Response of Osteoporotic Jaw Bone to Implantation of Biphasic Calcium Phosphate Bioceramics Supplemented with Autologous Mesenchymal Cells

2016 ◽  
Vol 721 ◽  
pp. 240-244
Author(s):  
Aleksandrs Grisulonoks ◽  
Inese Cakstina ◽  
Arnis Abolins ◽  
Janis Locs ◽  
Andrejs Skagers ◽  
...  
Keyword(s):  
Local Treatment ◽  
Mesenchymal Cells ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Experimental Osteoporosis ◽  
New Strategy ◽  
Adequate Blood Supply ◽  
Clinically Significant ◽  
The Individual

To target areas of the skeletal system which are clinically significant sites is a new strategy as the"local treatment of osteoporosis". Synthetic bioceramics implanted into critical sized bone defect of rats with experimental osteoporosis demonstrateds better effect to bone tissue repair in osteoporosis and/or osteoporosis status. Stem cell transplantation may improve bone mineral density in animal models of osteoporosis. An adequate blood supply of mesenchymal cells (MSCs and osteoprogenitors) is important for efficient bone regeneration. The concentration and quality of MSCs may vary significantly, depending on the individual (especially in older people), the cell obtaining sites and techniques used. Combination of BCP and stem cells are not studied on old experimental animals with double induced osteoporosis.

A Review on The Complications and Management of Osteoporosis

2021 ◽  
Vol 12 (4) ◽  
pp. 2345-2349
Author(s):  
Mohsin Aijaz Soomro ◽  
Raheel Akbar Baloch ◽  
Najeeb ur Rehman ◽  
Niaz Hussain Keerio ◽  
Muhammad Faraz Jokhio ◽  
...  
Keyword(s):  
Lifestyle Modification ◽  
Bone Fragility ◽  
Diagnostic Methods ◽  
Mineral Density ◽  
Pharmacological Interventions ◽  
Global Epidemic ◽  
Calcium Supplements ◽  
Skeletal Disease ◽  
The Individual

Osteoporosis is a skeletal disease that is characterized by low bone mineral density. It also disrupts the microarchitectural of the bone. In leads to increased bone fragility and risk of fractures. Even while it occurs in persons of various ages and ethnicities (including Caucasians and whites), it is more common among Caucasians (whites), elderly people, and women. Osteoporosis is becoming a global epidemic as the world's population ages and lives longer. Osteoporosis affects an estimated 200 million individuals worldwide. It affects a 3rd of women and one in every 12 men. This increases morbidity as well as mortality due to several complications. Moreover, It also reduces the patient's quality of life, lengthens their life expectancy when they are disabled, and places a heavy financial load on the health insurance systems of countries that are responsible for their care. Thus, it is essential to improve diagnostic methods and to introduce early intervention to prevent this disease. Lifestyle modification is an important recommendation for the population at risk. There are several pharmacological interventions that could be taken to prevent osteoporosis as vitamin D and calcium supplements and to treat osteoporosis as bisphosphonates and anabolic drugs. The most important step in the treatment is tailored to the individual patients and to optimize the treatment according to each case individually. Therefore, increasing doctor awareness, which promotes improved awareness among the general public, will be useful in averting this epidemic. 

scholarly journals Physical approach for prevention and treatment of osteoporosis

2010 ◽  
Vol 54 (2) ◽  
pp. 171-178 ◽  
Author(s):  
Ana Paula Rebucci Lirani-Galvão ◽  
Marise Lazaretti-Castro
Keyword(s):  
Pharmacological Treatment ◽  
Treatment Options ◽  
Mineral Density ◽  
Management Options ◽  
Pharmacological Management ◽  
Treatment Of Osteoporosis ◽  
Specific Strength ◽  
Positive Effects ◽  
Coordination Training

Osteoporosis and its consequent fractures are a major problem in public health. To complement the conventional pharmacological treatment for this metabolic disease, non-pharmacological treatment options have been developed in the last decades. Several studies demonstrate that physical exercise programs including impact exercises, specific strength training, balance and coordination training may maintain or increase spine and hip bone mineral density as well as decrease the frequency of falls among osteoporotic and osteopenic patients. Furthermore, some physical agents such as vibratory platforms, low intensity electrical stimulation, laser therapy and ultrasound show positive effects on osteoporotic tissue as well. Consequently, while planning treatment for an osteoporotic patient, non-pharmacological management options should be considered and integrated to the conventional treatment in order to maximize its effects and improve the quality of life of these patients.

