Cholera Outbreak in Hadhramout, Yemen: The Epidemiological Weeks 2019

Background and aims: Cholera is a disease of acute watery diarrhea caused by Vibrio cholerae usually transmitted through contaminated water. In this study, we collected and analyzed the related epidemiological data to determine cholera outbreak in Hadhramout, Yemen during the disease epidemic in 2019. Methods: A cross-sectional study was conducted according to screening rapid diagnostic and confirmatory laboratory culture testing methods for diagnosing clinically cholera cases. Results: Suspected cholera cases were tested by rapid diagnostic test (RDT) and 399 (50.5%) out of 794 cases were determined positive, and 76(9.6%) of them were confirmed by laboratory culture test (LCT) with statistically significant difference. Serotype V. cholerae O1 was also detected in patients’ diarrhea. Females were the most affected by the disease manifested in 201 (25.3%) and 43 (5.4%) when tested by RDT and LCT, respectively, with no statistically significant difference. The highest proportion of cholera cases (224) were reported in the age group less than 15 years (56.1%) with statistically significant difference when tested by RDT, and 45(13.3%) when tested by LCT with insignificant statistics difference. Hajr directorate was revealed to be the most affected with 242 (30.47%) followed by Mukalla city directorate with 108 (13.60%) when the cases were tested by RDT; while Hajr and Mukalla city directorates reported 55 (7.0%) and 15 (2.0%), respectively, when it was confirmed by LCT with a statistically significant difference. Conclusion: Severe cholera outbreak occurred during the epidemiological weeks in 2019 in Hadhramout coast. V. cholerae O1 serotype was the causative agent of cholera. Females and age group less than 15 years were the most affected by the disease. Hajr and Mukalla city directorates reported serious outbreak cholera cases.

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Genotyping and Clinicoepidemiological Characterization of Rotavirus Acute Gastroenteritis in Egyptian Children

Polish Journal of Microbiology ◽

10.5604/17331331.1227669 ◽

2016 ◽

Vol 65 (4) ◽

pp. 433-442 ◽

Cited By ~ 7

Author(s):

Niveen Saudy ◽

Walaa Othman Elshabrawy ◽

Ahmed Megahed ◽

Mona F. Foad ◽

Aly F. Mohamed

Keyword(s):

Acute Gastroenteritis ◽

Nile Delta ◽

Epidemiological Data ◽

Cross Sectional Study ◽

Watery Diarrhea ◽

Cross Sectional ◽

Egyptian Children ◽

Significant Difference ◽

Group A ◽

Autumn And Winter

Group A rotavirus (RVA) acute gastroenteritis (AGE) is a common cause of severe childhood diarrhea. The dominant circulating RVA genotypes in a given region may vary between and within the geographic regions and from year to year. Our cross-sectional study was designed to determine the burden of RVA genotypes among children with AGE admitted to referral Children Hospital at Egypt prior to implementation of the vaccine. Stool samples with clinico-epidemiological data were collected from 92 children ≤3 years-old with AGE. RVA G and P typing were performed with type-specific primers. RVA was detected in 48.9% of patients. Higher rates of RVA infections, 73.3% were detected in infants <1 year-old. Breast-fed infants were significantly fewer in RVA positive group (P=0.0006). Non-breastfeeding was a major risk factor for RVA AGE (OR 0.3, P=0.02). RVA diarrhea occurred mostly in autumn and winter months (55.4% and 26.6%) with a significant difference in autumn (P=0.0005) and was associated with vomiting and dehydration (OR; 1.66, P=0.021 & 1.4, P=0.03). RVA genotypes G1P[8] (26.7%), G9P[8] (20%) and G3P[8] (15.6%) were accounting for 62.3% of RVA AGE. G9 was significantly associated with mucus diarrhea, than G1 or G3 which were associated with watery diarrhea (P=0.025). Also, G9 was significantly associated with loose stool for >5 days (P=0.006) and 54.4% of G9 patients had severe dehydration. The diversity of RVA strains detected in Nile Delta Egypt and emergence of G9 RVA highlight the need to apply vaccines against this genotype in Egypt.

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EFFICACY OF SACCHAROMYCES BOULARDII IN THE MANAGEMENT OF ACUTE WATERY DIARRHEA

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i2.3742 ◽

2021 ◽

Vol 71 (2) ◽

pp. 686-89

Author(s):

Sajid Ali Shah ◽

Misbah Baloch ◽

Saeed Zaman ◽

Lutfullah Goheer ◽

Sana Bushra ◽

...

