scholarly journals Effect of Noni Fruit Extract (Morinda citrifolia) on Glucose Intake to Diabetes Mellitus White Rat Muscle Tissue

2020 ◽  
Vol 1 (1) ◽  
pp. 9-16
Author(s):  
Patricia Wulandari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Muscle Tissue ◽  
Morinda Citrifolia ◽  
Wild Plants ◽  
Fruit Extract ◽  
White Rats ◽  
Glucose Intake ◽  
Sugar Regulation ◽  
Sugar Levels

Noni fruit (Morinda citrifolia) is one of the most common plants inIndonesia. This plant is often found in various regions in Indonesia, where theseplants are often in the form of shrubs or wild plants that grow in yards orplantations. This study aims to assess the effect of noni (Morinda citrifolia) fruitextract on blood sugar levels and the expression of GLUT4 protein in muscletissue which shows the potential of the test extract's ability to improve bloodglucose intake to cells so that it can maintain blood sugar regulation. Thisresearch was an experimental study that used white rats as research subject.Induction of diabetes was done by injecting alloxan at a dose of 110 mg/kg BWintraperitoneally; then the white rats were given 10% glucose to drink. Alloxan-induced white rats showed a very significant increase in blood sugar levels,where the use of the drug metformin was able to reduce blood sugar levelssignificantly. In white rats induced with diabetes mellitus, there was a decreasein GLUT4 levels in muscle tissue. The administration of metformin drugs or nonifruit extracts shows the ability to increase levels of GLUT4 protein. In conclusion,noni fruit extract affects lowering blood sugar levels in diabetes mellitus whiterats by increasing glucose intake to cells and tissues.

scholarly journals Effect of Bay Leaf Extract (Syzygium polyanthum) on Blood Sugar Regulation via GLUT4 Protein Regulation in White Rat Muscle Tissue Induced Aloxan

2020 ◽  
Vol 1 (1) ◽  
pp. 24-31
Author(s):  
Rachmat Hidayat ◽  
Lusia Hayati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Muscle Tissue ◽  
Leaf Extract ◽  
Negative Control ◽  
Diabetes Group ◽  
White Rats ◽  
Target Blood Glucose ◽  
Sugar Regulation ◽  
Sugar Levels

Diabetes mellitus is a chronic condition that disturbs the body's bloodsugar regulation. Bay leaves contain entirely various secondary metabolites,where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. Thisstudy aims to assess the effect of bay leaf extract (Syzygium polyanthum) onblood sugar levels and the expression of GLUT4 protein in muscle tissue. A totalof 30 white rats (Rattus norvegicus) Wistar strain obtained from the EurekaResearch Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams.Bay leaf simplicia was obtained from the Tawangmangu Herbal Research Center,Karanganyar, Indonesia. After 1 week of adaptation, the mice were randomlydivided into the following six groups, each containing 5 animals: Normal controlgroup, diabetes group (negative control), diabetes + metformin group (Met; 45mg / kg), Diabetes + BLE (75 mg/kg), diabetes + BLE group (150 mg / kg) anddiabetes + BLE group (300 mg/kg). Alloxan-induced white rats showed a verysignificant increase in blood sugar levels, where the use of the drug metforminwas able to reduce blood sugar levels significantly even though they had notreached the target blood glucose target of less than 200 mg / dL. The treatmentwith bay leaf extract was able to reduce blood sugar levels significantly. Theadministration of metformin drugs or bay leaf extract showed the ability toincrease the level of GLUT4 protein. In conclusion, bay leaf extract affectsreducing blood sugar levels in diabetes mellitus white rats by increasing glucoseintake to cells and tissues.

scholarly journals Potential Combination of Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum and Momordica charantia Extracts Against Intake of Glucose in Muscle Rats-Induced Diabetes Mellitus

2021 ◽  
Vol 2 (1) ◽  
pp. 68-72
Author(s):  
Rachmat Hidayat ◽  
Patricia Wulandari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Secondary Metabolites ◽  
Protein Expression ◽  
Blood Sugar ◽  
Chronic Condition ◽  
Andrographis Paniculata ◽  
Glucose Intake ◽  
Sugar Regulation ◽  
Sugar Levels

Diabetes mellitus is a chronic condition that disturbs the body's blood sugarregulation. This disorder is characterized by a decrease in the ability of bodycells to intake glucose into cells. Due to the failure of cells in glucose intake,glucose buildup occurs in the extracellular, namely in the plasma. Thesemedicinal plants contain quite varied secondary metabolites, where theseplants are rich in flavonoids, alkaloids, terpenes and glycosides. The contentof these secondary metabolite compounds is believed to be rich in antioxidanteffects so that it has the effect of being able to suppress various oxidativestress conditions that cause damage to various organs due to blood sugardysregulation. The effect of Tinospora crispa, Andrographis paniculata,Cinamomum burmanii, Syzygium polyanthum and Momordica charantiaextracts on blood sugar levels and GLUT4 protein expression in muscle tissueshows the potential of the test extract's ability to improve blood glucose intaketo cells so as to maintain blood sugar regulation.

