scholarly journals Die invloed van blootstelling aan mirasidiums Schistosoma mansoni op mortaliteitskoerse van kohorte van vier geografiese stamme van Biomphalaria pfeifferi

1995 ◽  
Vol 14 (1) ◽  
pp. 12-16
Author(s):  
K. N. De Kock
Keyword(s):  
Life Expectancy ◽  
Schistosoma Mansoni ◽  
First Generation ◽  
Mortality Rates ◽  
Biomphalaria Pfeifferi ◽  
Generation Cohorts ◽  
The Mean ◽  
Per Capita

First generation cohorts of 25 specimens each of parental populations of Biomphalaria pfeifferi from four different localities, were each exposed to three Schistosoma mansoni miracidia per snail at an age of four weeks. The effect on survival was evaluated by calculating the weekly per capita mortality rates and the mean life-expectancy of the exposed snails. No significant differences could be demonstrated between the per capita mortality rates of F₁ cohorts of the two parental strains originating from localities in endemic bilharzia areas. Likewise there were no significant differences in this respect as far as F₁ cohorts of the two strains originating from localities in non-endemic bilharzia areas were concerned.

Compatibility of Schistosoma mansoni Cameroon and Biomphalaria pfeifferi Senegal

Parasitology ◽  
2000 ◽  
Vol 121 (5) ◽  
pp. 501-505 ◽  
Author(s):  
V. R. SOUTHGATE ◽  
L. A. TCHUEM TCHUENTÉ ◽  
A. THÉRON ◽  
J. JOURDANE ◽  
A. LY ◽  
...  
Keyword(s):  
Circadian Rhythm ◽  
Schistosoma Mansoni ◽  
Infection Rate ◽  
Post Infection ◽  
Vectorial Capacity ◽  
Patent Period ◽  
Snail Infection ◽  
Biomphalaria Pfeifferi ◽  
Emergence Pattern ◽  
The Mean

The vectorial capacity of Biomphalaria pfeifferi from Ndiangue, Senegal, was investigated with an allopatric isolate of Schistosoma mansoni from Nkolbisson, Cameroon. The snail infection rate after exposure to a single miracidium per snail (MD1) was 56·3%, and 91·6% for snails exposed to 5 miracidia per snail (MD5). The minimum pre-patent period was 21 days. The mean total cercarial production for the MD1 group was 18511 cercariae per snail, and 9757 cercariae for the MD5 group. The maximum production of cercariae for 1 day was 4892 observed in a snail from the MD1 group at day 43 post-infection. The mean longevity of snails was higher in group MD1 (88 days p.i.) than in group MD5 (65 days p.i.). The chronobiological emergence pattern revealed a circadian rhythm with one shedding peak at mid-day. Comparisons are made with the vectorial capacity of the sympatric combination of B. pfeifferi Senegal/S. mansoni Senegal.

scholarly journals The importance of the socioeconomic status of countries for mental disorders in old age: development of an epidemiological transition model

2007 ◽  
Vol 19 (4) ◽  
pp. 785-787 ◽  
Author(s):  
AJIT SHAH
Keyword(s):  
Socioeconomic Status ◽  
Life Expectancy ◽  
Old Age ◽  
Child Mortality ◽  
Univariate Analysis ◽  
Healthcare Services ◽  
Mortality Rates ◽  
Mental Illnesses ◽  
Per Capita Gdp ◽  
Per Capita

The prevalence of a disorder is a function of the incidence of the disorder and the duration of the illness (which may remit spontaneously, by treatment or death). The socioeconomic status of societies may influence the incidence and duration of mental illnesses in old age by influencing life expectancy and availability of appropriate healthcare services and treatments (Suh and Shah, 2001). The relationship between a proxy measure of the socioeconomic status (per capita gross national domestic product (GDP)) and (i) the life expectancy, (ii) child mortality rates and (iii) proxy measures of the quality and quantity of available healthcare services (the proportion of GDP spent on health, per capita expenditure on health and child mortality rates) was examined. The WHO website (www.who.int/countries/en/) provided data on these variables for 191 of the 192 countries for the year 2002. The inter-correlations between all the measured variables were examined using Pearson's correlation coefficient. Because of highly significant inter-correlations between all these variables, multiple linear regression analysis, with the Enter method, was undertaken with per capita GDP as the dependent variable, and all the variables that were significantly correlated with per capita GDP on univariate analysis as the independent variables.

