RESEARCH ON THE LONG-TERM EFFECTS OF THE CARBOHYDRATE-VITAMIN-MINERAL CONCENTRATE “LIZUNETS SOLEVIT”

2020 ◽  
Vol 15 (8) ◽  
pp. 1147-1153
Author(s):  
D.D. Khayrullin ◽  
Keyword(s):  
Aqueous Suspension ◽  
Animal Husbandry ◽  
The Body ◽  
Control Group ◽  
Long Term Effects ◽  
Rat Pups ◽  
White Rats ◽  
Production Increase ◽  
Different Doses

The main factors constraining the development of animal husbandry is a weak fodder base, due to insufficient supply of nutrients; the costs of its production increase and becomes the cause of metabolic disorders in animals. The aim of our research was to study the embryotoxic and teratogenic effect of the new CVMC “Lizunets-Solevit” on white rats. For this reason, the drug was administered to pregnant females in the form of an aqueous suspension in different doses for 19 days. By the end of the study, no visible signs of fetal abnormalities were found after autopsy of the experimental rats. There was no significant increase in the number of corpus luteum compared with the control group at 1/10 dose by 1.1% and 1/20 dose by 1.95%, respectively. The preimplantation death of zygotes was taken into account on the embryotoxic effect of the drug, in comparison with the control group at a dose of 1/10 more by 19.7%, and at a dose of 1/20 less by 6.23%. The total embryonic mortality is higher in the experimental groups of animals by 12.69% and 3.74% than in the control. Post-implantation death of embryos in the control group was 4.99%, in the experimental 1/10 dose - 4.69% and in the experimental 1/20 dose - 6.66%. In terms of physiological development, the rat pups of the experimental groups did not differ from the control. Thus, it was found that CVMC “Lizunets-Solevit”, in doses of 1/10 and 1/20, has no embryotoxic and teratogenic effects in the body of white rats, their embryos and young animals of the neonatal and postnatal periods of life.

scholarly journals The toxicity of the technical product, derived triazolinones

2020 ◽  
Vol 64 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Valery N. Rakitskii ◽  
E.G. Chkhvirkiya ◽  
T.M. Epishina
Keyword(s):  
Body Weight ◽  
Hematological Parameters ◽  
Oral Intake ◽  
Total Activity ◽  
The Body ◽  
Male Rats ◽  
Control Group ◽  
Long Term Effects ◽  
Technical Product

Introduction. Technical products that are part of pesticides recommended for use in agriculture must undergo a comprehensive sanitary and Toxicological examination, which is the basis for preventing the adverse effects of pesticides on the health of workers and the population, as well as on the sanitary state of the environment. Purpose of research - the study of the biological effect of the technical product derived triazolinthionov, with its repeated oral intake in mammals (rats), justification of the permissible daily dose (DSD) for humans. Material and methods. Chronic (12 months) experiment was conducted on male rats with a body weight of 200-210 g tested doses: 5.0; 50.0 and 500.0 mg/kg body weight (1 control and 3 experimental groups and 20 individuals each). In the dynamics of the experiment, we observed the condition and behavior of animals, water and food consumption, fixed the timing of death, recorded changes in body weight, physiological, biochemical and hematological parameters. Results. It was found that the dose of 5.0 mg/kg body weight does not cause significant changes in all studied parameters, doses of 50.0 and 500.0 mg/kg body weight had a polytropic effect on the body of experimental animals. Discussion. The studied technical product at repeated intake in doses of 50,0 and 500,0 mg/kg of body weight causes changes in the state of the Central nervous system of animals (statistically significant changes in SPP, total activity, path length, rest time), as well as changes in carbohydrate, lipid, and lipoprotein metabolism in the body, as evidenced by statistically significant changes in biochemical and hematological indicators. Consequently, doses of 50,0 and 500,0 mg/kg of body weight have a polytropic effect on the body of male rats and are effective. The dose of 5.0 mg/kg of body weight, when administered in animals of the experimental group in comparison with animals of the control group, there are no changes in all the studied parameters throughout the experiment, is accepted as invalid. On the basis of an inactive dose of 5.0 mg/kg of body weight and a reserve factor of 100, we have scientifically justified DSD for humans at the level of 0.05 mg/kg. Conclusion. Studies have shown that long-term repeated oral administration of the studied product into the body of animals (male rats) at a dose of 5.0 mg per 1 kg of body weight does not cause statistically significant changes in all the studied parameters, so the indicated dose is invalid. Doses of 50,0 and 500,0 mg/kg MT have a polytropic effect on the body of male rats and are effective. DSD for humans at the level of 0.05 mg/kg is justified based on the inactive dose at the level of 5.0 mg per 1 kg of body weight, established in a 12-month chronic experiment conducted on male rats, and the reserve coefficient of 100 (taking into account the unexpressed specific and long-term effects).

