Design and Performance of a Microfluidic Particle Sorting Device

2011 ◽  
Vol 52-54 ◽  
pp. 668-673
Author(s):  
Jun Yang ◽  
Jing Yang ◽  
Qing He You ◽  
Ning Hu ◽  
Yong Li ◽  
...  
Keyword(s):  
Incident Light ◽  
Microfluidic System ◽  
Optic Fiber ◽  
Detection Zone ◽  
Severe Injuries ◽  
Electric Voltage ◽  
Particle Sorting ◽  
Electric Deflection ◽  
Optic Fibers ◽  
And Performance

A microfluidic chip device was developed for rapid and automatic particle sorting. The chip was made up of six individual layers. Each layer was used to implement different functions such as the sample loading, electric voltage loading, optic detection, cell sorting, and product extraction. Sheath flow was used to form single-row cells in order to let cells flow through the optic detection zone one by one. Optic fiber based detector could distinguish particles with different sizes. When a particle flowed through the light beam between two opposite optic fibers, it induced the dispersion of the incident light. The size of the particle was related with the strength of the scattering light. Thus, different particles could be distinguished. In the detection method, light path was simple and label was not required. Furthermore, optic fiber based detector was helpful to decrease the volume of the whole system. When desired particle was detected, it would be separated in the downstream by using an electric deflection method. Two types of particles with different sizes were sorted by using a prototype device. The result showed that these particles could be obviously distinguished. This microfluidic system could also be used to sort biological cells. Instantaneous electric field on the cells could prevent cells from severe injuries.

An Automated System for Controlling the Laminar Flow Interface in a Microfluidic System

2004 ◽  
Author(s):  
Brandon Kuczenski ◽  
Philip R. LeDuc ◽  
William C. Messner
Keyword(s):  
Laminar Flow ◽  
Feedback System ◽  
Microfluidic System ◽  
Automated System ◽  
Time Varying ◽  
Relative Flow Rate ◽  
Microfluidic Network ◽  
Piezoresistive Pressure Sensor ◽  
Pressure Feedback ◽  
And Performance

The interface between adjacent laminar flow streams in the output channel of a Y-shaped confluent microfluidic network is useful for investigating the response of individual living cells to steep chemical gradients. This paper reports the design and performance of an automated pressure-feedback system for accurately and rapidly changing the position of that interface. The device will be employed to investigate the dynamic response of cells to time-varying chemical stimulation. The system works by controlling the pressure difference between the two adjoining inputs of the microfluidic network, altering the relative flow rate of the laminar streams in the output microchannel. Continuity of incompressible fluids dictates that the plane of the interface between the two streams will move from side to side as the flow rates change. The sample-data control system samples a temperature-compensated monolithic piezoresistive pressure sensor at 1 kilohertz, allowing the control of high-bandwidth microfluidic systems. This automated system enables long-duration, high-precision experiments that involve time-varying parameters to be performed simply, rapidly, and inexpensively.

Research on Optic Fiber Coatings and Curing Process Monitoring of Composites Based on FBG

2011 ◽  
Vol 189-193 ◽  
pp. 1184-1187 ◽  
Author(s):  
Jiu Xiao Sun ◽  
Yun Dong Ji ◽  
Yan Zi Yin ◽  
Ji Hui Wang
Keyword(s):  
Room Temperature ◽  
Optical Microscope ◽  
Bending Test ◽  
Stress And Strain ◽  
Optic Fiber ◽  
Curing Process ◽  
Optic Fibers ◽  
Relationship Of ◽  
The Relationship ◽  
Fiber Coatings

In this paper, effect of FBG coating in curing monitoring of composites was studied. In the experiment, three kinds of sensors were embedded in the composites. Excursion of the wavelength and temperature was tested in the whole curing process. 3-point bending test of composites which FBG was embedded in was done. Results showed that FBG could be exactly reflecting the relationship of stress and strain in bending state of composites. After cured, composites were heat up to 180°C for 1 hour. Sectional appearance of different optic fibers in room temperature and high temperature was got by optical microscope.

