scholarly journals Improvement of reparative regeneration in surgery

2018 ◽  
Vol 35 (3) ◽  
pp. 32-38
Author(s):  
D. V. Plecheva ◽  
V. P. Okroyan ◽  
T. R. Ibragimov ◽  
O. V. Galimov ◽  
V. O. Khanov
Keyword(s):  
Gastrointestinal Tract ◽  
Experimental Studies ◽  
Positive Influence ◽  
Experimental Models ◽  
Reparative Regeneration ◽  
The Body ◽  
Surgical Patients ◽  
Intestinal Anastomoses ◽  
Healing Of Skin Wounds ◽  
The Impact

Aim. To improve the reparative tissue regeneration, applying oxymethyluracil in surgical patients. Materials and methods. The impact of 5-oxymethyluracil-2,4-dioxo-5-hydroxy-6-methyl-1,2,3,4-tetrahydropirimidine (5-OMU) on the processes of regeneration stimulation in the tissues was studied in 4 groups, including different organs and systems of the body. The analysis of the results of using 5-OMU for torpid wounds in general surgery included 145 patients, erosive-ulcerous lesion of the upper parts of gastrointestinal tract – 126, reparative surgeries on GIT – 105 and revasculizing interventions on the heart – 63. To develop experimental models, mature rats, aged 11–12 months, with the body mass 2.9 ± 1.7 kg were used. Two sets of experiments with cut and burn wounds were implemented. Results. The experimental studies, aimed at investigation of histological and histochemical preparations, demonstrated positive influence of oxymethyluracil on the healing of skin wounds. Conclusions. On the basis of the studies carried out, the preparation is also recommended for use in other fields of surgery for the treatment of erosive-ulcerous lesions of the upper part of gastrointestinal tract, for intestinal anastomoses and when performing revasculizing surgeries on the heart. Different drug forms of this preparation were developed to reach its maximum concentration in the tissues, clinical trials were conducted and its efficient use in clinical practice was confirmed.

scholarly journals Experimental Modeling of Necrotizing Enterocolitis: Pathogenesis, Predictors, Prevention of the Disease

2020 ◽  
Vol 13 (3) ◽  
pp. 293-300
Author(s):  
Irina Karpova ◽  
Daria Molchanova ◽  
Tatiana Ladygina
Keyword(s):  
Necrotizing Enterocolitis ◽  
Systemic Disease ◽  
Interleukin 1 ◽  
Bacterial Flora ◽  
Experimental Studies ◽  
Experimental Models ◽  
Current Data ◽  
Experimental Modeling ◽  
Antibacterial Drug ◽  
The Impact

Introduction. The incidence rate of necrotizing enterocolitis is 2.4:1000 of newborns. The number of complications reaches 51-68%, and mortality rate varies from 4 to 80%. The aim of the study was to present current data of Russian and foreign experimental studies related to necrotizing enterocolitis in children. Results. Currently, infants with low and very low body weight constitute the most proportion of patients with enterocolitis; the development of the disease in this cohort of patients has its distinctive features. In this regard, the issues of pathogenesis, the impact of risk factors and methods of prevention of the pathological process remain underinvestigated. Experimental models were used to study the features of the toll-interleukin 1 receptor domain containing adapter protein (TIRAP), the etiology of Toll-like receptor 4 expression, and the reasons for the increased levels of inflammatory mediators. The mechanism of intestinal-brain reciprocal communication was confirmed. The role of the bacterial flora and effectiveness of the antibacterial drug effect on this flora was also determined. Biomarkers of enterocolitis, such as an epidermal growth factor, interleukins, claudins 2, 3, 4, were detected using experimental modeling. Various options for disease prevention ranging from ischemic preconditioning to probiotics application and breastfeeding were analyzed, the latter ones having beneficial ability to form natural defenses in newborns. Conclusions. Thus, necrotizing enterocolitis is a severe systemic disease. Experimental modeling allows analyzing the most complex, unsolved problems and introducing novel knowledge into clinical practice.