Prevalence, co-occurrence, and trajectories of pain, fatigue, depression, and anxiety in the year following multiple sclerosis diagnosis

2021 ◽  
pp. 135245852110233
Author(s):  
Thomas R Valentine ◽  
Kevin N Alschuler ◽  
Dawn M Ehde ◽  
Anna L Kratz
Keyword(s):  
Multiple Sclerosis ◽  
Self Report ◽  
Depression And Anxiety ◽  
Newly Diagnosed ◽  
Individual Level ◽  
Stability Change ◽  
Clinically Significant ◽  
The Individual ◽  
Multiple Sclerosis Diagnosis

Background: Pain, fatigue, depression, and anxiety are common in multiple sclerosis, but little is known about the presence, co-occurrence, and trajectories of these symptoms in the year after multiple sclerosis (MS) diagnosis. Objectives: To determine, during the postdiagnosis year: (1) rates of pain, fatigue, depression, and anxiety; (2) rates of symptom co-occurrence; and (3) stability/change in symptom severity. Methods: Newly diagnosed adults with MS/clinically isolated syndrome ( N = 230) completed self-report measures of pain, fatigue, depression, and anxiety at 1, 2, 3, 6, 9, and 12 months after MS diagnosis. Clinical significance was defined based on standardized cutoffs. Descriptive statistics and Sankey diagrams characterized rates and trajectories. Results: Participants endorsed clinically significant symptoms at some point in the postdiagnosis year at rates of 50.9% for pain, 62.6% for fatigue, 47.4% for depression, and 38.7% for anxiety. A majority of patients exhibited co-occurring symptoms—21.3% with two, 19.1% with three, and 17.4% with four. The proportions of patients with clinically significant symptoms were generally stable over time; however, rates of symptom development/recovery revealed fluctuations at the individual level. Conclusions: Pain, fatigue, depression, and anxiety are prevalent in newly diagnosed MS. Prompt screening and evidence-based interventions are necessary if quality of life is to be optimized.

scholarly journals Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial

2020 ◽  
pp. 153537022096875
Author(s):  
Sandra Kraljević Pavelić ◽  
Vedran Micek ◽  
Dragica Bobinac ◽  
Edo Bazdulj ◽  
Alessandra Gianoncelli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bone Formation ◽  
Rat Model ◽  
In Vivo Studies ◽  
Mineral Density ◽  
Double Blind ◽  
Treatment Of Osteoporosis ◽  
Positive Effects

The severity of osteoporosis in humans manifests in its high incidence and by its complications that diminish quality of life. A societal consequence of osteoporosis is the substantial burden that it inflicts upon patients and their families. Several bone-modifying drugs have been prescribed to patients with osteoporosis. However, evidence for their anti-fracture efficacy remains inconclusive. To the contrary, long-term use of anti-osteoporotic drugs such as bisphosphonates and Denosumab, an RANKL inhibitor, have resulted in adverse events. We now present an alternative and adjuvant approach for treatment of osteoporosis. The data derive from in vivo studies in an ovariectomized rat model and from a randomized double blind, placebo-controlled human clinical study. Both studies involved treatment with Panaceo Micro Activation (PMA)-zeolite-clinoptilolite, a defined cation exchange clinoptilolite, which clearly improved all bone histomorphometric parameters examined from ovariectomized animals, indicative for increased bone formation. Moreover, intervention with PMA-zeolite-clinoptilolite for one year proved safe in humans. Furthermore, patients treated with PMA-zeolite-clinoptilolite showed an increase in bone mineral density, an elevated level of markers indicative of bone formation, a significant reduction in pain, and significantly improved quality of life compared with patients in the control (placebo) group. These encouraging positive effects of PMA-zeolite-clinoptilolite on bone integrity and on osteoporosis warrant further evaluation of treatment with PMA-zeolite-clinoptilolite as a new alternative adjuvant therapy for osteoporosis.

scholarly journals The problem of low adherence to antiresorptive therapy with bisphosphonates: solutions