A Successful Population Policy: Potentials and Constraints (Distinguishedl Lecture)

1993 ◽  
Vol 32 (4I) ◽  
pp. 411-431
Author(s):  
Hans-Rimbert Hemmer
Keyword(s):  
Developing Countries ◽  
Economic Development ◽  
Population Growth ◽  
Capita Income ◽  
Population Policy ◽  
Mortality Rates ◽  
Per Capita Income ◽  
Access To Health Services ◽  
Industrial Countries ◽  
Per Capita

The current rapid population growth in many developing countries is the result of an historical process in the course of which mortality rates have fallen significantly but birthrates have remained constant or fallen only slightly. Whereas, in industrial countries, the drop in mortality rates, triggered by improvements in nutrition and progress in medicine and hygiene, was a reaction to economic development, which ensured that despite the concomitant growth in population no economic difficulties arose (the gross national product (GNP) grew faster than the population so that per capita income (PCI) continued to rise), the drop in mortality rates to be observed in developing countries over the last 60 years has been the result of exogenous influences: to a large degree the developing countries have imported the advances made in industrial countries in the fields of medicine and hygiene. Thus, the drop in mortality rates has not been the product of economic development; rather, it has occurred in isolation from it, thereby leading to a rise in population unaccompanied by economic growth. Growth in GNP has not kept pace with population growth: as a result, per capita income in many developing countries has stagnated or fallen. Mortality rates in developing countries are still higher than those in industrial countries, but the gap is closing appreciably. Ultimately, this gap is not due to differences in medical or hygienic know-how but to economic bottlenecks (e.g. malnutrition, access to health services)

Retrospective analysis of mortality within 30 days of systemic anticancer therapy and comparison with a previous audit at an Australian Regional Cancer Centre

2021 ◽  
pp. 107815522110160
Author(s):  
Bernadatte Zimbwa ◽  
Peter J Gilbar ◽  
Mark R Davis ◽  
Srinivas Kondalsamy-Chennakesavan
Keyword(s):  
Checkpoint Inhibitors ◽  
Anticancer Therapy ◽  
Mortality Rates ◽  
Feedback Process ◽  
Time To Death ◽  
Cancer Centre ◽  
Haematology Patients ◽  
The Mean ◽  
Regional Cancer Centre ◽  
Mean Time

Purpose To retrospectively determine the rate of death occurring within 14 and 30 days of systemic anticancer therapy (SACT), compare this against a previous audit and benchmark results against other cancer centres. Secondly, to determine if the introduction of immune checkpoint inhibitors (ICI), not available at the time of the initial audit, impacted mortality rates. Method All adult solid tumour and haematology patients receiving SACT at an Australian Regional Cancer Centre (RCC) between January 2016 and July 2020 were included. Results Over a 55-month period, 1709 patients received SACT. Patients dying within 14 and 30 days of SACT were 3.3% and 7.0% respectively and is slightly higher than our previous study which was 1.89% and 5.6%. Mean time to death was 15.5 days. Males accounted for 63.9% of patients and the mean age was 66.8 years. 46.2% of the 119 patients dying in the 30 days post SACT started a new line of treatment during that time. Of 98 patients receiving ICI, 22.5% died within 30 days of commencement. Disease progression was the most common cause of death (79%). The most common place of death was the RCC (38.7%). Conclusion The rate of death observed in our re-audit compares favourably with our previous audit and is still at the lower end of that seen in published studies in Australia and internationally. Cases of patients dying within 30 days of SACT should be regularly reviewed to maintain awareness of this benchmark of quality assurance and provide a feedback process for clinicians.

scholarly journals COVID-19 Mortality Rate and Its Incidence in Latin America: Dependence on Demographic and Economic Variables

2021 ◽  
Vol 18 (13) ◽  
pp. 6900
Author(s):  
Javier Cifuentes-Faura
Keyword(s):  
Latin America ◽  
Mortality Rate ◽  
Population Density ◽  
Life Expectancy ◽  
Latin American ◽  
Positive Influence ◽  
Death Rates ◽  
Per Capita ◽  
Latin American Countries ◽  
Quality Infrastructure

The pandemic caused by COVID-19 has left millions infected and dead around the world, with Latin America being one of the most affected areas. In this work, we have sought to determine, by means of a multiple regression analysis and a study of correlations, the influence of population density, life expectancy, and proportion of the population in vulnerable employment, together with GDP per capita, on the mortality rate due to COVID-19 in Latin American countries. The results indicated that countries with higher population density had lower numbers of deaths. Population in vulnerable employment and GDP showed a positive influence, while life expectancy did not appear to significantly affect the number of COVID-19 deaths. In addition, the influence of these variables on the number of confirmed cases of COVID-19 was analyzed. It can be concluded that the lack of resources can be a major burden for the vulnerable population in combating COVID-19 and that population density can ensure better designed institutions and quality infrastructure to achieve social distancing and, together with effective measures, lower death rates.

