Mineralization Behavior of Bioactive Ceramic Coatings Formed by Micro-Arc Oxidation on Titanium

2007 ◽  
Vol 330-332 ◽  
pp. 629-632 ◽  
Author(s):  
Kai Hui Nan ◽  
G.X. Pei
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Titanium Oxide ◽  
Body Fluid ◽  
Ceramic Coatings ◽  
P Elements ◽  
Micro Arc Oxidation ◽  
Bioactive Ceramic ◽  
The Difference ◽  
Titanium Oxide Films

Titanium oxide films were obtained by MAO at the applied voltages of 250-550V and their bio-mineralization behavior was investigated. The films were composed mainly of TiO2 phases in the form of anatase and rutile and enriched with Ca and P elements in the form of CaTiO3 and amorphous calcium phosphate. Their bio-mineralization behavior was evaluated in a simulated body fluid (SBF). After immersed in SBF for 72 h, white mineralized layers were observed on the samples obtained at high voltages. The bio-mineralized rate of samples increased with the applied voltages, which resulted in the difference on morphology of different samples. The structure and composition of the films have an important effect on their bio-mineralization behavior.

scholarly journals Degradation Behavior of Micro-Arc Oxidized ZK60 Magnesium Alloy in a Simulated Body Fluid

Metals ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 724 ◽  
Author(s):  
Ze-Xin Wang ◽  
Guan-Qun Chen ◽  
Liang-Yu Chen ◽  
Lei Xu ◽  
Sheng Lu
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Laser Scanning ◽  
Electrochemical Impedance ◽  
Ceramic Coatings ◽  
Laser Scanning Confocal Microscopy ◽  
Degradation Behavior ◽  
Scanning Confocal Microscopy ◽  
Ph Values ◽  
Micro Arc Oxidation

Bio-ceramic coatings were synthesized on ZK60 magnesium alloys by micro-arc oxidation (MAO). The degradation behavior of the ZK60 alloys with and without MAO coating in the simulated body fluid (SBF) was studied. The samples were characterized by means of scanning electron microscopy (SEM), laser scanning confocal microscopy (CLSM), and X-ray diffraction (XRD). Electrochemical impedance spectroscopy (EIS) was used to study the degradation behavior. The results showed that the porous MAO coating mainly consisted of MgO, Mg2SiO4, Mg3(PO4)2, and CaCO3. The pH values of both coated and uncoated samples increased over time. However, the pH values of the SBF for coated samples always maintained a lower level compared with those for the uncoated samples. Thereby, the coated samples showed a much lower degradation rate. After immersion in SBF for 5 days, corrosion product containing Ca and P was found on both samples, while the deposition was more active on the coated samples. The degradation models for the uncoated and coated samples in the SBF are also proposed and discussed.

IN-VITRO BEHAVIOUR OF BIPHASIC CALCIUM PHOSPHATE WITH DIFFERENT RATIO OF SILICA CONTENT IN SIMULATED BODY FLUID

2015 ◽  
Vol 23 (1) ◽  
pp. 1-14
Author(s):  
Sudirman Sahid ◽  
◽  
Nor Shahida Kader Bashah ◽  
Salina Sabudin ◽  
◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Biphasic Calcium Phosphate ◽  
Silica Content

scholarly journals Preparation and Degradation Characteristics of MAO/APS Composite Bio-Coating in Simulated Body Fluid

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 667
Author(s):  
Zexin Wang ◽  
Fei Ye ◽  
Liangyu Chen ◽  
Weigang Lv ◽  
Zhengyi Zhang ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Composite Coating ◽  
Body Fluid ◽  
Composite Coatings ◽  
Degradation Process ◽  
Ceramic Coatings ◽  
Immersion Test ◽  
Substrate Material ◽  
Atmospheric Plasma

In this work, ZK60 magnesium alloy was employed as a substrate material to produce ceramic coatings, containing Ca and P, by micro-arc oxidation (MAO). Atmospheric plasma spraying (APS) was used to prepare the hydroxyapatite layer (HA) on the MAO coating to obtain a composite coating for better biological activity. The coatings were examined by various means including an X-ray diffractometer, a scanning electron microscope and an energy spectrometer. Meanwhile, an electrochemical examination, immersion test and tensile test were used to evaluate the in vitro performance of the composite coatings. The results showed that the composite coating has a better corrosion resistance. In addition, this work proposed a degradation model of the composite coating in the simulated body fluid immersion test. This model explains the degradation process of the MAO/APS coating in SBF.

