In this study, the monodisperse Fe3O4 nanoparticles with a particles size of about 180 nm were first prepared via a solvothermal method. Subsequently, the core-shell structure Fe3O4/SiO2 and Fe3O4/SiO2/polypyrrole (PPy) composite nanospheres were successfully synthesized by coating Fe3O4 nanoparticles with SiO2 shell layer using the Stöber method and PPy shell by solvothermal method in turn. The as-prepared nanoparticles were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform-infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Ultraviolet-Visible spectrophotometer (UV-Vis). The results indicated that the as-prepared composite nanospheres displayed a well-defined core-shell structure and monodispersity. The thicknesses of SiO2 shell and PPy shell were ~6 nm and ~19 nm, respectively. Additionally, the as-prepared nanoparticles exhibited high saturation magnetization of 104 emu/g, 77 emu/g, and 24 emu/g, and have great potential applications in drug delivery. The drug loading and drug release of the Fe3O4/SiO2 and Fe3O4/SiO2/PPy composite nanospheres to ibuprofen (IBU) under stirring and ultrasonication were investigated. Their drug loading efficiency and drug release efficiency under ultrasonication were all higher than 33% and 90%, respectively. The drug release analyses showed sustained release of IBU from nanospheres and followed the Korsmeyer-Peppas model.

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