Differences in anti-type II Collegen antibody titers Among Degenerative Arthritis, Rheumatoid Arthritis and Control Groups

1995 ◽  
Vol 30 (2) ◽  
pp. 216
Author(s):  
Goo Hyun Baek ◽  
Moon Sang Chung ◽  
Yong Min Kim ◽  
Chung Soo Hwang ◽  
Piil Hyun Chung
Keyword(s):  
Rheumatoid Arthritis ◽  
Type Ii ◽  
Control Groups ◽  
Degenerative Arthritis ◽  
Antibody Titers ◽  
And Control ◽  
Arthritis Rheumatoid

scholarly journals Study of IL-33 and IL-1R4 in Iraqi Rheumatoid Arthritis Female Patient's with and without Dyslipidemia Prone to Atherosclerosis

2019 ◽  
Vol 32 (1) ◽  
pp. 47
Author(s):  
Lara Ali Nazar ◽  
Eiman AA.` Abass
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Interleukin 1 ◽  
Control Group ◽  
Control Groups ◽  
Interleukin 33 ◽  
Erythrocyte Sedimentation ◽  
And Control

   This study is planned to find relationship between interleukin-33 (IL-33) with its receptor interleukin-1 receptor 4 (IL-1R4), and assurance IL-33/IL-1R4 proportion as biomarker to atherosclerosisin rheumatoid arthritis (RA) Iraqi females patients with and without dyslipidemia. This study was attempted at Baghdad Teaching Hospital included 60 females patients with RA that were isolated into: 30 patients with dyslipidemia(G2), 30 patients without dyslipidemia(G3) and 30 individual as control group (G1) .Patients were experiencing treatment by methortexiene medication, analyzed by rheumatoid factor(RF) and erythrocyte sedimentation rate( ESR) tests. All patients and control groups age ranged from (30-55) years. The results show an increase in ESR, RF, IL-33, and IL-1R4 levels. In addition to decrease in IL-33/IL-1R4 ratio in the two patients groups when contrasted and control group. The momentum examine inferred that the level of ESR, and  IL-33 in RA Iraqi females  patients with dyslipidemia were higher than that in RA Iraqi females patients without dyslipidemia, while the level of IL-33/IL-1R4 ratio in RA Iraqi females patients with dyslipidemia was lower than that in RA Iraqi females patients without dyslipidemia patients; in this manner the IL-33/IL-1R4 ratio may be used as a biomarker in diagnostic early porn to atherosclerosis in RA females patients with dyslipidemia

scholarly journals Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis

2021 ◽  
Author(s):  
Faezeh Jamali ◽  
Arman Ahmadzadeh ◽  
Zahra Sahraei ◽  
Jamshid Salamzadeh
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Disease Activity Score ◽  
Activity Score ◽  
Control Group ◽  
Control Groups ◽  
Double Blind ◽  
Related Condition ◽  
And Control ◽  
The Impact

Rheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant agent. We aimed to explore the impact of oral NAC on cytokines activities and clinical indicators in RA patients. In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the routine regimen, for 8 weeks. Disease activity score with an erythrocyte sedimentation rate (DAS28-ESR), and serum concentrations of interleukin (IL)-1β and IL-17 were assessed at baseline and end of the trial for all participants in the test and control groups. The reduction of the DAS28-ESR was higher considerably in the NAC group compared to that of the control group. No statistically significant differences were seen in the reduction of IL- 1β and IL-17 cytokines between the NAC and control groups. In addition, improvements in the patient global assessment, number of tender joints, number of swollen joints, and the ESR rates were in favor of the NAC group. Our findings reveal that NAC may have a beneficial effect on all of the clinical features of RA. However, non-significant variations in the IL-1β and IL-17 levels suggest an alternative way of NAC effectiveness without influencing the measured cytokines. Nevertheless, these results need to be confirmed by further investigations.

scholarly journals Association between Rheumatoid Arthritis and Meniere’s Disease: A Longitudinal Follow-Up Study Using a National Health Screening Cohort