Effect of Electrical Polarization on the Behavior of Bioactive Glass Containing MgO and B2O3 in SBF

2006 ◽  
Vol 309-311 ◽  
pp. 333-336
Author(s):  
Emiko Amaoka ◽  
Erik Vedel ◽  
Satoshi Nakamura ◽  
Yusuke Moriyoshi ◽  
Jukka I. Salonen ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Bioactive Glass ◽  
Body Fluid ◽  
Charged Surface ◽  
Depolarization Current ◽  
Electrical Polarization ◽  
Thermally Stimulated Depolarization Current ◽  
Thermally Stimulated Depolarization ◽  
Calcium Phosphate Precipitation

We investigated the electrical polarizability of MgO and B2O3 containing bioactive glass (MBG). The MBG material with good manufacturing properties but low bioactivity was electrically polarized at a high dc field. The electrical polarizability of MBG was evaluated by thermally stimulated depolarization current (TSDC) measurements and immersion in simulated body fluid (SBF). The early precipitation of calcium phosphate on the negatively charged surface of the treated MBG demonstrated the increased bioactivity of the material and confirmed its polarizability. It is suggested that the electrical interactions between the polarized MBG and ions in SBF promoted the formation of the calcium phosphate precipitation. Accordingly, the increased bioactivity of the MBG in SBF is suggested to demonstrate the conversion of MBG into electrovector ceramics by the polarization treatment.

scholarly journals Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

2019 ◽  
Vol 10 (2) ◽  
pp. 455-470 ◽  
Author(s):  
Magdalena Prokopowicz ◽  
Adrian Szewczyk ◽  
Adrianna Skwira ◽  
Rafał Sądej ◽  
Gavin Walker
Keyword(s):  
Drug Delivery ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Body Fluid ◽  
Molecular Surface ◽  
Molar Ratio ◽  
Mineralization Potential

AbstractWe reported the new biphasic composites of calcium phosphate and mesoporous silica material (CaP@MSi) in the form of powders and pellets as a potential bone drug delivery system for doxycycline hydrochloride (DOX). The CaP@MSi powders were synthesized by cationic surfactant-templating method. The effects of 10, 20, and 30% CaP content in the CaP@MSi powders on the molecular surface structure, the cytotoxicity against osteoblast cells in vitro, and the mineralization potential in simulated body fluid were investigated. The CaP@MSi characterized by the highest mineralization potential (30% CaP content) were used for DOX adsorption and pelletization process. The CaP which precipitated in the CaP@MSi composites was characterized as calcium-deficient with the Ca:P molar ratio between 1.0 and 1.2. The cytotoxicity assays demonstrated that the CaP content in MSi increases osteoblasts viability indicating the CaP@MSi (30% CaP content) as the most biocompatible. The combination of CaP and MSi was an effective strategy to improve the mineralization potential of parent material. Upon immersion in simulated body fluid, the CaP of composite converted into the bone-like apatite. The obtained pellets preserved the mineralization potential of CaP@MSi and provided the prolonged 5-day DOX release. The obtained biphasic CaP@MSi composites seem to have an application potential as bone-specific drug delivery system.

