Impact of combined hazardous production factors on the development of comorbidal pathology in men working in a large industrial enterprise of Tyumen

2021 ◽  
Vol 22 (2) ◽  
pp. 120-123
Author(s):  
T. F. Blaginina ◽  
◽  
K. A. Semenova ◽  
T. V. Bolotnova ◽  
◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Electrical Equipment ◽  
Static Stress ◽  
Industrial Enterprise ◽  
Control Group ◽  
Control Panel ◽  
Study Group ◽  
Industrial Noise ◽  
Production Factors ◽  
Comorbidity Index

Aim. To establish the strength and direction of the correlation between the comorbidity index depending on the combined impact of harmful production factors in men working at a large industrial enterprise in Tyumen. Materials and methods. A single-stage retrospective cohort study of working men in industrial conditions was carried out. Anamnestic, clinical, laboratory, biochemical, instrumental methods were used. Diagnoses were made on the basis of modern clinical guidelines criteria. The groups were comparable in age and formed depending on the number of harmful production factors. Study group n = 52 – men with multiple 3-5 harmful production factors (industrial noise, general vibration, height at work, exposure to welding aerosol, night shifts, static stress) as the number of the following professions increases: crane operators, bulldozer operators, and compressor installations, fitters, electricians for maintenance of electrical equipment, batchers of concrete components. mixtures, electric and gas welders, Kamaz drivers of the 2nd class, locksmiths, repairmen, molders of reinforced concrete products and structures, loaders, operators of the equipment control panel, installers, plumber on duty; their average age in the group was 44.8 ± 14.7. Control group n = 50 – men with 1-2 harmful production factors (industrial noise, static stress) as the number increases in the presence of the following professions: site managers, janitor, auxiliary workers, class 1 bus drivers, construction and installation work foremen, fitters for the repair and maintenance of gas equipment, concrete workers, carpenters; their average age in the group was 43.8 ± 16.2. Results. Between the combined effects of harmful production factors with the comorbidity index, a direct strong correlation was established r = 0.841 ***, p < 0.001 (95% CI 0.672-0.926) according to the Pearson method in the study group, whose experience was 2.2 years longer, then as in the control group, no statically significant correlation was found r = 0.339, p > 0.05 (95% CI -0.065-0.647) according to Pearson’s method. Conclusion. The combined effect of 3-5 harmful production factors is statistically significant with an increase in length of service increases the risk of developing comorbid pathology in men of working age working at a large industrial enterprise, which increases the 10-year risk of fatal complications.

scholarly journals Neurometabolic Therapy in Patients with Encephalopathy Associated with COVID-19

2021 ◽  
Vol 18 (6) ◽  
pp. 30-37
Author(s):  
P. V. Dunts ◽  
O. V. Voennov ◽  
K. V. Mokrov ◽  
А. V. Turentinov ◽  
P. Yu. Gorozhin
Keyword(s):  
Neuron Specific Enolase ◽  
Neurological Status ◽  
Unfavorable Outcome ◽  
Early Warning Score ◽  
Control Group ◽  
Study Group ◽  
Comorbidity Index ◽  
Coronavirus Infection ◽  
Positive Effect ◽  
Rapid Regression

The objective: to evaluate the effectiveness of neurometabolic therapy in patients with severe course of the new coronavirus infection of COVID-19 complicated by the development of encephalopathy.Subjects and Methods. A pilot prospective study was carried out with the participation of 61 patients with a severe course of COVID-19 complicated by encephalopathy. The patients were randomized into two groups: the study group (n = 34), the patients in which, in contrast to the control group (n = 27), received Cytoflavin in addition to the main therapy in a daily dose of up to 40 ml for 5 days. The dynamics of the general and neurological status was assessed on days 3‒4 and 6‒7 days of treatment using the NEWS (National Early Warning Score), Glasgow coma and ICDSC (Intensive Care Delirium Screening Checklist) scales. Additionally, the blood level of neuron-specific enolase (NSE) was investigated at baseline and on days 6‒7.Results. Patients in most cases were elderly or senile with a high comorbidity index (up to 4 points according to Charlson). The persistence of delirious symptoms correlated with their age and low SpO2 levels. In half of the cases (50.8%), the disease had an unfavorable outcome. In the study group, by the 6‒7th day of treatment, there was a significant positive dynamics of the general condition, assessed by the NEWS scale (p = 0.012), a tendency towards a faster recovery of the overall score on the Glasgow scale (p = 0.083), a tendency towards more rapid regression of delirious symptoms by ICDSC scale (p = 0.055) versus the comparison group.Conclusions. Given the high risk of an unfavorable outcome in patients with a severe course of COVID-19 complicated by the development of encephalopathy, the additional use of Cytoflavin is advisable since it contributes to the regression of the symptoms of encephalopathy and may have a positive effect on the course of the disease.