2021 ◽  
Vol 10 (23) ◽  
pp. 5694
Author(s):  
So Young Kim ◽  
Dae Myoung Yoo ◽  
Ji Hee Kim ◽  
Mi Jung Kwon ◽  
Joo-Hee Kim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
National Health ◽  
Meniere’S Disease ◽  
Health Screening ◽  
Meniere's Disease ◽  
Ménière’S Disease ◽  
Menière's Disease ◽  
Control Groups ◽  
Ménière's Disease ◽  
And Control

This study aimed to evaluate the impact of pre-existing rheumatoid arthritis (RA) on the occurrence of Meniere’s disease (MD). The 2002–2015 Korean National Health Insurance Service—Health Screening Cohort data were retrospectively analyzed. A total of 3038 participants with RA were matched with 12,152 control participants for demographic factors. The occurrence of MD was evaluated in both the RA and control groups. The hazard ratios (HRs) of RA for participants with MD were calculated using a stratified Cox proportional hazard model. Additionally, subgroup analyses were conducted. The rate of MD was not different between the RA and control groups (1.5% vs. 1.3%, standardized difference = 0.01). The HR was not higher in the RA group than in the MD group (adjusted HR = 1.03, 95% confidence interval = 0.73–1.44, p = 0.885). A higher HR of RA for participants with MD was found in the ≥60-year-old subgroup in the crude model but not in the adjusted model. An association between RA and MD was not found in any of the other subgroups. A previous history of RA was not related to an increased risk of MD.

scholarly journals Temporal Expression of SOX9 and Type II Collagen in Spheno-Occipital Synchondrosis of Mice after Mechanical Tension Stimuli

2008 ◽  
Vol 78 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Teddy Cendekiawan ◽  
Ricky W. K. Wong ◽  
A. Bakr M. Rabie
Keyword(s):  
Tensile Stress ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Temporal Expression ◽  
Control Groups ◽  
Mechanical Tension ◽  
Tissue Sections ◽  
Pentobarbitone Sodium ◽  
And Control

Abstract Objective: To associate the expressions of SOX9 and type II collagen during growth in the synchondrosis with and without tensile stress in order to understand the role of these factors in the growth of cartilage in spheno-occipital synchondrosis. Materials and Methods: Sixty 1-day-old male BALB/c mice were randomly divided into experimental and control groups. Each group was subdivided again into five different time points which were 6, 24, 48, 72, and 168 hours. Each subgroup consisted of five mice. Each mouse was sacrificed using an overdose of pentobarbitone sodium. The synchondroses were aseptically removed and incubated in a 24-well plate with or without tensile stress in tissue culture. Tissue sections were stained immunohistochemically to quantitatively analyze the expression of SOX9 and type II collagen. Results: There was a statistically significant increase of 57% (P < .001) in the expression of SOX9 between the experimental and control groups at 24 hours, followed by a significant increase of 44.4% (P < .001) in the expression of type II collagen at 72 hours. Conclusions: SOX9 may play an important role for early differentiation of chondrocytes and increase the expression of type II collagen, a major component of the extracellular matrix, during the growth of cartilage in the spheno-occipital synchondrosis.

scholarly journals The time has come to limit the placebo period in rheumatoid arthritis trials to 3 months: a systematic comparison of 3- and 6-month response rates in trials of biological agents

2009 ◽  
Vol 69 (01) ◽  
pp. 186-192 ◽  
Author(s):  
M Boers
Keyword(s):  
Rheumatoid Arthritis ◽  
Active Control ◽  
Meta Analysis ◽  
Standard Of Care ◽  
Biological Agents ◽  
Control Groups ◽  
Placebo Period ◽  
Placebo Phase ◽  
The Mean ◽  
And Control

