The Effectiveness of Lumbricus rubellus Extract Toward Interleukin-10 and Immunoglobulin E and Atopic Dermatitis Scoring Index (SCORAD)

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by severe pruritic symptoms and chronic AD related to clinical features in form of lichenification associated with a history of atopic disease both for himself and family. AIM: This study aims to determine the effectiveness of using earthworm extract (Lumbricus rubellus) to increase interleukin (IL)-10 and decrease immunoglobulin E (IgE), and to describe the AD (SCORAD) scoring index of patients with AD. METHODS: This research used quantitative with quasi experiment method. The data were analyzed using SPSS v19 program. To determine the basic characteristics of numerical variables, the mean standard deviation is functioned if the data distribution amount is even, if it is not, it used the median. Meanwhile, to observe the relationship between L. rubellus extract and IgE, Mann-Whitney test analysis (U-Test) was used. RESULTS: The results of this study indicate that the administration of L. rubellus extract showed a changes and differences before and after being involved with the extract. IgE levels between ERL and no ERL groups had differences (p < 0.05), however on day 15 both groups did not show any differences. Meanwhile, the SCORAD index indicated that the influence of lumbricus rebellus extract has an effect on low number of AD patients. CONCLUSION: It can be concluded that the administration of L. rubellus extract in patients with AD is quite effective.

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Factors Influencing Atopic Dermatitis Incidence in Offspring

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v18i4.1413 ◽

2019 ◽

Author(s):

Siqi Ye ◽

Xiumei Mo ◽

Junfeng Liu ◽

Fenggen Yan ◽

Dacan Chen

Keyword(s):

Atopic Dermatitis ◽

Atopic Disease ◽

Skin Condition ◽

Breastfeeding Duration ◽

Protective Effects ◽

Short Period ◽

History Of ◽

Fundamental Research ◽

Genetic And Environmental Factors

Atopic dermatitis (AD) is a chronic, recurrent skin condition resulting from both genetic and environmental factors. In recent decades, the prevalence of AD has increased considerably in some countries. However, given that the role of genetics is unlikely to have changed over this short period, the increased prevalence is more likely to be explained by changes in environmental and maternal factors. The aim of this review is to comprehensively summarize the various factors impacting AD incidence in offspring and provide guidance for primary prevention. Recent research has demonstrated that environmental and climate factors, maternal history of allergies, gestational diabetes, and stress play essential roles in increasing the risk of AD in infants. Some factors have protective effects against the incidence of AD, including probiotic supplementation, fish intake, and moisturizers. This review also considers fundamental research into AD prevalence and factors that in the past were mistakenly thought to affect that prevalence, such as caesarean section and antigen avoidance. The potential influence of these factors on infant AD incidence remains inconclusive and needs further study. Furthermore, infants with a family history of atopic disease may benefit from early weaning or reduced breastfeeding duration.

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Immunoglobulin E in dermatoses. Levels in atopic dermatitis and urticaria

Archives of Dermatology ◽

10.1001/archderm.100.1.12 ◽

1969 ◽

Vol 100 (1) ◽

pp. 12-16 ◽

Cited By ~ 98

Author(s):

L. Juhlin

Keyword(s):

Atopic Dermatitis ◽

Immunoglobulin E

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Questionnaire Survey of Female Patients with Atopic Dermatitis Regarding Genital Skin Condition

Nishi Nihon Hifuka ◽

10.2336/nishinihonhifu.72.385 ◽

2010 ◽

Vol 72 (4) ◽

pp. 385-389

Author(s):

Miwa KOBAYASHI ◽

Yoshiki TOKURA ◽

Noriko SATO ◽

Yutaka TAKAGI ◽

Takashi KITAHARA ◽

...