scholarly journals Association of vitamin D deficiency with early onset sepsis in term neonates

2019 ◽  
Vol 6 (2) ◽  
pp. 440 ◽  
Author(s):  
Ashwani Kumar ◽  
Gursharan Singh Narang ◽  
Gurmeet Singh ◽  
Navneet Virk
Keyword(s):  
Vitamin D ◽  
Early Onset ◽  
Clinical Laboratory ◽  
Vitamin D Supplementation ◽  
Control Group ◽  
Study Group ◽  
Laboratory Findings ◽  
Term Neonates ◽  
Early Onset Sepsis ◽  
Vitamin D Levels

Background: Vitamin D is a fat-soluble steroid hormone. Vitamin D also has immunomodulatory effects on immune function. Early onset sepsis (EOS) is characterized by signs and symptoms of infection with or without accompanying bacteremia in the first three days of life. The objective of the study was to determine the possible association between neonatal vitamin D levels and EOS in term neonates.Methods: 100 term neonates with clinical and laboratory findings of EOS (study group) and 100 healthy infants with no signs of clinical/laboratory infection (control group) were enrolled. Sera was drawn during first 3 postnatal days of life in both groups for measurement of 25-hydroxyvitamin D (25-OHD) levels.Results: Neonatal 25-OHD levels (17.4ng/dL) in the study group were significantly lower than those of the control group (26.8 ng/dL) (p=0.001). In present study negative correlation was found between vitamin D level and CRP.Conclusions: Lower neonatal 25-OHD levels are associated with EOS. Adequate vitamin D supplementation during pregnancy may be helpful to prevent EOS in term neonates.

scholarly journals THE EFFECTS OF ALUMINUM EXPOSURE ON IMMUNE STATUS IN CHILDREN WITH FUNCTIONAL CARDIOVASCULAR SYSTEM DISORDERS

2019 ◽  
Vol 8 (3) ◽  
pp. 29-35
Author(s):  
О. V. Dolgikh ◽  
I. N. Alikina ◽  
A. V. Shabaldin
Keyword(s):  
Cardiovascular System ◽  
Heart Development ◽  
Analytical Study ◽  
Clinical Laboratory ◽  
Control Group ◽  
Study Group ◽  
Immunological Parameters ◽  
Chemical Changes ◽  
Aluminum Exposure ◽  
Functional Changes

Aim To estimate the prevalence of functional cardiovascular system disorders and immunological parameters in children living in the Irkutsk Region, a technogenic region of Southern Siberia.Methods A set of clinical, laboratory and instrumental, statistical and analytical methods were used in the study. Immunological parameters and the presence of functional cardiovascular system disorders were assessed in 63 children aged 5–11 years living in the technogenic region with aluminum exposure. The study group included children (n = 31) with functional changes in the cardiovascular system. Children (n = 32) without any functional changes in the cardiovascular system were enrolled in the control group. The functional status of the cardiovascular system was evaluated with the electrocardiography and physical examination. The immune parameters were measured with the flow cytometry and enzyme allegrosorbent testing. The analytical study of the chemical changes in the biomedia induced by aluminum exposure followed the national guidelines.Results Children permanently residing in the technogenic region with aluminum exposure suffer from mild anomalies of the heart development. These anomalies are associated reliably with the diseases of the blood and blood-forming organs involving the immune mechanism. The analytical study of the chemical changes in the biomedia showed that the study group has significantly elevated aluminum levels in blood and urine. Immune alterations have been found in the study, including a significant increase in the TNFR receptor, Bcl-2 protein, Treg cell differentiation clusters (CD4+CD25+CD127-) and CD3+CD25+. A significantly increased level of specific sensitization by the IgG criterion was established.Conclusion The study reported that functional cardiovascular system disorders among children living in the technogenic region with aluminum exposure are associated with alteration in the immune system. These alterations suggest the presence of the imbalance between apoptotic regulation and the initiation of adjuvant sensitivity to man-made haptens (aluminum).

scholarly journals Mortality and morbidity in COVID-19 orthopedic trauma patients: is early surgery the keystone?

