Application of Some Medicinal Plants and Their Constituents in the Treatment of Diabetes Mellitus

2021 ◽  
pp. 32-47
Author(s):  
Raghunath Satpathy
Keyword(s):  
Diabetes Mellitus ◽  
Research Area ◽  
The Body ◽  
Inhibition Assay ◽  
Glucosidase Inhibitors ◽  
The World ◽  
Common Strategy ◽  
Treatment Of Diabetes ◽  
The Common ◽  
Alpha Glucosidase

The rapidly increasing incidence of diabetes mellitus as a chronic disease is becoming a serious threat to mankind health in all parts of the world. However, the currently available therapies are not of much use in prevention or reduction of disease. There are a large number of plants and natural biomolecules that have been discussed in the literature for their antidiabetic effects. Recently, the screening of many types of plant derived alpha-amylase, alpha-glucosidase inhibitors and other compounds that reduce the glucose level in the body and have fewer side effects has been successfully isolated. In this chapter, the mechanism of diabetes mellitus has been discussed. Also, the plants having anti-diabetic property along with its constituents has been presented summarized with the available literature resource. In addition to this, the common strategy that is followed for inhibition assay for an anti-diabetic compound has been discussed. Finally, future opportunities and challenges in this research area are proposed.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Yoga in the management of Diabetes Mellitus

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Sreeharsha N. ◽  
Bargale Sushant Sukumar ◽  
Divyasree C. H.
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Eating Habits ◽  
Cost Effective ◽  
The Body ◽  
Positive Thinking ◽  
The World ◽  
Diabetic Population ◽  
Major Factors ◽  
Excess Glucose

Diabetes mellitus is a chronic metabolic disorder in which the body is unable to make proper utilisation of glucose, resulting in the condition of hyperglycaemia. Excess glucose in the blood ultimately results in high levels of glucose being present in the urine (glycosuria). This increase the urine output, which leads to dehydration and increase thirst. India has the largest diabetic population in the world. Changes in eating habits, increasing weight and decreased physical activity are major factors leading to increased incidence of Diabetes. Lifestyle plays an important role in the development of Diabetes. Yoga offers natural and effective remedies without toxic side-effects, and with benefits that extend far beyond the physical. This system of Yoga is a simple, natural programme involving five main principles: proper exercise, proper breathing, proper relaxation, proper diet and positive thinking and meditation. It is a cost effective lifestyle intervention technique.

scholarly journals Characterisation of nitrogen-containing organic compounds by UHPLC-Qtof-MS and anti-amylase activity from the chloroform extract of the bark of Rhizophora mucronata

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
P. Resmi ◽  
G. Jitha ◽  
Vishnu Murali ◽  
Anu Gopinath
Keyword(s):  
Diabetes Mellitus ◽  
Amylase Activity ◽  
Chloroform Extract ◽  
Significant Activity ◽  
Rhizophora Mucronata ◽  
Inhibition Assay ◽  
Mangrove Plant ◽  
Starting Point ◽  
Treatment Of Diabetes ◽  
Nitrogen Containing Compounds

Abstract Background Medicinal importance of mangrove plant Rhizophora mucronata, a red mangrove species found in the Asian countries, has long been recognised in traditional systems of medicine. The identification of its phytoconstituents can be a starting point for the drug development. The aim of the work was to extend the current knowledge of phytoconstituents from R. mucronata and to explore its pharmacological importance in the treatment of diabetes mellitus. In the present study, we analysed the chloroform extract from the bark of the mangrove plant R. mucronata for nitrogen-containing constituents using UHPLC QTOF MS profiling, and α-amylase inhibition assay was carried out. Results Four nitrogen-containing compounds were identified from the chloroform extract of the bark of R. mucronata using UHPLC QTOF MS profiling. The compounds identified were N,N′-dicyclohexyl urea, a cryptolepine derivative (C17H15N3O), an aliphatic cyclic compound with hydroxyl and amino groups (C22H43NO), and C16H19NO2 (m/z 258.1495). The anti-amylase activity, an in vitro antidiabetic bioassay, of chloroform extract showed an IC50 value of 220.09 μg/ml. Conclusions This is the first report on the identification of nitrogen-containing compounds from the chloroform extract of the bark of the R. Mucronata. One of the compounds identified was a novel cryptolepine derivative (C16H13N3O), and it falls under the rare category indoloquinoline alkaloid. The chloroform extract also showed significant activity towards α-amylase inhibition assay. Thus, the study has gone some way towards our understanding of the efficacy of bark of the R. mucronata for the treatment of diabetes mellitus and is open for further research.

scholarly journals TRADITIONAL MEDICINAL SYSTEMS FOR TREATMENT OF DIABETES MELLITUS: A REVIEW

