Lipids, Peptides, and Polymers as Targeted Drug Delivery Vectors in Cancer Therapy

2021 ◽  
pp. 255-275
Author(s):  
Mani Sharma ◽  
Neeraj Kumar Chouhan ◽  
Sandeep Vaidya ◽  
Mamta N. Talati
Keyword(s):  
Chemical Properties ◽  
Biological Properties ◽  
Delivery Systems ◽  
Dose Delivery ◽  
Target Delivery ◽  
Physico Chemical ◽  
Process Manufacturing ◽  
Targeted Drug ◽  
Delivery Route ◽  
Overall Efficiency

The authors aim to describe valuable information and experimental reviews that may help to develop and design different formulation, which can boost up the overall efficiency of the final product. Further, they explained the overall efficiency, method of preparation, target delivery approaches, drawbacks, and other characteristics in relation to lipids, peptides, polymers, and vaccines. In addition, they also propose to uncover the physico-chemical properties, in-process manufacturing issues, and external factors that influence the fate of a medicine. That major includes the excipients, method of preparation, dose, delivery route, chemical and biological properties, drug-drug interaction, drug-body interaction, patient compliance, modifications in lipid based nano-vectors, polymer-mediated delivery systems, conjugate delivery systems, and others. In conclusion, by the end of this chapter, the authors are able to explain a robust mode of delivering active constituents more safely and economically to the target site by showing maximum bioavailability.

scholarly journals Nano- and Microcarriers as Drug Delivery Systems for Usnic Acid: Review of Literature

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 156 ◽  
Author(s):  
Ana Zugic ◽  
Vanja Tadic ◽  
Snezana Savic
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Usnic Acid ◽  
Chemical Properties ◽  
Biological Properties ◽  
Delivery Systems ◽  
Physico Chemical ◽  
Wide Range ◽  
Number Of Publications ◽  
Promising Therapeutic Agent

Usnic acid is one of the most investigated lichen secondary metabolites, with several proven biological properties with potential medical relevance. However, its unfavorable physico-chemical properties, as well as observed hepatotoxicity, have discouraged wide-range utilization of usnic acid as a promising therapeutic agent. In accordance with the growing research interest in the development of nanotechnology, especially in the arena of preparations based on natural sources of medicinal compounds, usnic acid incorporated into nano- and microsized colloidal carriers has been a subject of a large number of publications. Therefore, this review discusses the overall results of the studies dealing with usnic acid encapsulated into lipid-based, polymeric and nonorganic micro- and/or nanocarriers, as potential drug delivery systems for this natural compound, in an attempt to introduce its usage as a potential antitumor, antimicrobial, wound-healing, antioxidative and anti-inflammatory drug.

Chitosan-Nanocellulose Composites for Regenerative Medicine Applications

2020 ◽  
Vol 27 (28) ◽  
pp. 4584-4592 ◽  
Author(s):  
Avik Khan ◽  
Baobin Wang ◽  
Yonghao Ni
Keyword(s):  
Regenerative Medicine ◽  
Preparation Method ◽  
Chemical Properties ◽  
Biological Properties ◽  
Next Generation ◽  
Structure Property ◽  
Physico Chemical ◽  
Structure Property Relationship ◽  
Attractive Candidate ◽  
Fundamental Understanding

Regenerative medicine represents an emerging multidisciplinary field that brings together engineering methods and complexity of life sciences into a unified fundamental understanding of structure-property relationship in micro/nano environment to develop the next generation of scaffolds and hydrogels to restore or improve tissue functions. Chitosan has several unique physico-chemical properties that make it a highly desirable polysaccharide for various applications such as, biomedical, food, nutraceutical, agriculture, packaging, coating, etc. However, the utilization of chitosan in regenerative medicine is often limited due to its inadequate mechanical, barrier and thermal properties. Cellulosic nanomaterials (CNs), owing to their exceptional mechanical strength, ease of chemical modification, biocompatibility and favorable interaction with chitosan, represent an attractive candidate for the fabrication of chitosan/ CNs scaffolds and hydrogels. The unique mechanical and biological properties of the chitosan/CNs bio-nanocomposite make them a material of choice for the development of next generation bio-scaffolds and hydrogels for regenerative medicine applications. In this review, we have summarized the preparation method, mechanical properties, morphology, cytotoxicity/ biocompatibility of chitosan/CNs nanocomposites for regenerative medicine applications, which comprises tissue engineering and wound dressing applications.

