scholarly journals Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Open Physics ◽  
2017 ◽  
Vol 15 (1) ◽  
pp. 1004-1014 ◽  
Author(s):  
Ting-Yun Kuo ◽  
Cuei-Fang Jhang ◽  
Che-Min Lin ◽  
Tzu-Yang Hsien ◽  
Hsyue-Jen Hsieh
Keyword(s):  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Gum Arabic ◽  
Release Time ◽  
Core Shell ◽  
The Core ◽  
Chitosan Nanofiber ◽  
Application Potential ◽  
Nanofiber Membranes ◽  
Model Drug

AbstractIt is difficult to fabricate chitosan-wrapped coaxial nanofibers, because highly viscous chitosan solutions might hinder the manufacturing process. To overcome this difficulty, our newly developed method, which included the addition of a small amount of gum arabic, was utilized to prepare much less viscous chitosan solutions. In this way, coaxial polyvinyl alcohol (PVA)/chitosan (as core/shell) nanofiber membranes were fabricated successfully by coaxial electrospinning. The core/shell structures were confirmed by TEM, and the existence of PVA and chitosan was also verified using FT-IR and TGA. The tensile strength of the nanofiber membranes was increased from 0.6-0.7 MPa to 0.8-0.9 MPa after being crosslinked with glutaraldehyde. The application potential of the PVA/chitosan nanofiber membranes was tested in drug release experiments by loading the core (PVA) with theophylline as a model drug. The use of the coaxial PVA/chitosan nanofiber membranes in drug release extended the release time of theophylline from 5 minutes to 24 hours. Further, the release mechanisms could be described by the Korsmeyer-Peppas model. In summary, by combining the advantages of PVA and chitosan (good mechanical strength and good biocompatibility respectively), the coaxial PVA/chitosan nanofiber membranes are potential biomaterials for various biomedical applications.

PREPARATION AND CHARACTERIZATION OF SURFACE-FUNCTIONALIZATION OF SILICA-COATED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY

NANO ◽  
2014 ◽  
Vol 09 (04) ◽  
pp. 1450042 ◽  
Author(s):  
CONG-WANG ZHANG ◽  
CHANG-CHUN ZENG ◽  
YING XU
Keyword(s):  
Drug Delivery ◽  
Shell Structure ◽  
Drug Carrier ◽  
Point Of View ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
The Core ◽  
Application Potential ◽  
Core Shell Structure ◽  
Core Shell Nanoparticles

Fe 3 O 4– SiO 2 core–shell structure nanoparticles containing magnetic properties were investigated for their potential use in drug delivery. The Fe 3 O 4– SiO 2 core–shell structure nanoparticles were successfully synthesized by a simple and convenient way. The Fe 3 O 4– SiO 2 nanoparticles showed superparamagnetic behavior, indicating a great application potential in separation technologies. From the application point of view, the prepared nanoparticles were found to act as an efficient drug carrier. Specifically, the surface of the core–shell nanoparticles was modified with amino groups by use of silane coupling agent 3-aminopropyltriethoxysilane (APTS). Doxorubicin (DOX) was successfully grafted to the surface of the core–shell nanoparticles after the decoration with the carboxyl acid groups on the surface of amino-modified core–shell structure nanoparticles. Moreover, the nanocomposite showed a good drug delivery performance in the DOX-loading efficiency and drug release experiments, confirming that the materials had a great application potential in drug delivery. It is envisioned that the prepared materials are the ideal agent for application in medical diagnosis and therapy.

Synthesis of Chitosan-Polyvinyl Alcohol Copolymers for Smart Drug Delivery Application

2017 ◽  
Vol 25 (3) ◽  
pp. 241-246 ◽  
Author(s):  
Neha Mulchandani ◽  
Nimish Shah ◽  
Tejal Mehta
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Morphological Changes ◽  
Crosslinking Agent ◽  
Ph Responsive ◽  
Thermal Transitions ◽  
Scanning Calorimetry ◽  
Model Drug

