scholarly journals Potention of nHAC/PLGA Based Syringetin as Bionano Bone Graft to Improved Osteoinductivity and Osteoconductivitas

2019 ◽  
Vol 2 (2) ◽  
pp. 51-57
Author(s):  
I Kadek Wahyu Putra Dyatmika ◽  
Jonathan Hubert Prasetya ◽  
I Wayan Windi Artha

Background: According to the data of Riskesdas in 2013, fracture incident rate in Sulawesi gets a 16% increase. The most common fracture incident happens to elderly age group and its predominant cause is traumatic incident like falls and traffic accident. Treatment now such as ORIF and External Fixation is far from cheap and has a high risk to the patient. Syringetin-based nHAC/PLGA usage can be a new bionano bone graft because it can target specific cells to increase osteoinductivity in bones. Method: This literature review is established by literature review method of collecting sources from valid scientific literature which has specific inclusion and exclusion criteria. Discussion: Syringetin-based nHAC usage has some targets like BMSC. Syringetin-based nHAC has effect in increasing the expression of BMP-2 and miRNA-21. BMP-2 and miRNA-21 are factors that take part in osteoblast proliferation and differentiation. That expression increase is marked by ALP activity and osteocalcin increase. Conclusion: Significantly, the usage of syringetin-based nHAC/PLGA can increase the proliferation and differentiation rate of BMSC to osteoblast.

2021 ◽  
Vol 7 (1) ◽  
pp. 131-148
Author(s):  
Sthefanny Meira Moreira ◽  
Roberta Sasha Guedes Vieira ◽  
Elisabete Agrela de Andrade

The current research analyzed the risk factors associated with committing homicide in adolescence. This research is a systematic literature review of the scientific literature. The databases that were used are: Scielo, Pubmed and CAPES journals. Only 10 articles met the inclusion and exclusion criteria and the removal of duplicates. Social, behavioral, psychological, psychopathological and biological factors associated with homicide in adolescence were found. No single factor was found to be decisive for the adolescent to commit homicide. The importance of preventive measures for this phenomenon is highlighted.


e-GIGI ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 347
Author(s):  
Glady A. Tetelepta ◽  
Michael A. Leman ◽  
Paulina N. Gunawan

Abstract: Maxillofacial trauma can be caused by various external and internal factors. The intervention to prevent the COVID-19 pandemic has caused changes in community social activities that contributes to the factors causing maxillofacial trauma during the pandemic. This study was aimed to obtain the factors that caused maxillofacial trauma before and during the COVID-19 pandemic. This was a literature review study using three databases, namely Google Scholar, Pubmed, and ClinicalKey, and the keywords "maxillofacial trauma", "etiology factors", and "COVID-19". The literatures were selected by using inclusion and exclusion criteria. A critical assessment was carried out and 11 literatures were obtained consisting of retrospective and cross-sectional studies. The results showed that the factors causing maxillofacial trauma in the period of before and during the pandemic belonged of three categories, as follows: falls, accidents, and violence. They consisted in detail of fall, traffic accident, sports injurie, industrial accident, suicide attempt, interpersonal violence, domestic violence. and animal-bite wound. In conclusion, fall is the most dominant etiology factor before and during the COVID-19 pandemic. Moreover, there is a difference in the factors causing maxillofacial trauma before and during the COVID-19 pandemic which is attempted suicide.Keywords: maxillofacial trauma; etiology; COVID-19 pandemic Abstrak: Trauma maksilofasial dapat disebabkan oleh berbagai faktor eksternal maupun internal. Adanya intervensi pencegahan pandemi COVID-19 menyebabkan perubahan aktifitas sosial masyarakat yang berkontribusi dalam berubahnya faktor penyebab trauma maksilofasial pada saat pandemi. Penelitian ini bertujuan untuk melihat faktor penyebab trauma maksilofasial pada masa sebelum dan saat pandemi COVID-19. Jenis penelitian ialah suatu literature review. Pencarian data melalui tiga database yaitu Google Scholar, Pubmed dan ClinicalKey menggunakan kata kunci trauma maksilofasial, faktor penyebab, dan COVID-19. Literatur diseleksi menggunakan kriteria inklusi dan eksklusi, dilakukan penilaian kelayakan dan diperoleh 11 literatur dengan desain studi retrospektif dan potong lintang. Hasil penelitian mendapatkan factor-faktor penyebab trauma maksilofasial pada masa sebelum dan saat pandemi tergolong atas tiga kategori yaitu: jatuh, kecelakaan, dan kekerasan, yang secara detil terdiri atas jatuh, kecelakaan lalu lintas, cedera olahraga, kecelakaan industri, percobaan bunuh diri, kekerasan interpersonal, kekerasan dalam rumah tangga, dan luka gigitan hewan. Simpulan penelitian ini ialah jatuh merupakan faktor penyebab trauma maksilofasial paling dominan pada masa sebelum dan saat pandemi COVID-19. Perbedaan faktor penyebab trauma maksilofasial pada masa sebelum dan saat pandemi COVID-19 yaitu percobaan bunuh diri.Kata kunci: trauma maksilofasial; etiologi; pandemi COVID-19


