scholarly journals Expression of CD133 and Aldehyde Dehydrogenase 1A1 in Borderline Ovarian Tumor and Their Correlation with International Federation of Gynecology and Obstetrics

2020 ◽  
Vol 8 (A) ◽  
pp. 160-163
Author(s):  
Birgitta M. Dewayani ◽  
Hasrayati Agustina ◽  
Desi Puspita ◽  
Bethy S. Hernowo ◽  
Sri Suryanti
Keyword(s):  
Cell Proliferation ◽  
Aldehyde Dehydrogenase ◽  
Ovarian Tumor ◽  
Figo Stage ◽  
International Federation ◽  
Borderline Ovarian Tumor ◽  
Chi Square ◽  
Cross Sectional ◽  
Epithelial Ovarian Tumor ◽  
Gynecology And Obstetrics

BACKGROUND: Borderline ovarian tumor (BOT) is an epithelial ovarian tumor with atypical epithelial proliferation without stromal invasion. BOTs may have an aggressive fashion with associated microinvasion feature, peritoneal “implants,” regional lymphadenopathy, and higher International Federation of Gynecology and Obstetrics (FIGO) stage. CD133 is cancer stem cells (CSCs) marker that promotes cell proliferation and tumor invasion through induction of nuclear factor kappa B and upregulation of MMP9. Aldehyde dehydrogenase 1A1 (ALDH1A1) is CSCs marker that promotes cell proliferation through the upregulation of c-MYC and cyclin-D1. AIM: The aim of this study was to investigate the correlation between CD133 and ALDH1A1 expression with FIGO stage. This research was performed as an analytic-observational with a cross-sectional design. METHODS: This research using a paraffin block of patients diagnosed as BOT in Hasan Sadikin Hospital Bandung. Samples were divided in two groups: FIGO stage IA and FIGO stage >IA. All samples were stained by immunohistochemistry CD133 and ALDH1A1. All data were analyzed using the Chi-square test with a significant level 5%. RESULTS: This study showed a statistically significant correlation between CD133 (p = 0.047) and ALDH1A1 (p = 0.042) expression with FIGO stage in BOT. Multivariate analysis showed there was no correlation between CD133 and ALDH1A1 in the affected of FIGO stage in BOT. CONCLUSION: CD133 and ALDH1A1 in BOT can be considered as a factor to predict the prognosis of BOT through predict FIGO stage.

scholarly journals HER2/Neu Expression was Different between Benign, Borderline and Malignant Epithelial Ovarian Tumors

2014 ◽  
pp. 46-49
Author(s):  
Yona S. Hadisubroto ◽  
Ketut Suwiyoga
Keyword(s):  
Ovarian Tumor ◽  
Cross Sectional Study ◽  
Ovarian Tumors ◽  
Chi Square ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Tissue Samples ◽  
Over Expression ◽  
Epithelial Ovarian Tumor ◽  
The Difference

Objective: To determine the difference of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumor. Method: An analytic cross-sectional study was performed on 49 samples of epithelial ovarian cases which were divided into three groups: twelve cases of benign epithelial ovarian tumor, 9 cases of borderline epithelial ovarian tumor and 28 cases of malignant epithelial ovarian tumor. Paraffin embedded tissue samples was cut, stained with HER2/neu imunohistochemistry and examined in Pathology Laboratory at Sanglah Hospital. The other data was collected from medical record samples. The data was analysed using One Way Anova test and Chi-square test with level of confidence α = 0.05. Result: There were 13 cases (46.43%) of the HER2/neu over expression in malignant epithelial ovarian tumors, 2 cases (22.22%) of the HER2/neu over expression in borderline epithelial ovarian tumors and 1 case (9.09%) of the HER2/neu over expression in benign epithelial ovarian tumors. With p = 0.048 (p < 0.05), there are differentiation of HER2/neu expression in benign, borderline and malignant epithelial ovarian tumors. Conclusion: In this study HER2/neu expression was different between benign, borderline and malignant epithelial ovarian tumors. Keywords: benign epithelial ovarian tumor, borderline epithelial ovarian tumor, HER2/neu, malignant epithelial ovarian tumor, ovarian cancer.