Chitosan is a natural polymer obtained from exoskeletons of crustaceans and polyvinyl alcohol (PVA) is a synthetic polymer which has excellent film forming ability along with non-toxic nature. The current work focuses on synthesizing a smart polymer by copolymerization of natural and synthetic polymers and exploring its applications in drug delivery. The copolymers were blended in different ratios and were synthesized using ammonium ceric nitrate as initiator and glutaraldehyde as a crosslinking agent which were converted to films by casting method. Amoxicillin, as a model drug was incorporated to the copolymerized films to study the in-vitro drug release. The films obtained were evaluated by varying the pH to study the pH responsive nature of films. Drug release studies were performed to obtain the release profile of drug; water uptake capacity of the copolymerized film were measured to determine the swelling behaviour of the films. The films were further characterized using Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetry (DSC) to identify the structural and morphological changes along with thermal transitions. The results indicate that the synthesized copolymers are pH responsive in nature having great potential for application in controlled and targeted drug delivery.

scholarly journals Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release

2020 ◽  
Vol 85 (9) ◽  
pp. 1223-1235 ◽  
Author(s):  
Milad Abniki ◽  
Ali Moghimi ◽  
Fariborz Azizinejad
Keyword(s):  
Drug Release ◽  
Gum Arabic ◽  
X Ray Diffraction ◽  
Sustained Drug Release ◽  
Experimental Conditions ◽  
X Ray ◽  
Model Drug ◽  
Diffraction Patterns ◽  
New Formulation

The study proposed a new formulation to the sustained delivery of mefenamate anions intercalated into Mg?Al layered double hydroxide (LDH) for oral administration. Different experimental conditions were evaluated to incorporate the mefenamic acid (MEF) and gum arabic (GUM) into LDH structure. The LDH?MEF and LDH?MEF/GUM were covered with chitosan (CHIT). In another experiment, LDH?Cl was used to adsorb mefenamate anions and evaluate the mechanism. The products of LDH were characterized by using different techniques such as FESEM (field emission scanning electron microscopy), XRD (X-ray diffraction), FTIR (Fourier transform infrared) spectroscopy and TGA (thermogravimetric analysis). The X-ray diffraction patterns and FTIR analyses confirmed that the MEF and GUM were successfully intercalated into the interlayer space of LDH. TG analysis verified that the thermal stability of intercalated MEF in the form of bionanocomposite (LDH?MEF/ /GUM/CHIT) was enhanced. Finally, In vitro drug release experiments of bionanocomposite at a pH of 1.2 (acidic medium) and a pH of 7.4 (phosphate buffer medium) showed sustained release profiles with mefenamate anions as an anti-inflammatory model drug.

scholarly journals 5FU-loaded PCL/Chitosan/Fe3O4 Core-Shell Nanofibers Structure: An Approach to Multi-Mode Anticancer System

2021 ◽  
Author(s):  
Mehdi Hadjianfar ◽  
Dariush Semnani ◽  
Jaleh Varshosaz ◽  
Sajad Mohammadi ◽  
Sayed Pedram Rezazadeh Tehrani
Keyword(s):  
Drug Release ◽  
Hepg2 Cell ◽  
Drug Loading ◽  
Study Drug ◽  
Core Shell ◽  
Cell Cytotoxicity ◽  
The Core ◽  
Surgical Implants ◽  
Chemical Assay ◽  
Multi Mode

Purpose: 5FU and Fe3O4 nanoparticles were encapsulated in core-shell Polycaprolactone/Chitosan nanofibers as a multi-mode anticancer system to study drug release sustainability. The structure of the core-shell drug delivery system was also optimized according to drug release behavior by artificial intelligence. Methods: The core-shell nanofibers were electrospun by a coaxial syringe. ANN was used for function approximation to estimate release parameters. A genetic algorithm was then used for optimizing the structure. Chemical assay of the optimized sample was performed by FTIR, XRD, and EDX. VSM test was conducted to measure the real amount of loaded magnetic nanoparticles. HepG2 cell cytotoxicity was studied and the results for the optimized samples with and without Fe3O4 after 72hrs were reported. Results: Feeding ratio of sheath to core and the amount of CS, Fe3O4, and 5FU had a statistical effect on nanofibers diameters, which were 300-450nm. The drug loading efficiency of these nanofibers was 65-86%. ANN estimated the release parameters with an error of 10%. The temperature increased about 5.6°C in the AMF of 216kA.m-1~300kHz and 4.8°C in the AMF of 154kA.m-1~400kHz after 20min. HepG2 cell cytotoxicity for the optimized samples with and without Fe3O4 after 72hrs were 39.7% and 38.8%, respectively. Conclusion: Since this core-shell drug release system was more sustainable compared to the blend structure despite the low half-life of 5FU, it is suggested to utilize it as post-surgical implants for various cancer treatments such as liver or colorectal cancer in the future. This system is capable of providing chemotherapy and hyperthermia simultaneously.