Bioactivity Assessment of Apatite Nuclei-PVDF Composite Thin Films

2018 ◽  
Vol 782 ◽  
pp. 78-83
Author(s):  
Hasnat Zamin ◽  
Takeshi Yabutsuka ◽  
Shigeomi Takai
Keyword(s):  
Thin Films ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Polyvinylidene Fluoride ◽  
Solution Casting ◽  
Casting Technique ◽  
Doctor Blade ◽  
Solution Casting Technique ◽  
Hydroxyapatite Formation

Particles of calcium phosphate were precipitated by raising the temperature and the pH of simulated body fluid (SBF) named Apatite Nuclei (AN). AN and polyvinylidene fluoride (PVDF) composites thin films with different weight percentages of AN in PVDF were fabricated by solution casting technique, using doctor blade method. In order to assess the bioactivity, the thin films were soaked in simulated body fluid (SBF). It was found that the film containing 30 wt.% of AN in PVDF actively induced hydroxyapatite formation in 3 days soaking period in SBF.

scholarly journals Evaluation of Photocatalytic and Protein Adsorption Properties of Anodized Titanium Plate Immersed in Simulated Body Fluid

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Ryoji Sawada ◽  
Yuya Katou ◽  
Hirofumi Shibata ◽  
Max Katayama ◽  
Toru Nonami
Keyword(s):  
Sulfuric Acid ◽  
Simulated Body Fluid ◽  
Oxide Film ◽  
Protein Adsorption ◽  
Titanium Oxide ◽  
Body Fluid ◽  
Titanium Plate ◽  
Titanium Oxide Film ◽  
Adsorption Ability ◽  
Anodized Titanium

Titanium-based materials are widely used for implant treatments such as artificial dental roots. Surface treatment has the potential to improve not only the biocompatibility but also the chemical and mechanical durability of the surface without changing the mechanical properties of the metal. A relatively thick titanium oxide film can be formed by the anodic oxidation method. Phosphoric acid or sulfuric acid electrolytic solution has previously been used for anodic oxidation. Such anodized films have excellent film hardness, abrasion resistance, and adhesion. In this study, titanium plate was anodized using an aqueous solution of sulfuric acid in which titanium oxide powder was suspended. A 2800-nm-thick titanium oxide film was formed, which was thicker than that obtained using phosphoric acid electrolyte. The titanium plate was immersed in simulated body fluid for 1 day to evaluate the photocatalytic activity and protein adsorption ability, and a homogeneous crack-free hydroxyapatite layer was formed. This titanium plate showed high methylene blue bleaching capacity. The adsorption ability of the acidic protein of the anodized titanium plate subjected to the above treatment was high. This suggests that this titanium plate has antimicrobial properties and protein adsorption ability. Thus, we report that a titanium plate, anodized with a sulfuric acid aqueous electrolyte solution containing suspended TiO2 powder and immersed in simulated body fluid, might behave as an antibacterial and highly biocompatible implant material.

Biodegradable Bone Cement Using Calcium Phosphate Glass

2006 ◽  
Vol 309-311 ◽  
pp. 861-864 ◽  
Author(s):  
Byung Hyun Lee ◽  
Min Chul Kim ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Weight Loss ◽  
Compressive Strength ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Dissolution Rate ◽  
Phosphate Glass ◽  
Body Fluid ◽  
Setting Time ◽  
Ageing Test ◽  
Dynamic Assay

In preliminary ageing test, the cement using only calcium phosphate glass as power phase cracked with 1 day in simulated body fluid because of high dissolution rate of the cement. We added 30 wt% of either β-TCP or HA to 70 wt% calcium phosphate glass as powder phase to control the dissolution rate of the cement and performed in vitro ageing test in simulated body fluid by dynamic protocol as well as static protocol to confirm the possibility of controlling. Adding either β-TCP or HA to the cement increases the setting time and decreases the compressive strength. In dynamic assay, the pH of extract is maintained over 7. However, pH decreased to around 5 in static assay. Therefore, weight loss by static protocol continuously increased for 14 days, while weight loss by dynamic protocol almost saturated. In XRD patterns of ageing cements, CaO peaks appeared. CaO peak was maximized most lately in dynamic assay of the cement adding HA and within 7 days, the cement adding HA showed higher weight loss. It is indicated that CaO formed in surface of the cement hinder the dissolution of the cement. In addition, compressive strength increased when the CaO peak was maximized.

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