scholarly journals Specialty choice determinants among Mexican medical students: a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Carlos Gutiérrez-Cirlos ◽  
J. Jesús Naveja ◽  
Manuel García-Minjares ◽  
Adrián Martínez-González ◽  
Melchor Sánchez-Mendiola
Keyword(s):  
Medical Students ◽  
Medical Specialty ◽  
Cross Sectional Study ◽  
Specialty Choice ◽  
Three Dimensions ◽  
Chi Square ◽  
Cross Sectional ◽  
Middle Income ◽  
Healthcare Needs ◽  
Gynecology And Obstetrics

Abstract Background The choice of medical specialty is related to multiple factors, students’ values, and specialty perceptions. Research in this area is needed in low- and middle-income countries, where the alignment of specialty training with national healthcare needs has a complex local interdependency. The study aimed to identify factors that influence specialty choice among medical students. Methods Senior students at the National Autonomous University of Mexico (UNAM) Faculty of Medicine answered a questionnaire covering demographics, personal experiences, vocational features, and other factors related to specialty choice. Chi-square tests and factor analyses were performed. Results The questionnaire was applied to 714 fifth-year students, and 697 provided complete responses (response rate 81%). The instrument Cronbach’s alpha was 0.8. The mean age was 24 ± 1 years; 65% were women. Eighty percent of the students wanted to specialize, and 60% had participated in congresses related to the specialty of interest. Only 5% wanted to remain as general practitioners. The majority (80%) wanted to enter a core specialty: internal medicine (29%), general surgery (24%), pediatrics (11%), gynecology and obstetrics (11%) and family medicine (4%). The relevant variables for specialty choice were grouped in three dimensions: personal values that develop and change during undergraduate training, career needs to be satisfied, and perception of specialty characteristics. Conclusions Specialty choice of medical students in a middle-income country public university is influenced by the undergraduate experience, the desire to study a subspecialty and other factors (including having skills related to the specialty and type of patients).

scholarly journals Treatment of cervical cancer in the Republic of Srpska

2011 ◽  
Vol 64 (11-12) ◽  
pp. 588-591 ◽  
Author(s):  
Nenad Lucic ◽  
Zora Antonic ◽  
Vesna Ecim ◽  
Dragica Draganovic ◽  
Ljiljana Latinovic
Keyword(s):  
Cervical Cancer ◽  
Postoperative Complications ◽  
Radical Hysterectomy ◽  
Invasive Cervical Cancer ◽  
Figo Stage ◽  
International Federation ◽  
Gynecology And Obstetrics ◽  
The Republic ◽  
Banja Luka ◽  
Cervical Tumors

Introduction. Since 1897, when the first radical hysterectomy with lymphadenectomy was done by Wertheim in Vienna, this operation has had the central role in the surgical treatment of invasive cervical tumors. Material and methods. In the period from 1997 to 2010, 177 patients diagnosed with invasive cervical cancer according to the International Federation of Gynecology and Obstetrics (FIGO) stage IB1 - II were operated at the Department of Obstetrics and Gynecology in Banja Luka. All patients underwent radical hysterectomy by Wertheim - Meigs. The aim of this study is to present the technique of this operation, as well as its effectiveness in the treatment of cervical cancer. Results. The distribution of the patients having invasive cervical cancer according to the International Federation of Gynecology and Obstetrics classification was as follows: I B1 - 35.67%, I B2 - 23.17%, II A - 15.48%, II B - 25.68% on average is 21.3 removed lymph glands. The rate of intraoperative and postoperative complications was 8 (4.51%) and 17 (9.60%), respectively. Of the 26 patients who were operated in the period from 2005 - 2010, 13 had stage II B according to the International Federation of Gynecology and Obstetrics; there were 6 lethal outcomes (23.08) and the five-year survival rate was 76.92%. Discussion and conclusion. By applying the proper surgical technique and early prevention of immediate complications, we achieved satisfactory results in operative morbity and mortality, intraoperative and postoperative complications of the lesion for radical surgery by the Wertheim- Meigs-in the treatment of cancer of the uterus in the I B - II B stage according to the International Federation of Gynecology and Obstetrics classification.

