Effect of lisinopril on indicators of electrocardiographic and echocardiographic studies in patients with liver cirrosis

2021 ◽  
Vol 22 (3) ◽  
pp. 4-8
Author(s):  
V. A. Zhmurov ◽  
◽  
Yu. S. Kuzmina ◽  
T. A. Mishchenko ◽  
Yu. A. Rogozhkina ◽  
...  

Chronic diffuse liver diseases (CDLD) of various etiologies remain a serious socio-economic and clinical-epidemiological health problem. Every year more than 1 million people die from cirrhosis of the liver of various etiology all over the world. According to the results of a study by a group of authors, it was found that in the Siberian Federal District there is an unfavorable situation in terms of gastroenterological mortality, in particular, hepatological mortality. CCM is characterized by lengthening of the QT interval, electromechanical dyssynchronization, and chronotropic insufficiency. The duration of the QTc interval in the subgroup of patients with liver cirrhosis who received basic therapy and the drug lisinopril (Diroton) was (418.21 ± 2.74 ms) and was significantly lower than in the subgroup of patients receiving only basic therapy. Evaluating the parameters of transthoracic echocardiography among patients with liver cirrhosis, it was noted that during treatment with basic drugs in combination with lisinopril (Diroton), the volume of LV EDV significantly decreased (p < 0.05). The appointment of an ACE inhibitor lisinopril to patients with cirrhosis of the liver as part of complex therapy leads to an improvement in general well-being, a decrease in shortness of breath, an increase in exercise tolerance, an improvement in basic laboratory parameters, as well as an improvement in some morphometric parameters (EDV) and cardiac electrical systole.

Author(s):  
L.K. Subrakova

The purpose of the study is to substantiate the relevance of introducing special measures of support for the population of small villages on the basis of a generalization of domestic and foreign practices of social benefits during the coronavirus pandemic. The poor situation of small villages, on the one hand, and the relatively low financial cost of payments, limited by territory and social categories, on the other hand, led to the proposal to preserve and develop small villages with the achievement of economic and socio-demographic well-being. In order to curb the process of depopulation in rural areas it is proposed to develop a strategy for the preservation and development of small villages, including a special state policy of income for the population of small villages on the basis of a guaranteed rural minimum income. The conceptual basis of this policy can be the idea of a universal basic income with variations of conditional, selective, both monetary and natural basic income. The implementation of this approach is proposed as an experiment in small villages of the regions of the Siberian Federal District. According to calculations, 50 million rubles a year will be required to pay 437 thousand residents in 5.8 thousand rural settlements of the regions of the Siberian Federal District, or 0.65 % of GRP. As a result, it is expected to reduce excessive income inequality, improve the demographic situation and increase employment. The research is based on the method of dialectical knowledge of processes and phenomena. When studying the issues of the state and trends of changes in the situation of small rural settlements, monographic, abstract-logical and economic-statistical methods were used.


2021 ◽  
pp. 138-146
Author(s):  
A. A. Bykov ◽  
◽  
◽  

Food export is one of the most sensitive indicators of the State economic well-being, which testifies to the provision of high quality products consumed by the population and independence from imports. At the same time, the country's weight and international prestige are being strengthened. The Siberian Federal District (SFD) is the largest grain producer, which is in demand in Russia and abroad. The purpose of the study is to analyze the current state of supplies of grain and its processed products from the Siberian Federal District, to identify problems and development prospects. The methodological basis of the work includes the works of scientists in the field of theory of international trade in cereals, as well as legislative and regulatory acts regulating this area. During the research, the following methods and techniques were used: abstractlogical, economic-statistical, statistical groupings, monographic. Results – an analysis of the current state of grain and grain products export from the Siberian Federal District by types (wheat, rye, barley, oats, flour, cereals, pasta) is presented. The reasons that impede the development of this industry are shown, the main vector of which is grain exports from the Siberian Federal District. The strengths and weaknesses, opportunities and threats that affect the development of grain market of the Siberian Federal District and export of products are identified. The most attractive markets for grain and grain products have been identified. Practical measures have been developed to expand them; the prospects for the development of exports from the Siberian Federal District until 2025 are reflected. Conclusions about its export potential are formulated. Recommendations are offered on priority areas contributing to the growth of export-oriented grain volumes. The proposals prepared on the basis of the research results serve as a basis for further increase in grain exports and a sustainable economic recovery in the Siberian Federal District.