scholarly journals Health capabilities and the determinants of infant mortality in Brazil, 2004–2015: an innovative methodological framework

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Alexandre Bugelli ◽  
Roxane Borgès Da Silva ◽  
Ladislau Dowbor ◽  
Claude Sicotte
Keyword(s):  
Infant Mortality ◽  
Educational Attainment ◽  
Health Professionals ◽  
Capita Income ◽  
Mortality Rates ◽  
Fertility Rate ◽  
Employment Rate ◽  
Infant Deaths ◽  
Bolsa Familia ◽  
Per Capita

Abstract Background Despite the implementation of a set of social and health policies, Brazil has experienced a slowdown in the decline of infant mortality, regional disparities and persistent high death levels, raising questions about the determinants of infant mortality after the implementation of these policies. The objective of this article is to propose a methodological approach aiming at identifying the determinants of infant mortality in Brazil after the implementation of those policies. Method A series of multilevel panel data with fixed effect nested within-clusters were conducted supported by the concept of health capabilities based on data from 26 Brazilian states between 2004 and 2015. The dependent variables were the neonatal, the infant and the under-five mortality rates. The independent variables were the employment rate, per capita income, Bolsa Família Program coverage, the fertility rate, educational attainment, the number of live births by prenatal visits, the number of health professionals per thousand inhabitants, and the access to water supply and sewage services. We also used different time lags of employment rate to identify the impact of employment on the infant mortality rates over time, and household income stratified by minimum wages to analyze their effects on these rates. Results The results showed that in addition to variables associated with infant mortality in previous studies, such as Bolsa Família Program, per capita income and fertility rate, other factors affect child mortality. Educational attainment, quality of prenatal care and access to health professionals are also elements impacting infant deaths. The results also identified an association between employment rate and different infant mortality rates, with employment impacting neonatal mortality up to 3 years and that a family income below 2 minimum wages increases the odds of infant deaths. Conclusion The results proved that the methodology proposed allowed the use of variables based on aggregated data that could hardly be used by other methodologies.

scholarly journals Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging

Biomedicines ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 111
Author(s):  
Aida Muntsant ◽  
Francesc Jiménez-Altayó ◽  
Lidia Puertas-Umbert ◽  
Elena Jiménez-Xarrie ◽  
Elisabet Vila ◽  
...  
Keyword(s):  
Life Expectancy ◽  
End Of Life ◽  
Mortality Rates ◽  
Disability Adjusted Life Years ◽  
Pharmacological Interventions ◽  
Compensatory Mechanisms ◽  
Healthy Life ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Bidirectional Interactions

Life expectancy decreases with aging, with cardiovascular, mental health, and neurodegenerative disorders strongly contributing to the total disability-adjusted life years. Interestingly, the morbidity/mortality paradox points to females having a worse healthy life expectancy. Since bidirectional interactions between cardiovascular and Alzheimer’s diseases (AD) have been reported, the study of this emerging field is promising. In the present work, we further explored the cardiovascular–brain interactions in mice survivors of two cohorts of non-transgenic and 3xTg-AD mice, including both sexes, to investigate the frailty/survival through their life span. Survival, monitored from birth, showed exceptionally worse mortality rates in females than males, independently of the genotype. This mortality selection provided a “survivors” cohort that could unveil brain–cardiovascular interaction mechanisms relevant for normal and neurodegenerative aging processes restricted to long-lived animals. The results show sex-dependent distinct physical (worse in 3xTg-AD males), neuropsychiatric-like and cognitive phenotypes (worse in 3xTg-AD females), and hypothalamic–pituitary–adrenal (HPA) axis activation (higher in females), with higher cerebral blood flow and improved cardiovascular phenotype in 3xTg-AD female mice survivors. The present study provides an experimental scenario to study the suggested potential compensatory hemodynamic mechanisms in end-of-life dementia, which is sex-dependent and can be a target for pharmacological and non-pharmacological interventions.