scholarly journals Re-staging surgery in endometrial cancer: an audit on its value

2020 ◽  
Vol 9 (12) ◽  
pp. 4898
Author(s):  
Sanjay Badesara ◽  
Ashitha R. Gangadharan ◽  
Rambeer Singh ◽  
Adarsh Dharmarajan
Keyword(s):  
Endometrial Cancer ◽  
Figo Stage ◽  
International Federation ◽  
Surgical Staging ◽  
Carcinoma Endometrium ◽  
Gynecology And Obstetrics ◽  
Anticancer Treatment ◽  
Staging Surgery ◽  
Completion Surgery

Background: Incomplete surgical staging in carcinoma endometrium is not an uncommon entity in developing world. Proper surgical staging has got a role in prognostication and planning adjuvant treatment. So, an audit was done to assess the extent of upstaging in women with endometrial cancers who were referred to index centre from outside hospitals with incomplete surgical staging.Methods: It is a retrospective study. The demographic, clinical and treatment details of women with complete data having at-least one follow up after completion surgery were analyzed. Patients who had any other anticancer treatment elsewhere were excluded. The extent of upstaging was studied based on International federation of gynecology and obstetrics (FIGO) 2008 staging.Results: A total of 88 patients of endometrial cancer were evaluated retrospectively, of which 10 had completion surgery. 10% of the patients were upstaged according to the FIGO stage (one from IA to IB), while one patient upstaged from IIIA to IVB after slide review by index centre. According to FIGO Grade, 40% patient upgraded (one upgraded from I to II, three from II to III) while one downgraded from II to I. Recurrence rate was 40%.Conclusions: Upstaging is seen in 10% of patient after completion surgery, which requires the necessity of evaluation by gynecologic oncologist selectively. However, larger and multi-centric studies needed to draw definite conclusion. There is a significant discordance in grade and histology after the review at index centre.

Interobserver Variability of the International Federation of Gynecology and Obstetrics Staging in Cervical Cancer

2013 ◽  
Vol 23 (5) ◽  
pp. 890-894 ◽  
Author(s):  
Philippe Tummers ◽  
Kees Gerestein ◽  
Jan Willem Mens ◽  
Hans Verstraelen ◽  
Helena van Doorn
Keyword(s):  
Cervical Cancer ◽  
Interobserver Agreement ◽  
Interobserver Variability ◽  
Figo Stage ◽  
International Federation ◽  
Clinical Staging ◽  
Pelvic Examination ◽  
Substantial Agreement ◽  
Gynecology And Obstetrics ◽  
Level Of Agreement

ObjectiveThe objective of this study was to assess the interobserver variability of pelvic examination under anesthesia (EUA) in cervical cancer.MethodsSubsequent patients undergoing a staging procedure under anesthesia for primary cervical cancer were enrolled in the study. All clinicians assessed “blinded” tumor size, and the involvement of vagina, parametria, sacrouterine ligaments, pelvic sidewalls, bladder, and/or rectum. Items were scored varying from 1 (“certainly no involvement”), 2 (“not sure about involvement”), to 3 (”involvement”). Each individual decided on the International Federation of Gynecology and Obstetrics (FIGO) stage; also, the urge for imaging and treatment proposal were accounted for. Final FIGO staging was obtained by consensus of the team. Investigators were classified as experienced after more than 50 EUAs. All others were classified less experienced. The free-marginal κ values between experienced and less experienced investigators were calculated for all previously mentioned items.ResultsBetween February 2009 and December 2010, a total of 86 patients were enrolled. Among experienced investigators, a moderate interobserver agreement was found with regard to FIGO stage (free-marginal κ value of 0.49) and an excellent interobserver agreement on their proposed therapy (free-marginal κ value of 0.84). A lower level of agreement was found when comparing experienced with less experienced investigators: only a slight level of agreement on FIGO stage and a substantial agreement on their therapy proposal (free-marginal κ values of 0.03 and 0.66).ConclusionsWe describe only a moderate interobserver agreement on clinical staging of patients with cervical cancer. The interobserver agreement increases in the group of experienced doctors, indicating that EUA can be learned.