2020 ◽  
Vol 99 (10) ◽  
pp. 1170-1176
Author(s):  
Oksana V. Ushakova ◽  
Natalia V. Efimova ◽  
Aleksandr Yu. Tarasov ◽  
Elena V. Katamanova

Introduction. The problems of preserving the health of the older generation are especially significant for society and determine the need to search for key indices of medical and social well-being. The purpose of the study is to develop a method for assessing the health losses of the population of the older age group and to test using the example of the Siberian Federal District. Material and methods. For a comprehensive assessment, the following groups of indices were used: the life expectancy, mortality, morbidity, chronic diseases, cumulative disability in group 60+. An integrated assessment of health by the sum of normalized indices by the average value for the Siberian Federal District (NP) is proposed. There was using cluster analysis. Results. Dysfunctional territories (NP≥3) include: Altai Territory, Altai Republic, Irkutsk Region. 4 clusters were identified, of which the 1st cluster has the highest mortality and morbidity rates. Levels of life expectancy, the coefficient of chronicity of diseases in the IV cluster is higher than in II cluster. Cluster III is characterized by the lowest mortality, morbidity, against the background of minimal life expectancy and high cumulative disability. Discussion. The value of the proposed method is limited by the completeness of information on indices of health loss, the different availability of medical care in the territories. Conclusion. The proposed approach to assessing health losses in a group of older people has shown medical and demographic problems in the Siberian Federal District to be very different, which determines a differentiated approach to maintaining public health.


2017 ◽  
pp. 123-141 ◽  
Author(s):  
S. Ageeva ◽  
A. Mishura

We examine the spatial distribution of banks in Russian regions to identify the factors that affect changing territorial architecture of the banking system. The object of the study is dynamics of the number of commercial banks and their branches in 1991-2016. Besides the well-known tendency of concentration of the banking business in Moscow and reducing the number of banks in other regions we analyzed situation in the federal districts taking as an example the Siberian Federal District. This approach allowed us to formulate hypotheses about the causes of differences in the availability of banking institutions in Russian regions.


2020 ◽  
Vol 18 (7) ◽  
pp. 1266-1285
Author(s):  
Sn.P. Mongush

Subject. This article explores the various aspects of the concept of Spatial Development. Objectives. The article aims to develop a conceptual basis for the spatial socio-economic development of the collaborating regions. Methods. For the study, I used the methods of comparative and statistical analyses. Results. The article shows how cooperation between the subjects of the Russian Federation increases the potential of economically united regions. Conclusions. When preparing national strategic planning documents, it is necessary to take into account the specifics of regions, their capacity, available resources, and focus on the relationship between regions.


2020 ◽  
Vol 18 (5) ◽  
pp. 891-908
Author(s):  
T.A. Smirnova

Subject. This article deals with the issues of functioning of the region as a system. Objectives. The article aims to identify the problems of the region's functioning as a system, develop methodological tools to monitor the sustainable development of the Siberian Federal District territories, and determine the the impact of socio-economic and environmental factors on the sustainable development of the region as a whole. Methods. For the study, I used the methods of theoretical, statistical, and empirical analyses taking into account an integrated approach. Results. The article reveals the impact of some individual components of regional development on the sustainability of the territorial system as a whole. Relevance. The results of the study can be used to analyze the sustainability of regions' development.


Author(s):  
Nina M. Edrenkina ◽  
◽  
Aleksandr E. Lisitsyn ◽  
Aleksey I. Suchkov ◽  
◽  
...  

Clustering of the regions of the Siberian Federal District (SFD) was carried out according to the state of reproduction of labor resources in rural areas. The modern problems of reproduction of labor resources in the regions of the SFD are identified, taking into account the peculiarities of each of them. As a result, the distribution of the regions of the Siberian Federal District by the state of labor resources of the rural territories was obtained by the following clusters: national, raw materials and leaders. Recommendations for the development of the reproduction of labor resources in rural areas are offered.


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