Keyword(s):

Cross Sectional Study ◽

Saccharomyces Boulardii ◽

Watery Diarrhea ◽

Military Hospital ◽

Control Group ◽

P Value ◽

Cross Sectional ◽

Reduced Frequency ◽

Acute Watery Diarrhea ◽

Significant Difference

Objective: To determine the Efficacy of probiotic (saccharomyces boulardii) in children (2 months to 5 years) with acute watery diarrhea. Study Design: Comparative cross sectional study. Place and Duration of Study: This study was carried out in the department of pediatrics, Combined Military Hospital, Quetta, from Jan 2017 to Jun 2018. Methodology: All children (2 months to 5 years) with acute watery diarrhea presenting within 24 hour of illness with no dehydration and some dehydration were enrolled and divided into two groups, study group and control group. Efficacy was assessed by reduced frequency of stools(less than 3 per day) and duration during the study period. Results: Mean age of the children in probiotic saccharomyces boulardii group was 3.42 ± 1.36 years, while mean age in control group was 3.91 ± 1.16 years (p-value 0.002). Significant difference was also observed in duration of stool and frequency of stool at day 1-5 (p-value <0.05). Statistically significant difference was observed among children in probiotic sacchramyces boulardii group 114 (53%) as compared to controls 101 (47%) (p-value 0.021). Conclusion: The Efficacy of probiotic (saccrharomyces boulardii) was found satisfactory in children (2 months to 5 years) with acute watery diarrhea. In children with acute watery diarrhea saccrharomyces boulardii may be recommended for better outcome.

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Assessment of COVID-19 Related Misinformation among the Community in Basrah, Iraq

Iraqi National Journal of Medicine ◽

10.37319/iqnjm.2.csi.2 ◽

2020 ◽

Vol 2 (CSI) ◽

pp. 12-18

Author(s):

Ali Al-Rubaye ◽

Dhurgham Abdulwahid ◽

Aymen Albadran ◽

Abbas Ejbary ◽

Laith Alrubaiy

Keyword(s):

Cross Sectional Study ◽

Bachelor's Degree ◽

Public Knowledge ◽

Age Group ◽

Cross Sectional ◽

Educational Levels ◽

The Public ◽

First Case ◽

Significant Difference ◽

Central District

Background: There has been a rapid rise in cases of COVID-19 infection and its mortality rate since the first case reported in February 2020. This led to the rampant dissemination of misinformation and rumors about the disease among the public. Objectives: To investigate the scale of public misinformation about COVID-19 in Basrah, Iraq. Methods: A cross-sectional study based on a 22-item questionnaire to assess public knowledge and understanding of information related to the COVID-19 infection. Results: A total of 483 individuals completed the questionnaire. The most frequent age group was 26–35 years (28.2%); there were 280 (58%) males and 203 (42%) females. Of the participants, 282 (58.4%) were with an education level below the Bachelor’s degree, 342 (70.8%) were married, and 311 (64%) were living in districts in Basra other than the central district. Overall, 50.8% (11.8/ 22 * 100%) of individuals had the correct information regarding COVID-19. There was a significant association between the level of COVID-19 related misinformation and participants’ educational levels and occupation (p <0.05). However, there was no significant difference found across sex, age group, marital state, and area of residence. Conclusions: Misinformation related to COVID-19 is widely spread and has to be addressed in order to control the pandemic. Keywords: COVID-19, misinformation, knowledge, Iraq

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The Incidence of Surgical Site Infection in Acute Non Perforated Appendicitis

Journal of Chitwan Medical College ◽

10.3126/jcmc.v9i2.24525 ◽

2019 ◽

Vol 9 (2) ◽

pp. 11-14

Author(s):

Suraj Raj Bhattarai ◽

Kishor Kumar Tamrakar

Keyword(s):