2018 ◽  
Vol 28 (2) ◽  
Author(s):  
Matodzi Rebecca Raphalalani ◽  
Mashudu Churchill Mashige

This study investigated, through observation of the Tshivenḓa female dress codes, the socio-cultural significance of such dress codes as a means of non-verbal communication. The non-verbal meaning embedded in different items of dresses conveys messages from the wearers to observers. The study adopted  a qualitative  design, since it used  document analysis and literature review as a means to adduce evidence that Tshivenḓa dress codes not only communicate socio-cultural meanings to the observer, but also signify gender, age group, rank, authority, status, and identity, as well as power relations—including the supernatural and the sacred. The study also revealed that there are dress codes that are specifically worn during initiation ceremonies among the Vhavenḓa people. In conclusion, we recommend that knowledge of Tshivenḓa dress codes should form part of the overall indigenous knowledge that needs to be studied in institutions of basic and higher education, and that for the sake of preserving this valuable information, communities need to be proactive in disseminating it to the younger generation.


2021 ◽  
Vol 13 (14) ◽  
pp. 7863
Author(s):  
Antonios Kolimenakis ◽  
Alexandra D. Solomou ◽  
Nikolaos Proutsos ◽  
Evangelia V. Avramidou ◽  
Evangelia Korakaki ◽  
...  

Urban green areas present a lucid example for the harmonious co-existence of the artificial and natural environments best illustrated by their interdependence and interconnection in urban spaces. Urban green areas are essential for the health and wellbeing of citizens. The present study aimed to investigate those multiple benefits for citizens that arise through the existence of urban green areas, as well as important policy dimensions that should be considered when designing the expansion of urban green spaces in urban development. The study was based on a literature review to examine for available evidence on the benefit levels derived by the existence of urban green areas. An extended literature review was followed by a structured review, based on specific inclusion and exclusion criteria, which partly followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search was conducted in two databases, and a total of 1674 articles and abstracts were identified through the database searches. After removing 114 duplicates, 1560 records were initially screened based on title and abstract. Following inclusion and exclusion criteria, 14 articles were incorporated in the structured review and a total of 47 in the extended review. The extended literature review identified 33 additional articles examining aspects of benefits that did not fall under the pre-established inclusion and exclusion criteria used in the structured review, such as health benefits and other social parameters associated with urban green spaces. The selected studies were allocated in five principal groups according to study types: three of the them consisted of studies employing “willingness to pay” (WTP) methods, five were based on property values, two studies assigned monetary values, while another two assigned CO2 values, and, finally, two studies were based on qualitative criteria. The results indicated benefits to citizens and increased welfare levels gained by the existence of urban green areas. The conducted review revealed a number of findings and recommendations that could direct future research and urban policy. Those hints could assist local authorities as well as stakeholders in order to measure and assess the benefits of green spaces and urban parks and promote measures and programs to assist their further deployment.


