scholarly journals Assessing the Intervention Factors of Oxidative Stress Among Elderly with Metabolic Syndrome: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 5 (S1) ◽  
pp. 1-11
Author(s):  
Asheila Meramat ◽  
Ratthisswari Naidu Rathakrishnan
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Systematic Review ◽  
Metabolic Syndrome ◽  
Dietary Intervention ◽  
Meta Analysis ◽  
Eligibility Criteria ◽  
Oxidative Stress Level ◽  
Total Antioxidant ◽  
Positive Effect

Oxidative stress is a known pathogenesis in the development of chronic diseases including metabolic syndrome (MetS). Hence, interventions should be taken to prevent or treat MetS. A systematic review and meta-analysis were performed to estimate the interventions of oxidative stress in MetS among elderly. Hindawi, Google Scholar, PubMed and Science Direct were the databases used for this systematic review and meta-analysis. Furthermore, heterogeneity was observed using the I-squared (I2) statistic to determine the source of heterogeneity if the I2-value was >40%. After all the screening processes, 20 studies met the eligibility criteria and were analysed. Meta-analysis found that physical activity on MetS shows reduction in malondialdehyde (MDA) level (MD = -0.24, 95% CI (-0.43, -0.04), P = 0.02) and increased glutathione peroxidase (GPx) level (MD = 22.92, 95% CI (10.77, 35.08), P<0.001). On the other hand, supplement intervention on MetS increased the GPx level (MD = 805.51, 95% CI (123.23, 1487.80), P = 0.02). Dietary changes on MetS may decrease the MDA level (MD = -0.78, 95% CI (-1.02, -0.54), P<0.001) however, it also increases the total antioxidant capacity (TAC) level (MD = 0.16, 95% CI (0.88 to 0.24), P<0.001). Thus, this meta-analysis showed a positive effect of physical activity, supplementation and dietary intervention as a tool to decrease oxidative stress level in elderly with MetS.

scholarly journals The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

2018 ◽  
Author(s):  
Elias de França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula A. Faria Waziry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
Protein Carbonyl ◽  
Human Model ◽  
Sod Activity ◽  
Beta Alanine ◽  
Total Antioxidant ◽  
Acute Increase ◽  
Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect beta-alanine (BA) or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). We searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. We search papers published before May 2018.&nbsp; A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young (21y) sedentary, recreationally active or athletic participants. After a chorionic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, BA/carnosine supplementation increased total antioxidant capacity (TAC) and glutathione concentrations while decreased pro-oxidant markers and superoxide dismutase (SOD) activity. BA or carnosine supplementation did not prevent the increase in peroxidation markers (e.g., 8-isoprostane, protein carbonyl or malonaldehyde). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in pro-oxidants, treatment did not decrease measured values of peroxidation markers.

scholarly journals Physical Activity Interventions and Their Effects on Cognitive Function in People with Dementia: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 18 (16) ◽  
pp. 8753
Author(s):  
Maria Isabel Cardona ◽  
Adel Afi ◽  
Nemanja Lakicevic ◽  
Jochen René Thyrian
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Cognitive Function ◽  
Meta Analysis ◽  
Medium Size ◽  
Eligibility Criteria ◽  
Physical Activity Interventions ◽  
People With Dementia ◽  
Measurement Tools ◽  
Comprehensive Measurement

Background: Physical activity (PA) has emerged as an alternative nonpharmacological approach to effectively address the effects of dementia. The primary aim was to identify and summarize PA interventions and their effects on cognitive function among persons with dementia (PwD). Methods: A systematic review was conducted with a meta-analysis using different electronic databases, such as PubMed, Embase, APA PsycNET, and the Web of Science. The identified and selected studies were randomized controlled trials (RCTs) that were written in English, published between 2000 and 2020, and implemented among PwD who received a PA intervention and whose cognitive function was measured at baseline and during a follow-up. Results: Twenty-two PA intervention studies met the eligibility criteria and showed a medium-size effect on the cognitive function of PwD, 0.4803 (95% CI = 0.1901–0.7704), with a high percentage of heterogeneity (I2 = 86%, p ≤ 0.0001). Moreover, this review complements other reviews by including eight studies that have not previously been considered. Overall, studies have methodological limitations. However, six studies implemented in the past five years have shown more robust methodological designs, including larger sample sizes and more comprehensive measurement tools. Conclusion: It is not yet possible to draw a conclusion on the ideal PA intervention for this population due to the high proportion of heterogeneity within the included studies. More emphasis is needed on the intensity of PA monitoring and adherence to such programs.