Long-term effects of two sizes of surgically implanted acoustic transmitters on a predatory marine fish (Pomatomus saltatrix)

2009 ◽  
Vol 60 (2) ◽  
pp. 183 ◽  
Author(s):  
Eva B. Thorstad ◽  
Sven E. Kerwath ◽  
Colin G. Attwood ◽  
Finn Økland ◽  
Christopher G. Wilke ◽  
...  
Keyword(s):  
Growth Rate ◽  
Specific Growth Rate ◽  
Specific Growth ◽  
The Body ◽  
Control Group ◽  
Fish Behaviour ◽  
Long Term Effects ◽  
Pomatomus Saltatrix ◽  
Tag Retention

Fish telemetry is increasingly used to study fish behaviour in marine systems and it is crucial that the tagging does not affect fish behaviour and welfare negatively. Hence, the long-term effects of surgically implanted acoustic telemetry transmitters on survival, tag retention, healing and growth on Pomatomus saltatrix (known as tailor in Australia, elf in South Africa and bluefish in North America) were studied over 144 days. P. saltatrix are well suited for transmitter implants because no tagging-related short- or long-term mortality or transmitter expulsion was recorded. Small transmitters (9 × 28 mm, 3.3 g in water) did not affect the specific growth rate of tagged fish compared with an untagged control group. In contrast, the fish tagged with large transmitters (13 × 50 mm, 6.9 g in water) had a reduced specific growth rate. The small, but not the large transmitter, seemed suitable for tagging P. saltatrix of the body sizes represented in this study (215–621 g). The specific growth rate was negatively affected by increasing the transmitter-mass-in-water to body-mass ratio. It is recommended that this ratio should not exceed 1.4%.

scholarly journals Chronic toxicity of the Iron (IV) clathrochelate complexes for white rats

2019 ◽  
Vol 21 (95) ◽  
pp. 15-21
Author(s):  
V. B. Dukhnitsky ◽  
I. M. Derkach ◽  
S. S. Derkach ◽  
I. O. Fritsky ◽  
M. O. Plutenko
Keyword(s):  
Body Weight ◽  
Chronic Toxicity ◽  
Experimental Period ◽  
The Body ◽  
Control Group ◽  
Blood Biochemical ◽  
White Rats ◽  
Liver And Kidney ◽  
Clathrochelate Complexes

The article presents the results of studies of chronic toxicity of the Iron in the rare unconventional valence – IV. During long-term use of the Iron(IV) clathrochelate complexes for white rats we have established the dynamics of the body weight of rats, the relative coefficients of mass of the internal organs, the content of hemoglobin and morphological parameters of blood, biochemical parameters of blood serum of animals of this species. The daily drinking of solution of the Iron(IV) clathrochelate complexes at the doses of 500 and 1000 mg/kg b. w. resulted in a decrease in body weight, an increase in the relative indices of masses of liver and kidney, and a decrease in the relative indices of masses of  spleen and heart on 30th day. The hemoglobin content in the blood of rats of the experimental group was less than the control indicator by 3–47% (P < 0.05), which is evidence of inhibition of its synthesis under the influence of the Iron (IV) clathrochelatе. Changes in the morphological composition of the blood were characterized by marked leukocytopenia. The use of rats of a solution of the Iron (IV) clathrochelate complexes at doses of 500 and 1000 mg/kg b. w. caused the development of hypoproteinemia, hypercreatinemia and hyperurinemia. Iron(IV) clathrochelate complexes reduced alaninaminotransferase activity in the serum of rats of both experimental groups by 15–80% (P < 0.05); aspartataminotransferase activity increased significantly by day 10 and decreased by day 30; the activity of alkaline phosphatase was independent of the doses of the drug during the experimental period. The content of Calcium total, Phosphor inorganic and Iron in the serum of rats of the experimental groups was at the level of indicators in the animals of the control group. Consequently, comprehensive studies of the effects of solution of the Iron (IV) clathrochelate complexes at doses of 500 and 1000 mg/kg b. w. were performed for the first time with long-term administration to white rats, which revealed the main patterns of metabolic disorders and physiological functions.