Societies ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 70
Author(s):  
Costas S. Constantinou ◽  
Andrew Timothy Ng ◽  
Chase Beverley Becker ◽  
Parmida Enayati Zadeh ◽  
Alexia Papageorgiou

This paper presents the results of a narrative literature review on the use of interpreters in medical education. A careful search strategy was based on keywords and inclusion and exclusion criteria, and used the databases PubMed, Medline Ovid, Google Scholar, Scopus, CINAHL, and EBSCO. The search strategy resulted in 20 articles, which reflected the research aim and were reviewed on the basis of an interpretive approach. They were then critically appraised in accordance with the “critical assessment skills programme” guidelines. Results showed that the use of interpreters in medical education as part of the curriculum is scarce, but students have been trained in how to work with interpreters when interviewing patients to fully develop their skills. The study highlights the importance of integrating the use of interpreters in medical curricula, proposes a framework for achieving this, and suggests pertinent research questions for enriching cultural competence.


Buildings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 244
Author(s):  
Ana Maria Bueno ◽  
Antonio Augusto de Paula Xavier ◽  
Evandro Eduardo Broday

The thermal environment is one of the main factors that influence thermal comfort and, consequently, the productivity of occupants inside buildings. Throughout the years, research has described the connection between thermal comfort and productivity. Mathematical models have been established in the attempt to predict changes in productivity according to thermal variations in the environment. Some of these models have failed for a number of reasons, including the understanding of the effect that several environment variables have had on performance. From this context, a systematic literature review was carried out with the aim of verifying the connection between thermal comfort and productivity and the combinations of different thermal and personal factors that can have an effect on productivity. A hundred and twenty-eight articles were found which show a connection between productivity and some thermal comfort variables. By means of specific inclusion and exclusion criteria, 60 articles were selected for a final analysis. The main conclusions found in this study were: (i) the vast majority of research uses subjective measures and/or a combination of methods to evaluate productivity; (ii) performance/productivity can be attained within an ampler temperature range; (iii) few studies present ways of calculating productivity.


Author(s):  
Krzysztof Wróbel ◽  
Mateusz Gil ◽  
Przemysław Krata ◽  
Karol Olszewski ◽  
Jakub Montewka

Although the safety of prospective Maritime Autonomous Surface Ships will largely depend on their ability to detect potential hazards and react to them, the contemporary scientific literature lacks the analysis of how to achieve this. This could be achieved through an application of leading safety indicators. The aim of the performed study was to identify the research directions of leading safety indicators in three safety-critical operational aspects of Maritime Autonomous Surface Ships: collision avoidance, intact stability, and communication. To achieve this, literature review is performed, taking into account scientific documents including journal and conference papers. The results indicate that the need for establishing operational leading safety indicators is recognized by numerous scholars, who sometimes make suggestions of what the set of indicators shall consist of. Some leading safety indicators for autonomous vessels are readily identifiable in the scientific literature and used in current practice. However, the research effort is lacking a holistic approach to the issue.


2013 ◽  
Vol 18 (6) ◽  
pp. 100-105 ◽  
Author(s):  
Mariana de Aguiar Bulhões Galvão ◽  
Gladys Cristina Dominguez ◽  
Sérgio Thomaz Tormin ◽  
Alex Akamine ◽  
André Tortamano ◽  
...  