scholarly journals A Simple Ultrasound Examination as Diagnostic Tool for Malignant Ovarian Tumor

2017 ◽  
pp. 222
Author(s):  
Christin Wigin ◽  
Andrijono Andrijono
Keyword(s):  
Logistic Regression ◽  
Predictive Value ◽  
Ovarian Tumor ◽  
Ultrasound Examination ◽  
Diagnostic Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Malignant Ovarian Tumor ◽  
Papillary Projection ◽  
Chi Square Test

Objective: To know the diagnostic value of simple ultrasound examination to detect malignant ovarian tumor. Method: This study used cross-sectional design in gynecology outpatientclinic at Dr. Cipto Mangunkusumo Hospital. We recruited the patients with ovarian tumor undergoing surgery between March and July 2015. Samples were taken using consecutive sampling. Analysis was done using Chi-square test and logistic regression to find the relationship between ultrasound morphologic patterns with histopathologic findings, where the significant relationship was p value less than 0.05. Furthermore, a model derived from logistic regression was made to calculate the probability having ovarian malignancy. Result: There were 80 subjects which 58 subjects (72.5%) had benign tumor and 22 subjects (27.5%) had malignant tumor. Ultrasound examination result using  2 morphologic patterns gave malignant result in 53.8% subjects with the sensitivity of 100%, specificity of 82.8%, positive predictive value of 68.8%, and negative predictive value of 100%. The most important patterns were irregular internal cyst wall, multilocular, presence of papillary projection, and presence of solid component. The probability of subject having ovarian malignancy with  3 morphologic patterns was more than 88.9%. Conclusion: Simple ultrasound examination can be used to detect malignant ovarian tumor. [Indones J Obstet Gynecol 2016; 4-4: 222-226] Keywords: diagnostic, histopathology, morphology pattern; ovarian tumor; ultrasonography

Platinum-Based Neoadjuvant Chemotherapy Followed by Radical Surgery for Cervical Carcinoma International Federation of Gynecology and Obstetrics Stage IB2-IIB

2013 ◽  
Vol 23 (9) ◽  
pp. 1647-1654 ◽  
Author(s):  
Lucas Minig ◽  
Nicoletta Colombo ◽  
Vanna Zanagnolo ◽  
Fabio Landoni ◽  
Luca Bocciolone ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Neoadjuvant Chemotherapy ◽  
Cervical Carcinoma ◽  
Progression Free Survival ◽  
Figo Stage ◽  
International Federation ◽  
Gynecology And Obstetrics ◽  
European Institute ◽  
Parametrial Involvement ◽  
Node Metastases

