scholarly journals THE EFFECT OF ENTEROSORPTION AND INTRATISSULAR ELECTROFORESIS OF ANTIBACTERIAL DRUGS ON PROGRESS OF BURN DISEASE

2020 ◽  
pp. 188-192
Author(s):  
B. V. Petriuk ◽  
I. I. Blуk ◽  
О. V. Rоtаr ◽  
L. P. Khomko ◽  
T. A. Petriuk ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Thermal Damage ◽  
Positive Influence ◽  
Reparative Regeneration ◽  
Comprehensive Treatment ◽  
Antibacterial Drugs ◽  
Average Mass ◽  
Thermal Burns ◽  
Burn Disease ◽  
Extensive Burns

Summary. The purpose of our research was to explore the appropriateness of combined usage of enterosorption amplification and intratissular electrophoresis (ITE) of antibiotics in cases of substantial thermal burns. The effect of intratissular electrophoresis (ITE) of antibacterial drugs and enterosorption was studied in 22 patients with dermal thermal burns from 28 to 54 % of their body surface. ITE of antibiotics started from the 3–4 day applying the direct current with density 0,03-0,05 mAh/cm² for 60 min. by the «POTOK-1» device. The authors determined the intoxication degree based on the leukocyte index, the number of average mass molecules and blood plasma electrical conductivity. Also, they observed the course of wound process, conducted bacteriological and cytological researches of the burn wounds in dynamics on 1–3, 6–7, 13–14 and 19–21 days of the burn disease progress. It was found that enterosorption usage in the comprehensive treatment of burn disease allows not only to reduce the level of endogenous intoxication but also to provide an indirect optimizing impact on the progressing of the wound process in the zone of thermal damage, stimulate the reparative regeneration. In the cases with extensive burns, combined usage of the enterosorption detoxification by Enterosgel with the ITE of antibacterial drugs contribute more qualitative positive influence on the wound process and burn disease in general.

scholarly journals THE EFFECT OF ENTEROSORPTION AND INTRATISSULAR ELECTROFORESIS OF ANTIBACTERIAL DRUGS ON PROGRESS OF BURN DISEASE

2021 ◽  
pp. 117-121
Author(s):  
B. V. Petryuk ◽  
T. A. Petryuk ◽  
L. P. Khomko ◽  
O. Yо. Khomko ◽  
I. E. Semenyuk
Keyword(s):  
Electrical Conductivity ◽  
Blood Test ◽  
Thermal Damage ◽  
Clinical Effect ◽  
Clinical Effectiveness ◽  
Reparative Regeneration ◽  
Complex Treatment ◽  
Antibacterial Drugs ◽  
Average Mass ◽  
Burn Disease

Summary. The purpose of the research was to explore the appropriateness of combined usage of enterosorption amplification and intratissular electrophoresis (ITE) of antibiotics in injured with the substantial thermal burns. Clinical effect of the enterosorbtion and ITE antibacterial drugs in burn disease cases was studied in 26 patients with superficial and deep dermal burns (IIb-III deg.) from 27 to 60 % of their body surface. Enterosgel was prescribed from 3rd day after injury for 15–20 g 3–4 times a day for 7–14 days. ITE of antibiotics conducted from the 3–4 day by the «Поток-1» device, applying the direct current with density 0,03-0,05 mAh/cm2 for 60 min. Materials and methods. The authors studied the leukocyte reaction by a general blood test. The degree of intoxication was determined by the level of molecules of average mass and blood plasma electrical conductivity. They evaluated the dynamics of the wound process, conducted bacteriological and cytological researches of the burn wounds in dynamics on 1–3, 6–7, 13–14, and 19-21 days after traumatization. Results and discussion. This treatment tactic allows to reduce the level of endogenous intoxication, to optimize the course of the wound process in the area of thermal damage, to intensify demarcation-cleansing processes and reparative regeneration, which increases the clinical effectiveness of treatment. Conclusions. As a result of the research, it was found that the combined usage of enterosorption detoxification by enterosgel and ITE of antibacterial drugs in the complex treatment of victims with widespread burns is appropriate and justified.

