scholarly journals Emerging prophylaxis strategies against COVID-19

2020 ◽  
Vol 90 (1) ◽  
Author(s):  
Sumita Agrawal ◽  
Akhil Dhanesh Goel ◽  
Nitesh Gupta
Keyword(s):  
High Risk ◽  
The Novel ◽  
Corona Virus ◽  
The World ◽  
Novel Coronavirus

The Novel corona virus 2019 which started as an outbreak in China in December 2019 has rapidly spread all over the world, such that on 11th March 2020 WHO declared this disease as pandemic. The emergency that the world faces today demands that we develop urgent and effective measures to protect people at high risk of transmission. WHO has accelerated research in diagnostics, vaccines and therapeutics for this novel coronavirus.

scholarly journals A PRE - EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF STRUCTURED TEACHING PROGRAM ON KNOWLEDGE REGARDING DOMICILIARY CARE IN POST COVID -19 PATIENTS AMONG PRIMARY CAREGIVER AT SELECTED AREA OF NAINITAL

2021 ◽  
Vol 9 (10) ◽  
pp. 225-226
Author(s):  
Chanchal Chaukrayat ◽  
G. Ramalakshmi ◽  
Renjith Thomas
Keyword(s):  
Experimental Study ◽  
Immune System ◽  
High Risk ◽  
Preventive Measures ◽  
Face Mask ◽  
The Novel ◽  
Teaching Program ◽  
Medical Practitioners ◽  
The World ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China in December 2019. The disease has since spread worldwide, leading to an ongoing pandemic.After COVID-19 infection, most people form adequate antibodies which prevents them from contracting the virus again. Nonetheless, its an unknown territory for the medical practitioners across the world, as to how long can that immunity stand. Cases where patients had the novel coronavirus again, have been reported too. More in this way, for individuals who are at a high risk of reinfection are either old or dont take enough preventive measures to additionally protect their immune system which makes post-COVID care important for them. While the standard laws of staying safe suggest everyone to cover their face with a face mask, wash hands regularly and practice social distancing.

scholarly journals To the question on vaccination of pregnant women during COVID-19 pandemic

2020 ◽  
Vol 14 (5) ◽  
pp. 656-666
Author(s):  
E. Yu. Yupatov ◽  
L. I. Maltseva ◽  
N. Z. Yusupova ◽  
L. Z. Safina ◽  
E. G. Ignashina ◽  
...  
Keyword(s):  
Septic Shock ◽  
High Risk ◽  
Pregnant Women ◽  
Disseminated Intravascular Coagulation ◽  
The Novel ◽  
Medical Doctors ◽  
Thromboembolic Complications ◽  
The World ◽  
Novel Coronavirus ◽  
Preventive Methods

The pandemic of the novel coronavirus disease 2019 (COVID-19) makes us to think about effective preventive methods in pregnant women, because the course of such infection is accompanied by a high risk of severe endotheliopathy, disseminated intravascular coagulation, septic shock, thromboembolic complications and maternal mortality. Undoubtedly, vaccination is the most effective method of protection during pandemic, which experience in some infections in pregnant women has been accumulated in the world practice and may be also used for the COVID-19 vaccine. Here we discuss the issues of vaccination for pregnant women to expand the view of medical doctors and eliminate prejudice against immunization of pregnant women.

scholarly journals A Review on the Novel Coronavirus and Its Effects on Children

2020 ◽  
Vol 8 (T1) ◽  
pp. 233-239
Author(s):  
Gholamreza Bahoush ◽  
Elham Zarei
Keyword(s):  
Immune System ◽  
High Risk ◽  
Risk Group ◽  
High Risk Group ◽  
Google Scholar ◽  
The Novel ◽  
Scientific Databases ◽  
The World ◽  
Effects On Children ◽  
Novel Coronavirus

