Polymethacrylates as Polymeric Film Formation in Patches Containing α-Mangostin and Resveratrol

2019 ◽  
Vol 819 ◽  
pp. 51-56
Author(s):  
Wipada Samprasit ◽  
Benchawan Chamsai ◽  
Praneet Opanasopit
Keyword(s):  
Film Formation ◽  
Polymeric Film ◽  
Solvent Casting ◽  
Qualitative And Quantitative Analysis ◽  
Drying Process ◽  
Thickness Swelling ◽  
Casting Method ◽  
Qualitative And Quantitative ◽  
Peg 400 ◽  
Ft Ir

Polymethacrylates polymeric film formation in patches containing α-mangostin and resveratrol were developed using solvent casting method. Eudragit® E100 (E) and Eudragit® L100 (L) were dissolved in ethanol and the plasticizer (propylene glycol (PG) and polyethylene glycol (PEG) 400) was individual added and followed with the drying process. The dried films were evaluated for the morphology and flexibility. After the stable film was achieved, the α-mangostin and resveratrol were incorporated into the film. The variation of weight and thickness, swelling property, pH surface, mechanical properties and drug content of patches was evaluated. Fourier transform infrared spectrophotometry (FT-IR) was also conducted to confirm that drugs were qualitatively loaded into the patches. The results indicated that patch of L and PG was found to be stable. PG enhanced the flexibility of patch. The patches were less variation in weight and thickness. This patch did not effect to the physiological pH in the human body. In addition, patch had a tensile strength high enough to withstand tearing during handing. The qualitative and quantitative analysis indicated the α-mangostin and resveratrol was well incorporated in this patch. These results suggest that polymethacrylate polymer could be a promising polymeric film formation in patches for drug delivery.

scholarly journals FT-IR/ATR Solid Film Formation: Qualitative and Quantitative Analysis of a Piperacillin-Tazobactam Formulation

Molecules ◽  
2020 ◽  
Vol 25 (24) ◽  
pp. 6051
Author(s):  
Ioanna Chrisikou ◽  
Malvina Orkoula ◽  
Christos Kontoyannis
Keyword(s):  
Quantitative Analysis ◽  
Film Formation ◽  
Spectroscopic Technique ◽  
Sample Treatment ◽  
Qualitative And Quantitative Analysis ◽  
Analytical Technique ◽  
Qualitative And Quantitative ◽  
Commercial Mixture ◽  
Solid Film ◽  
Ft Ir

FT-IR/ATR analytical technique is one of the most applicable techniques worldwide. It is closely associated with easy-to-use equipment, rapid analysis, and reliable results. This study reports the simultaneous qualitative and quantitative analysis of two active pharmaceutical ingredients (APIs), of a piperacillin and tazobactam formulation using a film formation method. This method requires film formation on the ATR crystal, resulting from solvent evaporation of a small amount of liquid sample. Good contact between the film and the crystal led to the identification of both APIs, although tazobactam was of low content in the formulation mixture. The quantification of the APIs in the commercial mixture was also achieved, using a single calibration line with a correlation coefficient equal to 0.999, not only after film formation but also in the initial dry formulation before reconstitution. The present spectroscopic technique combined with the proposed relatively simple sample treatment outweighs chromatographic protocols already applied, which require specialized staff and are costly, time-consuming, and not environmentally friendly. Taking all the above into consideration, it turns out that such an approach has the potential to be used for off-line quality control procedures in manufacture or, in terms of portable equipment and automated software, anywhere for on-site analysis, even in a hospital workflow.

scholarly journals Chemical constituents of Algerian mandarin (Citrus reticulata) essential oil by GC-MS and FT-IR analysis

2020 ◽  
Vol 33 (4) ◽  
pp. 197-201
Author(s):  
Hicham Boughendjioua ◽  
Nour El Houda Mezedjeri ◽  
Ilhem Idjouadiene
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Complex Mixture ◽  
Citrus Reticulata ◽  
Qualitative And Quantitative Analysis ◽  
Spectroscopy Analysis ◽  
Qualitative And Quantitative ◽  
Ft Ir ◽  
Ir Analysis

Abstract Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Citrus oils are a complex mixture of more than a hundred components of differing chemical natures. Qualitative and quantitative analysis by gas chromatography coupled with mass spectrometry (GCMS) of the Citrus reticulata essential oil collected from El Hadaïk, Skikda City (Algeria), identified 28 compounds representing a total of 99.41%. The essential oil is constituted mainly of: D-Limonene (85.10%), Sabinene (2.49%), Linalyl acetate (2.00%), Copaene (1.80%) et α-Pinene (1.75%) totaling approximately 93.14%. The essential oil was also analyzed by Fourier transform infrared spectroscopy analysis (FTIR). FTIR spectroscopy allowed us to identify 10 volatile compounds and indicated that the functional groups of the essential oils are C-H (Alkene), C-H (aromatic) and C=C. The obtained results have shown that the essential oil can be fully utilized for pharmacy, cosmetology and industry.