Single Dose ◽

Surgical Site Infection ◽

Perforated Appendicitis ◽

College Teaching ◽

Cross Sectional Study ◽

Age Group ◽

Site Infection ◽

Cross Sectional ◽

Significant Difference ◽

Group Sex

Background: Appendectomy is the most commonly performed emergency surgical procedure and has significant morbidity of surgical site infection (SSIs). Regarding this, there are conflicting reports and dilemma on use of optimal duration of antibiotics. The aim of this study was to evaluate the incidence of SSIs after three doses of perioperative prophylactic antibiotics (single dose before surgery and two doses postoperatively) after appendectomy in acute non- perforated appendicitis (NPA). Methods: This cross sectional study was conducted in the department of General surgery, Chitwan Medical College Teaching Hospital, from May 2018 to April 2019. All the cases received single dose of antibiotics (ceftriaxone and metronidazole) during the induction of anesthesia and two doses of the same antibiotics postoperatively within 24 hours. SSIs was assessed on 2nd and followed up till 7th postoperative day. The data collected was analyzed using SPSS version 16. Results: In the study of 100 patients, who received perioperative three doses of antibiotics, the overall frequency of SSIs on 2nd and 3rd post-operative day were 2% (p=.840) and 6% (p=.539) respectively, which was statistically not significant. In follow up after 3rd postoperative day, there was no evidence of SSIs. Statistically there was no significant difference in the incidence and grade of SSIs between age group, sex and duration of operation. Conclusions: A combined three doses of perioperative antibiotics was adequate for SSIs prevention in patients of any age group and sex with acute NPA after appendectomy in usual operative time.

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1491. Active Norovirus Surveillance in Children Under 5 Years with Diarrhea after Rotavirus Vaccine Introduction in Argentina (2017–2019)

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1355 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S543-S543

Author(s):

Angela Gentile ◽

Juan Stupka ◽

Juan I Degiuseppe ◽

María del Valle Juárez ◽

Maria Florencia Lucion ◽

...

Keyword(s):

Acute Diarrhea ◽

Epidemiological Data ◽

Cross Sectional Study ◽

Epidemiological Surveillance ◽

Watery Diarrhea ◽

Rotavirus Vaccine ◽

Cross Sectional ◽

Vaccine Introduction ◽

Rotavirus Vaccination ◽

Children Under 5

Abstract Background Acute diarrhea is one of the leading causes of infant morbidity and mortality. Argentina introduced massive rotavirus vaccination in 2015. In several countries, this introduction has changed the distribution of enteropathogens. The decrease in the prevalence of rotavirus has been described at the expense of an increase in Norovirus (NoV) activity worldwide. The aim of this study was to analyze the role of NoV in acute diarrhea cases in outpatient children under 5 years of age and their epidemiological profile. Methods A prospective and cross-sectional study in <5 years outpatients attended for acute diarrhea in Children’s Hospital “Dr. Ricardo Gutiérrez” in Buenos Aires, Argentina, between July 2017 and March 2019 was conducted. Active epidemiological surveillance was performed with a specific case reporting form. Stool samples were tested for NoV (RT-qPCR). Clinical and epidemiological data were recorded. Results A total of 252 patients were enrolled and 235 stools samples were tested. Median of age was 22.3 months (IQR: 11–30), 58.7% were male. The most frequent symptoms were fever and vomiting in 63.1% and 53%, respectively; 52% had watery diarrhea, 45.2% had moderate diarrhea according to Vesikari Scale, 95.6% were normohydrated and 22% had a household member with diarrhea. There were no immunocompromised children. A 72% had received rotavirus vaccine, 86% of them with full scheme. From samples tested, 27% (n = 63) were NoV positive. NoV was found throughout the year and the frequency of detection was higher in January and June (summer and winter in Argentina). Regarding genetic diversity the most frequent genogroup was GII (65%; 41/63) and genotype GII.P16-GII.4 Sydney (48%; 20/41). Bacterial co-infection was observed in 35%. Compared with negative cases, NoV were younger (18 vs. 20 months; P < 0.001) and were associated with higher prevalence of rotavirus vaccination (88% vs. 66%; P = 0.001). No statistically difference was found regarding to gender, clinical outcome and severity. Conclusion NoV was detected at high frequency (27%) in children presenting moderate acute diarrhea, mainly in those who received rotavirus vaccine. Regarding sporadic acute diarrhea cases in children, it is important to consider NoV as a frequent etiological agent. Disclosures All authors: No reported disclosures.

