scholarly journals Potential protective role of a NOD2 polymorphism in the susceptibility to multiple sclerosis is not associated with interferon therapy

2021 ◽  
Vol 15 (6) ◽  
Author(s):  
Aida Zečkanović ◽  
Aleš Maver ◽  
Smiljana Ristić ◽  
Nada Starčević Čizmarević ◽  
Borut Peterlin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Interferon Therapy ◽  
Protective Role ◽  
Nod2 Polymorphism

The protective role of Langerhans’ cells and sunlight in multiple sclerosis

2000 ◽  
Vol 55 (6) ◽  
pp. 517-520 ◽  
Author(s):  
M. Dumas ◽  
M.O. Jauberteau-Marchan
Keyword(s):  
Multiple Sclerosis ◽  
Langerhans Cells ◽  
Protective Role

Multiple sclerosis and solar exposure before the age of 15 years: case—control study in Cuba, Martinique and Sicily

2010 ◽  
Vol 16 (8) ◽  
pp. 899-908 ◽  
Author(s):  
F. Dalmay ◽  
D. Bhalla ◽  
A. Nicoletti ◽  
JA Cabrera-Gomez ◽  
P. Cabre ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Sun Exposure ◽  
Protective Role ◽  
Case Control ◽  
Solar Exposure ◽  
History Of ◽  
Water Sports ◽  
Control Study

Few studies report a protective role of childhood solar exposure to multiple sclerosis. Our objective was to confirm the protective role of childhood solar exposure in multiple sclerosis in Cuba, Martinique and Sicily. This was a matched case— control study, and cases met Poser criteria for clinically, laboratory (definite, probable) multiple sclerosis. Controls were resident population, without neurological disorder, living close to cases (within 100 km), matched for sex, age (±5 years), residence before age 15. We recruited 551 subjects during a 1-year period (193 cases, Cuba n = 95, Sicily n = 50, Martinique n = 48; 358 controls). Some (89%) met definite clinical multiple sclerosis criteria (relapsing remitting form (with and without sequel) (74%), secondary progressive (21%), primary progressive (5%)). Odds ratios in a uni-variate analysis were: family history of multiple sclerosis (5.1) and autoimmune disorder (4.0); wearing shirt (3.5), hat (2.7), pants (2.4); sun exposure causing sunburn (1.8); sun exposure duration (1 h more/day; weekends 0.91, weekdays 0.86); bare-chested (0.6); water sports (0.2). Independent factors in the multivariate analysis were family history of multiple sclerosis (4.8 (1.50—15.10)), wearing pants under sunlight (1.9 (1.10—3.20)), sun exposure duration (1 h more/ day, weekdays 0.90 (0.85—0.98), weekends 0.93 (0.87—0.99)), water sports (0.23 (0.13—0.40)). We conclude that outdoor leisure activities in addition to sun exposure reports are associated with a reduced multiple sclerosis risk, with evidence of dose response.

scholarly journals Regulatory role of local tissue signal Del-1 in cancer and inflammation: a review

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Meng Li ◽  
Di Zhong ◽  
Guozhong Li
Keyword(s):  
Multiple Sclerosis ◽  
Bone Marrow ◽  
Protective Role ◽  
Regulatory Role ◽  
Cancer Microenvironment ◽  
Local Tissue ◽  
Domain Protein ◽  
And Migration ◽  
Cancer And Inflammation

AbstractDevelopmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer microenvironment and inflammation. Del-1 has destructive effects in most cancers and is associated with the progression and invasion of some cancers. In contrast, Del-1 also plays a protective role in inflammation. Del-1 regulates inflammation by regulating the generation of neutrophils in bone marrow, inhibiting the recruitment and migration of neutrophils and accelerating the clearance of neutrophils by macrophages. Del-1 and IL-17 are reciprocally regulated, and their balance maintains immune system homeostasis. Del-1 is expected to become a new therapeutic target for inflammatory disorders such as multiple sclerosis.

scholarly journals The protective role of TBX21-1514T>C polymorphism in susceptibility to multiple sclerosis

2019 ◽  
Author(s):  
Fatemeh Akbarian ◽  
Mitra Ataei ◽  
Zivar Salehi ◽  
Masoud Nabavi ◽  
Mohammad Hossein Sanati
Keyword(s):  
Multiple Sclerosis ◽  
Protective Effect ◽  
Strong Association ◽  
Single Strand Conformation Polymorphism ◽  
Protective Role ◽  
Allelic Frequency ◽  
Single Strand ◽  
Genotype Frequencies ◽  
Tbx21 Gene

Background: As a T-cell mediated disease, multiple sclerosis (MS) pathogenesis might be associated with the immune system and its involved genes. TBX21, which encodes T-bet transcription factor, is a critical regulator of the commitment to the Th1 lineage and Interferon gamma (IFNγ) production. Investigation of the association of -1514T > C polymorphism located upstream of TBX21 gene with MS susceptibility is reasonable due to its demonstrated significant association with some other immune-mediated diseases. Methods: We analyzed the genotype frequencies of -1514T > C polymorphism between 248 Iranian patients with MS and 163 matched healthy controls. By applying polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP)- technique, the single-strand conformation patterns of the amplicons were compared and sequenced. Results: Strong association between the wild -1514T allele and MS susceptibility was found with the allelic frequency of 99.6% in patients vs. 95.1% in controls (P = 0.002), and the CC genotype frequency of the TBX21 polymorphism (-1514T > C) reported potential protective effect against the disease (P = 0.014). Conclusion: The TBX21-1514T > C polymorphism confers possible protective effect on MS in Iranian population. Further comprehensive studies in different settings are required to clarify the exact role of TBX21 gene in MS disease.