2022 ◽  
pp. 175-180
Author(s):  
O. V. Yakushevskaya
Keyword(s):  
Cost Effective ◽  
Rehabilitation Program ◽  
Antiresorptive Therapy ◽  
Mineral Density ◽  
Osteoporosis Therapy ◽  
Treatment Of Osteoporosis ◽  
Demographic Situation ◽  
Natural Result

Over the past several decades, there has been a global aging of the population around the world. The demographic situation in the Russian Federation is no exception, being a natural result of an increase in the life expectancy of the population. In clinical practice, geriatric diseases have been identified and are widely studied, which deserve priority attention due to a sharp decline in the quality of life of elderly patients. Osteoporosis is called a “silent epidemic” among elderly and senile patients. This disease is associated with a high risk of low-traumatic fractures of various localization. The imperfect rehabilitation program after complex fractures and its insufficient funding are forcing clinicians to focus on more cost-effective solutions to this problem  – the  prevention and treatment of  osteoporosis. Osteomodifying agents are widely used by physicians of  various specialties. Bisphosphonates effectively reduce the risk of low-traumatic fractures against the background of an increase in bone mineral density. The  level of  effectiveness of  bisphosphonates depends on the  patient’s adherence to antiresorptive therapy and the degree of compensation for vitamin D and serum calcium. Low adherence to osteoporosis therapy is based on the need for long-term use of bisphosphonates and a different spectrum of adverse events. In the article, using alendronate as an example, the problem of low adherence to antiresorptive therapy will be considered and ways to solve it are presented.

scholarly journals Role of zoledronic acid in treatment of osteoporosis and prevention of fractures

2022 ◽  
pp. 102-109
Author(s):  
A. V. Krivova ◽  
V. P. Zakharov ◽  
A. N. Sharov
Keyword(s):  
Quality Of Life ◽  
Zoledronic Acid ◽  
Mineral Density ◽  
Treatment Of Osteoporosis ◽  
Vertebral Body Fractures ◽  
Bone Deficiency ◽  
Minimal Trauma ◽  
Primary Disability ◽  
Pharmacological Correction

Introduction. One of the causes of primary disability and high mortality, among patients with osteoporosis, are fractures that occur with minimal trauma, as a rule, it is a fall from the height of one’s own height. The final link in the chain of preventive measures to reduce the frequency of osteoporosis and fractures on its background is the introduction of pharmacological correction of bone deficiency into the practical activity of an orthopedic traumatologist. Currently, there are several drugs that can change the disturbed metabolism. For example, the use of zoledronic acid significantly reduces the risk of fractures.Aim: to study the effect of zoledronic acid on bone mineral density in patients with osteoporosis complicated by a fracture of proximal end of the femur.Materials and methods. In a prospective cohort study, 14 patients received zoledronic acid for 2 years.Results. When comparing BMD L2-L4, it was revealed that a year after the start of treatment, its increase relative to the baseline value was 4.6%, but was statistically insignificant (0.86 ± 0.078 g/cm2 versus 0.90 ± 0.08 g/cm2, p > 0.05). After 2 years of treatment, the BMD of this segment increased, relative to the baseline values, by 12% and the differences became statistically significant (0.86 ± 0.078 g/cm2 compared to 0.97 ± 0.076 g/cm2, p < 0.05). The increase in BMD for the second year of treatment by 6% was statistically significantly different from the increase for the first year of treatment (0.90 ± 0.08 g/cm2 compared to 0.97 ± 0.076 g/cm2, p < 0.05).A comparative analysis of the basic units of the IPC hip after 1 and 2 years of treatment did not reveal significant differences: 0.7075 ± 0.046 g/cm2 compared to 0.7079 ± 0.034 g/cm2 and 0.70751 ± 0.046 g/cm2 compared to 0.6630 ± 0.97 g/cm2, p > 0.05. In any case, for 2 years not marked new vertebral body fractures. Only one patient had a fracture of the radius in the distal third. The quality of life, after 2 years, significantly improved on the scale of “habitual daily activities” (p = 0.007), decreased indicators on the scale of “anxiety” and “depression” (p > 0.05).Discussion. The study confirmed that even in the presence of pronounced bone loss, pharmacological correction of impaired remodeling reduces the risk of new fractures and improves the quality of life.Conclusion. Pharmacotherapy with zoledronic acid, in our study, confirmed its effectiveness in the treatment of osteoporosis.

