scholarly journals Graves' disease: pathophysiological aspects and considerations about using the chemometric analysis in the study of the disease

Folia Medica ◽  
2021 ◽  
Vol 63 (4) ◽  
pp. 467-474
Author(s):  
Pavlina M. Koseva ◽  
Zdravko A. Kamenov ◽  
Mariana M. Nikolova ◽  
Pavlina A. Andreeva-Gateva
Keyword(s):  
Treatment Strategies ◽  
Well Being ◽  
Chemometric Analysis ◽  
Observation Group ◽  
Public Concern ◽  
High Prevalence ◽  
Societal Problem ◽  
System Disorder ◽  
Individualised Treatment

Graves’ disease is an immune system disorder that results in the overproduction of thyroid hormones (hyperthyroidism). Thyroid disorders are a societal problem of great public concern because of their high prevalence. This problem can affect the well-being and quality of life of patients. The predisposing factors leading to this disease are not yet fully established and are likely to be interconnected in a complex way.  Chemometric analysis allows for the detection of specific relationships between the medical parameter measurements obtained from the patients in an observation group, and the identification of patterns of similarity between these patients. It is not commonly used in clinical trials; however, it can provide reliable information which may help in creating more successful, individualised treatment strategies for established groups (patterns) of patients. The aim of this review is to summarize the latest knowledge about the risk factors for Graves’ disease and considerations about using the chemometric analysis in the study of the disease.

scholarly journals Cosmetic Gynecology: Present and Future Perspectives

2021 ◽  
Vol 6 (11) ◽  
pp. 845-853
Author(s):  
Prabhu Chandra Mishra ◽  
Diana Mihai ◽  
Nidhi Khurana ◽  
Manar Jabbar
Keyword(s):  
Well Being ◽  
Physical Structure ◽  
Fat Grafting ◽  
Functional Changes ◽  
Non Invasive ◽  
High Prevalence ◽  
Regulatory Guidelines ◽  
Stem Cells Therapy ◽  
Cosmetic Gynecology

Postmenopausal women and events like childbirth, and aging may cause structural and functional changes in women genitalia. The arising indications do not only cause psychological distress to women but negatively affect the sexual well-being and deteriorate the quality of their lives. Regenerative/ cosmetic gynecology procedures enable women to treat the functionality issues and modify the physical structure of vagina. This review discusses the latest developments in this field with regards to various kinds of procedures that are available, particularly the use of energy-based devices, and adipose tissue derived stem cells therapy for fat grafting which have revolutionized the regenerative gynecology procedures. These offer non-invasive modalities to treat the conditions like urinary incontinence among others which occur in high prevalence among women. Despite the advancements made in this field, it lacks regulatory guidelines and standardized procedures which imposes one of the biggest challenges of the field. Alongside, we have documented a procedure called Intimacell® which has been standardized for fat grafting procedures in vulvovaginal region.

scholarly journals Key Factors Contributing to Quality of Life for Breast Cancer Patients in Latvia: Supplementing Quantitative Surveys with Qualitative Interviews

2012 ◽  
Vol 12 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Agnese Dzērvīte ◽  
Maruta Pranka ◽  
Tana Lace ◽  
Ritma Rungule ◽  
Edvins Miklasevics ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Cancer Patients ◽  
Qualitative Interviews ◽  
Treatment Strategies ◽  
Well Being ◽  
University Hospital ◽  
Breast Cancer Patients ◽  
Key Factors

Summary Introduction. Health related quality of life is a much debated topic in medicine with much quantitative and qualitative research contributing to the understanding of how to improve the lives of patients, yet little has been published in relation to the quality of life of Latvian breast cancer patients. Aim of the Study. To gather base measurements of subjective and objective quality of life factors for breast cancer patients in Latvia and discover which key factors contribute most to quality of life of Latvian breast cancer patients at the start of treatment. Materials and Methods. This paper presents data collected from April 2010 to June 2011 at the Pauls Stradins Clinical University hospital on key factors influencing quality of life for breast cancer patients: health and physical well-being; state of surroundings and environment; social support and functionality; financial state, employment and leisure. Quantitative survey material has been supplemented with insight from qualitative in-depth interviews to better explain the objective and subjective implications for breast cancer patients’ quality of life. Results. Interviewed breast cancer patients rated their quality of life as being average or good at the beginning of treatment. Negative factors contributing to lowered quality of life were mainly linked to patient financial, social and emotional state at the first weeks of treatment and correspond to previous research done in Latvia on quality of life issues. Conclusions. Further follow-up surveys will contribute to the evaluation of breast cancer patients’ needs while undergoing treatment to further improve treatment strategies, especially if validated quality of life measurement surveys were to be implemented in Latvian hospitals.

scholarly journals Sleep Disturbance in Gynaecologic Malignancies-an Overview

2020 ◽  
Vol I (2) ◽  
pp. 29-32
Author(s):  
Pavan Deepak
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Sleep Disturbance ◽  
Cancer Patients ◽  
Sleep Disturbances ◽  
Treatment Strategies ◽  
Well Being ◽  
Systematic Research ◽  
Gynaecologic Cancer