Meaning of innovative technologies for improvement of results in treating burned patients

2020 ◽  
pp. 44-47
Author(s):  
A. A. Alekseev ◽  
A. E. Bobrovnikov ◽  
V. V. Bogdanov
Keyword(s):  
Clinical Practice ◽  
Medical Care ◽  
Clinical Effectiveness ◽  
High Tech ◽  
Comprehensive Treatment ◽  
Case Histories ◽  
Innovative Technologies ◽  
Treatment Technologies ◽  
Burn Disease ◽  
Complications And Mortality

In order to include innovative technologies in clinical recommendations, confirmation of their clinical effectiveness in comprehensive treatment of burned patients is necessary. 1,696 case histories of patients with burns were audited, which are divided into two groups depending on peculiarities of treatment. The use of innovative treatment technologies for burned patients has reduced the incidence of burn disease complications and mortality. Introduction of innovative technologies in treating burned patients into broad clinical practice improves results of provision of specialized, high-tech medical care for victims of burns.

scholarly journals Preparation and Properties of Layered SiC-Graphene Composites for EDM

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2916
Author(s):  
Ondrej Hanzel ◽  
Zoltán Lenčéš ◽  
Peter Tatarko ◽  
Richard Sedlák ◽  
Ivo Dlouhý ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Surface Layer ◽  
Positive Influence ◽  
Layered Composite ◽  
Layered Composites ◽  
Good Adhesion ◽  
Electric Discharge Machining ◽  
Layer Sequence ◽  
The Individual ◽  
Scratch Tests

Three and five-layered silicon carbide-based composites containing 0, 5, and 15 wt.% of graphene nanoplatelets (GNPs) were prepared with the aim to obtain a sufficiently high electrical conductivity in the surface layer suitable for electric discharge machining (EDM). The layer sequence in the asymmetric three-layered composites was SiC/SiC-5GNPs/SiC-15GNPs, while in the symmetric five-layered composite, the order of layers was SiC-15GNPs/SiC-5GNPs/SiC/SiC-5GNPs/SiC-15GNPs. The layered samples were prepared by rapid hot-pressing (RHP) applying various pressures, and it was shown that for the preparation of dense 3- or 5-layered SiC/GNPs composites, at least 30 MPa of the applied load was required during sintering. The electrical conductivity of 3-layered and 5-layered composites increased significantly with increasing sintering pressure when measured on the SiC surface layer containing 15 wt.% of GNPs. The increasing GNPs content had a positive influence on the electrical conductivity of individual layers, while their instrumented hardness and elastic modulus decreased. The scratch tests confirmed that the materials consisted of well-defined layers with straight interfaces without any delamination, which suggests good adhesion between the individual layers.

scholarly journals The Effect of Conductivity Changes on Temperature Rise During Irreversible Electroporation

2020 ◽  
Author(s):  
Amir Khorasani
Keyword(s):  
Electrical Conductivity ◽  
Cell Death ◽  
Electric Field ◽  
Electric Field Intensity ◽  
Thermal Damage ◽  
Pulse Sequence ◽  
Irreversible Electroporation ◽  
Tissue Temperature ◽  
Comsol Multiphysics ◽  
Simulation Results