Lamb survival in two hill flocks

1959 ◽  
Vol 1 (1) ◽  
pp. 85-91 ◽  
Author(s):  
A. F. Purser ◽  
G. B. Young
Keyword(s):  
Birth Weight ◽  
Survival Rate ◽  
Age Structure ◽  
Maternal Age ◽  
Mortality Rates ◽  
The Mean ◽  
Lamb Survival

The effects of birth weight, maternal age and parity on survival of single lambs have been studied in a Blackface and a Welsh Mountain flock.In both flocks the maximum survival rate was found to occur among lambs with birth weights just above the mean. Mortality increased as lambs' birth weight increased or decreased from the optimum, but was especially heavy at the lower extreme of the range of birth weights.Mortality decreased with age of dam to 14·3% for lambs from 4- to 6-year-old Blackface ewes and to 9·4% for lambs of 3- to 4-year-old Welsh ewes. Ewes having their first lambs gave mortality rates twice as great as for the mature ewes in the same flocks. The lower chances of survival of first born lambs irrespective of dam's age accounts for the apparent trend of mortality with maternal age in the Blackface.Changes in mortality rates associated with variation in lamb's birth weight and with the age structure of the ewe flock were estimated. Possible means of improvement of survival rate are discussed.

scholarly journals Plasmapheresis in the treatment of myasthenia gravis: retrospective study of 26 patients

2004 ◽  
Vol 62 (2b) ◽  
pp. 391-395 ◽  
Author(s):  
Rosana Carandina-Maffeis ◽  
Anamarli Nucci ◽  
José F.C. Marques Jr ◽  
Eduardo G. Roveri ◽  
Beatriz H.M. Pfeilsticker ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Myasthenia Gravis ◽  
Plasma Exchange ◽  
Mortality Rates ◽  
Motor Deficit ◽  
Myasthenic Crisis ◽  
Clinical Hospital ◽  
The Mean ◽  
Mean Time

We analyzed the experience of Unicamp Clinical Hospital with plasma exchange (PE) therapy in myasthenia gravis (MG). About 17.8 % of a totality of MG patients had PE performed: 26 cases, 19 women and seven men. The mean age-onset of MG was 28 years, extremes 11 and 69. Minimum deficit observed in the group was graded IIb (O & G) or IIIa (MGFA scale). One patient had prethymectomy PE. In seven the procedures were performed due to myasthenic crisis and in 18 patients due to severe myasthenic symptoms or exacerbation of previous motor deficit. Two patients were also submitted to chronic PE considering refractoriness to other treatments. Twenty-six patients had 44 cycles of PE and 171 sessions. The mean number of sessions was 3.9 (SD ± 1.4) each cycle; median 5, extremes 2 and 6. The mean time by session was 106,5 minutes (SD ± 35.2); median 100.5 (extremes of 55 and 215). The mean volume of plasma exchanged in each session was 2396 ml (SD ± 561); median 2225 (extremes 1512 and 4500). Side effects occurred: reversible hypotension (seven cases), mild tremor or paresthesias (seven cases). Infection and mortality rates due to PE were zero. All patients had immediate benefit of each PE cycle and usually they also received prednisone or other immunosuppressors. Good acceptance of the procedure was observed in 80.7% of patients.

scholarly journals SARS-COV-2 Vaccines: What Indicators are Associated with the Worldwide Distribution of the First Doses

2021 ◽  
Vol 58 ◽  
pp. 004695802110601
Author(s):  
Marcos Felipe Falcão Sobral ◽  
Brigitte Renata Bezerra de Oliveira ◽  
Ana Iza Gomes da Penha Sobral ◽  
Marcelo Luiz Monteiro Marinho ◽  
Gisleia Benini Duarte ◽  
...  
Keyword(s):  
Population Density ◽  
Life Expectancy ◽  
Human Development ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
The United States ◽  
Gdp Per Capita ◽  
Reproduction Rate ◽  
Worldwide Distribution ◽  
Per Capita

The present study aimed to identify the factors associated with the distribution of the first doses of the COVID-19 vaccine. In this study, we used 9 variables: human development index (HDI), gross domestic product (GDP per capita), Gini index, population density, extreme poverty, life expectancy, COVID cases, COVID deaths, and reproduction rate. The time period was until February 1, 2021. The variable of interest was the sum of the days after the vaccine arrived in the countries. Pearson’s correlation coefficients were calculated, and t-test was performed between the groups that received and did not receive the immunizer, and finally, a stepwise linear regression model was used. 58 (30.4%) of the 191 countries received the SARS-CoV-2 vaccine. The countries that received the most doses were the United States, China, the United Kingdom, and Israel. Vaccine access in days showed a positive Pearson correlation HDI, GDP, life expectancy, COVID-19 cases, deaths, and reproduction rate. Human development level, COVID-19 deaths, GDP per capita, and population density are able to explain almost 50% of the speed of access to immunizers. Countries with higher HDI and per capita income obtained priority access.

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