BACKGROUND: The outbreak of the new coronavirus was first reported in China and then spread to other parts of the world. The number of people infected with the virus is significantly increasing, making the disease an international concern. AIM: The present study aimed to investigate the coronavirus and its effects on children. MATERIALS AND METHODS: In the present study, search engines, and scientific databases of Google Scholar, Science Direct, PubMed, Medline, and Cochrane were searched to examine the effect of coronavirus on children. To collect information, keywords were also searched in the databases. RESULTS: In spite of contradictory results, among the children, those under 5 years old are the high-risk group. CONCLUSION: Some researchers believe that the virus shows fewer symptoms in children. However, the immune system of infants under six months develops pneumonia in rare cases.

scholarly journals SARS-CoV-2 - Understanding for the Preparation of Forthcoming Corona Virus Outbursts

2020 ◽  
pp. 46-55
Keyword(s):  
Virus Disease ◽  
Deep Understanding ◽  
Disease Outbreak ◽  
International Committee ◽  
Technological Advance ◽  
The Novel ◽  
Corona Virus ◽  
The World ◽  
Novel Coronavirus

A new major epidemic foci of corona virus disease 2019 known as COVID-19, previously known as 2019-nCoV have been identified and rapidly expanding throughout the world without traceable origin since early 2020. The disease has drastically increased and the affected number of countries, states or territories reporting infection to WHO was more than 2001. The 2019 novel corona virus disease outbreak was instigated from Wuhan, Hubei province, China at late December 2019 and affirmed as a public health threat emerging of International anxiety on 30th January 2020 by WHO2. International Committee on Taxonomy of Viruses (ICTV) declared “Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV2)” as the name of novel corona virus, because their genetically similarities with SARS outbreak in 2003. The present review focuses on morphological, genetical characterization of SARS – CoV – 2 as well as the clinical traits and clinical therapies for COVID – 19 endemic up to date. The novel coronavirus emergence awaken the echoes of SARS-CoV pandemic in past decades. Yet, with having best technological advance, the exact medication is still a question. It might be a great lesson to the world to equip to deal with most recent emergent viruses in future. The current work will give a deep understanding of CoV -2 to researcher for the further studies.

Epidemic risks during endoscopic examinations in the conditions of a specialized COVID-19 hospital in the pandemic of the novel coronavirus infection

2021 ◽  
pp. 12-25
Author(s):  
Sergey Anatolievich Babanov ◽  
Mikhail Lvovich Shteiner ◽  
Yuriy Iskhakovich Biktagirov ◽  
Aleksandr Viktorovich Zhestkov ◽  
Leonid Aleksandrovich Strizhakov ◽  
...  
Keyword(s):  
High Risk ◽  
Respiratory System ◽  
Scientific Community ◽  
Respiratory Diseases ◽  
The Novel ◽  
Daily Work ◽  
The World ◽  
Epidemiological Risk ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The pandemic of the novel coronavirus infection has posed additional challenges for endoscopy services. Endoscopy departments face a high risk of spreading airborne respiratory diseases in their daily work. This is especially true for endoscopic departments and offices that perform bronchoscopic examinations. The world scientific community recognizes the highest epidemiological risk of personnel infection during any interventional manipulations and operations related to the respiratory system, including bronchoscopic interventions.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals COVID-19 Vaccination: From Interesting Agent to the Patient

Vaccines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 120
Author(s):  
Anis Daou
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gastrointestinal Tract ◽  
Circulatory System ◽  
The Novel ◽  
Lead Compound ◽  
Fda Approval ◽  
The World ◽  
The Central Nervous System ◽  
Novel Coronavirus

The vaccination for the novel Coronavirus (COVID-19) is undergoing its final stages of analysis and testing. It is an impressive feat under the circumstances that we are on the verge of a potential breakthrough vaccination. This will help reduce the stress for millions of people around the globe, helping to restore worldwide normalcy. In this review, the analysis looks into how the new branch of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) came into the forefront of the world like a pandemic. This review will break down the details of what COVID-19 is, the viral family it belongs to and its background of how this family of viruses alters bodily functions by attacking vital human respiratory organs, the circulatory system, the central nervous system and the gastrointestinal tract. This review also looks at the process a new drug analogue undergoes, from (i) being a promising lead compound to (ii) being released into the market, from the drug development and discovery stage right through to FDA approval and aftermarket research. This review also addresses viable reasoning as to why the SARS-CoV-2 vaccine may have taken much less time than normal in order for it to be released for use.

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