scholarly journals The Prevalence of Metabolic Syndrome in Ethiopian Population: A Systematic Review and Meta-analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Sintayehu Ambachew ◽  
Aklilu Endalamaw ◽  
Abebaw Worede ◽  
Yalewayker Tegegne ◽  
Mulugeta Melku ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
The Metabolic Syndrome ◽  
Pooled Prevalence

Background. The metabolic syndrome is a clustering of hyperglycemia/insulin resistance, hypertension, dyslipidemia, and obesity which are risk factors for cardiovascular disease, type 2 diabetes and stroke, and all-cause mortality. The burden of metabolic syndrome is emerging alarmingly in low- and middle-income countries such as Ethiopia; however, there is lack of comprehensive estimation. This study aimed to determine the pooled prevalence of metabolic syndrome in Ethiopia. Methods. This systematic review and meta-analysis included original articles of observational studies published in the English language. Searches were carried out in PubMed, Google Scholar, and Africa Journals from conception to August 2020. A random-effects model was used to estimate the pooled prevalence of metabolic syndrome in Ethiopia. Heterogeneity was assessed using the I2 statistic. Subgroup analysis was also conducted based on sex/gender and study subjects. Egger’s test was used to assess publication bias. Results. Electronic and gray literature search retrieved 942 potentially relevant papers. After removing duplicates and screening with eligibility criteria, twenty-eight cross-sectional studies were included in this meta-analysis. The pooled prevalence of metabolic syndrome in Ethiopia was found to be 34.89% (95% CI: 26.77, 43.01) and 27.92% (95% CI: 21.32, 34.51) by using NCEP/ATP III and IDF criteria, respectively. The weighted pooled prevalence of metabolic syndrome was higher in females 36.74% (95% CI: 20.72, 52.75) and 34.09% (95% CI: 26.68, 41.50) compared to males 22.22% (95% CI: 14.89, 29.56) and 24.82% (95% CI: 18.34, 31.31) by using IDF and NCEP/ATP III criteria, respectively. Subgroup analysis based on the study subjects using NCEP/ATP III showed that the weighted pooled prevalence was 63.78%(95% CI: 56.17, 71.40), 44.55% (95% CI: 30.71, 52.38), 23.09% (95% CI: 19.74, 26.45), 20.83% (95% CI: 18.64, 23.01), and 18.45% (95% CI: 13.89, 23.01) among type 2 diabetes patients, hypertensive patients, psychiatric patients, HIV patients on HAART, and working adults, respectively. The most frequent metabolic syndrome components were low HDL-C 51.0% (95% CI: 42.4, 59.7) and hypertriglyceridemia 39.7% (95% CI: 32.8, 46.6). Conclusions. The findings revealed an emerging high prevalence of metabolic syndrome in Ethiopia. Therefore, early intervention is required for the primary prevention of the occurrence of metabolic syndrome and the further reduction of the morbidity and mortality related to it.

Cycling is associated with a lower incidence of cardiovascular diseases and death: Part 1 – systematic review of cohort studies with meta-analysis

2019 ◽  
Vol 53 (14) ◽  
pp. 870-878 ◽  
Author(s):  
Solveig Nordengen ◽  
Lars Bo Andersen ◽  
Ane K Solbraa ◽  
Amund Riiser
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Systematic Review ◽  
Dose Response ◽  
Meta Analysis ◽  
Effect Estimate ◽  
Cvd Risk ◽  
Eligibility Criteria ◽  
Relative Risks ◽  
Quantitative Studies