scholarly journals Core/Shell Glycine-Polyvinyl Alcohol/Polycaprolactone Nanofibrous Membrane Intended for Guided Bone Regeneration: Development and Characterization

Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1130
Author(s):  
Marwa Alazzawi ◽  
Nabeel Kadim Abid Alsahib ◽  
Hilal Turkoglu Sasmazel
Keyword(s):  
Polyvinyl Alcohol ◽  
Physical Properties ◽  
Bone Regeneration ◽  
Degradation Rate ◽  
Guided Bone Regeneration ◽  
Nanofibrous Membrane ◽  
Core Shell ◽  
The Core ◽  
Barrier Membrane ◽  
Shell Membrane

Glycine (Gly), which is the simplest amino acid, induces the inflammation response and enhances bone mass density, and particularly its β polymorph has superior mechanical and piezoelectric properties. Therefore, electrospinning of Gly with any polymer, including polyvinyl alcohol (PVA), has a great potential in biomedical applications, such as guided bone regeneration (GBR) application. However, their application is limited due to a fast degradation rate and undesirable mechanical and physical properties. Therefore, encapsulation of Gly and PVA fiber within a poly(ε-caprolactone) (PCL) shell provides a slower degradation rate and improves the mechanical, chemical, and physical properties. A membrane intended for GBR application is a barrier membrane used to guide alveolar bone regeneration by preventing fast-proliferating cells from growing into the bone defect site. In the present work, a core/shell nanofibrous membrane, composed of PCL as shell and PVA:Gly as core, was developed utilizing the coaxial electrospinning technique and characterized morphologically, mechanically, physically, chemically, and thermally. Moreover, the characterization results of the core/shell membrane were compared to monolithic electrospun PCL, PVA, and PVA:Gly fibrous membranes. The results showed that the core-shell membrane appears to be a good candidate for GBR application with a nano-scale fiber of 412 ± 82 nm and microscale pore size of 6.803 ± 0.035 μm. Moreover, the wettability of 47.4 ± 2.2° contact angle (C.A) and mechanical properties of 135 ± 3.05 MPa average modulus of elasticity, 4.57 ± 0.04 MPa average ultimate tensile stress (UTS), and 39.43% ± 0.58% average elongation at break are desirable and suitable for GBR application. Furthermore, the X-ray diffraction (XRD) and transmission electron microscopy (TEM) results exhibited the formation of β-Gly.

Development and Characterization of Novel Freeze-thawed Polyvinyl Alcohol/ Halloysite Hydrogels. An approach for drug delivery application

2017 ◽  
Vol 54 (1) ◽  
pp. 8-13
Author(s):  
Adi Ghebaur ◽  
Sorina Alexandra Garea ◽  
Sergiu Cecoltan ◽  
Horia Iovu
Keyword(s):  
Drug Delivery ◽  
Gastrointestinal Tract ◽  
Drug Release ◽  
Polyvinyl Alcohol ◽  
Acetylsalicylic Acid ◽  
Polymer Matrix ◽  
Swelling Degree ◽  
Model Drug ◽  
Thawing Procedure

The influence of aluminosilicates on the structure and drug release profiles of polyvinyl alcohol (PVA) - halloysite (HNT) hydrogels containing acetylsalicylic acid (ASA) as a model drug was monitored. The hydrogels were synthesized using a three cycle freeze - thawing procedure and were characterized by FTIR, XRD and SEM. The swelling degree and cytotoxicity were also determined. All hydrogels properties were influenced by HNT concentration from the polymer matrix. The release of ASA, from PVA - HNT hydrogels was monitored in the gastrointestinal tract conditions.

In Vitro Drug Release Activity from Core/Shell Electrospun MATS of sPLA-cPEG/GS and sPLA/CA-cPEG/GS

2012 ◽  
Vol 714 ◽  
pp. 263-270 ◽  
Author(s):  
Koravee Vichitchote ◽  
Poonsub Threepopnatkul ◽  
Supakij Suttiruengwong ◽  
Chanin Kulsetthanchalee
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Immersion Method ◽  
Electrospinning Technique ◽  
The Core ◽  
Buffer Solutions ◽  
Initial Release ◽  
Total Immersion ◽  
Core Section

