CLINICO HEMATOLOGICAL PROFILE OF PATIENTS WITH PANCYTOPENIA- A THREE-YEAR STUDY

2021 ◽  
pp. 65-66
Author(s):  
Sarita Devdhar ◽  
Manjari Kishore ◽  
Pallavi Sharma ◽  
Roopak Aggarwal
Keyword(s):  
Bone Marrow ◽  
Folic Acid ◽  
Viral Infections ◽  
Megaloblastic Anaemia ◽  
International Institute ◽  
Medical Sciences ◽  
Bone Marrow Aplasia ◽  
Common Cause ◽  
Medical College ◽  
Underlying Pathology

Background: Pancytopenia is a relatively common hematological entity. It may result from relatively benign causes such as viral infections and vitamin B12/folic acid deciency to more fatal bone marrow aplasia and leukaemias. The severity of pancytopenia and the underlying pathology determine the management and prognosis. Objectives: To study the etiology and clinic-hematological prole in patients of peripheral blood pancytopenia. Materials And Methods: This was a retrospective study conducted at G S Medical College, Hapur and Noida international institute of Medical Sciences Greater Noida, during the period of November 2017 to November 2020 Results: A total of 192 patients (103 males and 89 females) were diagnosed to have pancytopenia. Most of the patients presented with generalized weakness and fever. The commonest physical nding was pallor, followed by splenomegaly. The various causes of pancytopenia included infections(n=132), megaloblastic anaemia (MA)(n=46), drugs, aplastic anaemia and subleukaemic leukaemia. We found a signicant association between megaloblastic anaemia and pancytopenia. Conclusion: The present study concluded that infection and megaloblastic anaemia are the most common cause of pancytopenia. The more serious disorders affecting the bone marrow constitute only <5% of all cases of pancytopenia.

A study of clinico-haematological profiles of pancytopenia in children

2008 ◽  
Vol 38 (4) ◽  
pp. 241-243 ◽  
Author(s):  
V Gupta ◽  
S Tripathi ◽  
V Tilak ◽  
B D Bhatia
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Aspiration ◽  
Megaloblastic Anaemia ◽  
Trephine Biopsy ◽  
Medical Sciences ◽  
Common Cause ◽  
Detailed History ◽  
The Third ◽  
Kala Azar ◽  
Haematological Profile

We report on the clinico-haematological profile of pancytopenia in children from the Departments of Pediatrics and Pathology, Institute of Medical Sciences, Banaras Hindu University, India, over a period of 30 months. Pancytopenia was defined as: haemoglobin <10 g/dL, absolute neutrophil count 1.5 × 109/L and platelet count <100 × 109/L. A detailed history, clinical examination and haematological parameters were recorded. Bone marrow aspiration and trephine biopsy were carried out in all cases. One hundred and five cases aged 1.5–18 years, with a mean age of 8.6 years, were included in the study. Aplastic anaemia was the most common cause of pancytopenia (43%) followed by acute leukaemia (25%). Infections were the third most common cause of pancytopenia of which kala azar was the most common. Megaloblastic anaemia was seen in 6.7%.

scholarly journals Study of etiological spectrum and clinical profile of patients admitted in tertiary care hospital of South Gujarat, India

2020 ◽  
Vol 7 (4) ◽  
pp. 616
Author(s):  
Mohnish M. Patel ◽  
K. N. Bhatt ◽  
Khyati T. Jariwala
Keyword(s):  
Bone Marrow ◽  
Tertiary Care ◽  
Peripheral Blood Smear ◽  
Megaloblastic Anaemia ◽  
Care Hospital ◽  
Peripheral Smear ◽  
Normal Reference Range ◽  
Common Cause ◽  
Etiological Spectrum ◽  
Bone Marrow Study

Background: Pancytopenia is defined as reduction of all three formed elements of blood below normal reference range. The symptoms are fatigue, fever, dizziness and weight loss. Evaluation was done using complete hemogram and peripheral smear. The presenting marrow biopsy is most useful and accurate in evaluation of pancytopenia.Methods: Two ml of anticoagulated blood was collected for complete hemogram. The peripheral blood smear was stained with Leishman's stain and studied. Bone marrow biopsy and aspiration was done in all the patients to identify etiology.Results: Predominance was seen in the age group of 31-60 years. Most common cause of pancytopenia was megaloblastic anaemia in this study compared to other studies all over the world where most common cause was aplastic anaemia. This reflects higher prevalence of megaloblastic anaemia in the Indian subjects.Conclusions: A comprehensive clinical, haematological land bone marrow study of patients with pancytopenia usually helps in identification of the underlying cause.

scholarly journals Clinical profile of patients with pancytopenia in a tertiary care centre

2018 ◽  
Vol 6 (4) ◽  
pp. 1187
Author(s):  
Jyotsana . ◽  
Khan Afreen ◽  
Vishakha Sharma ◽  
Prem Kapur ◽  
Smita Manjavkar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Early Diagnosis ◽  
Clinical Presentation ◽  
Tertiary Care ◽  
Megaloblastic Anaemia ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Common Cause ◽  
Appropriate Treatment ◽  
One Year