scholarly journals EFFECT OF ETHANOL EXTRACT OF PICRIA FEL-TERRAE LOUR. LEAVES ON TRIGLYCERIDE AND CHOLESTEROL LEVELS OF WHITE RATS

2018 ◽  
Vol 11 (13) ◽  
pp. 243
Author(s):  
Urip Harahap ◽  
Marianne Marianne ◽  
Yuandani Yuandani ◽  
Hafiza Mitha Agustya ◽  
Dira Ummul Azizah ◽  
...  
Keyword(s):  
Triglyceride Level ◽  
Ethanol Extract ◽  
Control Group ◽  
Test Animal ◽  
Male And Female ◽  
Cholesterol Levels ◽  
White Rats ◽  
Group Extract ◽  
Different Doses

  Objective: The objective of the study was to evaluate the effect of Picria fel-terrae on triglyceride and cholesterol levels in long-term duration.Methods: The effect of ethanol extract of P. fel-terrae leaves was performed using white rats divided into several groups, which include control group, extract at doses of 125, 250, 500, and 1000 mg/kg body weight. The extract at different doses was orally administered to the test animal for 90 days. Then, the triglyceride and cholesterol levels were measured.Results: The ethanol extract of P. fel-terrae in long-term use did not affect the cholesterol level of male and female white rats. However, there was a significant increased in triglyceride level as compared to normal control (p<0.05).Conclusion: The ethanol extract of P. fel-terrae increased triglyceride level only without increasing the level of cholesterol.

The effects of liquids with different redox potential on caries and periodontitis

10.12737/6443 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Аджи ◽  
Yu. Adzhi ◽  
Енин ◽  
A. Enin ◽  
Брезднюк ◽  
...  
Keyword(s):  
Dental Caries ◽  
Redox Potential ◽  
Permanent Teeth ◽  
Control Group ◽  
Recovery Processes ◽  
Rat Pups ◽  
White Rats ◽  
Mucous Membranes ◽  
Prophylactic Use

The defeat of dental caries leads to premature loss of teeth and violates the chewing function, which affects the development of the dental system in the period of formation of permanent teeth and is the reason of the formation of anomalies of maxillofacial area. Materials and methods: 30 mature white rats of both sexes (with a mass 257-272 gr.) and 30 three-month-white rat pups (with a mass 87-92 gr.), having healthy teeth without pathological changes in tissues of the teeth and periodontitis. Results and discussion. 35-day observation in the experiment showed that the reduction of the area of caries was in 14 day – by 23%, 21 day – by 41%, at 28 days – 59%, 35 day – by 69% at the use a liquid with a positive redox potential. The remaining liquid didn’t cause changes in the dimensions of zones of caries in time. White rat pups were given oral liquids with negative redox potential during 8 weeks and the subsequent 30-days sucrose-lactose diet, the defeat of dental caries was only 3% (in the control group – 86%). In the paper the authors suggest that liquid with positive and negative redox potential doesn’t have a damaging effect on the mucous membrane of the mouth cavity and the hard tissue of teeth, but they optimize recovery processes at the chronic generalized periodontitis average degree. Liquid with negative redox potential reduces degree of the dental defeat during long-term prophylactic use and activates the healing of the injured mucous membranes of the oral cavity. The liquid with a positive redox potential stimulates the recovery processes in experimental caries.