Sleep plays a pivotal role in maintaining homeostasis and one of a few foremost determinants of Quality of Life. Quality of life is a well-studied topic in oncology and various measures are taken to improve quality of life in this setting, in order to achieve therapeutic outcome and compliance in general in cancer patients. Sleep disturbances and disruption in circadian rhythm is among a few common presenting complaints of patients with malignancy and affects between 30% to 75% of newly diagnosed or recently treated cancer patients,1 which are reported as double that of the general population, paving the way for decreased compliance and inefficacy of therapy and pose as a detriment to general well-being, and quality of life. It is evident that mood disorders and sleep disturbances are more prevalent in females (1.3 to 1.8 times more than men),2 one may theorize that the prevalence of sleep disturbance in gynaecologic malignancies is greater than that of general population. Sleep disturbances in gynaecologic cancer patients often include difficulty in initiation of sleep, frequent awakening, difficulty in staying asleep, and restless leg syndrome. Systematic research on various sleeps disorders and their therapeutic approach in gynaecologic cancers in general is lacking. This article aims at elucidating and giving overview of sleep pattern changes in gynaecologic malignancies and therapeutic approaches to foster better sleep in this subset of population. This article also emphasizes the need to envisage the treatment strategies targeting cytokines and cortisol in improvement of sleep parameters in gynaecologic malignancies.

scholarly journals Factors associated with Oral Health Related Quality of Life in children. Literature Review.

2019 ◽  
Vol 6 (1) ◽  
pp. 22-25
Author(s):  
Yanara Nauduam ◽  
Gabriela Sandoval
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Treatment Strategies ◽  
Well Being ◽  
Health Related Quality ◽  
Individual Level ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related

Quality of Life (QoL) refers to a concept that might comprise different levels, which are able to identify the biological, economic, social and psychological demands from individual level up to community level. The concept of oral health-related quality of life (OHRQoL) refers to the ability of performing daily activities and considers subjective aspects such as happiness, social well-being and emotional well-being, in order to know people’s perception about their life. The aim of this article is to review the main factors associated with OHRQoL in children. Socioeconomic status, family structure, overcrowded homes, number of children, parent’s educational attainment and psychological factors, among others, were significant predictors for children’s OHRQoL. In Chile, there is a scarcity of OHRQoL in children and adolescents. The knowledge of OHRQoL might help to improve the development of programs and the effectiveness of oral health services, since it allows the assessment of small children, perceived needs and effectiveness of treatment strategies.

scholarly journals The Balance of Spiritual and Nutritional Needs Improves the Well-being of Cancer Patients during Chemotherapy

2021 ◽  
Vol 9 (T6) ◽  
pp. 138-142
Author(s):  
Aat Sriati ◽  
Laili Rahayuwati ◽  
Maria Komariah ◽  
Hendrawati Hendrawati ◽  
Iceu Amira ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Well Being ◽  
Spiritual Support ◽  
Breast Cancer Patients ◽  
Depth Interview ◽  
High Prevalence ◽  
Nutritional Needs

Background. The high prevalence and incidence of breast cancer in Indonesia remains a disheartening issue, for it has turned out to be a threat for the quality of Indonesian women’s life. Let alone the fact that the patients and their families often lose interest in recognizing the issue of breast cancer, both benign and malignant. Besides, the problem faced by breast cancer patients in determining which kind of diagnosis or best therapy is still overlooked by the patients as well as their family members. This includes their indifference toward the patients’ nutrition during chemotherapy, which now thus must be taken into consideration. Purpose. This research aims at observing the needs in general breast cancer patients during their chemotherapy and post-therapy period. Methods. This research is the result of qualitative data collected by case study on 17 breast cancer patients undergoing chemotherapy in Al-Ihsan Hospital, Bandung District and Hasan Sadikin Hospital, Bandung City. These patients have undergone an in-depth interview either on their own or accompanied by a family member. Results. The result of the qualitative research is obtained through content analysis observation, showing a shallow understanding about therapy, both generally and specifically, regarding the importance of increasing spiritual support besides nutrition and the escalation of its amount on the patient and their families. In fact, one of the things that support the patient’s immune system during their chemotherapy is the sufficient condition of nutrition. Not only that, the result shows that cancer survivors claim they keep spiritual aspect and a balanced intake of nutrition during and after therapy. Conclusion. Therefore, it is necessary to make a formula about spiritual and nutritional needs of breast cancer patients, in the preparatory, momentary, and preempting stage of chemotherapy.