Sports Injuries in Team Handball

1998 ◽  
Vol 26 (5) ◽  
pp. 681-687 ◽  
Author(s):  
Romain Seil ◽  
Stefan Rupp ◽  
Siegbert Tempelhof ◽  
Dieter Kohn
Keyword(s):  
Sports Injuries ◽  
Knee Injuries ◽  
Performance Level ◽  
Injury Incidence ◽  
Severe Injuries ◽  
Team Handball ◽  
Severity Of Injury ◽  
And Performance ◽  
High Level ◽  
Level Group

One hundred eighty-six players of 16 teams in 2 male team handball senior divisions were observed prospectively for 1 season to study the injury incidence in relation to exposure in games and practices. Ninety-one injuries were recorded. Injury incidence was evaluated at 2.5 injuries per 1000 player-hours, with a significantly higher incidence in game injuries (14.3 injuries per 1000 game-hours) compared with practice injuries (0.6 injuries per 1000 practice-hours). Practice injury incidence was higher in the lower performance level group, and game injury incidence was higher in the high-level group. The upper extremity was involved in 37% of the injuries, and the lower extremity in 54%. The knee was the most commonly injured joint, followed by the finger, ankle, and shoulder. Knee injuries were the most severe injuries, and they were more frequent in high-level players. There was an increase in the severity of injury with respect to performance level. The injury mechanism revealed a high number of offensive injuries, one-third of them occurring during a counterattack. The injury pattern showed certain variations with respect to player position and performance level. Prophylactic equipment was used by a majority of players at the higher performance level.

Fabrication and Performance Characterization of a Disposable Micropump Actuated by Piezoelectric-Disc

2011 ◽  
Vol 254 ◽  
pp. 179-182 ◽  
Author(s):  
Ling Ling Sun ◽  
Shan Zhong Wang ◽  
Ling Na Li ◽  
Jin Lan Guo ◽  
Siti Fatimatuzzahra Binti Roseli
Keyword(s):  
Flow Rate ◽  
Applied Voltage ◽  
Glass Substrate ◽  
Performance Testing ◽  
Microfluidic System ◽  
Driving Voltage ◽  
Pump Rate ◽  
And Performance ◽  
Piezoelectric Disc

Micropumps represent one of the major components in microfluidic technology. This paper describes the fabrication and performance testing of a simple, compact, inexpensive and disposable micropump suitable for microfluidic applications. The micropump was fabricated with polydimethylsiloxane (PDMS) which was bonded permanently on glass substrate. Piezoelectric-discs were used to actuate the micropumps. As a flow-rectifying element, the diffusers were used instead of passive check valves. The performances of the micropump, such as pump rate, were characterized. The flow rate of micropump increases with enhancing the applied voltage to piezoelectric-disc due to the increase of diaphragm deflection. The flow rate of the micropump with diffusers were about 9 μl/min when applying a 20 V square wave driving voltage at 300 Hz. This prototype can be used as a platform to develop an inexpensive micropump which is suitable to be part of a disposable microfluidic system.

Fabrication and Performance Analysis of PMMA Substrate Diffuser/Nozzle Micro-Pump by CNC Milling Machine

2009 ◽  
Vol 60-61 ◽  
pp. 198-201
Author(s):  
Li Tian ◽  
Wei Wang ◽  
Xiao Wei Liu ◽  
Ying Zhang ◽  
Shu Yi Ji
Keyword(s):  
High Performance ◽  
Low Cost ◽  
Maximum Flow ◽  
Microfluidic System ◽  
Milling Process ◽  
Cnc Milling ◽  
Micro Pump ◽  
Orifice Flow ◽  
And Performance ◽  
Nozzle Structure

A new low cost high performance PMMA micropump, developed for microfluidic system, is presented. According to the orifice flow theory, a diffuser/nozzle structure is fabricated with precision milling process, and packaged with the film-sealing at the condition of thermal bonding process. The size parameter of the diffuser/nozzle structure is 2.5mm *150µm, 8° conical angle, the volume of PMMA micropump is 14×14×2.5 mm3. And experimental results show that the PMMA micropump can produce a maximum back pressure of 1906.1Pa and a maximum flow rate of 564µL/min under 220 V, 500Hz squired wave power supply.

