The influence of Mediterranean diet in acne pathogenesis and the correlation with insulin-like growth factor-1 serum levels: implications and results

Acne is a chronic inflammatory disease of the pilosebaceous unit and its etiology is complex and multifactorial. The role of the diet in its pathogenesis is still debated. The purpose of this study was to assess the association between MD and IGF-1 in acne patients and, as secondary objective, the role of systemic treatment on IGF-1 serum levels, in accordance to the patients’ diet. This study included 35 patients aged 14-30 years affected by acne and treated in line with the EDF guidelines. Patients were divided into 2 groups based on a questionnaire score assessing the adherence to the Mediterranean diet: the Mediterranean Group (score ≥ 6) and the Western Group (score < 5). IGF-1 serum levels were measured in all patients before and after treatment and then compared to healthy population. IGF-1 levels were higher in patients than in controls and in the Western group than in the Mediterranean group. We speculate that the Mediterranean diet can have a protective role in the pathogenesis of acne by acting on the systemic route of IGF-1.

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The role of Mediterranean diet in the course of subjective cognitive decline in the elderly population of Greece: results from a prospective cohort study

British Journal Of Nutrition ◽

10.1017/s0007114521005109 ◽

2021 ◽

pp. 1-29

Author(s):

George S. Vlachos ◽

Mary Yannakoulia ◽

Costas A. Anastasiou ◽

Mary H. Kosmidis ◽

Efthimios Dardiotis ◽

...

Keyword(s):

Cognitive Decline ◽

Mediterranean Diet ◽

The Elderly ◽

Protective Role ◽

Subjective Cognitive Decline ◽

Preventive Strategy ◽

Food Groups ◽

Medical Disorders ◽

The Mediterranean

Abstract Very few data are available regarding the association of adherence to the Mediterranean Diet (MeDi) with Subjective Cognitive Decline (SCD) evolution over time. A cohort of 939 cognitively normal individuals reporting self-experienced, persistent cognitive decline not attributed to neurological, psychiatric or medical disorders from the Hellenic Epidemiological Longitudinal Investigation of Aging and Diet (HELIAD study) was followed-up for a mean period of 3.10 years. We defined our SCD score as the number of reported SCD domains (memory, language, visuoperceptual and executive), ranging from 0 to 4. Dietary intake at baseline was assessed through a food frequency questionnaire; adherence to the MeDi pattern was evaluated through the Mediterranean Diet Score (MDS) that ranged from 0 to 55, with higher values indicating greater adherence to the MeDi. The mean SCD score in our cohort increased by 0.20 cognitive domains during follow-up. After adjustment for multiple potential confounders, we showed that an MDS higher by 10 points was associated with a 7% reduction in the progression of SCD within one year. In terms of food groups, every additional vegetable serving consumption per day was associated with a 2.3% reduction in SCD progression per year. Our results provide support to the notion that MeDi may have a protective role against the whole continuum of cognitive decline, starting at the first subjective complaints. This finding may strengthen the role of the MeDi as a population-wide, cost-effective preventive strategy targeting the modifiable risk factors for cognitive decline.

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The Protective Role of the Mediterranean Diet on the Prevalence of Metabolic Syndrome in a Population of Greek Obese Subjects

Journal of the American College of Nutrition ◽

10.1080/07315724.2010.10719815 ◽

2010 ◽

Vol 29 (1) ◽

pp. 41-45 ◽

Cited By ~ 26

Author(s):

Konstantinos Paletas ◽

Eleni Athanasiadou ◽

Maria Sarigianni ◽

Paschalis Paschos ◽

Aikaterini Kalogirou ◽

...

Keyword(s):

Metabolic Syndrome ◽

Mediterranean Diet ◽

Protective Role ◽

Obese Subjects ◽

The Mediterranean

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Dextrose Hydration May Promote Cisplatin-induced Nephrotoxicity in Rats: Gender-related Difference

The Indonesian Biomedical Journal ◽

10.18585/inabj.v11i2.502 ◽

2019 ◽

Vol 11 (2) ◽

pp. 136-44

Author(s):

Farzaneh Karimi ◽

Sayyedehnikta Kasaei ◽

Azar Baradaran ◽

Farzaneh Ashrafi ◽

Ardeshir Talebi ◽

...