Purpose: Irreversible electroporation is a physical process which is used for killing the cancer cells. The process that leads to cell death in this method is a unique process. Thermal damage does not exist in this process. However, the temperature of the tissue also increases during the electroporation. In this study, we aim to investigate the effect of conductivity changes on tissue temperature increase during the irreversible electroporation process. Materials and Methods: To perform simulations and solve equations, COMSOL MultiPhysics has been used. Standard electroporation pulse sequence (8 pulses with different electric field intensities) was used as a pulse sequence in the simulation. Results: During the electroporation process, the electrical conductivity and the temperature of the tissue were increased. Changes in the tissue temperature in the simulation with variable electrical conductivity are more than in the simulation with constant electrical conductivity during the electroporation process. This difference for pulses with more vigorous electric field intensity and points closer to the electrodes has been achieved more. Conclusion: To more accurately estimate and calculate the temperature and thermal damage inside the tissue during the irreversible electroporation process, it is suggested to consider the effect of conductivity changes during this process.

scholarly journals High-conductivity flexible Ag films formed by low-temperature and short-time sintering of PVP-modified silver oxalate composite ink

2022 ◽  
Author(s):  
PeiYuan Fan ◽  
WenHua Zhang ◽  
Xianglei Yu ◽  
GuoYou Gan
Keyword(s):  
Electrical Conductivity ◽  
Low Temperature ◽  
Flexible Electronics ◽  
Production Efficiency ◽  
Silver Film ◽  
Sintering Temperature ◽  
Positive Influence ◽  
Complexing Agent ◽  
Silver Oxalate ◽  
The Impact

Abstract Attaining low-temperature sintering and high electrical conductivity is vital in the field of flexible electronics. Inks with silver oxalate as the precursor have recently received significant attention in this field; however, the high sintering temperature and long sintering time limit commercial applicability. High sintering temperature can shorten the sintering timereducing the conductivity. but lead to porous and uneven filmOn the other hand, morphology;low sintering temperature prolongthus,s thesintering time; thus, reducing the production efficiency. To solve the abovementionedproblems, a silver composite conductive ink modified by polyvinylpyrrolidone (PVP)was prepared in this study. The ink used silver oxalate as the precursor, methanol and acetone as the solvent, and 1, 2-diaminopropane as the complexing agent, and could reduce the sintering temperature and time to 160℃ and 20 min, respectively. After sintering, the silver film showed good electrical conductivity, and low resistivity (4.56 μΩ·cm). Furthermore, the impact of sintering temperature on the surface morphology and electrical conductivity were also studied, and the results showed that PVP had a positive influence on the nucleation of silver and the microstructure of the sintered silver film.

Surface Quality and Contamination on Si Wafer Surfaces Sliced Using Wire-Electrical Discharge Machining

2019 ◽  
Vol 141 (4) ◽  
Author(s):  
Kamlesh Joshi ◽  
Pradeep Padhamnath ◽  
Upendra Bhandarkar ◽  
Suhas S. Joshi
Keyword(s):  
Surface Quality ◽  
Electrical Discharge ◽  
Thermal Damage ◽  
Electrical Discharge Machining ◽  
Wafer Surface ◽  
Comprehensive Treatment ◽  
Wire Electrical Discharge Machining ◽  
Dielectric Flushing ◽  
Wafer Surfaces ◽  
Si Wafer

Abstract In the past, studies on wire-electrical discharge machining (EDM) of Si wafers have often focused on the effect of energy-related parameters on various wafer characteristics. However, comprehensive treatment on analyzing the effect of non-energy parameters of the Si wafer slicing process is not available thus far. This work, therefore, presents an extensive experimental work considering the parameters like wire tension (WT), wire feed rate (WF), and dielectric flushing pressure (WaP) on crucial wafer characteristics such as wafer-thickness and its uniformity, thermal damage, wire material contamination on wafer surfaces, and surface quality. A total of 72 experiments were performed at low and high servo voltage (SV) conditions. The sliced wafers were characterized by SEM, EDAX, and ICP-AES techniques. Ultrathin wafers with a uniform thickness of ∼107 µm were sliced at high SV conditions, while a lower thermal damage (∼10 µm) with low wire contamination was observed during low SV conditions. The percentage of contamination was further found to decrease with an increase in WT, WF, and WaP during low SV conditions. The wafer surface etching showed the diffusion of contaminates like Cu/Zn up to a depth of 25–30 µm. The wafer surface roughness in the middle section has always been observed to be poor due to short-circuiting and arcing within that zone.