scholarly journals The Impact of Time of Day on Energy Expenditure: Implications for Long-Term Energy Balance

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2383 ◽  
Author(s):  
Shaw ◽  
Leung ◽  
Jong ◽  
Coates ◽  
Davis ◽  
...  
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Energy Intake ◽  
Experimental Studies ◽  
Time Of Day ◽  
Circadian System ◽  
The Body ◽  
Energy Regulation ◽  
Meal Timing ◽  
The Impact

There is evidence to indicate that the central biological clock (i.e., our endogenous circadian system) plays a role in physiological processes in the body that impact energy regulation and metabolism. Cross-sectional data suggest that energy consumption later in the day and during the night is associated with weight gain. These findings have led to speculation that when, as well as what, we eat may be important for maintaining energy balance. Emerging literature suggests that prioritising energy intake to earlier during the day may help with body weight maintenance. Evidence from tightly controlled acute experimental studies indicates a disparity in the body’s ability to utilise (expend) energy equally across the day and night. Energy expenditure both at rest (resting metabolic rate) and after eating (thermic effect of food) is typically more efficient earlier during the day. In this review, we discuss the key evidence for a circadian pattern in energy utilisation and balance, which depends on meal timing. Whilst there is limited evidence that simply prioritising energy intake to earlier in the day is an effective strategy for weight loss, we highlight the potential benefits of considering the role of meal timing for improving metabolic health and energy balance. This review demonstrates that to advance our understanding of the contribution of the endogenous circadian system toward energy balance, targeted studies that utilise appropriate methodologies are required that focus on meal timing and frequency.

scholarly journals Cultural Pluralism and Social Connectedness as Predictors of Immigrant Students’ Social Wellbeing and Achievements

2021 ◽  
Vol 8 (4) ◽  
pp. 154
Author(s):  
Abu Bakar HM
Keyword(s):  
Social Connectedness ◽  
Survey Methodology ◽  
Immigrant Students ◽  
Positive Impact ◽  
Perceived Discrimination ◽  
Positive Influence ◽  
Cultural Pluralism ◽  
The Body ◽  
Social Wellbeing ◽  
The Impact

Based on the utmost importance of respecting cultural differences to foster learning among immigrant students from diverse cultures and grounded in Social Psychology Theory, this study investigates the impact of cultural pluralism and social connectedness on immigrant students’ achievement through social wellbeing. Moreover, the contingent impact of perceived discrimination in decreasing the positive influence of students’ social wellbeing has been assessed. This study advances the body of literature regarding cultural diversity as well as the importance of cultural pluralism and social connectedness in promoting social wellbeing to enhance the achievements of immigrant students. Applying a time-lagged survey methodology, data were collected from the 323 immigrant students from the universities located at Kalimantan Island of Indonesia. Data were analyzed using SmartPLS software. The results revealed the positive impact of cultural pluralism and social connectedness on immigrant students’ social wellbeing leading to high achievements. Results also showed that the positive influence of immigrant students’ social wellbeing on their achievements decreases in the presence of perceived discrimination as a moderator.

scholarly journals Integrated Bioinformatics Data Analysis and Experimental Studies Reveals Prognostic Significance of ALDH Family in Endometria Cancer

2021 ◽  
Author(s):  
Zhou-Tong Dai ◽  
Yuan Xiang ◽  
Xing-Hua Liao
Keyword(s):  
Cell Lines ◽  
Cox Regression ◽  
Prognostic Significance ◽  
Experimental Studies ◽  
Female Reproductive Tract ◽  
The Body ◽  
Mouse Tumor ◽  
The Impact