Background:Most registration trials in rheumatoid arthritis (RA) include a placebo arm in the setting of an incomplete response to disease-modifying antirheumatic treatment (DMARD-IR). A minimum duration of 6 months is required despite serious methodological and ethical shortcomings.Objective:To study whether a 3-month placebo period is sufficient to prove efficacy.Methods:Meta-analysis of placebo- or active control trials of biological agents in DMARD-IR RA, comparing the contrast in ACR response between experimental and control groups at 3 and 6 months.Results:Twenty trials yielded 15 placebo and 18 active control contrasts (>10 000 patients). At 3 months active treatment showed a highly significant contrast with placebo for ACR20 and ACR50 in every instance. As all groups improved further the mean contrast at 6 months was unchanged. For ACR70 the contrast was clearly greater at 6 months owing to further improvement only in the experimental groups. In active control trials contrasts were smaller, and for ACR50 and ACR70 these decreased somewhat owing to “catch-up” responses in the control groups.Conclusion:The placebo phase of registration trials for RA can be limited to 3 months. An accompanying viewpoint proposes that patients receiving placebo should then be switched to standard of care, allowing a more valid and comprehensive assessment, including safety.

AB1090 BIOMARKERS TO DIFFERENTIATE EARLY INDISTINGUISHABLE CASES OF OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS.

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1834.1-1834
Author(s):  
A. Elbeialy ◽  
H. El Abd ◽  
A. Shahin ◽  
R. Ibrahim
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Level ◽  
Matrix Metalloproteinase ◽  
Serum Levels ◽  
Significant Elevation ◽  
Control Groups ◽  
Matrix Metalloproteinase 3 ◽  
Early Stages ◽  
Early Ra ◽  
And Control

Background:Osteoarthritis (OA) and rheumatoid arthritis (RA) are the most frequent inflammatory diseases of the musculoskeletal system, which could not be differentiated in their early stages, and characterized by degradation of articular cartilage and impairment of joint function. Sometimes, criteria and radiography are not insufficient to distinguish early-stages of RA and OA and predict disease course, and therefor biomarkers that help clinicians to early diagnose disease are essential.Objectives:The aim of this study is to estimate serum level of Matrix metalloproteinase 3 (MMP3) and hrdroxyproline (HP) in early RA and OA patients to see if they can be used to differentiate both diseases at their early stagesMethods:The aim of this study is to estimate serum level of Matrix metalloproteinase 3 (MMP3) and hrdroxyproline (HP) in early RA and OA patients to see if they can be used to differentiate both diseases at their early stagesResults:We found a highly significant elevation of serum MMP3 in OA patients group compared to RA patients and control groups. We also found a highly significant elevation of MMP3 in RA patients than control group,(P < 0.001). Meanwhile, we found a highly significant elevation of HP in OA patients than in RA patients and control groups, (P < 0.001), whereas there was no significant difference between HP in RA patients and control groups (P > 0.05).Table 1.Demonstration of serum levels of MMP3 and HP in all groups.“Enzyme”OA(n=40)RA(n=40)Control(n=40)p-valueMMP3 pg/mL559.92±1112.84153.25±162.0559.79±63.54<0.001HPµg/mL12.87±18.754.81±6.894.52±1.55<0.001HPµg/mL4.81±6.894.52±1.55> 0.05Conclusion:Our results suggest that serum levels of Hydroxyproline (HP) rather than MMP3 could be used as a potential biomarker for early differentiation between osteoarthritis (OA) and rheumatoid arthritis (RA) when diagnostic criteria failed to be fulfilled.References:[1]Benedetti S, Canino C, Tonti G, Medda V, Calcaterra P, Nappi G, Salaffi F, Canestrari F. (2010): Biomarkers of oxidation, inflammation and cartilage degradation in osteoarthritis patients undergoing sulfur-based spatherapies. ClinBiochem.; 43: 973-8.[2]Fenton, S. A. M., Veldhuijzen van Zanten, J. J. C. S., Duda, J. L., Metsios, G. S., and Kitas, G. D. (2018). Sedentary behaviour in rheumatoid arthritis: definition, measurement and implications for health. Rheumatology. (Oxford) 57(2), 213-226.[3]Murphy, G., and Nagase, H. (2008). Progress in matrix metalloproteinase research. Mol. Aspects Med. 29(5), 290-308.[4]Bonnans, C., Chou, J., and Werb, Z. (2014). Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 15(12), 786-801.[5]Hofman, K., Hall, B., Cleaver, H., & Marshall, S. (2011): High-throughput quantification of hydroxyproline for determination of collagen. Analytical biochemistry, 417(2), 289-291.[6]Barranco, C. (2015): Osteoarthritis: activate autophagy to prevent cartilage degeneration? Nat. Rev. Rheumatol. 11, 127.[7]M.S. Radha and Dr. M.R. Gangadhar (2015), Serum enzyme of matrix metalloproteinase-3 in patients with knee osteoarthritis, International Journal of Recent Scientific Research Vol. 6, Issue, 6, pp.4457-4460, June, 2015.[8]Bassiouni, H. M., El-Deeb, M., Kenawy, N., Abdul-Azim, E., & Khairy, M. (2011). Phonoarthrography, musculoskeletal ultrasonography, and biochemical biomarkers for the evaluation of knee cartilage in osteoarthritis. Modern rheumatology, 21(5), 500-508.[9]Ahmed, U., Anwar, A., Savage, R. S., Costa, M. L., Mackay, N., Filer, A., Raza, K., Watts, R. A., Winyard, P. G., Tarr, J., Haigh, R. C., Thornalley, P. J., and Rabbani, N. (2015). Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health. Sci. Rep. 5, 9259.Acknowledgments:We are indebted to Dr El Shaimaa Abdel Hakim, and Dr Asmaa Fouaad for their great help in this studyDisclosure of Interests:None declared