Keyword(s):

Atopic Dermatitis ◽

Questionnaire Survey ◽

Skin Condition ◽

Female Patients

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ANALISIS KINERJA KEUANGAN PERUSAHAAN PROPERTI YANG TERDAFTAR DI BEI SEBELUM DAN SESUDAH KEBIJAKAN LOAN TO VALUE

Jurnal Riset Manajemen dan Bisnis (JRMB) Fakultas Ekonomi UNIAT ◽

10.36226/jrmb.v4i1.243 ◽

2019 ◽

Vol 4 (1) ◽

pp. 79-90

Author(s):

Ghaniy Ridha Prima ◽

Hermanto Siregar ◽

Ferry Syarifuddin

Keyword(s):

Real Estate ◽

Financial Performance ◽

Stock Exchange ◽

Sample Selection ◽

Test Analysis ◽

Asset Return ◽

Return On Equity ◽

Analysis Technique ◽

Significant Difference ◽

Before And After

The purpose of this study is to provide empirical evidence of the effects of the Loan to Value (LTV) policy on the financial performance of property and real estate companies listed on the Indonesia Stock Exchange (IDX). The sample selection uses a purposive sampling method of 42 property and real estate companies that meet the criteria. The research period is divided into 2 namely before the Loan to Value policy (2013-2014) and after the Loan to Value policy (2016-2017) with the Paired Sample t Test analysis technique. The test results show if the current ratio, Return on Asset, Return on Equity and Debt to Asset have significant differences between before and after the LTV policy is applied. While the fast ratio, cash ratio, net profit margin and Debt to Equity did not show a significant difference. Keywords: Financial Performance, Loan to Value, Property and Real Estate, Profitability Ratio, Liquidity Ratio, Solvability Ratio.

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Effects of mineral complex material treatment on 2,4- dinitrochlorobenzene-induced atopic dermatitis like-skin lesions in mice model

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03259-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Johny Bajgai ◽

Jing Xingyu ◽

Ailyn Fadriquela ◽

Rahima Begum ◽

Dong Heui Kim ◽

...

Keyword(s):

Atopic Dermatitis ◽

Water Loss ◽

Immunoglobulin E ◽

Skin Barrier ◽

Skin Lesions ◽

Total Serum ◽

Skin Barrier Function ◽

Barrier Dysfunction ◽

Complex Material ◽

Mineral Complex

Abstract Background Atopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by complex pathogenesis including skin barrier dysfunction, immune-redox disturbances, and pruritus. Prolonged topical treatment with medications such as corticosteroids, calcineurin inhibitors, and T-cell inhibitors may have some potential side-effects. To this end, many researchers have explored numerous alternative therapies using natural products and mineral compounds with antioxidant or immunomodulatory effects to minimize toxicity and adverse-effects. In the current study, we investigated the effects of mineral complex material (MCM) treatment on 2, 4-dinitrochlorobenzene (DNCB)-induced AD-like skin lesions in SKH-1 hairless mice. Methods Animals were divided into four groups; normal control (NC), negative control treated with DNCB only (DNCB only), positive control treated with DNCB and tacrolimus ointment (PC) and experimental group treated with DNCB and MCM patch (MCM). Skin inflammation and lesion severity were investigated through analyses of skin parameters (barrier score and strength, moisture and trans-epidermal water loss level), histopathology, immunoglobulin E, and cytokines. In addition, reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxidase (GPx), and catalase (CAT) levels were measured in both serum and skin lysate. Results Our results demonstrates that MCM patch improved the progression of AD-like skin lesions by significantly increasing skin barrier strength and decreasing trans-epidermal water loss. Additionally, dermal administration of MCM patch significantly reduced epidermal thickness, ROS, and NO levels in skin lysate. Furthermore, we found that MCM suppressed the levels of AD-involved (Th1 and Th2) cytokines such as IL-2, IFN-γ, and IL-4 in blood. In addition, the levels of other Th1, and Th2 and inflammatory cytokines such as IL-1β, TNF-α, IL-6, IL-12(p70) and IL-10 were found lowest in the MCM group than in the DNCB only and PC groups. Moreover, we found total serum IgE level significantly increased after DNCB treatment, but decreased in the PC and MCM groups. Conclusion Taken together, our findings suggest that MCM application may have beneficial effects either systemic or regional on DNCB-induced AD lesional skin via regulation of the skin barrier function and immune-redox response.