Epidemiology of injuries in judo: a cross-sectional survey of severe injuries based on time loss and reduction in sporting level

2017 ◽  
Vol 52 (17) ◽  
pp. 1109-1115 ◽  
Author(s):  
Ralph Akoto ◽  
Christophe Lambert ◽  
Maurice Balke ◽  
Bertil Bouillon ◽  
Karl-Heinz Frosch ◽  
...  
Keyword(s):  
Injury Severity ◽  
Exclusion Criterion ◽  
Time Loss ◽  
Severe Injuries ◽  
Injury Type ◽  
Body Regions ◽  
Performance Reduction ◽  
Vertebral Disc ◽  
And Performance ◽  
Sporting Performance

BackgroundSport injury severity can be detected by duration of time loss and reduction of sporting performance.AimTo detect injury type-specific time loss duration and sporting performance reduction in judo.MethodsAn online survey of active and former judo athletes was conducted (exclusion criterion: incomplete questionnaire). Only injuries causing more than 3 weeks’ time loss were recorded. Athletes classified themselves into performance classes. Injury type-specific frequencies were recorded according to gender, age and performance level. Injury severity was assessed by time loss duration and performance reduction.ResultsThe study included 4659 athletes (65% male, 38% competitive sports). The most commonly injured body regions were the upper extremity (41%) and the lower extremity (39%). Anterior cruciate ligament (ACL) ruptures were the most severe injury type (time loss: 4% of cases 3–6 weeks, 6% 6–12 weeks, 26% 3–6 months, 32% 6–9 months, 18% 9–12 months, 14%>12 months; performance reduction: 32% same level, 39% slightly reduced, 24% strongly reduced, 5% stopped judo). The second most severe type of injury was a vertebral disc prolapse (time loss: 26% 3–6 weeks, 31% 6–12 weeks, 20% 3–6 months, 7% 6–9 months, 3% 9–12 months 13%>12 months; reduction of sporting performance: 39% same level, 34% slightly reduced, 20% strongly reduced, 8% stopped judo).ConclusionAcross genders and performance levels, ACL ruptures and vertebral disc prolapses were the most severe injuries with respect to time loss and sporting performance reduction.

scholarly journals Dual Band Thin Film Infrared Detector Design and Performance Improvement using Plasmonic Nanostructure

2021 ◽  
Author(s):  
Mohammad Bashirpour ◽  
Saeed Khankalantary ◽  
Mohammadreza Kolahdouz
Keyword(s):  
Thin Film ◽  
Quantum Efficiency ◽  
Incident Light ◽  
Infrared Detector ◽  
Antireflection Coating ◽  
Dual Band ◽  
Absorption Enhancement ◽  
Metal Semiconductor Metal ◽  
Conventional Structure ◽  
And Performance

Abstract A new dual band thin film metal-semiconductor-metal infrared photodetector base on InGaAs for wavelength of 1.1–1.7 µm and InSb for wavelength of 3–5 µm is proposed and investigated numerically. One major problem of thin film photodetectors is low quantum efficiency that originates from low optical absorption. The quantum efficiency of proposed structure is improved by locating the array of optimized aluminum nanostructure (Al-NS) between the InGaAs and InSb layers. Using optimized Al-NS between the stack of InGaAs and InSb (InSb/Al-NS/InGaAs) results in plasmon excitation inside the photosensitive layers and so, higher photocarrier generation. Moreover, locating zinc oxide nanorode as an antireflection coating on top of detector reduces the incident light reflection in both spectrum of 1.1–1.7 µm and 3–5 µm. The finite different time domain method is used to investigated the optical properties of proposed structure and optimize the structure. According to the simulation results, designed structure gives rise to 108.1%, 110% and 320% light absorption enhancement at wavelength of 1.33 µm, 1.55 µm and 4 µm, respectively compared to reference conventional structure.