2020 ◽  
Author(s):  
Paolo Capitani ◽  
Enrico Gallazzi
Keyword(s):  
Clinical Laboratory ◽  
Perioperative Complications ◽  
Trauma Surgery ◽  
Early Surgery ◽  
Control Group ◽  
Study Group ◽  
Trauma Patients ◽  
Orthopedic Trauma ◽  
Mortality And Morbidity ◽  
Infection Age

Purpose. In the pandemic disease caused by Sars-Cov-2 virus, trauma surgery continued the management of patients with fractures. The purpose of the study is to evaluate mortality and morbidity in orthopedic trauma patients surgically treated with a diagnosis of COVID-19 infection, comparing them to a control group of COVID-19 negative.Methods. We retrospectively identified patients admitted to our Emergency Room from March 8th to May 4th 2020 with a diagnosis of fracture that were subsequently surgically treated. For each patient included demographics, clinical, laboratory, radiological data and type of treatment for COVID-19 infection were collected.Results. 65 patients were identified. Of those, 17 (6 women and 11 men) were COVID-19 positive (study group), while the others were control group. Preoperative laboratory tests showed leukocytosis in six and lymphopenia in 15 cases. 14 patients had a high level of C-reactive protein. 15 patients had an abnormal level of D-dimer. The overall mortality of our series was 4.6% (3 patients). Of those, one patient was in the study group (5.8%) and 2 were in the control group (4.1%) (p&gt;0.05). Perioperative adverse events were registred in 5 cases (29.4%) in the study group and in 8 (16.6%) in the control group (p&gt;0.05).Conclusion. Early surgery and short hospitalization could be key for a better clinical outcomes in trauma patients with a concomitant COVID-19 infection. Age and ASA grade could represent independent risk factors for perioperative complications

Multifactorial analysis of clinical laboratory signs, the levels of IL-17A, IL-23, IL-33, IL-35, and specific antibodies in the serum of patients with Lyme borreliosis without erythema migrans

2020 ◽  
Vol 4 (11) ◽  
pp. 676-681
Author(s):  
V.V. Sapozhnikova ◽  
◽  
A.L. Bondarenko ◽  
Keyword(s):  
Principal Component Analysis ◽  
Lyme Borreliosis ◽  
Clinical Laboratory ◽  
Acute Infection ◽  
Erythema Migrans ◽  
Principal Component ◽  
Component Analysis ◽  
Control Group ◽  
Multifactorial Analysis ◽  
Specific Antibodies

Aim: to determine the association between clinical laboratory parameters, the production of cytokines (IL-17A, -23, -33, -35), and specific IgM and IgG in the serum of patients with Lyme borreliosis without erythema migrans. Patients and Methods: complete blood count, the concentrations of IL-17A, -23, -33, -35, and the levels of specific IgM and IgG were measured during acute infection and convalescence (n=30). The control group included age- and sex-matched healthy individuals (n=30). Statistical analysis was performed using the StatSoft Statistica v 10.0 software (parametric and non-parametric methods and multifactorial analysis, i.e., principal component analysis). Results: most (80%) patients with Lyme borreliosis without erythema migrans are the people of working age. In most patients, the combination of the specific antibodies against Borrelia afzelii and Borrelia garinii (76.7%) and severe intoxication and inflammatory process (100%) were detected. Moderate and severe disease associated with meningism was diagnosed in 90% and 10%, respectively. The mean duration of hectic period was 8.3±1.27 days. Abnormal ECG was reported in 40% of patients, i.e., conduction abnormalities in 20%, sinus bradycardia in 16.7%,and sinus tachycardia in 3.3%. The clinical laboratory signs of hepatitis without jaundice were identified in 26.7%. During treatment, the significant reduction in band and segmented neutrophil counts as well as the significant increase in platelet count were revealed compared to these parameters at admission. Abnormal cytokine levels (i.e., the increase in IL-17A, -23, -33 and the deficiency of IL-35) were detected. Conclusions: multifactorial analysis has demonstrated that the severity of immunological abnormalities in patients with Lyme borreliosis without erythema migrans is associated with fever, cardiac and liver disorders, the high levels of IL-23 and IL-33, and the lack of IL-35 and specific IgM and IgG. KEYWORDS: tick-borne borreliosis, Lyme disease without erythema migrans, clinical laboratory signs, cytokines, specific antibodies, multifactorial analysis, principal component analysis. FOR CITATION: Sapozhnikova V.V., Bondarenko A.L. Multifactorial analysis of clinical laboratory signs, the levels of IL-17A, IL-23, IL-33, IL-35, and specific antibodies in the serum of patients with Lyme borreliosis without erythema migrans. Russian Medical Inquiry. 2020;4(11):676–681. DOI: 10.32364/2587-6821-2020-4-11-676-681.

Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

2015 ◽  
Vol 18 (4) ◽  
pp. 171 ◽  
Author(s):  
Tolga Demir ◽  
Mehmet Umit Ergenoglu ◽  
Hale Bolgi Demir ◽  
Nursen Tanrikulu ◽  
Mazlum Sahin ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Myocardial Protection ◽  
Troponin T ◽  
Artery Bypass ◽  
Control Group ◽  
Study Group ◽  
Cabg Surgery ◽  
Anti Inflammatory ◽  
Pump Coronary Artery Bypass

<strong>Background</strong>: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).<br /><strong>Methods</strong>: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. <br /><strong>Results</strong>: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: <br />P &lt; .001; T4: P &lt; .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group <br />(P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001).<br /><strong>Conclusions</strong>: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.<br /><br />

Condition of the psychoemotional and vegetative status at women with a repeated placental dysfuction

2016 ◽  
pp. 50-52
Author(s):  
D.A. Govseev ◽  
Keyword(s):  
Nervous System ◽  
Single Channel ◽  
Clinical Laboratory ◽  
Cardiac Activity ◽  
Psychological Status ◽  
Control Group ◽  
Vegetative Nervous System ◽  
Previous Pregnancy ◽  
Placental Dysfunction ◽  
Vegetative Status

The objective: studying of features of the psychoemotional and vegetative status at women with placental dysfunction at the previous pregnancy. Patients and methods. Complex clinical-laboratory examination of 89 women, from which was conducted: control group – 42 obstetrically and somatically healthy multipara, delivery through natural patrimonial ways; І group – 47 women with placental dysfunction at the previous pregnancy. Carried out a cardiointervalografia by means of a single-channel electrocardiograph and used a scale questionnaire of a condition of the pregnant woman. Results. It is established that regulation of cardiac rhythm at women at the previous pregnancy happens to placental dysfunction in the conditions of an autonomous contour which controls normal work of heart and vegetative nervous system. Further, there is an expressed strain of regulatory mechanisms that is shown by centralization of management of cardiac activity and sharp rising of activity of sympathetic nervous system. At the final stage influence of the central contour considerably decreases and patofunctionale vegetative equilibrium is again formed. Conclusions. The received results need to be considered when developing tactics of conducting pregnancy at these women. Key words: placental dysfunction, vegetative and psychological status.

CARDIOVASCULAR RISK FACTORS PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND CHRONIC INFLAMMATORY LUNG DISEASES

2020 ◽  
pp. 21-25
Author(s):  
Tupitsyn V.V. ◽  
Bataev Kh.M. ◽  
Men’shikova A.N. ◽  
Godina Z.N.
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Digestive System ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Internal Organs ◽  
History Of

Relevance. Information about the cardiovascular diseases risk factors (CVD RF) for in men with chronic lung inflam-matory pathology (CLID) is contradictory and requires clarification. Aim. To evaluate the peculiarities of CVD RF in men under 60 years of age with CLID in myocardial infarction (MI) to improve prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CLID - 142 patients; II - control, without it - 424 patients. A comparative analysis of the frequency of observation of the main and additional cardiovascular risk fac-tors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hereditary burden of is-chemic heart disease (40.8 and 31.6%, respectively; p = 0.0461) and arterial hypertension (54.2 and 44.6%; p = 0.0461), frequent colds (24.6 and 12.0%; p = 0.0003), a history of extrasystoles (19.7 and 12.7%; p = 0.04); chronic foci of infections of internal organs (75.4 and 29.5%; p˂0.0001), non-ulcer lesions of the digestive system (26.1 and 14.6%; p = 0.007), smoking (95.1 and 66.3%; p˂0.0001), MI in winter (40.8 and 25.9%; p = 0.006). Less commonly were observed: oral cavity infections (9.2 and 23.6%; p˂0.0001); hypodynamia (74.5 and 82.5%; p = 0.0358), over-weight (44.4 and 55.2%; p = 0.0136), a subjective relationship between the worsening of the course of coronary heart disease and the season of the year (43.7 and 55.2%; p = 0.0173) and MI - in the autumn (14.1 and 21.9%; p = 0.006) period. Conclusions. The structure of CVD RF in men under 60 years of age with CLID with MI is characterized by the pre-dominance of smoking, non-ulcer pathology of the digestive system, frequent pro-student diseases, meteorological dependence, a history of cardiac arrhythmias and foci of internal organ infections. It is advisable to use the listed factors when planning preventive measures in such patients.