2018 ◽  
Vol 10 (5) ◽  
pp. 7
Author(s):  
Dimple . ◽  
Ashwani Kumar ◽  
Vikas Kumar ◽  
Vidisha Tomer
Keyword(s):  
Diabetes Mellitus ◽  
Functional Foods ◽  
Medical Science ◽  
Herbal Medicines ◽  
Diabetes Treatment ◽  
Active Components ◽  
The World ◽  
Increasing Trend ◽  
Current Scenario ◽  
Treatment Of Diabetes

Diabetes mellitus (DM) is a chronic disease which has clinched the world. More than 300 million people of the world are suffering from this disease and the number is still increasing at a rapid rate as modern medical science has no permanent solution for the disease. Current scenario of the nutraceuticals has increased patient’s faith on the traditional medicinal system and world nutraceutical industry is estimated to reach $285.0 billion by 2021. The increasing trend of nutraceuticals in diabetes treatment makes it important to collect the traditional knowledge of medicines under one heading as it can help researchers to formulate new functional foods and nutraceuticals which can either lower down the risk or cure DM. In addition, the discussion of market available food products, their active components and possible health benefits can help the patients to understand the herbal medicines in a better way.

scholarly journals Human as a phenomenon of unity of corporeal and spiritual in various-system languages (based on the material of euphemisms in the English and Buryat languages)

2020 ◽  
pp. 58-66
Author(s):  
Oyuna Tsydendambaeva ◽  
Olga Dorzheeva
Keyword(s):  
Scientific Discourse ◽  
The Body ◽  
Linguistic Expression ◽  
The West ◽  
The World ◽  
Key Concepts ◽  
The Subject ◽  
The Common

This article is dedicated to the examination of euphemisms in the various-system languages – English and Buryat that contain view of the world by a human, and the ways of their conceptualization. Euphemisms remain insufficiently studied. Whereupon, examination of linguistic expression of the key concepts of culture is among the paramount programs of modern linguistics, need for the linguoculturological approach towards analysis of euphemisms in the languages, viewing it in light of the current sociocultural transformations, which are refer to euphemisms and values reflected by them. The subject of this research is the euphemisms in the English and Buryat languages, representing the semiosphere “corporeal and spiritual”. The scientific novelty consists in introduction of the previously unexamined euphemism in Buryat language that comprise semiosphere “corporeal and spiritual” into the scientific discourse. The analysis of language material testifies to the fact that in various cultures the topic of intimacy and sex is euphemized differently. The lexis indicating the intimate parts of the body is vividly presented in the West, while in Buryat language – rather reserved. The author also determines the common, universal, and nationally marked components elucidating the linguistic worldview of different ethnoses and cultures.

scholarly journals EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020

2021 ◽  
Vol 3 (2) ◽  
pp. 74-80
Author(s):  
Loraetta Brety Sebayang ◽  
Romauli Anna Teresia Marbun ◽  
Dewi Kartika
Keyword(s):  
Diabetes Mellitus ◽  
Oral Treatment ◽  
Type Ii Diabetes Mellitus ◽  
The Body ◽  
Quality Assurance Process ◽  
Experimental Type ◽  
Treatment Of Diabetes ◽  
Assurance Process ◽  
The Right

Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients  female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs.  the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient.

scholarly journals Alpha-glucosidase inhibitors for type 2 diabetes mellitus

2002 ◽  
Author(s):  
F Van de Laar ◽  
S Wang ◽  
P Lucassen ◽  
E Van de Lisdonk ◽  
H Van den Hoogen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glucosidase Inhibitors ◽  
Alpha Glucosidase

Emerging strategies for the activity assay and inhibitor screening of alpha-glucosidase

2020 ◽  
Vol 11 (1) ◽  
pp. 66-82 ◽  
Author(s):  
Xianlong Zhang ◽  
Guoliang Li ◽  
Di Wu ◽  
Yanxin Yu ◽  
Na Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Diseases ◽  
Activity Assay ◽  
Inhibitor Screening ◽  
High Incidence ◽  
The World ◽  
Alpha Glucosidase

The high incidence of diabetes mellitus has caused widespread concern around the world, and has quickly become one of the most prevalent and costly chronic diseases.

scholarly journals MicroRNA, Diabetes Mellitus and Colorectal Cancer

Biomedicines ◽  
2020 ◽  
Vol 8 (12) ◽  
pp. 530
Author(s):  
Hsiuying Wang
Keyword(s):  
Diabetes Mellitus ◽  
Colorectal Cancer ◽  
The Body ◽  
Incidence And Mortality ◽  
The Common ◽  
Regulation Of Cell Cycle ◽  
The Relationship ◽  
Development Regulation ◽  
Inhibit Cell Proliferation ◽  
Improve Glucose Tolerance

Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC.

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