scholarly journals Long-term effects of premature birth on somatic development in women through adolescence and adulthood

2017 ◽  
Vol 46 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Katarzyna Kaczmarczyk ◽  
Aleksandra Pituch-Zdanowska ◽  
Ida Wiszomirska ◽  
Andrzej Magiera ◽  
Aleksander Ronikier
Keyword(s):  
Preterm Birth ◽  
Bioelectrical Impedance ◽  
The Body ◽  
Control Group ◽  
Long Term Effects ◽  
Anthropometric Parameters ◽  
Somatic Development ◽  
Waist Hip Ratio ◽  
Preterm Born

Objectives To evaluate the long-term consequences of preterm birth on anthropometric parameters in women in adolescence and into adulthood. Methods Seventy girls born preterm (age 12.22 ± 1.52 years) and 48 born at term participated in the first stage. Eighteen years later, 13 of the same women participated in a follow-up and were compared with a control group of 27 women. We compared anthropometric results across the two examinations, and in the second stage, also assessed body composition using bioelectrical impedance analysis. Results No significant differences were found in anthropometric parameters or the content of individual components of the body between the preterm-born and control groups. However, the preterm-born group showed a tendency for higher average fat mass and lower fat-free and soft lean mass compared with the control group, and had a significantly higher mean waist–hip ratio. Conclusions Preterm birth does not adversely affect somatic development in girls during adolescence, but shows a correlation with an elevated waist–hip ratio in adulthood.

The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽  
2005 ◽  
Vol 34 (4) ◽  
pp. 243-249 ◽  
Author(s):  
Drinda ◽  
Neumann ◽  
Pöhlmann ◽  
Vogelsang ◽  
Stein ◽  
...  
Keyword(s):  
Laser Doppler Flowmetry ◽  
Raynaud’S Phenomenon ◽  
Raynaud's Phenomenon ◽  
Plasma Viscosity ◽  
Laser Doppler ◽  
Erythrocyte Aggregation ◽  
Control Group ◽  
Long Term Effects ◽  
Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

scholarly journals A Clinical Study of Platelet-Rich Fibrin Combined With Autologous High-Density Fat Transplantation in Augmentation Rhinoplasty

2021 ◽  
pp. 014556132110169
Author(s):  
Dan Yan ◽  
Shuai-Hua Li ◽  
An-Li Zhang ◽  
Yao Xiao ◽  
Ze-Chun Huang
Keyword(s):  
Retention Rate ◽  
Statistical Significance ◽  
High Density ◽  
Control Group ◽  
Long Term Effects ◽  
Fat Transplantation ◽  
Augmentation Rhinoplasty ◽  
Platelet Rich Fibrin ◽  
Autologous Fat

Objective: This study was designed to analyze the clinical effect of autologous fat-granule transplantation in augmentation rhinoplasty and explore methods to improve the fat retention rate. Methods: A total of 70 enrolled patients were randomly divided into 2 groups: the platelet-rich fibrin (PRF) combined with high-density fat transplantation group (combined group) and the conventional fat-granule transplantation group (control group; n = 35 in each group). In the combined group, an appropriate amount of autologous fat was extracted and centrifuged, and the lower layer of high-density fat was taken and mixed with PRF isolated from whole blood for autotransplantation. In the control group, only fat was extracted and centrifuged for transplantation. The patients were followed up with for more than one year to observe the short- and long-term effects, complications, safety, and patient satisfaction. Results: Six months after the operation, the nasal shape was stable, the contour was higher and more stereoscopic than before, the average increase of nasal height was 3.0 mm in the combined group and 2.0 mm in the control group. No complications, such as fat embolism, infection, or necrosis occurred during the 1-year follow-up. The satisfaction rate between the 2 groups has statistical significance ( P < .05). Conclusion: Overall, PRF combined with autologous high-density fat transplantation is simple to perform, has a significantly increased fat-retention rate than the control group, and has stable long-term effects without obvious adverse reactions. A sufficient amount of fat and PRF transplantation can achieve a good orthopedic effect. Thus, this method can be widely used in clinical augmentation rhinoplasty.