Background: Pancytopenia is a condition in which all three cell lines i.e. erythroid, myeloid and megakaryocytic are affected resulting in anaemia, leukopenia and thrombocytopenia. It can be a manifestation of a wide variety of disorders which primarily or secondarily affect the bone marrow. Early diagnosis of these conditions will help in implementing the appropriate treatment. The objective of the study was to know the clinical presentation and etiology of patients presenting with pancytopenia.Methods: A one year study from April 2016 to March 2017 was conducted in the department of medicine at a tertiary care centre. Total 32 patients with pancytopenia were studied to determine their clinical features and etiology through relevant investigations.Results: Our study revealed megaloblastic anaemia (46.87%) as the most common cause of pancytopenia, followed by malaria (12.5%). Other causes included hypothyroidism (6.2%), hypersplenism (6.2%), drugs (12.5%) and miscellaneous (9.43%).Conclusions: Megaloblastic anaemia was found to be the major cause of pancytopenia in patients. Other causes of pancytopenia were malaria, drugs, hypersplenism and hypothyroidism. These should be kept in mind while evaluating patients with pancytopenia.

scholarly journals Pancytopenia: etiologies and manifestation in eastern India

2017 ◽  
Vol 5 (12) ◽  
pp. 5212
Author(s):  
Vikram Singh ◽  
Mridu Singh ◽  
Prem Shankar Singh
Keyword(s):  
Developing Countries ◽  
Megaloblastic Anemia ◽  
Megaloblastic Anaemia ◽  
Western World ◽  
Simultaneous Presence ◽  
Eastern India ◽  
Medical Sciences ◽  
Common Cause ◽  
Biochemical Investigation ◽  
Kala Azar

Background: Pancytopenia is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The aetiologies causing pancytopenia varies depending upon factors e.g. age, sex, occupation, and geographical distribution. Unfortunately, the major treatises of haematology give more emphasis to Aplastic anaemia; while Megaloblastic anaemia is more common in developing countries than western world. Therefore, this Observational study was carried out over a period of two years in the Department of Medicine of Institute of Medical Sciences (IMS), BHU with the aim to identify etiologies of pancytopenia and its manifestation in eastern India.Methods: All the patients with features of anemia, thrombocytopenia or leukopenia were screened for pancytopenia and a total 214 cases were selected. A detailed physical examination, hematological and biochemical investigation was done.Results: The most common cause of pancytopenia in our study was Aplastic anemic (36.9%) followed by Megaloblastic anaemia (18.7%), Kala-azar (11.7%) and Myelodysplastic syndrome (10.5%).Conclusions: Megaloblastic anemia should be considered as important cause of Pancytopenia, especially when serum LDH level of patient is raised. 

scholarly journals Haematological Evaluation in Patients of Pancytopenia by Bone Marrow Aspiration

2021 ◽  
Vol 10 (19) ◽  
pp. 1398-1402
Author(s):  
Pallavi Agrawal ◽  
Yogesh Singh ◽  
Nutan Agrawal
Keyword(s):  
Bone Marrow ◽  
Developing Countries ◽  
Blood Count ◽  
Complete Blood Count ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Definitive Diagnosis ◽  
Megaloblastic Anaemia ◽  
Medical College ◽  
Uncommon Condition

BACKGROUND Pancytopenia is a reduction in all three major series of formed elements of blood i.e. erythrocytes, leucocytes and platelets. Pancytopenia is not an uncommon condition encountered in day to day clinical practice. The underlying aetiology of pancytopenia determines the management and prognosis of patients. Bone marrow aspiration is a minimally invasive, out-patient procedure which provides definitive diagnosis in a case of pancytopenia. In developing countries like India, the causes of pancytopenia are not well defined, hence, we conducted this study in Bundelkhand region of India to evaluate causes of pancytopenia. We wanted to evaluate haematological findings in patients of pancytopenia, and to study bone marrow findings by bone marrow aspiration to understand the underlying aetiology of pancytopenia. METHODS This prospective study was conducted in the Department of Pathology at MLB Medical College, Jhansi, among 65 patients over a one and a half year period from March 2018 to September 2019, to evaluate the causes of pancytopenia. RESULTS We found that out of 65 cases, 32 cases were of megaloblastic anaemia (49.23 %), 20 cases were of dimorphic anaemia (30.77 %), 6 cases were of hypersplenism (9.23 %), 4 cases were of subleukemic leukemia (6.15 %), 2 cases of aplastic anaemia (3.7 %) and 1 case was of myelodysplastic syndrome (1.54 %). CONCLUSIONS Along with detailed clinical examination and complete blood count, bone marrow examination is indispensable to diagnose the aetiology of pancytopenia, thereby helping clinician in planning management of these patients. KEY WORDS Pancytopenia, Megaloblastic Anaemia, Dimorphic Anaemia, Bone Marrow Examination

Pancytopenia: A Challenging Problem for Treating Physician

2018 ◽  
Vol 2 (01) ◽  
pp. 22-28
Author(s):  
Md. Rezaul Karim Chowdhury ◽  
Amina Begum ◽  
Md. Haroon Ur Rashid ◽  
Md. Kamrul Hasan
Keyword(s):  
Bone Marrow ◽  
Physical Examination ◽  
Blood Smear ◽  
Peripheral Blood Smear ◽  
Bone Marrow Examination ◽  
Challenging Problem ◽  
Trephine Biopsy ◽  
Life Threatening ◽  
Underlying Pathology ◽  
Careful History

Pancytopenia is an important clinico-haematological entity and striking feature of many serious and life-threatening illnesses. Many haematological and non-haematological diseases involve the bone marrow primarily or secondarily and cause pancytopenia. Decrease in haemopoietic cell production, ineffective haemopoiesis and peripheral sequestration or destruction of the cells are the main pathophysiology of pancytopenia. The cause of pancytopenia thus may be lying in the bone marrow or in the periphery or both. Careful history, physical examination, simple blood work, review of the peripheral blood smear, sometimes bone marrow examination and trephine biopsy are required for diagnosis. Treatment and prognosis depend on the severity of pancytopenia and underlying pathology.

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