Semi-automated methods for 3-D reconstruction of macromolecular complexes

1995 ◽  
Vol 53 ◽  
pp. 42-43
Author(s):  
B. Carragher ◽  
M. Whittaker
Keyword(s):  
Three Dimensional ◽  
Time Saving ◽  
Macromolecular Complexes ◽  
Symmetry Properties ◽  
Dimensional Reconstruction ◽  
Experienced Operator ◽  
Projection Images ◽  
The Individual ◽  
Natural Symmetry

Techniques for three-dimensional reconstruction of macromolecular complexes from electron micrographs have been successfully used for many years. These include methods which take advantage of the natural symmetry properties of the structure (for example helical or icosahedral) as well as those that use single axis or other tilting geometries to reconstruct from a set of projection images. These techniques have traditionally relied on a very experienced operator to manually perform the often numerous and time consuming steps required to obtain the final reconstruction. While the guidance and oversight of an experienced and critical operator will always be an essential component of these techniques, recent advances in computer technology, microprocessor controlled microscopes and the availability of high quality CCD cameras have provided the means to automate many of the individual steps.During the acquisition of data automation provides benefits not only in terms of convenience and time saving but also in circumstances where manual procedures limit the quality of the final reconstruction.

Effect of local treatment of seminal vesiculitis on the quality of equine frozen semen

2014 ◽  
Author(s):  
Yame F R Sancler-Silva ◽  
Gabriel A Monteiro ◽  
Carlos Ramires Neto ◽  
Dell'aqua Camila P Freitas ◽  
Andre M Crespilho ◽  
...  
Keyword(s):  
Local Treatment ◽  
Frozen Semen

Manageable Self in the Early Hellenistic Era

2010 ◽  
Vol 39 (2) ◽  
pp. 34-36
Author(s):  
Vaia Touna
Keyword(s):  
Social Economic ◽  
Ancient Greece ◽  
The Self ◽  
Hellenistic Period ◽  
Political Conditions ◽  
The Individual

This paper argues that the rise of what is commonly termed "personal religion" during the Classic-Hellenistic period is not the result of an inner need or even quality of the self, as often argued by those who see in ancient Greece foreshadowing of Christianity, but rather was the result of social, economic, and political conditions that made it possible for Hellenistic Greeks to redefine the perception of the individual and its relationship to others.

Reflecting the Sky in Water

2017 ◽  
Vol 3 (1) ◽  
pp. 112-126 ◽  
Author(s):  
Ilaria Cristofaro
Keyword(s):  
The Unconscious ◽  
Related Case ◽  
Quality Of Water ◽  
Fluid Properties ◽  
Phenomenological Perspective ◽  
Auto Ethnography ◽  
The Individual ◽  
Artificial Water ◽  
Land Water

From a phenomenological perspective, the reflective quality of water has a visually dramatic impact, especially when combined with the light of celestial phenomena. However, the possible presence of water as a means for reflecting the sky is often undervalued when interpreting archaeoastronomical sites. From artificial water spaces, such as ditches, huacas and wells to natural ones such as rivers, lakes and puddles, water spaces add a layer of interacting reflections to landscapes. In the cosmological understanding of skyscapes and waterscapes, a cross-cultural metaphorical association between water spaces and the underworld is often revealed. In this research, water-skyscapes are explored through the practice of auto-ethnography and reflexive phenomenology. The mirroring of the sky in water opens up themes such as the continuity, delimitation and manipulation of sky phenomena on land: water spaces act as a continuation of the sky on earth; depending on water spaces’ spatial extension, selected celestial phenomena can be periodically reflected within architectures, so as to make the heavenly dimension easily accessible and a possible object of manipulation. Water-skyscapes appear as specular worlds, where water spaces are assumed to be doorways to the inner reality of the unconscious. The fluid properties of water have the visual effect of dissipating borders, of merging shapes, and, therefore, of dissolving identities; in the inner landscape, this process may represent symbolic death experiences and rituals of initiation, where the annihilation of the individual allows the creative process of a new life cycle. These contextually generalisable results aim to inspire new perspectives on sky-and-water related case studies and give value to the practice of reflexive phenomenology as crucial method of research.

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