scholarly journals Protective effect of Cassia glauca Linn. on the serum glucose and hepatic enzymes level in streptozotocin induced NIDDM in rats

2009 ◽  
Vol 41 (1) ◽  
pp. 19 ◽  
Author(s):  
Mamta Farswan ◽  
PapiyaMitra Mazumder ◽  
V Percha
Keyword(s):  
Protective Effect ◽  
Serum Glucose ◽  
Hepatic Enzymes

Hyperglycemia and Sickness

PEDIATRICS ◽  
1974 ◽  
Vol 54 (4) ◽  
pp. 516-517
Author(s):  
Michael Klein ◽  
Arthur Kopelman ◽  
Ruth Lawrence
Keyword(s):  
Protective Effect ◽  
Premature Infants ◽  
Intraventricular Hemorrhage ◽  
Serum Glucose ◽  
Glucose Infusion ◽  
Frequent Occurrence ◽  
Oral Glucose ◽  
Glucose Levels ◽  
Glucose Feeding ◽  
Group 3

Dweck and Cassady1 have done an excellent job of bringing to our attention the frequent occurrence of hyperglycemia in very small premature infants. They implicate as the major cause of this phenomenon glucose infusion rates of >0.4 gm/kg/hr. Based on the association between the highest glucose and osmolality values in their series and intraventricular hemorrhage, they imply causality. The authors suggest further that oral glucose feeding confers a protective effect against hyperglycemia. The premature infants in the authors group 3, those with serum glucose levels of 300 mg/100 ml, have the lowest birth weights.

scholarly journals The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily

Nutrients ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1435
Author(s):  
Francesca Oppedisano ◽  
Carolina Muscoli ◽  
Vincenzo Musolino ◽  
Cristina Carresi ◽  
Roberta Macrì ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Protective Effect ◽  
Liver Steatosis ◽  
Serum Glucose ◽  
Cynara Cardunculus ◽  
Alcoholic Fatty Liver ◽  
Oral Supplementation ◽  
Increased Risk ◽  
Enhanced Expression ◽  
Alcoholic Fatty Liver Disease

Hyperlipidemia and insulin-resistance are often associated with Non-Alcoholic Fatty Liver Disease (NAFLD) thereby representing a true issue worldwide due to increased risk of developing cardiovascular and systemic disorders. Although clear evidence suggests that circulating fatty acids contribute to pathophysiological mechanisms underlying NAFLD and hyperlipidemia, further studies are required to better identify potential beneficial approaches for counteracting such a disease. Recently, several artichoke extracts have been used for both reducing hyperlipidemia, insulin-resistance and NAFLD, though the mechanism is unclear. Here we used a wild type of Cynara Cardunculus extract (CyC), rich in sesquiterpens and antioxidant active ingredients, in rats fed a High Fat Diet (HFD) compared to a Normal Fat Diet (NFD). In particular, in rats fed HFD for four consecutive weeks, we found a significant increase of serum cholesterol, triglyceride and serum glucose. This effect was accompanied by increased body weight and by histopathological features of liver steatosis. The alterations of metabolic parameters found in HFDs were antagonised dose-dependently by daily oral supplementation of rats with CyC 10 and 20 mg/kg over four weeks, an effect associated to significant improvement of liver steatosis. The effect of CyC (20 mg/kg) was also associated to enhanced expression of both OCTN1 and OCTN2 carnitine-linked transporters. Thus, present data suggest a contribution of carnitine system in the protective effect of CyC in diet-induced hyperlipidemia, insulin-resistance and NAFLD.

scholarly journals Efficiency of savory (Satureja Khuzestanica Jamzad) essential oil on performance, carcass traits, some blood parameters and immune function of Male Ross 308 heat stressed broiler chicks

2019 ◽  
Vol 9 (4) ◽  
pp. 515-520 ◽  
Author(s):  
Y. Mohammad ◽  
G. Hasan ◽  
D. Mohsen
Keyword(s):  
Essential Oil ◽  
Broiler Chickens ◽  
Body Weight Gain ◽  
Relative Weight ◽  
Blood Parameters ◽  
Serum Glucose ◽  
The Body ◽  
Broiler Chicks ◽  
Hepatic Enzymes ◽  
Feed Conversion

To investigate the efficiency of savory essential oil on performance, organs relative weight, some blood parameters, immune response and hepatic enzymes of broiler chickens, a total 320 male Ross 308 chicks were allocated to four treatments and four replicates of twenty birds as a completely randomized design from. The varidifferent levels savory oil. The body weight gain (BWG), feed intake (FI) and feed conversion ratio (FCR) was recorded at continues weeks of the experiment. Relative weight of visceral organs was determined and blood serum glucose and activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were measured after blood sampling at 42 days old and plasma IgG immunoglobulin was quantified. Data showed that BW and FI increased with savory oil inclusion (p≤0.05). Besides, the savory oil decreased the plasma glucose, AST and ALT and serum blood Ig G of heat stressed broilers, increased significantly (p?0.05) instead. In conclusion we may suggested that, the savory oil at 0.4 ml/L could improve economic proficiency in broiler flocks due to accumulation of minute advantages in greater BWG, FI, and improved immune system and lowered hepatic enzymes under heat stress condition.

scholarly journals Preventive Effects of Flavonoids on Alloxan-Induced Diabetes Mellitus in Rats

