scholarly journals Effect of dietary combinations on plaque pH recovery after the intake of pediatric liquid analgesics

2015 ◽  
Vol 09 (03) ◽  
pp. 340-345 ◽  
Author(s):  
Shaam Saeed ◽  
Nada Bshara ◽  
Juliana Trak ◽  
Ghiath Mahmoud
Keyword(s):  
Clinical Trial ◽  
Statistical Analysis ◽  
Randomized Clinical Trial ◽  
Sampling Method ◽  
Chewing Gum ◽  
P Value ◽  
Plaque Ph ◽  
Significant Difference ◽  
Before And After ◽  
Difference Test

ABSTRACT Objectives: To study the effect of water, halloumi cheese and sugar-free (SF) chewing gum on plaque pH recovery after the intake of sweetened PLAs. Settings and Design: A randomized clinical trial was conducted on 17 children (10 females, 7 males) aged 11–12 years with DFT/dft of more than 3. Materials and Methods: Each volunteer tested paracetamol and ibuprofen suspension alone or followed with water, halloumi cheese or SF gum, as well as 10% sucrose and 10% sorbitol as controls. Plaque pH was measured using the sampling method before and after 5, 10, 15, 20, 30 min of ingestion. Statistical Analysis: Statistical analysis was performed using analysis of variance followed by least significant difference test to assess minimum pH (min pH), maximum pH drop (ΔpH), and the area under baseline pH, and P value was set as 0.05. Results: Both ibuprofen and paracetamol were not significantly different from 10% sucrose in terms of min pH, ΔpH, and area under baseline pH except for min pH of ibuprofen (P = 0.034). Water and halloumi cheese did not have a significant effect on plaque pH recovery after the intake of both analgesics as min pH, ΔpH, and area under baseline pH were similar to 10% sucrose except for min pH of ibuprofen + water (P = 0.048). However, plaque pH variables after chewing SF gum for 20 min were similar to 10% sorbitol. Conclusion: Chewing SF gum immediately after the intake of sweetened PLAs for 20 min restores plaque pH and could be recommended as a complementary aid in caries prevention.

scholarly journals A comparative study on the effect of calcitriol and cinacalcet on hyperparathyroidism in hemodialysis patients; a double-blinded randomized clinical trial

2021 ◽  
Vol 11 (1) ◽  
pp. e12-e12
Author(s):  
Saeed Mardani ◽  
Faranak Sadat Filsouf
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Hemodialysis Patients ◽  
Significant Difference ◽  
Before And After ◽  
Calcium Phosphorus ◽  
Stage Renal Disease ◽  
Double Blinded ◽  
End Stage ◽  
Calcium And Phosphate Metabolism

Introduction:Chronic kidney disease (CKD) has lots of complication like calcium and phosphate metabolism disorders, hyperparathyroidism, vitamin D deficiency and metabolic acidosis. Objectives: The aim of this study was to determine and compare the effect of calcitriol and cinacalcet on hyperparathyroidism in hemodialysis patients due to end-stage renal disease (ESRD). Patients and Methods: This study was a double-blinded randomized clinical trial, which was conducted on 60 hemodialysis patients in 2017-2018. The patients were randomly assigned to two groups of 30 patients, which one group was treated with cinacalcet and the other group was treated with calcitriol. During this study, phosphorus, calcium and iPTH were measured. Results: The results showed that in the group treated with cinacalcet, the amount of calcium [t(22)=0.294, P>0.05] and the amount of phosphorus [t(22)=1.87, P>0.05] did not change significantly while iPTH values before and after the study had statistically significant difference [t(22)=4.37, P<0.05]. In group treated with calcitriol, the calcium, phosphorus and iPTH values did not change significantly (P>0.05). Calcium changes in the cinacalcet group compared to the calcitriol group [t (47) =-1.14, P>0.05] and also, the amount of phosphorus changes [t (47) =-1.022, P>0.05] was not statistically significant. The iPTH changes were not statistically significant between the two groups however iPTH in the calcitriol group was higher than the cinacalcet group [t (47) =-1.13, P>0.05]. Conclusion: In contrast to calcitriol, cinacalcet significantly reduced iPTH and did not significantly change calcium and phosphorus levels. Trial Registration: The trial was registered by Iranian Registry of Clinical Trials (IRCT) (identifier: IRCT20190702044076N1; https://en.irct.ir/trial/40547, Ethical code# IR.SKUMS.REC.1397.026).