scholarly journals To the Question about the Methods Used in Combustiology Practice to Assess the Condition of Patients and Predict General and Local Complications

2021 ◽  
Vol 6 (6) ◽  
pp. 33-43
Author(s):  
О. V. Shapoval ◽  
◽  
N. А. Komaromi ◽  
M. M. Patsatsyia
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
Thermal Damage ◽  
Glycosylated Hemoglobin ◽  
Abdominal Pressure ◽  
Burn Wound ◽  
Doppler Flowmetry ◽  
Hematological Indices ◽  
Local Complications ◽  
Burn Disease

The aim. The article is devoted to the methods used in combustiology practice to assess the condition of patients and predict general and local complications. Results. With severe thermal trauma, there is a risk of developing life-threatening conditions in the victims, in particular, sepsis and multiple organ failure. Informative for assessing the course of burn disease is a modified scale of physiological disorders, which takes into account the syndrome of systemic inflammatory response, endogenous intoxication during periods of toxemia and septicotoxemia, and concomitant pathology. The development of intoxication in severe burn injuries requires determining the degree of severity of the process and its assessment in dynamics. The toxicity of blood plasma is studied by the resistance of red blood cell membranes in the acid hemolysis reaction, indicators of the red blood cell intoxication index, and the content of universal markers of intoxication, in particular, medium-weight molecules. Methods for biosensor indication of cytotoxic factors have also been developed. Assessment of the severity of the condition of victims with burns and monitoring the effectiveness of therapy is carried out taking into account the level of procalcitonin and presepsin. To determine the effect of the wound process on the formation of early sepsis in patients with burns in the capillary zone of thermal damage, the content of homocysteine, endothelin and nitric oxide is studied. To assess the severity of the condition of burn patients and predict the development of complications, the values of integral hematological indices are informative. Reliable data on the depth of a burn wound are obtained using thermotopometry and pH measurement of burn wounds, the method of magnetic resonance imaging. In order to assess violations and dynamics of blood supply restoration in the area of thermal damage, the method of laser Doppler flowmetry and optical tissue oximetry is used. Determination of interstitial pressure in burns of the extremities and intra-abdominal pressure in common burns is a way to predict the development of compartment syndrome. To monitor the patient's glycemic status, it is proposed to determine the level of glycosylated hemoglobin. Microbiological research data is used to predict the risk of developing general complications of burn disease, as well as – together with cytological data and methods for determining the maturity of granulation tissue – to assess the readiness of granulating wounds for autodermoplasty. Conclusion. The development of new effective ways to predict and prevent the development of complications in burns is promising

scholarly journals Evaluation of Repellent Effectiveness of Polyvinyl Alcohol/Eucalyptus globules Nanofibrous Membranes against Forcipomyia taiwana

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 870
Author(s):  
Ching-Wen Lou ◽  
Ming-Chun Hsieh ◽  
Chao-Tsang Lu ◽  
Mei-Feng Lai ◽  
Mong-Chuan Lee ◽  
...  
Keyword(s):  
Electrical Conductivity ◽  
Essential Oil ◽  
Polyvinyl Alcohol ◽  
Cell Viability ◽  
Slow Release ◽  
Positive Influence ◽  
Fiber Formation ◽  
Nanofibrous Membranes ◽  
Pva Solutions ◽  
Eucalyptus Globules