scholarly journals EFEKTIFITAS KAPSUL MENGKUDU (Morinda citrifolia) TERHADAP PENURUNAN KADAR GULA DARAH PADA PASIEN DIABETES MELLITUS DI RS BRAWIJAYA

2017 ◽  
Vol 10 (01) ◽  
Author(s):  
Yuni Irianti ◽  
Ngadiani Ngadiani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Alternative Hypothesis ◽  
Morinda Citrifolia ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Post Test ◽  
Sugar Levels

We report the supplementation of noni (Morinda citrifolia) to decrease blood sugar levels in patients with diabetes mellitus Brawijaya Hospital Surabaya, and noni problems whether supplementation is effective in reducing blood sugar levels in diabetes patients mellitus.The goal of this study was to determine the effectiveness of capsule morinda to decrease blood sugar levels in patients with Diabetes Mellitus in Brawijaya Hospital Surabaya. This type of research is to ekperimem quasi control group design with pre-test and post test. The population in this study are patients with diabetes mellitus in hospital outpatient Brawijaya. The sampling technique with a number of 60 people who were divided into 30 groups of control (can drug from a doctor) and 30 in the experimental group (can medicine from the doctor and consumption of noni capsules) .Instrumen this study is the laboratory results of random blood sugar levels with the tools glucometer ( gluko Dr). Data analysis was performed using univariate and bivariate (parametric test, Kolmogorov-Smirnov test z and Independent T-Test). From the results, no significant difference the difference in the results of pre-test and post-test in the control group and the experiment is p = 0.020 (<0.05), then the alternative hypothesis (Ha) is accepted (the results are meaningful). It is concluded that supplementation of noni effective in helping to decrease blood sugar levels of patients with diabetes mellitus, it is advisable to consume noni capsules and routine checks of blood sugar levels so that the blood sugar levels under control.

scholarly journals Tea Bag Biji Alpukat (Persea Americana Mill) terhadap Kadar Gula Darah Tikus Putih (Rattus Norvegicus)

2018 ◽  
Vol 11 (2) ◽  
pp. 56-62
Author(s):  
Ida Eliza ◽  
Erlin Yustin Tatontos ◽  
Rohmi Rohmi ◽  
Yunan Jiwintarum
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Persea Americana ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Body Activity ◽  
Sugar Levels ◽  
Microvascular And Macrovascular Complications

ABSTRACT Blood sugar levels are a very important factor for body activity because blood sugar is the main energy source whose metabolism is liver. High blood sugar levels are called hyperglycemic conditions. The hyperglycemic state is a symptom of diabetes mellitus. Diabetes mellitus is a problem that is often found in Indonesian society. This disease can cause microvascular and macrovascular complications. Giving traditional medicine such as avocado seeds (P. americana Mill) in the form of tea bag is expected to reduce the level of blood sugar. Objective: To find out the effect of avocado seeds (P. americana Mill.) In the form of tea bag on blood sugar levels of white mice (R. norvegicus) wistar strains that are hyperglycemic Method: This study is a Pre-experiment research with a Pretest-One Group research design Posttes, using 6 rats aged two to four months. After a week of adaptation and successfully induced with alloxan, a pretest blood sugar level was tested at the time. The treatment was given for one week and posttest blood glucose levels were examined. Results: The study showed a mean blood sugar level of hyperglycemic wistar white rats before being given avocado seeds (P. americana Mill.) In the form of tea bag 226.4 and average after being given avocado seeds (P. americana Mill.) In the form tea bag is 154 mg / dL. Conclusion: Avocado seeds (P. americana Mill) in the form of tea bag have an influence on the decrease in blood sugar levels of white rats (R. norvegicus) hyperglycemic wistar strains Keywords: Avocado Seeds, Hyperglycemic, Blood Sugar Levels, Tea Bag

scholarly journals The Effects of Sambiloto Leaf Extract (Andrographis peniculata) on Blood Sugar Regulation: an In Vivo Study

2020 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Lusia Hayati ◽  
Rachmat Hidayat
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Leaf Extract ◽  
Negative Control ◽  
Control Group ◽  
Diabetes Group ◽  
White Rats ◽  
Sugar Regulation ◽  
Sugar Levels