INTRODUCTION: Moyers analysis is widely used for analyzing mixed dentition, however, the accuracy of its theoretical probability tables has been recently questioned. Taking into consideration the fact the mixed dentition analysis is of paramount importance to precisely determine the space needed for alignment of canines and premolars, this research aimed at objectively assessing in the literature such an important step for orthodontic diagnosis. METHODS: A computerized search involving articles published on PubMed and Lilacs between 1990 and September, 2011 was conducted in accordance with the method described in the Cochrane 5.1.0 handbook. RESULTS: The research resulted in a sample composed of 629 articles. The inclusion criteria were: Articles using the Moyers analysis with a sample greater or equal to 40 patients. Conversely, the exclusion criteria were: Dental casts of patients with syndromes or oral cleft, researches conducted with a literature review, only, or clinical case reports and researches conducted before 1990. For this systematic review, 19 articles were selected. CONCLUSION: Based on the literature available, we can conclude that the Moyers mixed dentition analysis must be carefully used, since the majority of the articles analyzed showed that the probability of 75% was not as accurate as expected, leading to the need of adapting the probability levels depending on the study population.


2013 ◽  
Vol 16 (1) ◽  
pp. 193-197 ◽  
Author(s):  
R. Lechowski ◽  
J.P. Cotard ◽  
H.J. Boulouis ◽  
M. Kietzman ◽  
A.M. Farca ◽  
...  

Abstract The literature analysed by REQUEST (REassesing QUinolone European STandard) using inclusion and exclusion criteria allows to make the conclusion that the proper use of fluoroquinolones (FQ) in canine colitis requires rigorously performed qualification to specific antimicrobial treatment. An infectious agent responsive to FQ therapy plays an integral role in the clinical manifestation of canine colitis, especially histiocytic ulcerative colitis (HUC) in young Boxer dogs. This supports the use of FQ in these cases. The Request guidelines for proper use of FQ in canine colitis is established, according to the available literature data.


Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Mayowa Owolabi ◽  
FRED S SARFO ◽  
Onoja Akpa ◽  
Joshua Akinyemi ◽  
Albert Akpalu ◽  
...  

Background: Age is a non-modifiable risk factor for stroke occurrence due its influence on vascular risk factor acquisition. In sub-Saharan Africa, the effect sizes of vascular risk factors for stroke occurrence by age is unknown. Objective: To quantify the magnitude and direction of the effect sizes of key modifiable risk factors of stroke according to three age groups: <50years(young), 50-65 years(middle age) and >65 years(elderly) in West Africa. Methods: The Stroke Investigative Research and Educational Network (SIREN) is a multicenter, case-control study involving 15 sites in Ghana and Nigeria. Cases include adults aged ≥18 years with evidence of an acute stroke. Controls were age-and-gender matched stroke-free adults. Detailed evaluations for vascular, lifestyle, stroke severity and outcomes were performed. We used conditional logistic regression to estimate adjusted odds ratios (aOR) of vascular risk factors of stroke. Results: Among 3,553 stroke cases, 813(22.9%) were young, 1441(40.6%) were middle-aged and 1299(36.6%) were elderly. Five modifiable risk factors were consistently associated with stroke occurrence regardless of age namely hypertension, dyslipidemia, diabetes mellitus, regular meat consumption and non-consumption of green vegetables. Among the 5 co-shared risk factors, the effect size, aOR(95%CI) of dyslipidemia, 4.13(2.64-6.46), was highest among the young age group, hypertension, 28.93(15.10-55.44) and non-consumption of vegetables 2.34(1.70-3.23) was highest among the middle-age group while diabetes, aOR of 3.50(2.48-4.95) and meat consumption, 2.40(1.76-3.26) were highest among the elderly age group. Additionally, among the young age group cigarette smoking and cardiac disease were associated with stroke. Furthermore, physical inactivity and salt intake were associated with stroke in the middle-age group while cardiac disease was associated with stroke in the elderly age group. Conclusions: Age has a profound influence on the profile, magnitude and direction of effect sizes of vascular risk factors for stroke occurrence among West Africans. Population-level prevention of stroke must target both co-shared dominant risk factors as well as factors that are unique to specific age bands in Africa.


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