STUDY ON THE EFFECT OF THE CATGUT-EMBEDDING METHOD COMBINING WITH HERBAL MEDICINE ON THE TREATMENT OF SCIATICA BY WIND-COLD-DAMP ARTHRALGIA

2014 ◽  
pp. 206-215
Author(s):  
Huu Tham Nguyen ◽  
Thi Tan Nguyen
Keyword(s):  
Herbal Medicine ◽  
Traditional Medicine ◽  
Clinical Characteristics ◽  
Day Treatment ◽  
Patient Treatment ◽  
Control Group ◽  
Controlled Trials ◽  
Study Group ◽  
Moderate Pain ◽  
Embedding Method

Objectives: To investigate clinical characteristics of patients with sciatica in Traditional Medicine Hospital in Thua Thien Hue province; To evaluate the effectiveness of the catgut-embedding method combining with herbal medicine on the treatment of sciatica by wind-cold-damp arthralgia. Subjects and Methods: Patients diagnosed with sciatica by wind-cold-damp arthralgia in-patient treatment in Traditional Medicine Hospital in Thua Thien Hue province. Methods: Clinical and controlled trials, a survey of 72 patients, which were divided into 2 groups: The study group: 36 patients: receiving treatment by catgut-embedding and herbal medicine; The control group: 36 patients: only use herbal medicine. 28-day treatment period. Patients were assessed at admission (T0), after 14 days (T14), after 28 days of treatment (T28). Results: After 28 days of treatment: no severity both 2 groups. The study group fell to 8.3% moderate pain, mostly mild pain (91.7%); the control group was 44.4% moderate pain, mild 55.6%.The catgut-embedding method does not cause any side effects. Key words: catgut-embedding method, sciatica by wind-cold-damp arthralgia

Promoting Key Family Practices of Common Childhood Illnesses among Mothers with Under-Five Children in Selected Military Communities

2019 ◽  
Vol 31 (2) ◽  
pp. 153-158
Keyword(s):  
Health Promotion ◽  
Health Promotion Program ◽  
Control Group ◽  
Study Group ◽  
Post Intervention ◽  
Under Five ◽  
Under Five Children ◽  
Eta Squared ◽  
Family Practices ◽  
Knowledge And Practice

Mothers are fundamental caregivers for under-five children and thus, family participation in child health services is very important. Therefore, a quasi-experimental study for promoting key family practices of mothers with under-five children was conducted among 278 respondents from Oaktwin Cantonment and Inndaing Cantonment in 2014. Data were collected by face-to-face interview with pretested structured questionnaire. Health promotion program including health education and advocacy for unit supports was implemented in study group. Before intervention, baseline data of respondents and pre-intervention knowledge and practices levels were identified. In the three-month and six-month after interventions, post-intervention data collection was done in both groups and data were analyzed. Findings show that there was a statistically significant difference of knowledge and practice scores between study group and control group after three-month interventions (t=10.827, p<0.0001, eta squared=0.297 and t=8.2, p<0.0001, eta squared=0.195, respectively), and six-month post-intervention (t=10.035, p<0.0001, eta squared=0.267 and t=8.773, p<0.0001, eta squared=0.304, respectively). Moreover, knowledge and practice level within study groups have a significant effect for time (F=160.45, p<0.0001 and F=113.06, p<0.0001, respectively) and the magnitude of this effect was also large (eta squared=0.699 for knowledge and 0.621 for practice). At the same time, knowledge and practice of control group have a significant effect for time (F=3.648, p=0.029 and F=19.564, p<0.0001, respectively) but this effect was very small. It can be asserted that health promotion program can improve the knowledge and practice of mothers regarding key family practices. The findings of current study might be a cornerstone for improvement of maternal knowledge and practice on caring for children in the military community.

Sign in / Sign up

Export Citation Format

Share Document