scholarly journals Overcoming Poor Solubility of Dimenhydrinate: Development, Optimization and Evaluation of Fast Dissolving Oral Film

2018 ◽  
Vol 8 (4) ◽  
pp. 721-725 ◽  
Author(s):  
Yuvraj Govindrao Jadhav ◽  
Upendra Chandrakant Galgatte ◽  
Pravin Digambar Chaudhari
Keyword(s):  
Pediatric Population ◽  
Solvent Casting ◽  
Casting Method ◽  
Polyethylene Glycol 400 ◽  
Disintegration Time ◽  
Surface Ph ◽  
Peg 400 ◽  
Sodium Saccharin ◽  
Croscarmellose Sodium ◽  
Oral Films

Purpose: To develop fast dissolving oral film to address vomiting and nausea in pediatric population. Methods: Oral films of Dimenhydrinate were prepared by solvent casting method by using hydroxypropylmethyl cellulose E5 (HPMC E5), polyethylene glycol 400 (PEG 400) and croscarmellose sodium. Solubility of dimenhydrinate was enhanced by ethanol as a co-solvent. To make dimenhydrinate palatable sodium saccharin and peppermint oil were used. All films were evaluated for mechanical parameters, surface pH, morphology, disintegration time and percent dissolution. Results: Films were smooth, acceptable and white in colour. For optimized batch, drug content (99.106%), disintegration time (25 sec), dissolution (99.10% in 210 sec), surface pH (6.81) were acceptable. Conclusion: Optimized batch, due to its potential to deliver through fast dissolving film, can be developed for clinical use.

DEVELOPMENT AND CHARACTERIZATION OF SUBLINGUAL FILM CONTAINING ROPINIROLE HYDROCHLORIDE

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (07) ◽  
pp. 33-42
Author(s):  
P. B. Patil ◽  
D. A. Patil ◽  
L. R. Zawar ◽  
B. Patil ◽  
G. B. Patil ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Solvent Casting ◽  
Casting Method ◽  
Percentage Elongation ◽  
Peg 400 ◽  
Film Forming ◽  
Folding Endurance ◽  
Ropinirole Hydrochloride

In the present work films of ropinirole hydrochloride were prepared by using polymers such as hydroxy propyl methyl cellulose (HPMC E-15) and polyethylene glycol (PEG-400) as plasticizers, by a solvent casting method, for treatment of Parkinson's disease. HPMC E-15 was used as film forming agent in the range of concentration 50 mg – 600 mg and PEG-400 was used as plasticizer in the range of concentration 0.3-1.0 ml for solvent casting method. the optimized concentration of film forming agent was 400 mg and plasticizer concentration was 0.7ml. By using optimized concentration, Ropinirole Hydrochloride mouth dissolving films (MDFs) were prepared by additionof other excipients. The formulated MDFs were evaluated for different physical characteristics like uniformity of weight, thickness, folding endurance, drug content uniformity, percentage elongation, and tensile strength, disintegration, in vitro drug release studies and provided agreeable results. The FTIR and DSC studies confirmed that no physicochemical interaction in between drug and excipients accured. Mouth dissolving film of Ropinirole Hydrochloride containing HPMC E-15 as polymer showed 97.66 % drug release at 30 min. Mouth dissolving films of ropinirole hydrochloride containing HPMC E-15 showed better tensile strength (70.56 ± 0.9 g/mm2), percentage elongation (33.33 ± 2.88 %), folding endurance (168± 2.081 numbers of folds), in vitro disintegration time (35± 3.511 sec.) and thickness (0.4± 0.17 mm).

Designing a business unit and creating the first ever responsive kitchen

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Paolo FESTA ◽  
Tommaso CORA ◽  
Lucilla FAZIO
Keyword(s):  
Value Creation ◽  
Product Innovation ◽  
Research Laboratory ◽  
Direct Relationship ◽  
Multidisciplinary Approach ◽  
Design Thinking ◽  
Business Unit ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
The Relationship

Is it possible to transform stone into a technological and innovative device? The meeting with one of the main stone transformers in Europe produced the intention of a disruptive operation that could affect the strategy of the whole company. A contagious singularity. By intertwining LEAN methodologies and the human-centric approach of design thinking, we mapped the value creation in the company activating a dialogue with the workers and the management, listening to people, asking for ambitions, discovering problems and the potential of production. This qualitative and quantitative analysis conducted with a multidisciplinary approach by designers, architects and marketing strategists allowed us to define a new method. We used it to design a platform that could let all the players express their potential to the maximum. This is how the group's research laboratory was born, with the aim of promoting the relationship between humans and stone through product innovation. With this goal, we coordinated the new team, developing technologies that would allow creating a more direct relationship between man and surface, making the stone reactive. The result was the first responsive kitchen ever.

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