scholarly journals Essential tremor

2015 ◽  
Vol 62 (4) ◽  
pp. 357-362
Author(s):  
Gabriela Mihăilescu ◽  
◽  
Keyword(s):  
Clinical Trials ◽  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Essential Tremor ◽  
Movement Disorders ◽  
Imaging Techniques ◽  
Symptomatic Treatment ◽  
Genetic Studies ◽  
Parkinsonian Syndromes ◽  
Advanced Stages

Essential tremor is a frequent disease, but rather often under-diagnosed, due to the fact that the patients with mild essential tremor don’t visit the neurologist, or due to some confusion in establishing the diagnosis in advanced stages of the disease. The clinical diagnosis is the most important, and is sustained today by imaging techniques such as Datscan using 123I-Ioflupane, used in the differential diagnosis between essential tremor and Parkinsonian syndromes. The precise and early diagnosis permit the specific, customized symptomatic treatment, taking care of al the particularities of every patient, and in case of no-response to medical treatment, neurosurgical methods are available, some of them very recent, some still in clinical trials, as well as the genetic studies in order to establish the etiology of the most frequent disease in the field of movement disorders.

scholarly journals Covid-19: Doomsday, Shoved Away?

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Zahid Dar ◽  
Lucky Chauhan ◽  
Monika Chauhan ◽  
Navpreet Kaur ◽  
Tanzeer Kaur ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Disease Surveillance ◽  
Clinical Manifestations ◽  
Symptomatic Treatment ◽  
Contact Tracing ◽  
Safety And Efficacy ◽  
Behavioural Characteristics ◽  
The World

: The world has been pushed to the edge of a precipice commonly been addressed to as Coronavirus S (SARSCoV2), one of the world’s most widespread viral pandemic in recent times. Many studies are underway and investigating the new role of existing drugs, exploring the safety and efficacy of recently developed vaccines,after getting detailed insights into the behavioural characteristics of SARS-CoV2. Presently supportive &symptomatic treatment along with practices like disease surveillance, contact tracing, and early diagnosis mayhelp control the future of COVID-19 outbreaks. Effort has been made to compile the information about coronavirus; its clinical manifestations, differential diagnosis, preventive aspects, and therapeutic options as a review.

scholarly journals Contribution of Imaging Techniques in the Management of Cutaneous Pathology

2019 ◽  
Vol 70 (1) ◽  
pp. 87-91
Author(s):  
Ioana Alina Grajdeanu ◽  
Laura Statescu ◽  
Dan Vata ◽  
Cristina Grigorescu ◽  
Ioana Adriana Popescu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Retrospective Study ◽  
Early Diagnosis ◽  
Cutaneous Melanoma ◽  
Morphological Analysis ◽  
Imaging Techniques ◽  
Vascular Pattern ◽  
Treatment Algorithms ◽  
Histological Data ◽  
Advanced Stages

The management of skin pathology of tumors and inflammatory disorders is difficult due to the existence of constantly changing diagnostic and treatment algorithms. The incidence of cutaneous melanoma and other melanocytic or non-melanoma tumors is currently increasing. Melanoma is difficult to treat in advanced stages due to its aggressiveness, and early diagnosis is required to improve the prognosis of these patients. Imaging techniques, such as classical and digital dermatoscopy can provide information on structure, vascular pattern, prognostic factors and detailed morphological analysis that can lead to improved individual management. This article presents a retrospective study that aims to analyze the contribution of imaging techniques to clinical and histological data.

Strontium 87m Scanning of Pelvic Bones

1968 ◽  
Vol 07 (01) ◽  
pp. 28-36 ◽  
Author(s):  
Władysław Jasiński ◽  
Janina Malinowska ◽  
Henryk Mackiewicz ◽  
Henryk Siwicki ◽  
Krystyna Lukawska
Keyword(s):  
Body Weight ◽  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Femoral Neck ◽  
Early Period ◽  
Early Recurrence ◽  
Physical Activities ◽  
External Irradiation ◽  
Pelvic Bones ◽  
Strontium 87M

SummaryThe purpose of this investigation was to study the accumulation of 87mSr in the proximal parts of the femoral bones of patients treated previously by external irradiation due to cancer of the uterine cervix. It was assumed that this method may be used in the future for the early diagnosis of postirradiation changes of bone (osteoradionecrosis).The incidence of postirradiation changes of the femoral neck among 5735 patients treated between 1950 and 1961 at the Department of Gynaecology of the Institute, was 0.8%. In the early period of postirradiation changes the patients complain only of pain and limitation of physical activities. If radiological and gynaecological findings were negative, the differential diagnosis between early recurrence and early osteoradionecrosis became impossible.49 selected patients were scanned after intravenous injection of 10—115 μCi of 87mSr per kg of body weight (0.5 up to 6.0 mCi). Illustrative cases of normal pelvic bones as well as postirradiation changes are presented and discussed. The authors conclude that the findings justify further systematic studies on the morphology of accumulation of 87mSr in the bones.

Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson’s Disease

2020 ◽  
Vol 26 (37) ◽  
pp. 4738-4746
Author(s):  
Mohan K. Ghanta ◽  
P. Elango ◽  
Bhaskar L. V. K. S.
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Diagnosis ◽  
Neurodegenerative Disorder ◽  
Therapeutic Strategies ◽  
Neuroprotective Agents ◽  
Striatal Neurons ◽  
The Status ◽  
Advanced Stages ◽  
Dopaminergic Pathways

Parkinson’s disease is a progressive neurodegenerative disorder of dopaminergic striatal neurons in basal ganglia. Treatment of Parkinson’s disease (PD) through dopamine replacement strategies may provide improvement in early stages and this treatment response is related to dopaminergic neuronal mass which decreases in advanced stages. This treatment failure was revealed by many studies and levodopa treatment became ineffective or toxic in chronic stages of PD. Early diagnosis and neuroprotective agents may be a suitable approach for the treatment of PD. The essentials required for early diagnosis are biomarkers. Characterising the striatal neurons, understanding the status of dopaminergic pathways in different PD stages may reveal the effects of the drugs used in the treatment. This review updates on characterisation of striatal neurons, electrophysiology of dopaminergic pathways in PD, biomarkers of PD, approaches for success of neuroprotective agents in clinical trials. The literature was collected from the articles in database of PubMed, MedLine and other available literature resources.

State-of-the-art MR Imaging of Fat-containing Focal Lesions of the Liver

2019 ◽  
Vol 15 (5) ◽  
pp. 435-442
Author(s):  
Joanna Podgorska ◽  
Agnieszka Anysz-Grodzicka ◽  
Andrzej Cieszanowski
Keyword(s):  
Differential Diagnosis ◽  
Imaging Techniques ◽  
Hepatobiliary Phase ◽  
Focal Lesions ◽  
Dysplastic Nodules ◽  
Nodular Hyperplasia ◽  
Specific Finding ◽  
Magnetic Resonance Imaging Mri ◽  
Adrenal Rest ◽  
Mri Characteristics

Background: Fat can be identified in numerous liver lesions, and usually is not a specific finding. Distinguishing between different kinds of fatty deposits is an important part of differential diagnosis. Magnetic Resonance Imaging (MRI) is superior to other imaging techniques because it allows distinguishing intracellular from macroscopic fat. Discussion: Intracellular lipid may be found in focal hepatic steatosis, hepatic adenoma, hepatocellular carcinoma and, less commonly, in focal nodular hyperplasia as well as regenerative and dysplastic nodules. Macroscopic fat is seen in angiomyolipoma, lipoma, metastases from fatcontaining neoplasms, primary or metastatic liposarcoma, hydatid cyst, pseudolipoma of the Glisson capsule, pericaval fat collection, lipopeliosis, hepatic teratoma, focal hepatic extramedullary haematopoiesis and adrenal rest tumour. Conclusion: Liver nodules should be characterised with regard to underlying liver condition, MRI characteristics and contrast enhancement pattern, including hepatobiliary phase. In many cases, identification of fatty content may help narrowing the differential diagnosis.

scholarly journals Uric Acid and Hypertension: Prognostic Role and Guide for Treatment

2021 ◽  
Vol 10 (3) ◽  
pp. 448
Author(s):  
Federica Piani ◽  
Arrigo F. G. Cicero ◽  
Claudio Borghi
Keyword(s):  
Clinical Trials ◽  
Uric Acid ◽  
Mendelian Randomization ◽  
Strong Association ◽  
Epidemiological Studies ◽  
Hypertensive Disease ◽  
Genetic Studies ◽  
Lowering Therapy ◽  
The Relationship

The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies.