Progress and Prospects in Translating Nanobiotechnology in Medical Theranostics

2020 ◽  
Vol 16 (5) ◽  
pp. 685-707 ◽  
Author(s):  
Amna Batool ◽  
Farid Menaa ◽  
Bushra Uzair ◽  
Barkat Ali Khan ◽  
Bouzid Menaa
Keyword(s):  
Biological Properties ◽  
Chemical Characteristics ◽  
Intrinsic Properties ◽  
The Past ◽  
Profound Influence ◽  
Functionalized Nanomaterials ◽  
Physico Chemical ◽  
Properties Of Materials ◽  
Targeted Drug ◽  
And Performance

: The pace at which nanotheranostic technology for human disease is evolving has accelerated exponentially over the past five years. Nanotechnology is committed to utilizing the intrinsic properties of materials and structures at submicroscopic-scale measures. Indeed, there is generally a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical characteristics, biological properties, and performance. The exploration of nature’s components to work effectively as nanoscaffolds or nanodevices represents a tremendous and growing interest in medicine for various applications (e.g., biosensing, tunable control and targeted drug release, tissue engineering). Several nanotheranostic approaches (i.e., diagnostic plus therapeutic using nanoscale) conferring unique features are constantly progressing and overcoming all the limitations of conventional medicines including specificity, efficacy, solubility, sensitivity, biodegradability, biocompatibility, stability, interactions at subcellular levels. : This review introduces two major aspects of nanotechnology as an innovative and challenging theranostic strategy or solution: (i) the most intriguing (bare and functionalized) nanomaterials with their respective advantages and drawbacks; (ii) the current and promising multifunctional “smart” nanodevices.

scholarly journals OPPORTUNITIES OF BIOMEDICAL USE OF CARBON NANOTUBES

2014 ◽  
Vol 13 (1) ◽  
pp. 135-144
Author(s):  
I. V. Mitrofanova ◽  
I. V. Milto ◽  
I. V. Suhodolo ◽  
G. Yu. Vasyukov
Keyword(s):  
Carbon Nanotubes ◽  
Chemical Properties ◽  
Tissue Level ◽  
Pathological Process ◽  
The Body ◽  
Therapeutic Effects ◽  
Target Delivery ◽  
Physico Chemical ◽  
Near Future ◽  
Biological And Medical Applications

Nanomaterials  –  materials,  whouse  structure  elements  has  proportions  doesn’t  exceed  100  nm.  In superdispersed state matter acquire new properties. In the last decade, carbon nanotubes become the most popular nanomaterials, that cause attention of representatives of various scientific field. The сarbon nanotubes offer new opportunities for biological and medical applications: imaging at the molecular, cellular and tissue levels, biosensors and electrodes based on carbon nanotubes, target delivery of various substances, radiation and photothermal therapy. The most promising of carbon nanotubes in the context of biomedical applications is their ability to penetrate the various tissues of the body and carry large doses of agents, providing diagnostic and therapeutic effects. Functionalized nanotubes are biodegradable. Other current direction of using carbon nanotubes in medicine and biology is to visualize objects on the molecular, cellular and tissue level. Associated with carbon nanotubes contrasting substances improve the visualization of cells and tissues, which can detected new patterns of development of the pathological process. Due to the vagueness of the question of biocompatibility and cytotoxicity of carbon nanotubes possibility of their practical application is hampered. Before the introduction of carbon nanotubes into practical health care is necessary to provide all the possible consequences of using nanotubes. High rates of properties and development of new nanostructures based on carbon nanotubes in the near future will lead to new advances related to the application and development of new parameters that will determine their properties and effects. In these review attention is paid to the structure, physico-chemical properties of nanotubes, their functionalization, pharmacokinetics and pharmacodynamics and all aspects of using of carbon nanotubes.