ObjectivesPhysical inactivity is a risk factor for cardiovascular disease (CVD). Cycling as a physical activity holds great potential to prevent CVD. We aimed to determine whether cycling reduces the risk of CVD and CVD risk factors and to investigate potential dose-response relationships.DesignSystematic review and meta-analysis of quantitative studies.Eligibility criteria for selecting studiesWe searched four databases (Web of Science, MEDLINE, SPORTDiscus and Scopus). All quantitative studies, published until August 2017, were included when a general population was investigated, cycling was assessed either in total or as a transportation mode, and CVD incidence, mortality or risk factors were reported. Studies were excluded when they reported continuous outcomes or when cycling and walking were combined in them. We pooled adjusted relative risks (RR) and OR. Heterogeneity was investigated using I.ResultsThe search yielded 5174 studies; 21 studies which included 1,069,034 individuals. We found a significantly lower association in combined CVD incidence, mortality and physiological risk factors with total effect estimate 0.78 (95% CI (CI): 0.74–0.82; P<0.001; I2=58%). Separate analyses for CVD incidence, mortality and risk factors showed estimates of RR 0.84 (CI, 0.80 to 0.88; P<0.001; I2=29%), RR 0.83 (CI, 0.76 to 0.90; P<0.001; I2=0%), and OR 0.75 (CI, 0.69 to 0.82; P<0.001; I2=66%), respectively. We found no dose-response relationship or sex-specific difference.ConclusionsAny form of cycling seems to be associated with lower CVD risk, and thus, we recommend cycling as a health-enhancing physical activity.Systematic review registrationProspero CRD42016052421.

scholarly journals Effects of Physical Activity and Micronutrients on Cognitive Performance in Children Aged 6 to 11 Years: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Medicina ◽  
2021 ◽  
Vol 58 (1) ◽  
pp. 57
Author(s):  
Atiah Munirah Meli ◽  
Asma’ Ali ◽  
Abbe Maleyki Mhd Jalil ◽  
Hayati Mohd Yusof ◽  
Michelle M. C. Tan
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Randomized Controlled Trials ◽  
Cognitive Performance ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Future Studies ◽  
Randomized Controlled ◽  
Comprehensive Intervention ◽  
Positive Effect

Background and Objectives: Cognitive performance is essential for children, given this is a critical stage of brain growth and development. This systematic review and meta-analysis aimed to ascertain if physical activity or micronutrients impact cognitive performance in children. Materials and Methods: Electronic databases (PubMed and Scopus®) were searched for relevant articles published between 2012 and 2021. We emphasized randomized controlled trials (RCTs) that examined the effect of physical activity and micronutrients on cognitive performance. Data from eligible studies were gathered and evaluated using random-, fixed- or pooled-effects models with 95% confidence intervals (95% CI). Results: Physical activity appeared to improve both Mathematics (d = 1.12, 95% CI: 0.56, 1.67) and attention (d = 0.65, 95% CI: 0.15, 1.14) performances. The micronutrient vitamin B12 had a positive effect on Mathematics (d = 2.39, 95% CI: 0.79, 3.98), English (d = 5.29, 95% CI: 2.76, 7.83), Geography (d = 5.29, 95% CI: 2.76, 7.83), Science (d = 3.39, 95% CI: 2.62, 4.16) and Arts (d = 3.32, 95% CI: 1.84, 4.79). Zinc was found to positively affect English (d = 3.78, 95% CI: 0.44, 7.13), Geography (d = 4.77, 95% CI: 0.56, 8.98) and Arts (d = 2.39, CI: 0.33, 4.45). Iron positively affected Mathematics (d = 1.29, 95% CI: 0.54, 2.06), English (d = 1.29, 95% CI: 0.44, 7.13), Geography (d = 4.77, 95% CI: 0.56, 8.98) and Arts (d = 2.39, 95% CI: 0.33, 4.45). Conclusions: A more comprehensive intervention with a specific dose/level of physical activity, an increased range of cognitive performance, and a well-designed study design that accounts for dietary intake and other health outcomes are required for future studies.

scholarly journals The use of eHealth to promote physical activity in thoracic malignancies survivors: a systematic review and meta-analysis.