Keyword(s):

Kidney Tissue ◽

Serum Levels ◽

Protective Role ◽

Female Rats ◽

Male And Female ◽

Cisplatin Nephrotoxicity ◽

Male And Female Rats ◽

Before And After ◽

Different Doses

BACKGROUNDS: Cisplatin (CP) as an anticancer drug may affect the plasma glucose level while diabetic subjects are protected against CP-induced nephrotoxicity. In the current study, the role of dextrose hydration during CP therapy on CP-induced nephrotoxicity was evaluated.METHODS: Sixty-nine male and female rats were divided into 12 groups. The rats were hydrated with 15 mL/kg vehicle or different doses of 2%, 10% and 20% dextrose before and after 7.5 mg/kg CP administration. One week later, the biochemical and kidney function markers, and histology finding were determined.RESULTS: All the animals co-treated with CP and 20% dextrose, were dead during one week of the experiment. Administration of CP alone increased kidney tissue damage score (KTDS) and kidney weight (KW). It also elevated the blood urea nitrogen (BUN) and BUN-creatineine ratio (BUN/Cr) levels in the serum. In addition, CP decreased body weight and creatinine (Cr) clearance (ClCr) significantly in both male and female rats (p<0.05). However, 2% and 10% dextrose did not alter the mentioned parameters in male, but 10% dextrose supplement increased the serum levels of BUN, Cr and BUN/Cr ratio, KW and KTDS significantly in female rats (p<0.05).CONCLUSION: Our data suggest that not only do not support the nephro-protective role of dextrose hydration during CP therapy, the dextrose hydration can act as risk factor to promote CP-induced nephrotoxicity in female rats. Prohibition of high carbohydrate (glucose) diet during CP therapy is recommended.KEYWORDS: cisplatin, nephrotoxicity, dextrose, rat, gender

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Protective role of the Mediterranean diet on several cardiovascular risk factors: Evidence from Sicily, southern Italy

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2013.09.020 ◽

2014 ◽

Vol 24 (4) ◽

pp. 370-377 ◽

Cited By ~ 44

Author(s):

G. Grosso ◽

A. Pajak ◽

A. Mistretta ◽

S. Marventano ◽

T. Raciti ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Mediterranean Diet ◽

Southern Italy ◽

Protective Role ◽

The Mediterranean

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Relationship Among Adherence to The Mediterranean Diet and Anthropometric and Metabolic Parameters in Subjects with Obesity

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530320999201111161220 ◽

2020 ◽

Vol 20 ◽

Author(s):

Luisa Lampignano ◽

Roberta Zupo ◽

Rossella Donghia ◽

Vito Guerra ◽

Fabio Castellana ◽

...

Keyword(s):

Mediterranean Diet ◽

Hdl Cholesterol ◽

Fat Distribution ◽

Serum Levels ◽

Overweight And Obesity ◽

Height Ratio ◽

Anthropometric Parameters ◽

Cross Sectional ◽

Waist To Height Ratio ◽

The Mediterranean

Background: There is moderate-to-high evidence that the Mediterranean diet prevents increases in body weight and waist circumference in non-obese individuals but less is known about its effects in subjects with overweight and obesity. The present study was focused on exploring the cross-sectional association among the adherence to Mediterranean diet and the most commonly used variables of metabolic and cardiovascular risk factors in a cohort of overweight subjects from a typical Mediterranean region, Apulia, in Southern Italy. Methods:: The study was performed in a cohort of 1214 individuals, all with overweight or obesity but no other clinical condition. We investigated the association among adherence to Mediterranean diet, assessed with the PREDIMED score, and anthropometric parameters [namely body mass index (BMI), WC, waist to height ratio (WHtR) and neck circumference (NC)], fasting serum levels of glucose, insulin, uric acid and lipids (triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol), and blood pressure and insulin resistance, measured by HOMA-IR. Results:: The waist to height ratio was negatively associated to a PREDIMED score ≥7 (p<0.04), whereas HDL cholesterol was positively associated to a PREDIMED score ≥7 (p<0.04) Conclusion: This study suggests that body fat distribution and HDL-cholesterol are the parameters most strongly influenced by MedDiet in Apulian subjects.

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The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer

Nutrients ◽

10.3390/nu11092036 ◽

2019 ◽

Vol 11 (9) ◽

pp. 2036 ◽

Cited By ~ 5

Author(s):

Beatriz Martínez-Poveda ◽

José Antonio Torres-Vargas ◽

María del Carmen Ocaña ◽

Melissa García-Caballero ◽

Miguel Ángel Medina ◽

...

Keyword(s):

Mediterranean Diet ◽

Essential Role ◽

Chemopreventive Agents ◽

Angiogenic Potential ◽

Slowing Down ◽

Interesting Approach ◽

The Mediterranean ◽

Tumor Growth And Metastasis ◽

Early Phases

Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention strategy. In this review, we focus on natural bioactive compounds derived from the main foods included in the Mediterranean diet that display anti-angiogenic activity, as well as their possible use as angiopreventive agents.

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Role of vitamin D serum levels in prevention of primary and recurrent melanoma

Scientific Reports ◽

10.1038/s41598-021-85294-3 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

M. Lombardo ◽

A. Vigezzi ◽

G. Ietto ◽

C. Franchi ◽

V. Iori ◽

...