Change of Anti-type II Collagen Antibody in Rheumatoid Arthritis and Degenerative Arthritis

2000 ◽  
Vol 35 (3) ◽  
pp. 519
Author(s):  
Sang Ho Moon ◽  
Phil Hyun Chung ◽  
Jung Su Hwang ◽  
Suk Gang ◽  
Dong Ju Chae ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Degenerative Arthritis

scholarly journals Effect of Physical Activity on Pain and Functional Abilities in Patients with Rheumatoid Arthritis at an Autoimmune Clinic in Accra, Ghana

2021 ◽  
Vol 3 (2) ◽  
pp. 85-91
Author(s):  
Evelyn Ohenewa ◽  
◽  
Samuel Kwakye ◽  
Henry Lawson ◽  
Tawagidu Mohammed ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Physical Activity ◽  
Experimental Study ◽  
Functional Ability ◽  
Intervention Group ◽  
Health Concern ◽  
Functional Abilities ◽  
Control Groups ◽  
Quasi Experimental ◽  
And Control

Background: Rheumatoid arthritis is a chronic systemic disease that affects the joints, connective tissues, tendons, and fibrous tissues. Despite early interventions, there is significant activity limitation due to moderate and high pain intensities in majority of affected individuals.The study set out to determine the effect of physical activity on pain and functional ability among rheumatoid arthritis patients.Methods:A pre-test, post-test quasi experimental study conducted among 60 rheumatoid arthritis patients (divided into intervention and control groups) were recruited from the Autoimmune clinic of Korle Bu Teaching Hospital for this quasi-experimental study. The international physical activity questionnaire, multidimensional health assessment questionnaire and numerical pain rating scale were used to obtain data. Pedometers and a stationary cycle were used for physical activity (intervention). Paired t-test was used to compare outcomes between the level of physical activity in relation to pain and functional ability and outcomes between pre and post functional abilities at a 0.05 level of significance.Results: Majority 24 (80.0%) of participants from the intervention group reported low, while 6 (20.0%) reported moderate physical activity levels. Thirteen (43.4%) and 10 (33.3%) participants from the intervention and control groups reported moderate pain on NPRS before intervention, which reduced to 7 (23.3%) in the intervention group, as compared to 9 (30%) in the control group. There was a significant difference (p<0.05) for functional ability among the intervention group before and after the intervention programmes but no significant differences (p>0.05) for most domains of functional ability except health concern (p = 0.034) among the control group.Conclusion: Patients with RA have a relatively low physical activity level but benefit significantly from a moderate intensity aerobic exercises such as cycling and walking by improving pain levels, functional ability and general health.Clinicians should promote and encourage patients with RA to engage in physical and recreational activities.