This study aims to develop nanofibrous membranes where Eucalyptus globules oil (EGO) is wrapped in polyvinyl alcohol (PVA). The EGO-based nanofibrous membranes are then evaluated for the protection against Forcipomyia taiwana (F. taiwana). In the first stage, the PVA solutions are formulated with different concentrations and are measured for viscosity and electrical conductivity. In the next stage, PVA solution and EGO are blended at different ratios and electrospun into PVA/EGO nanofibrous membranes (i.e., EGO-based repellent). In this study, a PVA concentration of 14 wt% has a positive influence on fiber formation. Furthermore, the finest nanofibers of 291 nm are presented when the voltage is 15 kV. The repellent efficacy can reach 80% in a 60-min release when the repellent is composed of a PVA/oil ratio of 90/10. To sum up, the nanofibrous membranes of essential oil exhibit good repellent efficacy against F. taiwana and significant slow-release effect, instead of adversely affecting the cell viability.

scholarly journals Improvement of reparative regeneration in surgery

2018 ◽  
Vol 35 (3) ◽  
pp. 32-38
Author(s):  
D. V. Plecheva ◽  
V. P. Okroyan ◽  
T. R. Ibragimov ◽  
O. V. Galimov ◽  
V. O. Khanov
Keyword(s):  
Gastrointestinal Tract ◽  
Experimental Studies ◽  
Positive Influence ◽  
Experimental Models ◽  
Reparative Regeneration ◽  
The Body ◽  
Surgical Patients ◽  
Intestinal Anastomoses ◽  
Healing Of Skin Wounds ◽  
The Impact

Aim. To improve the reparative tissue regeneration, applying oxymethyluracil in surgical patients. Materials and methods. The impact of 5-oxymethyluracil-2,4-dioxo-5-hydroxy-6-methyl-1,2,3,4-tetrahydropirimidine (5-OMU) on the processes of regeneration stimulation in the tissues was studied in 4 groups, including different organs and systems of the body. The analysis of the results of using 5-OMU for torpid wounds in general surgery included 145 patients, erosive-ulcerous lesion of the upper parts of gastrointestinal tract – 126, reparative surgeries on GIT – 105 and revasculizing interventions on the heart – 63. To develop experimental models, mature rats, aged 11–12 months, with the body mass 2.9 ± 1.7 kg were used. Two sets of experiments with cut and burn wounds were implemented. Results. The experimental studies, aimed at investigation of histological and histochemical preparations, demonstrated positive influence of oxymethyluracil on the healing of skin wounds. Conclusions. On the basis of the studies carried out, the preparation is also recommended for use in other fields of surgery for the treatment of erosive-ulcerous lesions of the upper part of gastrointestinal tract, for intestinal anastomoses and when performing revasculizing surgeries on the heart. Different drug forms of this preparation were developed to reach its maximum concentration in the tissues, clinical trials were conducted and its efficient use in clinical practice was confirmed.

Modelling the Stress Concentration in CFRP at Notches with a Thermally Influenced Cut Edge

2016 ◽  
Vol 1140 ◽  
pp. 288-295 ◽  
Author(s):  
Johannes W. Stock ◽  
Johanna Kerschreiter
Keyword(s):  
Heat Affected Zone ◽  
Laser Cutting ◽  
Thermal Damage ◽  
Fatigue Behaviour ◽  
Positive Influence ◽  
Static Strength ◽  
Measured Temperature ◽  
Cut Edge ◽  
Critical Tension ◽  
Open Hole

The use of higher laser powers in laser cutting of CFRP results in both an increase of productivity and in a growth of the heat affected zone at the cut edge. This thermal damage was related to a loss of the static strength due to the reduce load bearing cross section in various studies. In contrast, the thermal damage caused an increase of the average number of load cycles and to a significant reduction of the deviation among the repetitions of each parameter during dynamic open hole tensile testing in recent studies. To explain this positive influence of laser cutting on the fatigue behaviour of CFRP, an analytical model of the load concentration in a plate with a circular notch could be adapted and modified. The orthotropic property of the material is considered in the model. The static strength of thermally treated CFRP was determined in experiments and applied to the model. By inserting the measured temperature-dependent values of the Young´s modulus, the critical tension at the notch could be determined related to the dimensions of the heat affected zone.

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