ObjectiveThe objective of this study was to determine the response rate to chemotherapy, as well as the progression-free survival (PFS), the overall survival (OS), and the main prognostic factors in patients treated at the European Institute of Oncology in Milan, Italy.MethodsRetrospective data were collected on patients with uterine cervical carcinoma, International Federation of Gynecology and Obstetrics (FIGO) stage IB2 to IIB, who underwent platinum-based neoadjuvant chemotherapy (NACT) followed by radical hysterectomy.ResultsA total of 121 patients were studied. The median (range) age was 45 years old (23–69 years). The distribution of patients by International Federation of Gynecology and Obstetrics stage was as follows: n = 88 (73%) with stage IB2, n = 7 (6%) with stage IIA, and n = 26 (21%) with stage IIB. The median (range) tumor size was 50 mm (20–90 mm). Neoadjuvant chemotherapy involved a combination of cisplatin, paclitaxel, and ifosfamide in 80 patients (65%). Using this treatment, 112 patients (93%) received 3 cycles of NACT, whereas 6 (5%) received 4 cycles. Complete and partial pathology response was observed in 9 patients (7%) and 79 patients (66%), respectively. Adjuvant radiotherapy was not necessary in 65% of patients. A 5-year PFS and OS of 58% and 71%, respectively, were observed. Independent prognostic factors for PFS and OS were identified, including response to NACT, persistent lymph node metastases, and parametrial involvement.ConclusionsNeoadjuvant chemotherapy in this group of tumors is a promising treatment strategy and should be discussed with patients. Although these results are comparable to those obtained by standard chemoradiation treatment, one strategy should not be recommended over the other until the results of the ongoing phase 3 trial for NACT are released.

scholarly journals Prognostic Importance of Preoperative CA-125 in International Federation of Gynecology and Obstetrics Stage I Epithelial Ovarian Cancer: An Australian Multicenter Study

2005 ◽  
Vol 23 (25) ◽  
pp. 5938-5942 ◽  
Author(s):  
Sellva Paramasivam ◽  
Lee Tripcony ◽  
Alex Crandon ◽  
Micheal Quinn ◽  
Ian Hammond ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Overall Survival ◽  
Figo Stage ◽  
International Federation ◽  
Histologic Grade ◽  
Stage I ◽  
Surgical Staging ◽  
Ca 125 ◽  
Histologic Type ◽  
Gynecology And Obstetrics

Purpose To evaluate the prognostic significance of preoperative CA-125 levels on overall survival of patients with International Federation of Gynecology and Obstetrics (FIGO) stage I epithelial ovarian cancer (EOC). Patients and Methods Data from 518 patients with FIGO stage I EOC treated in seven gynecologic oncology centers throughout Australia between 1990 and 2002 were analyzed. Patients with borderline tumors and nonepithelial ovarian carcinomas were excluded, as were women in whom CA-125 had not been determined preoperatively. Preoperative CA-125 levels were studied in surgically staged and incompletely staged patients and compared with prognostic factors, such as substage, grade, and histologic type. Multivariate Cox models were calculated. Results CA-125 levels more than 30 U/mL were associated with higher grade, substage 1B and 1C, nonmucinous histologic type, and older age. In univariate analysis, higher histologic grade, the absence of surgical staging, and preoperative CA-125 levels more than 30 U/mL were associated with impaired survival. Multivariate analysis identified histologic grade, preoperative CA-125, and surgical staging as independent predictors for survival. In the subgroup of completely surgically staged patients, the 5-year overall survival rate was 82% (95% CI, 76% to 88%) for patients with CA-125 levels more than 30 U/mL and 95% (95% CI, 90% to 99%) for patients with CA-125 levels of 30 U/mL or less (P = .028). In the group of incompletely staged patients, the 5-year survival rates were similar for patients with elevated and normal serum CA-125 levels. Conclusion Complete surgical staging, histologic grade, and preoperative serum CA-125 levels are independent prognostic factors and should be included in the decision making for chemotherapy.

scholarly journals Association between Expression of CD133 and Aldehyde Dehydrogenase 1A1 (ALDH1A1) with FIGO Stage in Serous Ovarian Cancer

2019 ◽  
Vol 6 (05) ◽  
pp. 4449-4454
Author(s):  
Desi Puspita ◽  
Hasrayati Agustina ◽  
Birgitta Maria Dewayani ◽  
Bethy Surjawathy Hernowo ◽  
Sri Suryanti
Keyword(s):  
Ovarian Cancer ◽  
Early Stage ◽  
Staging System ◽  
Figo Stage ◽  
P Value ◽  
Serous Ovarian Cancer ◽  
Prognostic Information ◽  
Chi Square ◽  
Cross Sectional ◽  
Figo Staging