scholarly journals Antibiotics at birth and later antibiotic courses: effects on gut microbiota

2021 ◽  
Author(s):  
Sofia Ainonen ◽  
Mysore V Tejesvi ◽  
Md. Rayhan Mahmud ◽  
Niko Paalanne ◽  
Tytti Pokka ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Control Group ◽  
List Type ◽  
Antibiotic Exposure ◽  
Microbiota Composition ◽  
Long Term Effects ◽  
The Impact ◽  
Antibiotic Courses ◽  
Gut Microbiota Composition

Abstract Background Intrapartum antibiotic prophylaxis (IAP) is widely used, but the evidence of the long-term effects on the gut microbiota and subsequent health of children is limited. Here, we compared the impacts of perinatal antibiotic exposure and later courses of antibiotic courses on gut microbiota. Methods This was a prospective, controlled cohort study among 100 vaginally delivered infants with different perinatal antibiotic exposures: control (27), IAP (27), postnatal antibiotics (24), and IAP and postnatal antibiotics (22). At 1 year of age, we performed next-generation sequencing of the bacterial 16S ribosomal RNA gene of fecal samples. Results Exposure to the perinatal antibiotics had a clear impact on the gut microbiota. The abundance of the Bacteroidetes phylum was significantly higher in the control group, whereas the relative abundance of Escherichia coli was significantly lower in the control group. The impact of the perinatal antibiotics on the gut microbiota composition was greater than exposure to later courses of antibiotics (28% of participants). Conclusions Perinatal antibiotic exposure had a marked impact on the gut microbiota at the age of 1 year. The timing of the antibiotic exposure appears to be the critical factor for the changes observed in the gut microbiota. Impact Infants are commonly exposed to IAP and postnatal antibiotics, and later to courses of antibiotics during the first year of life. Perinatal antibiotics have been associated with an altered gut microbiota during the first months of life, whereas the evidence regarding the long-term impact is more limited. Perinatal antibiotic exposure had a marked impact on the infant’s gut microbiota at 1 year of age. Impact of the perinatal antibiotics on the gut microbiota composition was greater than that of the later courses of antibiotics at the age of 1 year.

Significance of graded doses of aqueous seed extract of Moringa oleifera (L) on live body weight, gonadal, extragonadal dimensions and sperm reserves of Yankasa rams

2021 ◽  
pp. 33-40
Keyword(s):  
Body Weight ◽  
Moringa Oleifera ◽  
Seed Extract ◽  
The Body ◽  
Control Group ◽  
Live Body Weight ◽  
And Control ◽  
Standard Techniques ◽  
Different Doses ◽  
Apparently Healthy

The aim of the study was to investigate the effects of Moringa oleifera aqueous seed extract on live body weight, gonadal and extragonadal dimensions and sperm reserves of Yankasa rams. Twenty five apparently healthy Yankasa rams aged 1-2 years and weighing 19.0 ± 2.1 Kg were used for the study. The rams were randomly selected into five groups: A, B, C, D and E with five rams in each group as treatment and control groups respectively. Groups A - D were given oral dose of Moringa oleifera aqueous seed extract at a dose rate of 1000, 2000, 3000, 4000 (mg/kg), respectively while group E was given 10 ml/kg water orally, daily for five months. Live body weight, gonadal and extragonadal reserves were determined according to standard techniques. The results showed a significant increase in live body weight in the months of April to June among rams treated with different doses of Moringa oleifera aqueous seed extract compared with the control group. The control group showed no significant differences in the body weight, gonadal and extragonadal dimensions and sperm reserves. In conclusion, the treatment of Yankasa rams with Moringa oleifera aqueous seed extract increased live body weight, but had no significant effects on gonadal and extragonadal dimensions and sperm reserves in Yankasa rams. Therefore, it is recommended that M. oleifera aqueous seed extract can be used at doses of 2000mg/kg to 3000mg/kg in Yankasa rams for optimum gain in live body weight.

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