scholarly journals HLA-DPB1*03 as Risk Allele and HLA-DPB1*04 as Protective Allele for Both Early- and Adult-Onset Multiple Sclerosis in a Hellenic Cohort

2020 ◽  
Vol 10 (6) ◽  
pp. 374 ◽  
Author(s):  
Maria Anagnostouli ◽  
Artemios Artemiadis ◽  
Maria Gontika ◽  
Charalampos Skarlis ◽  
Nikolaos Markoglou ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Allele Frequency ◽  
Risk Allele ◽  
Laboratory Data ◽  
Protective Role ◽  
Adult Onset ◽  
Protective Allele ◽  
Hla Dr ◽  
Hla Dq

Background: Human Leucocyte Antigens (HLA) represent the genetic loci most strongly linked to Multiple Sclerosis (MS). Apart from HLA-DR and HLA–DQ, HLA-DP alleles have been previously studied regarding their role in MS pathogenesis, but to a much lesser extent. Our objective was to investigate the risk/resistance influence of HLA-DPB1 alleles in Hellenic patients with early- and adult-onset MS (EOMS/AOMS), and possible associations with the HLA-DRB1*15:01 risk allele. Methods: One hundred MS-patients (28 EOMS, 72 AOMS) fulfilling the McDonald-2010 criteria were enrolled. HLA genotyping was performed with standard low-resolution Sequence-Specific Oligonucleotide techniques. Demographics, clinical and laboratory data were statistically processed using well-defined parametric and nonparametric methods and the SPSSv22.0 software. Results: No significant HLA-DPB1 differences were found between EOMS and AOMS patients for 23 distinct HLA-DPB1 and 12 HLA-DRB1 alleles. The HLA-DPB1*03 allele frequency was found to be significantly increased, and the HLA-DPB1*02 allele frequency significantly decreased, in AOMS patients compared to controls. The HLA-DPB1*04 allele was to be found significantly decreased in AOMS and EOMS patients compared to controls. Conclusions: Our study supports the previously reported risk susceptibility role of the HLA-DPB1*03 allele in AOMS among Caucasians. Additionally, we report for the first time a protective role of the HLA-DPB1*04 allele among Hellenic patients with both EOMS and AOMS.

Protective role of the HLA–A*02 allele in Portuguese patients with multiple sclerosis

2009 ◽  
Vol 15 (6) ◽  
pp. 771-774 ◽  
Author(s):  
AM Silva ◽  
A Bettencourt ◽  
C Pereira ◽  
E Santos ◽  
C Carvalho ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Logistic Regression ◽  
Cd8 T Cells ◽  
Significant Interaction ◽  
Logistic Regression Model ◽  
Human Leukocyte ◽  
Hla Class I ◽  
Protective Role ◽  
Leukocyte Antigen

Background Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA–DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA–A*02 and A*03 alleles has been described. Objectives We examined the influence of HLA–A*02 and HLA–A*03 in Portuguese patients with MS, independently of HLA–DRB1*15 using a logistic regression model. Conclusions DRB1*15 increased the risk of developing MS and HLA–A*02 decreased the risk. A*03 had no effect. To analyze if HLA–A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found.

scholarly journals Increased multiple sclerosis relapses related to lower prevalence of pain

2015 ◽  
Vol 73 (7) ◽  
pp. 593-600 ◽  
Author(s):  
José Vinícius Martins da Silva ◽  
Beatriz Fátima Alves de Oliveira ◽  
Osvaldo José Moreira do Nascimento ◽  
João Gabriel Dib Farinhas ◽  
Maria Graziella Cavaliere ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Protective Role ◽  
Anxiety And Depression ◽  
Inverse Association ◽  
Depression And Anxiety ◽  
Chi Square ◽  
Disability Status ◽  
Strong Inverse Association ◽  
Prevalence Of Pain

Objective The study aims to investigate the presence of pain amongst multiple sclerosis (MS) patients. Method One hundred MS patients responded to questionnaires evaluating neuropathic and nociceptive pain, depression and anxiety. Statistical analysis was performed using the Mann–Whitney U, Chi-Square and two-tailed Fisher’s exact tests and multivariate logistic regression. Results Women had a statistically higher prevalence of pain (p = 0.037), and chances of having pain after the age of 50 reduced. Women with pain had a statistically significant lower number of relapses (p = 0.003), restricting analysis to those patients with more than one relapse. After the second relapse, each relapse reduced the chance of having pain by 46%. Presence of pain was independent of Expanded Disability Status Scale (EDSS) anxiety, and depression. Conclusion Our findings suggest a strong inverse association between relapses and pain indicating a possible protective role of focal inflammation in the control of pain.

Sign in / Sign up

Export Citation Format

Share Document