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COVID-19 Cluster in School: A Study on Epidemiology and Clinical Manifestations among Cases from Rengas Cluster in Perak, Malaysia

Borneo Epidemiology Journal ◽

10.51200/bej.v2i2.3633 ◽

2021 ◽

Vol 2 (2) ◽

pp. 125-134

Author(s):

Syahrizal Abdul Halim ◽

Nor Azila Muhd Aris ◽

Muhammad Zikri Fadzil ◽

Husna Maizura Ahmad Mahir

Keyword(s):

Clinical Manifestations ◽

Movement Control ◽

Epidemiological Data ◽

Cross Sectional Study ◽

Effective Control ◽

Age Group ◽

District Health ◽

Cross Sectional ◽

Notification System ◽

Co Morbidity

Background: A COVID-19 cluster named as Rengas Cluster was declared on 6th November 2020 after nine students from a boarding school in Padang Rengas, Perak diagnosed as positive COVID-19. Risk assessment was conducted and Targeted Enhanced Movement Control Order (TEMCO) was enforced at the school to contain the viral transmission. An investigation was carried out to analyze epidemiological data, clinical manifestations among cases and effect of TEMCO on this cluster. Methods: A retrospective cross-sectional study was conducted from 2nd August 2021 until 3rd September 2021 using data that obtained from Kuala Kangsar District Health Office Crisis Preparedness and Response Centre (CPRC) Surveillance System through e-COVID notification system. The variables used in this current study include socio-demographic and clinical characteristics that include age group, gender, occupation, co-morbidities, symptoms and signs. Results: There were 132 cases out of 324 exposed populations whereby most cases were students (87.9%) and aged between 11 and 20 years old (84.8%). More than half of cases were female (57.6%) with only one case had existing co-morbidity. Majority of cases were asymptomatic (64.4%). Those symptomatic mainly presented with cough (66%) and the strongest significant positive correlation were observed between anosmia and ageusia (r = 0.807, n = 47, p < 0.001). There was no significant association between age group and development of symptoms [χ2 (6, N = 132) = 6.014, p > 0.05]. An abrupt decline in number of cases was observed following TEMCO enforcement. Conclusion: COVID-19 cases in Rengas Cluster were mostly among young students, asymptomatic and mildly symptomatic. This cluster was timely and effectively controlled by TEMCO enforcement which contributed towards early diagnosis, isolation and treatment for more effective control and preventive measures.

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Perfil de usuários e motivos da consulta de enfermagem em estomaterapia

Revista de Enfermagem UFPE on line ◽

10.5205/1981-8963.2020.245710 ◽

2020 ◽

Vol 14 ◽

Author(s):

Rosaura Soares Paczek ◽

Andreia Inês Engelmann ◽

Giulia Pedroso Perini ◽

Glória Pinto Soares de Aguiar ◽

Erica Rosalba Mallmann Duarte

Keyword(s):