Abstract Background Uterine Corpus Endometrial Cancer (UCEC) is one of the three common malignant tumors of the female reproductive tract. According to reports, the cure rate of early UCEC can reach 95%. Therefore, the development of prognostic markers will help UCEC patients to find the disease earlier and develop treatment earlier. The ALDH family was first discovered to be the essential gene of the ethanol metabolism pathway in the body. Recent studies have shown that ALDH can participate in the regulation of cancer. Methods We used the gene profile data of 33 cancers in the TCGA database to analyze the expression and survival of the ALDH family. GO, KEGG, PPI multiple functional analysis was used to predict the regulatory role of ALDH family in cancer. In addition, using CCK-8, colony formation, nude mouse tumor formation and other methods, the in vitro function of UCEC cancer cell lines was tested to further confirm the key role of ALDH2 expression in the proliferation of UCEC cell lines. Finally, Lasso and Cox regression methods were used to establish an overall survival prognosis model based on ALDH2 expression. Result In our research, we explored the expression of ALDH family in 33 cancers. It was found that ALDH2 was abnormally expressed in UCEC. Besides, in vivo and in vitro experiments were conducted to explore the effect of ALDH2 expression on the proliferation of UCEC cell lines. Meanwhile, the change of its expression is not due to gene mutations, but is regulated by miR-135-3p. At the same time, the impact of ALDH2 changes on the survival of UCEC patients is deeply discussed. Finally, a nomogram for predicting survival was constructed, with a C-index of 0.798 and AUC of 0.764. Conclusion This study suggests that ALDH2 may play a crucial role in UCEC progression and has the potential as a prognostic biomarker of UCEC.

scholarly journals Hemoglobin stimulates vigorous growth of Streptococcus pneumoniae and shapes the pathogen's global transcriptome

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fahmina Akhter ◽  
Edroyal Womack ◽  
Jorge E. Vidal ◽  
Yoann Le Breton ◽  
Kevin S. McIver ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Positive Influence ◽  
The Body ◽  
Host Proteins ◽  
Vigorous Growth ◽  
Cultivation In Vitro ◽  
The Impact ◽  
Heme Binding Protein

Abstract Streptococcus pneumoniae (Spn) must acquire iron from the host to establish infection. We examined the impact of hemoglobin, the largest iron reservoir in the body, on pneumococcal physiology. Supplementation with hemoglobin allowed Spn to resume growth in an iron-deplete medium. Pneumococcal growth with hemoglobin was unusually robust, exhibiting a prolonged logarithmic growth, higher biomass, and extended viability in both iron-deplete and standard medium. We observed the hemoglobin-dependent response in multiple serotypes, but not with other host proteins, free iron, or heme. Remarkably, hemoglobin induced a sizable transcriptome remodeling, effecting virulence and metabolism in particular genes facilitating host glycoconjugates use. Accordingly, Spn was more adapted to grow on the human α − 1 acid glycoprotein as a sugar source with hemoglobin. A mutant in the hemoglobin/heme-binding protein Spbhp-37 was impaired for growth on heme and hemoglobin iron. The mutant exhibited reduced growth and iron content when grown in THYB and hemoglobin. In summary, the data show that hemoglobin is highly beneficial for Spn cultivation in vitro and suggest that hemoglobin might drive the pathogen adaptation in vivo. The hemoglobin receptor, Spbhp-37, plays a role in mediating the positive influence of hemoglobin. These novel findings provide intriguing insights into pneumococcal interactions with its obligate human host.

Elevated dietary sugar and the heart: experimental models and myocardial remodeling

2010 ◽  
Vol 88 (5) ◽  
pp. 525-540 ◽  
Author(s):  
Kimberley M. Mellor ◽  
Rebecca H. Ritchie ◽  
Amy J. Davidoff ◽  
Lea M.D. Delbridge
Keyword(s):  
Insulin Resistance ◽  
Stress Responses ◽  
Metabolic Response ◽  
Myocardial Dysfunction ◽  
Experimental Studies ◽  
Experimental Models ◽  
Sugar Intake ◽  
High Fructose ◽  
Dietary Sugar ◽  
The Impact