2008 ◽  
Vol 77 (2) ◽  
pp. 175-182 ◽  
Author(s):  
A. Lukačínová ◽  
J. Mojžiš ◽  
R. Beňačka ◽  
J. Keller ◽  
T. Maguth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Protective Effect ◽  
Serum Glucose ◽  
Protective Effects ◽  
Experimental Diabetes Mellitus ◽  
Glucose Reabsorption ◽  
Renal Glucose Reabsorption ◽  
Preventive Effects ◽  
Alloxan Injection ◽  
Diabetes Induction

The aim of the present study was the evaluation of possible protective effects of quercetin and chrysin in experimental alloxan-induced diabetes in rats. Alloxan was injected at a single dose of 60 mg/kg (into the tail vein) for diabetes induction. Quercetin (50 and 100 mg/kg; orally) and chrysin (50 and 100 mg/kg; orally) were administered daily for 3 days prior and 7 days after alloxan injection. Alloxan induced a significant increase of glycaemia (p < 0.001) in comparison with control animals. Quercetin at both doses prevented serum glucose elevation (p < 0.001). However, the protective effect of chrysin was weaker and surprisingly, most prominent at the lower dose (p < 0.05; p < 0.01). On the other hand, glycosuria was increased in all groups of animals receiving alloxan. We suggest that the protective effect of the used flavonoids in experimental diabetes mellitus may be related to their antioxidative/chelatory properties. Increased glycosuria indicated that inhibition of renal glucose reabsorption may also play a role in the hypoglycaemic effect of both flavonoids.

scholarly journals The Effect of Oral Administration of Hypericum Perforatum on Serum Glucose and Lipids, Hepatic Enzymes and Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats

2017 ◽  
Vol 6 (4) ◽  
pp. 319-329
Author(s):  
MohammadHassan Ghosian Moghadam ◽  
Iman Ansari ◽  
Mehrdad Roghani ◽  
Ali Ghanem ◽  
Neda Mehdizade
Keyword(s):  
Oral Administration ◽  
Total Cholesterol ◽  
Serum Triglyceride ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Male Rats ◽  
Control Treatment ◽  
Hepatic Enzymes ◽  
Glucose Levels

Background: In this research, the beneficial effects of oral administration of Hypericum perfo­ratum (HP) on serum glucose and lipids, hepatic enzymes and the amount of malondialdehyde in Streptozotocin-induced diabetic rats are studied. Materials and Methods: In this experi­mental study, 32 male rats where randomly divided into 4 groups of control, treatment-control, diabetic and treatment-diabetic. HP was orally administered to treatment groups over a period of 6 weeks. Serum glucose levels, triglyceride, total cholesterol along with HDL and LDL were all evaluated prior to initiation of the treatment, and at 3rd and 6th (last) week of treatment initiation, and in the end of the treatment, malondialdehyde and aminotransferase enzymes of the liver were evaluated. Results: regarding serum glucose levels and body weight measured in the 3rd and 6th week, the treatment-diabetic group didn’t show a significant change compared to the diabetic group, regarding serum total cholesterol and LDL levels, a significant decrease was observed and regarding serum HDL, a significant increase was documented. Furthermore, treating the treatment-diabetic group with HP did not result in any significant decrease in serum triglyceride, malondialdehyde or alanine aminotransferase but, in fact, did cause a significant decrease in aspartate aminotransferase. Conclusions: Oral administration of HP did in fact have a beneficial effect on lowering serum levels of total cholesterol, LDL and the hepatic enzyme as­partate aminotransferase and on raising the levels of HDL in diabetized rats with Streptozotocin. [GMJ.2017;6(4):319-29] DOI: 10.22086/gmj.v6i4.889

scholarly journals Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Takako Yokozawa ◽  
Eun Ju Cho ◽  
Chan Hum Park ◽  
Ji Hyun Kim
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Serum Glucose ◽  
Ros Generation ◽  
Diabetic Mice ◽  
Polymeric Form ◽  
Inflammatory Reactions ◽  
Oligomeric Form ◽  
Type 2 Diabetic

We investigated the antidiabetic potential of proanthocyanidin and its oligomeric form in STZ-induced diabetic model rats anddb/dbtype 2 diabetic mice. Proanthocyanidin ameliorated the diabetic condition by significant decreases of serum glucose, glycosylated protein, and serum urea nitrogen as well as decreases of urinary protein and renal-AGE in STZ-induced diabetic rats and decrease of serum glucose as well as significant decrease of glycosylated protein indb/dbtype 2 diabetic mice. The suppression of ROS generation and elevation of the GSH/GSSG ratio were also observed in the groups administered proanthocyanidin. Moreover, proanthocyanidin, especially its oligomeric form, affected the inflammatory process with the regulation of related protein expression, iNOS, COX-2 and upstream regulators, NF-κB, and the IκB-α. In addition, it had a marked effect on hyperlipidemia through lowering significant levels of triglycerides, total cholesterol, and NEFA. Moreover, expressions in the liver of SREBP-1 and SREBP-2 were downregulated by the administration of proanthocyanidins. The protective effect against hyperglycemia and hyperlipidemia in type 1 and 2 diabetic models was significantly strong in the groups administered the oligomeric rather than polymeric form. This suggests that oligomers act as a regulator in inflammatory reactions caused by oxidative stress in diabetes.

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