Keyword(s):

Vitamin D ◽

Serum Levels ◽

Mitotic Rate ◽

Control Group ◽

Healthy Population ◽

Histological Subtype ◽

Melanoma Diagnosis ◽

Significant Difference ◽

Tumour Location

AbstractPatients afflicted with melanoma show lower vitamin D serum levels (VDSL) than the healthy population. This hypothesis agrees with its well-known antiproliferative features. An observational study was carried out to collect VDSL in patients suffering from melanoma. Our aim was to identify a potential connection between low VDSL and the risk to incur melanoma. Furthermore, we studied the association between VDSL at the diagnosis of melanoma and other germane prognostic factors. The population held in regard was composed of 154 patients with a diagnosis of melanoma between 2016 and 2019. These patients were retrospectively collected from our follow-up storage. We compared VDSL to clinical and pathological parameters (age, sex, tumour location, Breslow’s depth, Clark’s level, histological subtype, ulceration, et aliqua). Moreover, we recruited a control group with negative melanoma history. Mean and median of VDSL were significantly lower in the melanoma group. Instead, we found a negative association between melanoma and VDSL > 30 ng/L (OR 0.11; p < 0.0001). No correlation between VDSL and both Breslow’s depth and Clark’s level was discovered, but the VDSL comparison between thin (depth ≤ 1 mm) and thick tumours (depth > 1 mm) revealed a statistically significant difference (21.1 ± 8.2 ng/L vs 17.8 ± 8.1; p = 0.01). Moreover, VDSL were significantly lower in melanomas with mitotic rate ≥ 1/mm2 (22.1 ± 8.3 ng/L; p < 0007). Nevertheless, no connection was found between VDSL and both ulceration and positive sentinel nodes (p = 0.76; p = 0.74). Besides, our study revealed no association between VDSL and histological subtype (p = 0.161). Lower VDSL correlate with thick and high mitotic rate tumours. Future prospective studies would investigate if appropriate upkeep of suitable VDSL can decrease the risk of primary and recurrent melanoma diagnosis.

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Factors Associated With Components of Arterial Pressure Among Older Individuals (the Multinational MEDIS Study): The Role of the Mediterranean Diet and Alcohol Consumption

Journal of Clinical Hypertension ◽

10.1111/jch.12370 ◽

2014 ◽

Vol 16 (9) ◽

pp. 645-651 ◽

Cited By ~ 8

Author(s):

Stefanos Tyrovolas ◽

Josep Maria Haro ◽

Evangelos Polychronopoulos ◽

Anargiros Mariolis ◽

Suzanne Piscopo ◽

...

Keyword(s):

Alcohol Consumption ◽

Arterial Pressure ◽

Mediterranean Diet ◽

Older Individuals ◽

Factors Associated ◽

The Mediterranean

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The Protective Role of Sestrin2 in Atherosclerotic and Cardiac Diseases

International Journal of Molecular Sciences ◽

10.3390/ijms22031200 ◽

2021 ◽

Vol 22 (3) ◽

pp. 1200

Author(s):

Yoshimi Kishimoto ◽

Kazuo Kondo ◽

Yukihiko Momiyama

Keyword(s):

Oxidative Stress ◽

Protective Role ◽

Chronic Inflammatory Disease ◽

Atherosclerotic Disease ◽

Cardiac Diseases ◽

Compensatory Response ◽

Age Related ◽

Anti Oxidant ◽

Progression Of Atherosclerosis

Atherosclerotic disease, such as coronary artery disease (CAD), is known to be a chronic inflammatory disease, as well as an age-related disease. Excessive oxidative stress produced by reactive oxygen species (ROS) contributes to the pathogenesis of atherosclerosis. Sestrin2 is an anti-oxidant protein that is induced by various stresses such as hypoxia, DNA damage, and oxidative stress. Sestrin2 is also suggested to be associated with aging. Sestrin2 is expressed and secreted mainly by macrophages, endothelial cells, and cardiomyocytes. Sestrin2 plays an important role in suppressing the production and accumulation of ROS, thus protecting cells from oxidative damage. Since sestrin2 is reported to have anti-oxidant and anti-inflammatory properties, it may play a protective role against the progression of atherosclerosis and may be a potential therapeutic target for the amelioration of atherosclerosis. Regarding the association between blood sestrin2 levels and atherosclerotic disease, the blood sestrin2 levels in patients with CAD or carotid atherosclerosis were reported to be high. High blood sestrin2 levels in patients with such atherosclerotic disease may reflect a compensatory response to increased oxidative stress and may help protect against the progression of atherosclerosis. This review describes the protective role of sestrin2 against the progression of atherosclerotic and cardiac diseases.

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