In this research, the core-shell structured fiber was fabricated by coaxial electrospinning technique. A set of biodegradable polymers namely polylactic acid (PLA) and cellulose acetate (CA) were used as the shell material. Gentamicin sulfate (GS) as antimicrobial drug with polyethylene glycol (PEG) was used as the core structure. PEG formed the core section of the coreshell fibers for GS encapsulation.In-vitrodrug release activity of the core-shell fibers was determined by total immersion method in pH 7.4 phosphate buffer solutions (PBS). It was found that core-shell fibers sPLA-cPEG/GS exhibit higher initial release compared to that of core-shell fibers sPLA/CA-cPEG/GS.

scholarly journals Core/Shell Gel Beads with Embedded Halloysite Nanotubes for Controlled Drug Release

Coatings ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 70 ◽  
Author(s):  
Lorenzo Lisuzzo ◽  
Giuseppe Cavallaro ◽  
Filippo Parisi ◽  
Stefana Milioto ◽  
Rawil Fakhrullin ◽  
...  
Keyword(s):  
Drug Release ◽  
Coating Layer ◽  
Controlled Drug Release ◽  
Halloysite Nanotubes ◽  
Release Profile ◽  
Core Shell ◽  
Gel Beads ◽  
Relevant Effect ◽  
Hollow Cavity ◽  
Model Drug

The use of nanocomposites based on biopolymers and nanoparticles for controlled drug release is an attractive notion. We used halloysite nanotubes that were promising candidates for the loading and release of active molecules due to their hollow cavity. Gel beads based on chitosan with uniformly dispersed halloysite nanotubes were obtained by a dropping method. Alginate was used to generate a coating layer over the hybrid gel beads. This proposed procedure succeeded in controlling the morphology at the mesoscale and it had a relevant effect on the release profile of the model drug from the nanotube cavity.

scholarly journals Itraconazole Coated Super Paramagnetic Iron Oxide Nanoparticles for Antimicrobial Studies

2020 ◽  
Vol 10 (5) ◽  
pp. 6218-6225 ◽  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Iron Oxide Nanoparticles ◽  
Release Kinetics ◽  
Diffusion Method ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Drug Release Profile ◽  
The Core ◽  
Antimicrobial Studies

In this present study, Superparamagnetic Iron Oxide Nanoparticles (SPIONs) were produced using FeCl3 and FeCl2 which were reduced to iron oxides using NaOH and ammonia solution (chemical co-precipitation). These naked SPIONs were further fabricated to form drug laden core-shell for controlled drug release and delivery. The fabrication was achieved by subjugating the naked SPIONs for oleic acid functionalization, drug tagging (Itraconazole) and finally encapsulated with a microbial derived polyester namely Polyhydroxybutyrate (PHB). Every stage of fabrication was characterized by scanning electron microscopy (SEM). The core-shell produced was checked for drug release kinetics, antibacterial and antifungal activities. These synthesized core-shells were carrying the drug and showed a slow drug release profile. The antimicrobial studies against bacteria - Pseudomonas aeruginosa & Brevibacillus brevis and fungi - Candida albicans by diffusion method proved that the core-shells inhibited bacterial and fungal activity. Furthermore, the naked SPIONs was found to be a good contrasting agent in X-ray imaging.

Synthesis and Characterization of α-ZrP@CHI Drug Deliver System

2016 ◽  
Vol 16 (4) ◽  
pp. 3628-3631 ◽  
Author(s):  
Shiyong Yu ◽  
Xuechuan Gao ◽  
Renfei Zhang ◽  
Zhao Li ◽  
Zhibing Tan ◽  
...  
Keyword(s):  
Drug Release ◽  
Lamellar Structure ◽  
Structural Features ◽  
Release Time ◽  
Synthesis And Characterization ◽  
Controlled Synthesis ◽  
Delivery Vehicles ◽  
Model Drug ◽  
Prolonged Drug Release

This paper described the controlled synthesis and release properties of a new kind of multifunctional drug-release system which was prepared by encapsulation of zirconium bis-(monohydrogen orthophosphate) monohydrate (α-ZrP) with chitosan (CHI). As obtained the α-ZrP@CHI nanocomposites were found to possess the structural features of both α-ZrP and CHI. The release properties of the α-ZrP@CHI nanocomposites were evaluated using Gentamicin sulfate as the model drug. And α-ZrP@CHI composites showed a prolonged drug release time compared with α-ZrP, which can be attributed to the unique lamellar structure and the encapsulation with CHI. The controlled synthesis of α-ZrP@CHI nanocomposite thus provided a new opportunity for future development of delivery vehicles.

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