Medical Records ◽

Self Care ◽

Cross Sectional Study ◽

Study Data ◽

Neoplastic Disease ◽

Age Group ◽

Cross Sectional ◽

Significant Difference ◽

Quantitative Descriptive ◽

Care Nursing

Objetivo: analisar o perfil de usuários e os motivos da consulta de enfermagem em estomaterapia. Método: trata-se de um estudo quantitativo, descritivo, exploratório e transversal. Coletaram-se os dados em prontuários de 252 usuários nos quais foram consultados em 1116 consultas de enfermagem. Analisaram-se os dados pelo programa SPSS versão 20, empregando-se a estatística descritiva. Resultados: revela-se, quanto ao sexo, que não houve diferença significativa; quanto à faixa etária, 53,6% dos participantes tinham 65 anos ou mais de idade; a causa do estoma foi a doença neoplásica maligna em 65,5% da amostra; o motivo da consulta, em 56%, foi a troca de bolsa de ostomia e 50,4% dos pacientes realizaram somente uma consulta no período analisado. Conclusão: mostrou-se, que o enfermeiro estomaterapeuta precisa refletir no planejamento e nas estratégias de cuidados prestados, contemplando a educação do autocuidado do usuário e educação permanente da equipe, enfatizando a sensibilidade do acolhimento, visto que a maioria dos pacientes tem neoplasia maligna, situação de grande impacto na vida do usuário e de sua família. Descritores: Estomia; Consulta de Enfermagem; Educação Permanente; Estomaterapia; Autocuidado; Cuidados de Enfermagem.AbstractObjective: to analyze the profile of users and the reasons for the nursing consultation in stomatherapy. Method: this is a quantitative, descriptive, exploratory and cross-sectional study. Data was collected from medical records of 252 users, who were consulted in 1116 nursing consultations. Data was analyzed using the SPSS version 20 program, using descriptive statistics. Results: it is revealed, as for sex, that there was no significant difference; as for the age group, 53.6% of the participants were 65 years old or older; the cause of the stoma was malignant neoplastic disease in 65.5% of the sample; the reason for the consultation, in 56%, was to change the ostomy bag and 50.4% of the patients had only one consultation during the analyzed period. Conclusion: it was shown that the stoma nurse needs to reflect on the planning and care strategies provided, contemplating the education of the user's self-care and permanent education of the team, emphasizing the sensitivity of the welcoming, since the majority of patients have malignancy, situation of great impact on the life of the user and their family. Descriptors: Ostomy; Nursing Consultation; Education Continuing; Stomatherapy; Self Care; Nursing Care.ResumenObjetivo: analizar el perfil de los usuarios y los motivos de la consulta de enfermería en estomaterapia. Método: se trata de un estudio cuantitativo, descriptivo, exploratorio y transversal. Se recopilaron datos de registros médicos de 252 usuarios, que fueron consultados en 1116 consultas de enfermería. Los datos se analizaron utilizando el programa SPSS versión 20, utilizando estadísticas descriptivas. Resultados: se revela, en cuanto al sexo, que no hubo diferencia significativa; en cuanto al grupo de edad, el 53,6% de los participantes tenían 65 años o más; la causa del estoma fue la enfermedad neoplásica maligna en el 65.5% de la muestra; el motivo de la consulta, en el 56%, fue cambiar la bolsa de ostomía y el 50,4% de los pacientes tuvieron una sola consulta durante el período analizado. Conclusión: se demostró que el enfermero de estomas necesita reflexionar sobre la planificación y las estrategias de atención provistas, contemplando la educación del autocuidado del usuario y la educación permanente del equipo, enfatizando la sensibilidad de la recepción, ya que la mayoría de los pacientes tienen neoplasia maligna, situación de gran impacto en la vida del usuario y su familia. Descriptores: Estomia; Consulta de Enfermería; Educación Permanente; Estomaterapia; Autocuidado; Cuidados de Enfermería.

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Comparison of Anxiolytic Drugs of Diazepam and Zolpidem in Patients Undergoing Extraction

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2020/v32i1830701 ◽

2020 ◽

pp. 178-187

Author(s):

Anupama Deepak ◽

Dhanraj Ganapathy ◽

Visalakshi Ramanathan

Keyword(s):

Rating Scale ◽

Extraction Procedure ◽

Cross Sectional Study ◽

Age Group ◽

Cross Sectional ◽

Significant Difference ◽

Anxiolytic Drugs ◽

The Central Nervous System ◽

Hamilton Anxiety Rating Scale ◽

Anxiety Levels

Anxiolytic drugs are a class of drugs that reduce the anxiety levels in the individuals by nonspecifically binding to the GABAα located throughout the central nervous system. The aim of this study was to compare the anxiolytic effects of diazepam and Zolpidem in patients undergoing extraction. This was a cross-sectional study conducted at a university setting, with a sample size of 100 patients, of the age group 25-45 years. 50 patients were administered with Tab. Diazepam and 50 patients with Tab. Zolpidem one hour before the surgical procedure. The Hamilton Anxiety Rating Scale (HAM-A Scale) was used to record the patient's anxiety levels before and during the extraction procedure. These data were then recorded in MS Excel Sheet and imported to SPSS for statistical analysis. From this study, it can be seen that most of the patients were females and mainly between the age group 25-35 years. Diazepam had significantly lesser post sedation anxiety levels in comparison with its post sedation levels than zolpidem with, a statistically significant difference (p<0.001). Therefore, it can be concluded that diazepam had better post sedation effects than zolpidem in patients undergoing extraction as patients presented with lesser severity in their anxiety levels.

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Degree Of Proteinuria In Post-Icteric State Of Hepatitis E Virus (Hev) Infected Patients

Journal of Armed Forces Medical College Bangladesh ◽

10.3329/jafmc.v7i2.10395 ◽

2012 ◽

Vol 7 (2) ◽

pp. 37-39

Author(s):

W Nargis ◽

BU Ahamed ◽

S Zabeen ◽

F Alam ◽

MA Wahab ◽

...