2021 ◽  
Author(s):  
Janet Rodríguez-Torres ◽  
Andrés Calvache-Mateo ◽  
Araceli Ortíz-Rubio ◽  
Natalia Muñoz-Vigueras ◽  
Laura López-López ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Mobile Application ◽  
Meta Analysis ◽  
Survival Rates ◽  
Telephone Counseling ◽  
Medical Subject Headings ◽  
Eligibility Criteria ◽  
Organ Systems ◽  
Thoracic Malignancies

Abstract PurposeSurvival rates for many forms of thoracic malignancies have improved over the past few decades, however, many survivors are coping with the side effects of cancer treatment for longer. Physical activity has been proposed as a therapeutic strategy to act across multiple organ systems and improve clinical outcomes and eHealth could be a good way to encourage patients. The aim of this systematic review was to explore the effects of eHealth in the promotion of PA among thoracic malignancies.MethodsSuitable articles were searched using PubMed, Web of Science and Scopus databases using a combination of medical subject headings. Articles were screened by two independent reviewers and were included if they presented an eHealth intervention to improve PA in thoracic malignancies.ResultsIn total, 4781 articles were identified, of which ten met eligibility criteria. Different eHealth interventions were described in these studies: mobile application (app) (n=3), website (n=2), email (n=2), web and mobile application (n=1), telephone counseling (n=1) and online sheet (n=1). All studies reported improvements in PA, with 8/10 studies reporting statistically significant changes. ConclusionMeta-analysis revealed eHealth is a good way to improve PA in thoracic malignancies survivors, compared to no intervention, conventional treatment or a diet approach. Future studies are needed to clarify the specific intervention to improve these patients’ recovery.

The effect of Nigella sativa on oxidative stress and inflammatory biomarkers: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Sanaz Malekian ◽  
Nafiseh Ghassab-Abdollahi ◽  
Mojgan Mirghafourvand ◽  
Azizeh Farshbaf-Khalili
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Superoxide Dismutase ◽  
Total Antioxidant Capacity ◽  
Nigella Sativa ◽  
Meta Analysis ◽  
Inflammatory Biomarkers ◽  
Controlled Trials ◽  
Tnf Α ◽  
Total Antioxidant

Abstract Objectives The present systematic review of literature was conducted to study the effect of Nigella sativa (N.S) on oxidative stress and inflammatory biomarkers. Content Different online databases such as Cochrane Central Register of Controlled Trials, MEDLINE (PubMed), Scopus, Web of Sciences, EMBASE, and Clininaltrial.gov for English articles and national databases of SID, Magiran, Irandoc, and Iranmedex for Persian articles, which were published until March; 2019 were scrutinized. All Randomised Controlled Trials (RCTs) and quasi-experimental studies that aimed to compare the impact of N.S along, with placebo or without supplementation, on inflammatory factors and oxidative stress were entered in the present study. Summary Finally, 11 RCTs covering 710 women and men, in total, were participated in the present meta-analysis. Significant differences were observed in Tumor Necrosis Factor alpha (TNF-α) (Weighted Mean Difference (WMD) =−2.15 pg/mL, 95% Confidence Interval (CI) =−3.22–−1.09, I2=32%; 5 trials with 262 participants) superoxide dismutase (WMD=63.79 µ/gHb, 95% CI=6.84–120.75, I2=0%; 2 trials, with 88 participants), and total antioxidant capacity (WMD=0.34 mmol/L, 95% CI=0.04 to 0.63, I2=94%; 5 trials with 232 participants). Nevertheless, there was no significant difference in high sensitivity C-reactive protein (WMD=−0.98 mg/L, 95% CI=−1.98–0.03, I2=78%; 5 trials with 267 participants), Interleukin 6 (IL-6) (WMD=−0.25 pg/mL, 95% CI=−0.65 to 0.16, I2=0%; 2 trials with 134 participants), and malondialdehyde (WMD=−0.95 nmol/mL, 95% CI=−1.97–0.08, I2=68%; 4 trials with 179 participants). Outlook Generally speaking, N.S probably results in the improvement of superoxide dismutase serum levels, TNF-α, and total antioxidant capacity. Thus, further studies are required to fully assess its impacts on all oxidative stress and inflammatory biomarkers.

scholarly journals The effect of grape products containing polyphenols on oxidative stress: a systematic review and meta-analysis of randomized clinical trials

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Sahar Sarkhosh-Khorasani ◽  
Zohreh Sadat Sangsefidi ◽  
Mahdieh Hosseinzadeh
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Confidence Interval ◽  
Randomized Clinical Trials ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Mean Difference ◽  
Weighted Mean ◽  
Stress Markers ◽  
Total Antioxidant