scholarly journals Synthesis, physico-chemical properties of 3-thio and 3-thio -4-amino derivatives of 1,2,4-triazole

2019 ◽  
pp. 28-44
Author(s):  
V. V. Parchenko
Keyword(s):  
Chemical Properties ◽  
Biological Properties ◽  
Modern Medicine ◽  
Toxic Substances ◽  
Triazole Derivatives ◽  
Synthetic Drugs ◽  
Physico Chemical ◽  
Methods Of Synthesis ◽  
Amino Derivatives ◽  
Derivatives Of

Modern medicine and pharmacy has at its disposal highly efficient synthetic drugs. Large extent of these drugs accounted for derivatives of 1,2,4-triazole. The purpose of the work was an attempt to summarize the literature in recent years related to the methods of synthesis and study of physico-chemical properties 3-thio- and 3-thio-4-amino derivatives of 1,2,4-triazole. Studies national scientists in recent years indicates prospects of the search in this direction, since this class of organic compounds is interest not only to scientists pharmaceutical, medical and veterinary field, but also among researchers of engineering, metallurgical and agricultural areas. 1,2,4-triazole derivatives are also widely used in practice for optical materials, photosensitizers are used as coloring agents, antioxidants, additives for fuels and oils, some of which are widely used as corrosion inhibitors for controlling various pests in agriculture. In addition, 1,2,4-triazole derivatives belong to the class low toxic or essentially non-toxic substances. The presence of a growing number of publications about methods of synthesis, reactions, physico-chemical and biological properties of 1,2,4-triazole, inspires scientists around the world search for perspective molecules of substituted 1,2,4-triazole. It should be noted that in spite of a sufficient amount of information about the derivatives of 1,2,4-triazole, some issues related to the generalization of data in the literature synthesis presented insufficient.

In vitro elucidation of suppression effects of composts to soil-borne pathogen Phytophthora nicotianae on pepper plants using 16S amplicon sequencing and metaproteomics

2018 ◽  
Vol 35 (2) ◽  
pp. 206-214 ◽  
Author(s):  
Margarita Ros ◽  
Josefa Blaya ◽  
Petr Baldrian ◽  
Felipe Bastida ◽  
Hans H Richnow ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Amplicon Sequencing ◽  
Biological Properties ◽  
Phytophthora Nicotianae ◽  
Wall Structure ◽  
Inorganic Ion ◽  
Physico Chemical ◽  
Phylogenetic Level ◽  
Pepper Plants

AbstractCompost production is a critical component of organic waste management. One of the most important properties of compost is its ability to suppress soil-borne pathogens such as Phytophthora nicotianae in pepper plants. Both the physico-chemical and biological properties of composts can be responsible for the suppression of pathogens, although biological properties are the main driver. In this study, we analyzed composts with various levels of suppressiveness against P. nicotianae. We analyzed both physico-chemical properties like pH and electrical conductivity and biological properties like microbial activity, amplicon sequencing and metaproteomics. We believed that the link between community structures and proteins could provide deep insights into the mechanism of compost suppressiveness. Our results indicate that there are differences between suppressive and non-suppressive composts at the phylogenetic level (sequencing) and at the functional level (based on analysis of the cluster of orthologous groups, COGs). The proteins identified were assigned to the carbohydrate process, cell wall structure and inorganic ion transport and metabolism. Proteobacteria could also be new indicators of P. nicotianae suppression.

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