Longevity, Esthetic Perception, and Psychosocial Impact of Teeth Bleaching by Low (6%) Hydrogen Peroxide Concentration for In-office Treatment: A Randomized Clinical Trial

2017 ◽  
Vol 42 (1) ◽  
pp. 41-52 ◽  
Author(s):  
E Fernández ◽  
C Bersezio ◽  
J Bottner ◽  
F Avalos ◽  
I Godoy ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Hydrogen Peroxide ◽  
Randomized Clinical Trial ◽  
Positive Impact ◽  
Color Difference ◽  
Psychosocial Impact ◽  
Bleaching Procedure ◽  
Significant Difference ◽  
Before And After ◽  
Shade Guide

SUMMARY Objective: The aim was to evaluate the color longevity after nine months of in-office bleaching with gel (6% hydrogen peroxide), to compare this to a control concentration of 35% in a split-mouth study model, and to assess the dental confidence and psychosocial impact on patients. Methods and Materials: Twenty-seven patients were assessed at the nine-month recall. The bleaching procedure with 6% or 35% hydrogen peroxide gel was performed randomly in the upper hemi-arch of each patient. The color was measured at baseline and at one week, one month, and nine months after the procedure, using the Vita Easyshade spectrophotometer, the Vita classical shade guide organized by value, and Vita Bleach Guide 3DMaster. Moreover, two surveys, OHIP-Esthetics and PIDAQ, were used to assess the esthetic self-perception and psychosocial impact of the bleaching procedure. During the nine-month recall, the color was assessed before and after dental prophylaxis. Results: Twenty-seven patients participated in the nine-month recall. There was a significant difference in ΔE between the two groups at all times assessed (p&lt;0.011). The ΔL, Δa, and Δb showed a difference between the two groups at all times assessed (p&lt;0.038), except for ΔL from the baseline vs nine-month after prophylaxis value (p&gt;0.20). There was no significant difference in ΔSGU at all times (p&gt;0.05). There was a significant difference in OHIP-Esthetics and PIDAQ sums compared with baseline scores (p&lt;0.03). Conclusion: The two compounds remained effective at nine months, with a slight rebound of color, and maintained their objective color difference but not the subjective color difference. Patients were satisfied with the bleaching procedure, and this had a positive impact on esthetic perception and a positive psychosocial impact at the nine-month recall.

scholarly journals The Effect of Oral Administration of Pistacia Atlantica Kurdica Gum on the Eradication of Helicobacter Pylori in Patients with Dyspepsia: A Randomized Clinical Trial

2016 ◽  
Vol 9 (2) ◽  
pp. 256 ◽  
Author(s):  
Hamidollah Afrasiabian ◽  
Mohammad Hadi Imanieh ◽  
Mohammad Ali Nejati ◽  
Alireza Salehi
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Demographic Situation ◽  
Significant Difference ◽  
Before And After ◽  
Group A ◽  
H Pylori ◽  
Group B ◽  
Group D ◽  
Common Infections

<p><em>H. pylori</em><strong> </strong>infection is one of the most common infections in the world so that the aim of this study was to evaluate the antimicrobial <em>P. Atlantica Kurdica</em> gum in the eradication of <em>H. pylori</em>. This study is a randomized clinical trial; Patients with positive Urea Breath Test and symptoms of dyspepsia were entered. Patients were randomly divided into four groups. Group A: three drugs including 500 mg of Amoxicillin twice a day (bd), Clarithromycin 500 mg bd and Omeprazole 20 mg (bd) and Group B: Group A drugs plus the capsule containing 1 g of powdered <em>P. Atlantica Kurdica </em>gum (bd). In Group C: the capsule containing 1 g of powdered <em>P. Atlantica Kurdica</em> gum (bd) and Group D: this group took placebo-containing capsule (bd) for 14 days respectively. Dyspeptic symptoms before and after healing period and the UBT results two days before the start of treatment and 30 days after the completion were compared in 4 groups. Patients were not statistically significant difference from each other in the four groups regarding the demographic situation. Moreover, <em>H. pylori</em> eradication rate was 19/24 in Group A, 18/24 in Group B, 10/23 in Group C and 2/24 in Group D. Relieving symptoms of dyspepsia in Groups B and C were significantly higher than in Group D (P=0.025 and p=0.006 respectively). <em>P. Atlantica Kurdica</em> significantly led to the treatment of dyspepsia symptoms and <em>H. pylori</em> eradication.</p>

