This review refers to the all-inclusive details of Lorcaserin Hydrochloride on comprehensive
information about the synthesis, analytical methods, pharmacodynamics, pharmacokinetics, drug interactions
and adverse effects. Lorcaserin Hydrochloride is chemically (R)-8-Chloro-1-methyl-2,3,4,5-
tetrahydro-1H-3-benzazepine hydrochloride. Lorcaserin HCl is a novel, synthetic, centrally-acting selective
serotonin C (5-HT2c) receptor, l agonist, which results in increased satiety and decreased food
consumption in patients. Headache, dizziness and nausea are the most common side effects associated
with this drug. Lorcaserin HCl has two major metabolites, one conjugated with glucuronide called
N-carbamoyl glucuronide which is excreted in urine and the second Lorcaserin N-sulfamate, which is
circulated in the blood. Lorcaserin HCl is synthesized using four different schemes of which a six-step
method that resulted in 92.3% yield with 99.8% of purity is employed for scale-up production. It is analyzed
quantitatively in the plasma and brain tissue matrix of rats by Ultra Performance Liquid chromatographic
(UPLC) method using MS-MS (Mass Spectrometric) detection.