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Analysis of pediatric atopic dermatitis: The relationship between disease progression and total immunoglobulin E and percent positive immunocaps

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2012.12.705 ◽

2013 ◽

Vol 68 (4) ◽

pp. AB170

Keyword(s):

Atopic Dermatitis ◽

Disease Progression ◽

Immunoglobulin E ◽

The Relationship ◽

Total Immunoglobulin

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Electrospun PCL Patches with Controlled Fiber Morphology and Mechanical Performance for Skin Moisturization via Long-Term Release of Hemp Oil for Atopic Dermatitis

Membranes ◽

10.3390/membranes11010026 ◽

2020 ◽

Vol 11 (1) ◽

pp. 26

Author(s):

Sara Metwally ◽

Daniel P. Ura ◽

Zuzanna J. Krysiak ◽

Łukasz Kaniuk ◽

Piotr K. Szewczyk ◽

...

Keyword(s):

Mechanical Properties ◽

Atopic Dermatitis ◽

Mechanical Performance ◽

Antibacterial Properties ◽

Skin Condition ◽

Fiber Morphology ◽

Suitable Material ◽

Hemp Oil ◽

Skin Moisture

Atopic dermatitis (AD) is a chronic, inflammatory skin condition, caused by wide genetic, environmental, or immunologic factors. AD is very common in children but can occur at any age. The lack of long-term treatments forces the development of new strategies for skin regeneration. Polycaprolactone (PCL) is a well-developed, tissue-compatible biomaterial showing also good mechanical properties. In our study, we designed the electrospun PCL patches with controlled architecture and topography for long-term release in time. Hemp oil shows anti-inflammatory and antibacterial properties, increasing also the skin moisture without clogging the pores. It can be used as an alternative cure for patients that do not respond to traditional treatments. In the study, we tested the mechanical properties of PCL fibers, and the hemp oil spreading together with the release in time measured on skin model and human skin. The PCL membranes are suitable material as patches or bandages, characterized by good mechanical properties and high permeability. Importantly, PCL patches showed release of hemp oil up to 55% within 6 h, increasing also the skin moisture up to 25%. Our results confirmed that electrospun PCL patches are great material as oil carriers indicating a high potential to be used as skin patches for AD skin treatment.

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Ubiquitous Overexpression of Chromatin Remodeling Factor SRG3 Exacerbates Atopic Dermatitis in NC/Nga Mice by Enhancing Th2 Immune Responses

International Journal of Molecular Sciences ◽

10.3390/ijms22041553 ◽

2021 ◽

Vol 22 (4) ◽

pp. 1553

Author(s):

Sung Won Lee ◽

Hyun Jung Park ◽

Jungmin Jeon ◽

Yun Hoo Park ◽

Tae-Cheol Kim ◽

...

Keyword(s):

Atopic Dermatitis ◽

Mast Cells ◽

Immune Responses ◽

Chromatin Remodeling ◽

Skin Diseases ◽

Immunoglobulin E ◽

Critical Role ◽

Interleukin 4 ◽

Inflammatory Skin Diseases ◽

Immune Disorder

The SWItch (SWI)3-related gene (SRG3) product, a SWI/Sucrose Non-Fermenting (SNF) chromatin remodeling subunit, plays a critical role in regulating immune responses. We have previously shown that ubiquitous SRG3 overexpression attenuates the progression of Th1/Th17-mediated experimental autoimmune encephalomyelitis. However, it is unclear whether SRG3 overexpression can affect the pathogenesis of inflammatory skin diseases such as atopic dermatitis (AD), a Th2-type immune disorder. Thus, to elucidate the effects of SRG3 overexpression in AD development, we bred NC/Nga (NC) mice with transgenic mice where SRG3 expression is driven by the β-actin promoter (SRG3β-actin mice). We found that SRG3β-actin NC mice exhibit increased AD development (e.g., a higher clinical score, immunoglobulin E (IgE) hyperproduction, and an increased number of infiltrated mast cells and basophils in skin lesions) compared with wild-type NC mice. Moreover, the severity of AD pathogenesis in SRG3β-actin NC mice correlated with expansion of interleukin 4 (IL4)-producing basophils and mast cells, and M2 macrophages. Furthermore, this accelerated AD development is strongly associated with Treg cell suppression. Collectively, our results have identified that modulation of SRG3 function can be applied as one of the options to control AD pathogenesis.

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