scholarly journals Association Between a History of Nontyphoidal Salmonella and the Risk of Systemic Lupus Erythematosus: A Population-Based, Case-Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Ting-Yu Tu ◽  
Chiu-Yu Yeh ◽  
Yao-Min Hung ◽  
Renin Chang ◽  
Hsin-Hua Chen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Multiple Sclerosis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Lupus ◽  
Control Groups ◽  
And Control ◽  
Control Study

ObjectiveWe investigated the correlation between nontyphoidal Salmonella (NTS) infection and systemic lupus erythematosus (SLE) risk.MethodsThis case-control study comprised 6,517 patients with newly diagnosed SLE between 2006 and 2013. Patients without SLE were randomly selected as the control group and were matched at a case-control ratio of 1:20 by age, sex, and index year. All study individuals were traced from the index date back to their NTS exposure, other relevant covariates, or to the beginning of year 2000. Conditional logistic regression analysis was used to analyze the risk of SLE with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) between the NTS and control groups.ResultsThe mean age was 37.8 years in the case and control groups. Females accounted for 85.5%. The aOR of having NTS infection were significantly increased in SLE relative to controls (aOR, 9.20; 95% CI, 4.51-18.78) in 1:20 sex-age matching analysis and (aOR, 7.47; 95% CI=2.08-26.82) in propensity score matching analysis. Subgroup analysis indicated that the SLE risk was high among those who dwelled in rural areas; had rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome; and developed intensive and severe NTS infection during admission.ConclusionsExposure to NTS infection is associated with the development of subsequent SLE in Taiwanese individuals. Severe NTS infection and other autoimmune diseases such as rheumatoid arthritis, multiple sclerosis, or Sjogren’s syndrome also contributed to the risk of developing SLE.

scholarly journals Carbonic Anhydrases III and IV Autoantibodies in Rheumatoid Arthritis, Systemic Lupus Erythematosus, Diabetes, Hypertensive Renal Disease, and Heart Failure

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Chengeng Liu ◽  
Yue Wei ◽  
Jianmin Wang ◽  
Langan Pi ◽  
Jianjun Huang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Heart Failure ◽  
Systemic Lupus Erythematosus ◽  
Antioxidant Enzymes ◽  
Renal Disease ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Control Groups ◽  
Antibody Titers

In the present study, the CA III and IV autoantibodies, CA activity, antioxidant enzymes and cytokines in rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), diabetes, hypertensive renal disease, and heart failure were investigated. The anti-CA III antibody titers in patients with RA, SLE, and type 1 diabetes (T1D) were significantly higher than that in control groups (P<0.05). The anti-CA IV antibody titers in patients with RA, SLE, type 1 diabetic nephropathy (T1DN), and heart failure were significantly higher than that in control groups (P<0.05) while anti-CA IV antibody could suppress the total CA activity. The SOD and GPx levels in patients with RA, SLE, and T1DN were significantly lower than that in control groups (P<0.05). IL-6, IL-17, IFN-γ, and TNF-αlevels were significantly higher in SLE group compared with the control group (P<0.05). Weak but significant correlations were found between anti-CA III antibodies and ESR in RA (r=0.403,P=0.013) and SLE patients (r=0.397,P=0.007). These results suggested that the generation of CA III and IV autoantibodies, antioxidant enzymes, and cytokines might influence each other and CA autoantibodies might affect the normal physiology function of CA.

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