scholarly journals The TOPAZ study: a home-based trial of zoledronic acid to prevent fractures in neurodegenerative parkinsonism

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Caroline M. Tanner ◽  
Steven R. Cummings ◽  
Michael A. Schwarzschild ◽  
Ethan G. Brown ◽  
E. Ray Dorsey ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Zoledronic Acid ◽  
Support Groups ◽  
Movement Disorders ◽  
Fracture Prevention ◽  
Parenteral Therapy ◽  
Controlled Clinical Trials ◽  
Multiple Sources ◽  
Parenteral Treatment ◽  
Home Based

AbstractThe Trial of Parkinson’s And Zoledronic acid (TOPAZ, https://clinicaltrials.gov/ct2/show/NCT03924414) is a unique collaboration between experts in movement disorders and osteoporosis to test the efficacy of zoledronic acid, an FDA-approved parenteral treatment for osteoporosis, for fracture prevention in people with neurodegenerative parkinsonism. Aiming to enroll 3,500 participants age 65 years or older, TOPAZ is one of the largest randomized, placebo-controlled clinical trials ever attempted in parkinsonism. The feasibility of TOPAZ is enhanced by its design as a U.S.- wide home-based trial without geographical limits. Participants receive information from multiple sources, including specialty practices, support groups and websites. Conducting TOPAZ in participants’ homes takes advantage of online consent technology, the capacity to confirm diagnosis using telemedicine and the availability of research nursing to provide screening and parenteral therapy in homes. Home-based clinical research may provide an efficient, convenient, less expensive method that opens participation in clinical trials to almost anyone with parkinsonism.

scholarly journals FM Combined With NIHSS Score Contributes to Early AIS Diagnosis and Differential Diagnosis of Cardiogenic and Non-Cardiogenic AIS

2021 ◽  
Vol 27 ◽  
pp. 107602962110001
Author(s):  
Dan Wu ◽  
Yong’e Liu
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Diagnostic Efficacy ◽  
Stroke Treatment ◽  
Nihss Score ◽  
Stroke Group ◽  
Diagnosis And Classification ◽  
Toast Classification ◽  
Thrombotic Diseases ◽  
D Dimer

A growing researchers have suggested that fibrin monomer (FM) plays an important role in early diagnosis of thrombotic diseases. We explored the application of FM in the diagnosis and classification of acute ischemic stroke (AIS). The differences in FM, D-dimer, and NIHSS scores between different TOAST (Trial of ORG 10172 in Acute Stroke Treatment) types were analyzed with one-way ANOVA; the correlation between FM, D-dimer and NIHSS score in patients with different TOAST classification was analyzed by Pearson linear correlation. The ROC curve was utilized to analyze the diagnostic performance. 1. FM was more effective in diagnosing patients with AIS than D-dimer. 2. The FM level in cardiogenic AIS was significantly different from that in non-cardiogenic patients ( P < 0.05); the NIHSS score in cardiogenic stroke was significantly higher than in atherosclerotic and unexplained stroke group. Whereas, no statistical difference was observed in the D-dimer level between these groups ( P > 0.05). 3. The correlation between FM and NIHSS scores in the cardiogenic (r = 0.3832) and atherosclerotic (r = 0.3144) groups was statistically significant. 4. FM exhibited the highest diagnostic efficacy for cardiogenic AIS; furthermore, FM combined with the NIHSS score was more conducive to the differential diagnosis of cardiogenic and non-cardiogenic AIS. FM detection contributes to the early diagnosis of AIS, and is important for the differential diagnosis of different TOAST types of AIS. Moreover, FM combined with the NIHSS score is valuable in the differential diagnosis of cardiogenic and non-cardiogenic AIS.

Cardiomyopathies in the clinical picture of emergency cardiology

1998 ◽  
Vol 79 (1) ◽  
pp. 23-27
Author(s):  
I. A. Latfullin ◽  
O. V. Bogoyavlenskaya
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Transesophageal Echocardiography ◽  
Clinical Picture

The peculiarities of the clinical picture and diagnosis of uncoronarogenic lesions of the myocardium in a period of 5 years are studied. The differential diagnosis of cardiomyopathies and myocardial dystrophies is performed, emphasizing the informativity of contrast and transesophageal echocardiography. Registration of electrocardiographic and echocardiographic data allows to choose among patients the persons demanding the expanding cardiologic examination that provides early diagnosis of latent forms of cardiomyopathies.

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