FC30-05 - Psychiatric co-morbidities in patients with pemphigus: An issue to be considered

2011 ◽  
Vol 26 (S2) ◽  
pp. 1987-1987
Author(s):  
M. Arbabi ◽  
A. Mahdanian ◽  
Z. Ghodsi ◽  
N. Noormohammadi ◽  
H. Parsafar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Health Status ◽  
Skin Diseases ◽  
Psychiatric Morbidity ◽  
Well Being ◽  
Newly Diagnosed ◽  
Likert Score ◽  
High Prevalence

Background and objectivesThere exists a high prevalence of psychiatric disorders in dermatological patients. However, investigators have so far evaluated psychiatric aspects of the patients suffering from several specific skin diseases, there are a few studies concerning mental health in pemphigus patients. Our objective was to evaluate mental health status, quality of life and psychological well-being of newly diagnosed pemphigus patients.MethodsBetween April 2007 and February 2008, all newly-diagnosed pemphigus patients attending the pemphigus outpatient clinic of a dermatological hospital were given a questionnaire comprising the GHQ-28 and DLQI to fill out.ResultsOut of 283 patients, 212 complete forms were returned and analyzed. The bimodal score of GHQ ranged from 0 to 26 (Mean = 9.4) and the Likert score of GHQ ranged from 6 to 68 (Mean = 31.9). The DLQI score ranged between 0 and 30 (Mean of 13.8). A total of 157 patients (73.7%) were yielded to be possible cases of mental disorder considering GHQ-28 bimodal scores. Significant correlation between the DLQI score and bimodal and Likert scoring of GHQ-28 was detected.ConclusionOur study has depicted the prevalence of psychiatric morbidity in pemphigus patients. It underlines the fact that physicians, who are in charge of care for these patients, are in an exceptional position to distinguish the psychiatric morbidity and to take appropriate measures.

scholarly journals Hormonal Treatment Strategies Tailored to Non-Binary Transgender Individuals

2020 ◽  
Vol 9 (6) ◽  
pp. 1609 ◽  
Author(s):  
Carlotta Cocchetti ◽  
Jiska Ristori ◽  
Alessia Romani ◽  
Mario Maggi ◽  
Alessandra Daphne Fisher
Keyword(s):  
Treatment Strategies ◽  
Hormonal Treatment ◽  
Well Being ◽  
Clinical Approach ◽  
Treatment Protocols ◽  
Treatment Regimens ◽  
Transgender Persons ◽  
Standardized Treatment ◽  
Current Guidelines

Introduction: To date no standardized hormonal treatment protocols for non-binary transgender individuals have been described in the literature and there is a lack of data regarding their efficacy and safety. Objectives: To suggest possible treatment strategies for non-binary transgender individuals with non-standardized requests and to emphasize the importance of a personalized clinical approach. Methods: A narrative review of pertinent literature on gender-affirming hormonal treatment in transgender persons was performed using PubMed. Results: New hormonal treatment regimens outside those reported in current guidelines should be considered for non-binary transgender individuals, in order to improve psychological well-being and quality of life. In the present review we suggested the use of hormonal and non-hormonal compounds, which—based on their mechanism of action—could be used in these cases depending on clients’ requests. Conclusion: Requests for an individualized hormonal treatment in non-binary transgender individuals represent a future challenge for professionals managing transgender health care. For each case, clinicians should balance the benefits and risks of a personalized non-standardized treatment, actively involving the person in decisions regarding hormonal treatment.

Musical Anhedonia

2020 ◽  
Vol 31 (2) ◽  
pp. 62-68
Author(s):  
Sara E. Holm ◽  
Alexander Schmidt ◽  
Christoph J. Ploner
Keyword(s):  
Quality Of Life ◽  
Nucleus Accumbens ◽  
Brain Damage ◽  
Parietal Cortex ◽  
Neurological Disorders ◽  
Brain Regions ◽  
Precise Information ◽  
Exact Localization ◽  
High Prevalence

Abstract. Some people, although they are perfectly healthy and happy, cannot enjoy music. These individuals have musical anhedonia, a condition which can be congenital or may occur after focal brain damage. To date, only a few cases of acquired musical anhedonia have been reported in the literature with lesions of the temporo-parietal cortex being particularly important. Even less literature exists on congenital musical anhedonia, in which impaired connectivity of temporal brain regions with the Nucleus accumbens is implicated. Nonetheless, there is no precise information on the prevalence, causes or exact localization of both congenital and acquired musical anhedonia. However, the frequent involvement of temporo-parietal brain regions in neurological disorders such as stroke suggest the possibility of a high prevalence of this disorder, which leads to a considerable reduction in the quality of life.

Perceived Overprotection and Its Association With Quality of Life in Dementia

GeroPsych ◽  
2019 ◽  
Vol 32 (3) ◽  
pp. 125-134
Author(s):  
Mechthild Niemann-Mirmehdi ◽  
Andreas Häusler ◽  
Paul Gellert ◽  
Johanna Nordheim
Keyword(s):  
Quality Of Life ◽  
Patient Autonomy ◽  
Positive Association ◽  
Well Being ◽  
Negative Association ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
People With Dementia ◽  
Mental Well Being

Abstract. To date, few studies have focused on perceived overprotection from the perspective of people with dementia (PwD). In the present examination, the association of perceived overprotection in PwD is examined as an autonomy-restricting factor and thus negative for their mental well-being. Cross-sectional data from the prospective DYADEM study of 82 patient/partner dyads (mean age = 74.26) were used to investigate the association between overprotection, perceived stress, depression, and quality of life (QoL). The analyses show that an overprotective contact style with PwD has a significant positive association with stress and depression, and has a negative association with QoL. The results emphasize the importance of avoiding an overprotective care style and supporting patient autonomy.

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