Ovarian cancer (OC) is the fifth most common cancer in women and has become the main cause of gynecologic malignancy death. The incidence rate of OC increase and overall survival (OS) is relatively low because most of patients are diagnosed at advanced stages. Serous ovarian cancer (SOC) is the most frequent histopathological type and often occurs at late stage. Stage and optimal treatment are independently associated with chemo-response in SOC. FIGO staging system in SOC can provide prognostic information and guidance on personalized management of ovarian cancer. Cancer stem cells (CSC) are pivotal players in SOC progression and prognosis.  CD133 and ALDH1A1 are related CSC markers in SOC. This study aimed to investigate the expression of CD133 and ALDH1A1 in SOC and their correlation with FIGO stage. This research was carried out as analytic-observational with cross-sectional design using paraffin block of patients diagnosed with SOC in the Department of Anatomic Pathology Hasan Sadikin Hospital Bandung. Samples were divided in two groups: early stage (FIGO stage I and II) and advanced stage (FIGO stage III and IV).  All samples were stained by immunohistochemistry CD133 and ALDH1A1. All data were analysed using Chi-Square test with significant level 5%. The results of this study showed that there was correlation between expression of CD133 with FIGO staging in SOC (p value 0.004) and there was no correlation between expression of ALDH1A1 with FIGO staging in SOC (p value 0.197). It can be concluded that higher CD133 expression showed higher tumour cells ability to do invasion and metastasis and had higher influenced FIGO stage.

Fertility Preservation Is Safe for Serous Borderline Ovarian Tumors

2016 ◽  
Vol 26 (8) ◽  
pp. 1399-1406 ◽  
Author(s):  
Eveline Vancraeynest ◽  
Philippe Moerman ◽  
Karin Leunen ◽  
Frédéric Amant ◽  
Patrick Neven ◽  
...  
Keyword(s):  
Fertility Preservation ◽  
Young Patients ◽  
Progression Free Survival ◽  
Figo Stage ◽  
Borderline Ovarian Tumor ◽  
Low Grade ◽  
Risk Of Recurrence ◽  
Gynecology And Obstetrics ◽  
Significant Difference

ObjectivesThis study aimed to determine the overall survival (OS) and progression-free interval and the influence of fertility-preserving surgery (FPS) versus radical surgery (RS) in patients with serous borderline ovarian tumor (BOT).MethodsClinical parameters of patients with serous BOT treated between 1993 and 2013 in one institution were retrospectively investigated. All tumors were examined by one pathologist with experience in gynecological pathology.ResultsOne hundred thirty-two patients with serous BOT (inclusive 16 microinvasive) were analyzed (45% were ≤40 years), with a median follow-up of 6 years. Thirty-two percent (42/132) of the patients received FPS; 14% (18/132) relapsed (invasive or borderline). The 5-year progression-free survival was 89%. The risk of recurrence was higher in patients 40 years or younger (P = 0.019), after FPS (P = 0.002), in patients with a higher International Federation of Gynecology and Obstetrics (FIGO) stage (P = 0.016), for bilateral BOT (P = 0.0132), and for the micropapillary variant (P = 0.067). The OS at 5 years was 97%. There was no statistically significant difference in OS between FPS and RS [all (6 of 90) patients, except for 1, with RS died]. One patient died of relapsed BOT. Among the recurrences, low-grade invasive carcinoma was diagnosed in 4 patients. Three of these 4 patients were originally operated radically, 2 had a micropapillary variant FIGO stage III, and 1 had a papillary pattern FIGO stage II with microinvasion; all 3 had noninvasive implants and are alive. One patient with a micropapillary variant, FIGO stage IIIC with microinvasion and invasive implants, received FPS and died of disease.ConclusionsThe risk of recurrence is higher after FPS compared with RS; however, no influence on OS was observed. This was because most of the patients relapsed as BOT. Fertility preservation is justified in young patients with serous borderline tumors.

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