Abstract Background The literature showed that Grape Products Containing Polyphenols (GPCP) had anti-oxidant activity. However, the effects of GPCP on different biomarkers of oxidative stress are still controversial. In this regard, this systematic review and meta-analysis aimed to evaluate the effect of Grape Products Containing Polyphenols (GPCP) intake on oxidative stress markers. Methods PubMed, Scopus, Web of Science, and Google Scholar data bases were searched up to August 20, 2020. A random-effects model, weighted mean difference (WMD), and 95% confidence interval (CI) were applied for data analysis. Meta-analysis was conducted over 17 eligible RCTs with a total of 633 participants. The study registration number is CRD42019116696. Results A significant increase was observed in Total Antioxidant Capacity (TAC) (weighted mean difference (WMD) = 1.524 mmol/L, 95% confidence interval (CI): 0.83, 2.21). Intake of GPCP enhanced Superoxide Dismutase (SOD) (WMD = 0.450 mmol/L, 95% CI: 0.23, 0.66), TAC (WMD = 2.829 mmol/L, 95% CI: 0.13, 5.52), and Oxygen Radical Absorbance Capacity (ORAC) (WMD = 0.524 μmol/L, 95% CI: 0.42, 0.62) among healthy participants. Higher GPCP doses increased SOD (WMD = 0.539 U/mgHb, 95% CI: 0.24, 0.82) and ORAC (WMD = 0.377 μmol/L, 95% CI: 0.08, 0.67), whereas longer intervention periods enhanced ORAC (WMD = 0.543 μmol/L, 95% CI: 0.43, 0.64). Conclusion GPCP intake may partly improve status of oxidative stress, but further well-designed trials are required to confirm these results.

scholarly journals The Antioxidant Effect of Beta-Alanine or Carnosine Supplementation on Exercise-Induced Oxidative Stress: A Systematic Review and Meta-Analysis

2018 ◽  
Author(s):  
Elias de França ◽  
Fábio Santos Lira ◽  
Marcio Flávio Ruaro ◽  
Vinicius Barroso Hirota ◽  
Paula A. Faria Waziry ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Meta Analysis ◽  
Human Model ◽  
Sod Activity ◽  
Beta Alanine ◽  
Total Antioxidant ◽  
Acute Increase ◽  
Randomized Control ◽  
Exercise Induced

The objective of this study was to perform a systematic review and meta-analysis of the articles that addressed the effect BA or carnosine supplementation on Physical exercise (PE)-induced oxidative stress (OS). Before May 2018 we searched throughout PubMed, CAPES Periodic and SPORTDiscus human model peer review, randomized control studies with chronic BA or carnosine supplementation on PE-induced OS. A total of 128 citations were found. Only four articles met criteria for inclusion. All four studies used healthy young sedentary, recreationally active or athletic participants. After a chronic BA (~30 days) or carnosine (14 days) supplementation, the studies evaluated PE-induced OS both immediately and several hours after exercise (0.5 to 48 h). In response to PE-induced OS, when compared to placebo, BA/carnosine supplementation increased total antioxidant capacity [TAC; Effect Size (ES) = 0.35, 95% Confidence Interval (CI) 0.06 to 0.65, p = 0.02] and glutathione (GSH; ES = 0.75, 95% CI 0.32 to 1.19, p = 0.0007) concentrations while decreased direct OS markers (ES = &minus;1.19, 95% CI &minus;1.48 to &minus;0.80, p &lt; 0.01) and superoxide dismutase (SOD) activity (ES = &minus;0.58, 95% CI &minus;1.10 to &minus;0.06, p = 0.03). BA or carnosine supplementation did not prevent the increase in indirect OS markers (ES: &minus;0.20, 95% CI &minus;0.59 to 0.20, p = 0.33). In humans, following PE-induced OS, initial treatment trials of BA or carnosine supplementation seemed to increase TAC and GSH concentrations, while decreasing SOD activity. Also, albeit mitigating the acute increase in direct OS species (reactive nitrogen and oxygen species), treatment did not decrease measured values of indirect OS markers (peroxidation or molecule oxidation).

Sign in / Sign up

Export Citation Format

Share Document