A dramatic rise in the prevalence of insulin resistance has been paralleled by increasing dietary consumption of sugar. The use of added sweeteners containing fructose (sucrose and high-fructose corn syrup) has increased by 25% over the past 3 decades. High fructose intake has the potential to adversely influence systemic and cellular metabolism via insulin resistance and glycolytic dysregulation. As a tissue that is both insulin sensitive and glycolysis dependent, the heart may be especially vulnerable to fructose over-consumption. In this review, experimental studies of elevated dietary sugar intake are evaluated, including sucrose and fructose dietary manipulation models. The possible role of the GLUT5 transporter as a mediator of cardiomyocyte fructose uptake is considered. The impact of dietary sucrose and fructose on cardiac insulin-dependent signaling in the context of perturbed systemic metabolic response is detailed. Myocardial dysfunction, modified growth, and oxidative stress responses associated with high dietary sugar intake are discussed. Finally, the involvement of the renin–angiotensin system in mediating fructose cardiopathology is considered. This review highlights the importance of obtaining new mechanistic data that can contribute to a more developed understanding of how high sugar intake directly contributes to structural and functional cardiomyopathy.

scholarly journals The impact of anorexigenic peptides in experimental models of Alzheimer’s disease pathology

2019 ◽  
Vol 240 (2) ◽  
pp. R47-R72 ◽  
Author(s):  
Lenka Maletínská ◽  
Andrea Popelová ◽  
Blanka Železná ◽  
Michal Bencze ◽  
Jaroslav Kuneš
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Energy Homeostasis ◽  
Neurodegenerative Disorder ◽  
Experimental Studies ◽  
The Elderly ◽  
Experimental Models ◽  
New Drugs ◽  
Neuroprotective Effects ◽  
The Impact

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder in the elderly population. Numerous epidemiological and experimental studies have demonstrated that patients who suffer from obesity or type 2 diabetes mellitus have a higher risk of cognitive dysfunction and AD. Several recent studies demonstrated that food intake-lowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases. In this review, the neuroprotective effects of anorexigenic peptides of both peripheral and central origins are discussed. Moreover, the role of leptin as a key modulator of energy homeostasis is discussed in relation to its interaction with anorexigenic peptides and their analogs in AD-like pathology. Although there is no perfect experimental model of human AD pathology, animal studies have already proven that anorexigenic peptides exhibit neuroprotective properties. This phenomenon is extremely important for the potential development of new drugs in view of the aging of the human population and of the significantly increasing incidence of AD.

Aesthetics-based mystery in advertising: the roles of consumers’ high-end product perceptions and the construal level of ad words

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Bing Shi
Keyword(s):  
Experimental Studies ◽  
Positive Influence ◽  
Verbal Description ◽  
Content Type ◽  
Verbal Stimuli ◽  
Product Features ◽  
Quality Product ◽  
Effective Option ◽  
Carry Over ◽  
The Impact

Purpose This study aims to focus on whether and furthermore how aesthetics-based mystery affects consumers’ responses toward relevant products. Design/methodology/approach Three experimental studies are reported. In Studies 1–2, smartphone ad flyers varying in mystery and non-mystery styles were adopted. A total of 187 undergraduate participants were recruited in Study 1 and 245 undergraduate participants in Study 2. In Study 3, a total of 193 participants who work in a range of businesses were recruited and wristwatch ad flyers were adopted. Findings Findings demonstrate that consumers are more willing to pay for products promoted via mystery appeal (versus non-mystery). Such positive impacts occur through consumers’ high-end perceptions of the products. Concrete, rather than abstract, verbal description of quality product features facilitate the impact of mystery appeal on consumer purchase decisions. Research limitations/implications The findings advance an extant understanding of mystery appeal in advertising. It is among the first few to demonstrate that high-end product perceptions carry over the positive influence of mystery on consumers. This research is enlightening by suggesting an incongruity effect between pictorial stimuli and verbal information in the advertisement. This study’s scope is limited to visual mystery-evoking stimuli and Chinese participants. Practical implications When marketers/advertisers promoting products/brands with high prices, aesthetics-based mystery appeal should be considered as an effective option. This appeal is implicated as effective across gender. Moreover, visual mystery-evoking stimuli, combined with a concrete (not abstract) verbal description of product features should be optimal in promoting products. Originality/value The findings contribute to the limited empirical research on the influence processes of aesthetics-based mystery appeal. Different from the intuition, it is suggested that incongruity between visual and verbal stimuli in mystery ads that enhances the positive effect of mystery appeal.