Sambiloto (Andrographis peniculata) is one of the most common plants inIndonesia. Sambiloto contains quite varied secondary metabolites, where thisplant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aimsto assess the effect of Sambiloto (Andrographis peniculata) leaf extract on bloodsugar levels and the expression of GLUT4 protein in muscle tissue whichindicates the potential of the test extract's ability to improve blood glucose intaketo cells so that it can maintain blood sugar regulation. The process of extractingsambiloto is carried out by maceration in which 500 grams of simplicia aremacerated with 96% ethanol for 72 hours. After 1 week of adaptation, the micewere randomly divided into the following six groups, each containing 5 animals:Normal control group, diabetes group (negative control), diabetes + metformingroup (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group(100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambilotoextract was able to reduce blood sugar levels significantly, were at the ES 100and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach thetarget below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extractare believed to be responsible for the effect of blood glucose regulation. Inconclusion, Sambiloto extract affects lowering blood sugar levels in diabetesmellitus white rats by increasing glucose intake to cells and tissues.

scholarly journals Pengaruh Edukasi Senam Kaki Diabetes Mellitus Berbahasa Tetum Terhadap Sirkulasi Ekstremitas Bawah Dan Kadar Gula Darah Sewaktu Di Centru Saude Comoro, Dili, Timor Leste.

2020 ◽  
Vol 5 (1) ◽  
pp. 16-24
Author(s):  
Carmelita Barros ◽  
Fitri Arofiati
Keyword(s):  
Diabetes Mellitus ◽  
Lower Extremity ◽  
Blood Sugar ◽  
Blood Circulation ◽  
Blood Sugar Level ◽  
Statistical Tests ◽  
Wilcoxon Test ◽  
Timor Leste ◽  
Post Test ◽  
Sugar Levels

ABSTRACT Diabetes mellitus (DM) in Indonesia is better known as diabetes and in Timor Leste DM known as Ra'an Midar has become a very serious health problem, and is the most common endocrine disease. Diabetes mellitus is a degenerative disease that is characterized by metabolic disorders or pancreatic damage so that the pancreas is unable to produce enough insulin to the maximum so that it can cause insulin deficiency in the body both absolute and relative can increase blood sugar levels or hyperglycemia. Data from the Dili District Health Office in 2018 showed that there were 2690 patients with diabetes mellitus, so that diabetic foot exercises were needed. The purpose of this study was to determine the effect of Tetum Language Diabetes Foot Gymnastic Education on Lower Circulation and Lower Blood Sugar Levels at the Saude Comoro Center, Dili, Timor Leste. Method : using the Pre-Experiment method. Independent variable: Education of Tetum Language Diabetes Foot Gymnastics Education, dependent variable: Circulation of Lower Extremity and Blood Sugar Level at a Time. Population 100 people, sample 28 people, sample technique: simple random, data collection: Examination of blood sugar levels, blood circulation, statistical tests: Wilcoxon Test. Results : Most respondents who had good blood circulation were 15 pre- test (53.6%) and 18 post-test (64.3%). And the majority of respondents whose blood sugar levels were good were 14 people pre-test (50.0%) and 20 people post test (71.4%). Based on the results of statistical tests using the Wilcoxon Signed Rank Test, the value of blood circulation is a significant level of 0.005 and the blood sugar level is at a significant level of 0,000. Conclusion : Conclusion there is the influence of Education on Tetun Language Diabetes Foot Gymnastics on Lower Extracurricular Circulation and Blood Sugar Levels At the Saude Comoro Center, Dili, Timor Leste.  Keyword: Leg exercise, lower extremity bloodd circulation, Blood sugar levels, Diabetes mellitus.

scholarly journals Pengaruh Pelayanan Kefarmasian di Rumah pada Pasien Diabetes Melitus Tipe 2 di Puskesmas Wilayah Kota Yogyakarta

2020 ◽  
Vol 10 (2) ◽  
pp. 126
Author(s):  
Nur Rasdianah ◽  
Suwaldi Martodiharjo ◽  
Tri Murti Andayani ◽  
Lukman Hakim
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Medication Adherence ◽  
Glycemic Control ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Level Of Knowledge ◽  
Sugar Levels

The increasing prevalence of diabetes mellitus (DM) in Indonesia requires participation of all parties including pharmacists. This study aims to determine the impact of the implementation of home pharmacy service guidelines for patients with type 2 diabetes mellitus on the level of knowledge, medication adherence, therapeurical satisfaction and glycemic control. This study used a quasi-experimental design with one group pre-test and post-test design involving 37 patients with type 2 diabetes mellitus who met the requirements of inclusion and exclusion criterias. The Diabetes Knowledge Questionnaire (DKQ-24) and the Diabetes Medication Satisfaction Tool (DMSAT) were used for collecting the data. Patient adherence was measured using a pillcount method and fasting blood sugar levels (FSB) data were obtained from the laboratory results. The study was conducted in two community health centers and patient’s home in the Yogyakarta Municipality area. The data were analysed using Wilcoxon and Spearman test. The results showed the change of the level of knowledge, medication adherence, therapeutic satisfaction and glycemic control before and after intervention of pharmacy services at home. The average decreasing of fasting blood sugar levels 17.09 mg/dL ± 1.43

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