scholarly journals Investigation of the Shear Bond Strength of Orthodontic Buttons by Light Curing Using an Extended Optic Fiber

2021 ◽  
Vol 48 (1) ◽  
pp. 105-114
Author(s):  
Garam Yoon ◽  
Nanyoung Lee ◽  
Sangho Lee ◽  
Myeongkwan Jih ◽  
Wonseok Choi ◽  
...  
Keyword(s):  
Bond Strength ◽  
Shear Bond Strength ◽  
Fiber Diameter ◽  
Statistical Significance ◽  
Large Diameter ◽  
Optic Fiber ◽  
Group Iii ◽  
Group I ◽  
Curing Light ◽  
Optic Fibers

The objective of this study is to analyze the shear bond strength of orthodontic buttons according to light tip distance and optic fiber diameter when an extended optic fiber was applied to the tip of a curing light unit.In this study, 315 extracted premolar teeth were divided into 3 groups. Orthodontic buttons were attached using no optic fibers (Group I), 3.0 mm diameter optic fibers (Group II), or 5.0 mm diameter optic fibers (Group III). Each group was divided into subgroups A - C (5.0, 10.0, and 15.0 mm light tip distance), respectively. Shear bond strength was then measured while varying the light tip distance.In group I, shear bond strength significantly decreased as the light tip distance increased. When the shear bond strength was evaluated according to the optic fiber diameter, no statistical significance was observed in group of 5.0 mm light tip distance. Compared with group IB, group IIIB showed significantly greater shear bond strength. Compared with group IC, all groups using 3.0 or 5.0 mm diameter optic fibers showed significantly greater shear bond strength.Therefore, when a curing light unit has poor accessibility, optic fibers with a large diameter should be considered.

scholarly journals DESIGN AND CONSTRUCTION OF A LAB-ON-A-PAPER FOR LOW-COST AND DISPOSABLE POINT-OF CARE DIAGNOSTICS

2017 ◽  
Vol 5 (1) ◽  
pp. 26
Author(s):  
Afnidar Afnidar ◽  
Bambang Kuswandi
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Diagnostic System ◽  
Microfluidic System ◽  
Clinical Diagnostics ◽  
Detection Zone ◽  
Power Sources ◽  
Point Of Care Diagnostics ◽  
Paper Based Microfluidics ◽  
Analysis System

Abstract This paper presents a low-cost and disposable paper based microfluidic analysis system for point-of-care diagnostics. Detection is achieved by using a colorimetric or visual indicator. Immobilized specific reagent or enzymes designed for the parameter under consideration act as capture molecules on the surface of the detection zone. The sensor is integrated into a microfluidic system made of paper (cellulose). An additional component of the analysis system is a capillary unit which is used to introduce the analyte to the detection zone. For this purpose well- defined, millimeter-sized channel, comprising hydrophobic polymer bounded onto hydrophilic paper was created. Then the detection zone was coated with a sensitive reagent layer as a sensor region. The paper based microfluidics also called lab on paper, has been fabricated using screen printing technology as the basis for low-cost, disposable, portable and technically simple fabrication for mass production. Microfluidics in paper make it feasible to run single, dual or even multiple clinical analyses on one strip of paper while still using only small volumes of a single sample. The capability of lab on paper for detection of importance clinical analyte protein in urine, saliva and blood samples has been demonstrate successfully. Lab on paper as a diagnostic system is small, disposable, and easy to use and requires no external equipment, reagents, or power sources. This kind of diagnostic system is attractive for use in developing countries, in the field, or as a low-cost alternative to more-advanced technologies already used in clinical diagnostics. Keywords: Lab-on-a-paper, Point-of-care, Visual detection, Clinical diagnostic, Disposable sensor

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