Hygiene of microbiota of broiler chickens with introduction of sorbent additive based on tripoli

2020 ◽  
pp. 25-27
Author(s):  
Ivan I. Kochish ◽  
◽  
Petr A. Krasochko ◽  
Elena A. Kapitonova ◽  
Aleksandr A. Lysenko ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Broiler Chickens ◽  
Qualitative Change ◽  
The Body ◽  
Feed Additive ◽  
Quantitative Composition ◽  
Qualitative And Quantitative ◽  
The Impact ◽  
Toxic Load ◽  
Poultry Farming

Currently, mycotoxicosis and losses of poultry farming from non-communicable diseases are not a solved problem. The microflora of the gastrointestinal tract of broiler chickens, under the influence of the feed components, undergoes a qualitative change throughout the entire period of poultry growing. Authors in dynamics carried out studies to study the qualitative and quantitative composition of the microbiota of broiler chickens and its response to the impact of the feed additive «MeKaSorb». Introduction of various sorbent additives into the diet, including those based on tripoli, improves detoxification processes, regulates mineral, enzyme, hormonal and vitamin metabolism in the body of poultry. Ensuring maximum hygiene of the broiler microbiota allows to reduce the toxic load on the body of young poultry, ensure high safety of the livestock and get the maximum amount of products. Improving the sanitary quality and safety of food, as well as the prevention of diseases in poultry and humans is the most important task that must be addressed by the chief specialists at poultry farms. It has been established that the introduction of a patented additive-sorbent of mycotoxins based on tripoli «MeKaSorb» ensures the hygiene of the microbiota of broiler chickens, stimulates the growth and development of lacto- and bifidoflora, reduces the number of aerobic microorganisms and inhibits the reproduction and colonization of the gastrointestinal tract by bacteria of the intestinal group. Feed additive «MeKaSorb» is recommended for use in compound feeds for preventive purposes when growing poultry.

scholarly journals Effects of oxidative stress during human and animal reproductions: A review

2015 ◽  
Vol 08 (01) ◽  
pp. 006-011
Author(s):  
Carolina B. Berchieri-Ronchi ◽  
Paula T. Presti ◽  
Ana Lucia A. Ferreira ◽  
Camila R. Correa ◽  
Daisy Maria F. Salvadori ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Deoxyribonucleic Acid ◽  
Experimental Studies ◽  
The Body ◽  
Defense Strategies ◽  
Reproduction Process ◽  
Reproduction Period ◽  
Cellular Components ◽  
The Impact

ABSTRACTGiven its high ability to damage important cellular components (lipids, proteins and deoxyribonucleic acid), oxidative stress is now recognized as one of the most common mechanisms associated with development of a variety of diseases and natural events such as pregnancy. During reproduction period, there is a change in the pro-oxidant and antioxidant balance due to the body and circulation modifications that are inherent to the pregnancy process. The present paper discusses the role of oxidative stress on the reproduction process. More effective defense strategies are needed to decrease the deleterious effects of oxidative-stress-induced gestation. This approach could be achieved by antioxidant status alteration. Further clinical and experimental studies are needed for better understanding of oxidative stress mechanism and the impact of antioxidant supplementation on reproduction.

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