Keyword(s):

Hepatitis E Virus ◽

Hepatitis E ◽

Cross Sectional Study ◽

Urinary Protein ◽

Age Group ◽

Cross Sectional ◽

Group I ◽

Significant Difference ◽

The Mean ◽

Group Ii

Introduction: Nephropathies, as one of the multiple extrahepatic features of Hepatitis E virus (HEV) infection, can occur in clinically improved HEV hepatitis patients which in majority of the cases remain clinically silent for a long period. By the time these are reported, patients have already developed renal insufficiency which may even lead to renal replacement therapy. Proteinuria, a simple test in practice, can be a useful tool for early detection of the underlying renal impairment. Objective: The aim of this study was to detect the presence of proteinuria and to evaluate the degree of proteinuria in HEV- hepatitis patients during post-icteric state. Materials and Methods: This cross sectional study was conducted on 50 diagnosed patients of clinically improved HEV-hepatitis at the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University (BSMMU) with active cooperation of the Department of Hepatology, BSMMU, between July 2006 and June 2007. Cases were chosen carefully, to exclude the acute state of illness and the patients of HEV were selected during their third or fourth follow-up, in their post-icteric phase. The study subjects were grouped according to equal age ranges in group-I (18-26 year) and group-II (27-35 year). Depending on the level of spot urinary protein (mg/dl) the subjects were also categorized as having trace, mild and moderate proteinuria. Results: The mean age of HEV infected subjects was 24.72±2.59 years. The mean spot urinary protein in age group-II patients was raised compared to age group-I and the difference was highly significant (p<0.001). Moreover, there was no significant difference (p>0.05) of spot urinary protein of male and female. Majority of HEV patients (42%) presented with mild proteinuria and mostly (53.3%) was of age group-I. Conclusion: Spot urinary protein concentration should be checked in every HEV- hepatitis patient to detect the presence and level of proteinuria. DOI: http://dx.doi.org/10.3329/jafmc.v7i2.10395 JAFMC 2011; 7(2): 37-39

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CO-St (COVID 19- study): impact of the management of men versus women in the treatment of Covid 19. A Multi-Centric Observational study

10.20944/preprints202108.0119.v1 ◽

2021 ◽

Author(s):

Tiziana Ciarambino ◽

filomena pietrantonio ◽

Sara Rotunno ◽

Alessandra Fiorentini ◽

Rosalba Cipriani ◽

...

Keyword(s):

Oxygen Therapy ◽

Signs And Symptoms ◽

Epidemiological Data ◽

Cross Sectional Study ◽

Antiviral Drugs ◽

Laboratory Findings ◽

Cross Sectional ◽

Significant Difference ◽

Rehabilitation Ward ◽

Epidemiological Link

Background: from December 2019 and the spreading of syndemics, a lot of medical centers reg-istered data about their patients. In Italy, the most relevant quantity of patients was hospitalized in internal medicine wards. Methods: In this observational, retrospective cross-sectional study, all data of the COVID-19 patients, admitted Latio hospitals, from March 01 to December 31, 2020, were collected and their Epidemiological data, demographics, signs and symptoms on admission, comorbidities, laboratory findings, chest radiography and CT findings, treatment received and mortality rate were analyzed by gender to find any differences of gravity of disease. Clinician details were registered on database (one for every hospital). Cost analysis was performed by length of stay and antiviral drugs use, using point of view of Italian Healthcare System. Results: 2256 patients with mean age of 71.01 ± 28.02 years were included. For men, frequency of hyper-tension, COPD, use of oxygen therapy, Tocilizumab were significantly higher and epidemiolog-ical link was related to rehabilitation ward and community. The gender difference about hospi-talization was one day more for man. No strong significant difference by gender in the death rate was observed. Considering antiviral drugs and hospitalization, a man costs €1000 more than woman. Conclusions: In male patients, hypertension and COPD were observed more frequently and the epidemiological link was related to rehabilitation ward and community. In female sub-jects, the epidemiological link was related to Hospital and we observed significantly higher atypical chest-X ray. Tocilizumab, oxygen therapy and antiviral drugs were prescribed more in male subjects. No differences by gender we report in other treatments and outcomes. Future studies should be analyzed to get a more comprehensive understanding of COVID-19 by gender.

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