scholarly journals Evaluation of Clonidine Augmentation Therapy for Obsessive-Compulsive Disorder Treatment; a Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Shahla Akouchakian ◽  
Mohammad Javad Tarrahi ◽  
Elham Mohebati
Keyword(s):  
Clinical Trial ◽  
Adverse Effects ◽  
Randomized Clinical Trial ◽  
Obsessive Compulsive Disorder ◽  
P Value ◽  
Augmentation Therapy ◽  
Obsessive Compulsive ◽  
Global Improvement ◽  
Compulsive Disorder ◽  
Significant Difference

Background: Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disorder worldwide. Inadequate response of OCD patients to a usual agent makes this disorder a great challenge, and recent studies have recommended augmentation therapy as a new choice. Objectives: As traces of noradrenergic dysfunction have been noted in OCD pathophysiology, the current study aimed to assess the efficacy of clonidine augmentation therapy for treating OCD. Methods: This was a randomized clinical trial conducted on 57 OCD patients divided into the two groups of 1-mg clonidine augmentation therapy (n = 28) and placebo group (n = 29). The medication was administered for 12 weeks. Patients’ primary treatment, including SSRIs or clomipramine, continued by receiving the same dose used before participation in this study. The Yale-Brown Obsessive-Compulsive scale (Y-BOCS) and Clinical Global Impression-Severity scale (CGI-S) were used to assess the patients at the start of the study and then at four-week intervals. Drug-related adverse effects and global improvement were assessed and compared between the two groups. Results: The initial CGI scores were 3.89 ± 1.57 and 4.10 ± 1.61 at the baseline and 2.29 ± 1.18 and 3.07 ± 1.51 at the end of the study in the intervention and control groups, respectively. Both groups revealed a significant improvement (P-value = 0.001) with no significant difference between them (P-value = 0.22). The primary Y-BOCS score in the clonidine-treated group was 27.61 ± 8.08 versus 28.69 ± 7.44 in the control group at the baseline, which declined to 20.25 ± 6.08 versus 25.45 ± 7.35 at the end of the study, respectively. Both groups revealed a significant improvement (P-value = 0.001), but there was no statistically significant difference between them (P-value = 0.06). Drug-related complications were not statistically different between the two groups (P-value > 0.05); however, the clonidine-treated patients presented more adverse effects than control subjects. Conclusions: Although the use of clonidine posed no remarkable drug-related adverse effects, it was not superior to placebo considering symptom relief.

scholarly journals Effect of Ear Acupressure on Anxiety and Cortisol Levels in Women Receiving Premastectomy Radiotherapy: A Randomized Clinical Trial

2019 ◽  
Vol 12 (3) ◽  
pp. 8-16
Author(s):  
Reza Eghdam-Zamiri ◽  
Abbasali Dorosti
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Intervention Group ◽  
Serum Cortisol Level ◽  
Control Group ◽  
P Value ◽  
Breast Cancer Patients ◽  
Significant Difference ◽  
Cortisol Levels ◽  
Manifest Anxiety

Introduction: Radiation therapy before mastectomy increases the severity of stress and cortisol hormone. Because of the preference of patients and physicians for nonpharmacologic stress management methods, we conducted the present study with the aim of evaluating the effect of ear acupressure on anxiety and cortisol hormone levels in women receiving premastectomy radiotherapy. Methods: This randomized clinical trial was carried out on 66 patients (based on sample size formula) at Imam Reza Hospital in Tabriz during the years 2018-19. The intervention group was given acupressure, twice a day (8 minutes on each ear), for three days before surgery. Serum cortisol level and latent and manifest anxiety (the Spielberger State-Trait Anxiety Inventory) were measured before and after the intervention. Data were analyzed using SPSS 20 software. A P value less than 0.05 were considered significant. Results: There was no significant difference in latent anxiety, manifest anxiety, or cortisol levels between the groups at baseline. Ear acupressure caused a significant decrease in latent anxiety (from 43.22 ± 6.41 to 33.09 ± 4.91), explicit anxiety (from 49.50 ± 5.52 to 32.18 ± 5.01), and plasma cortisol levels (from 156.15 ± 18.95 to 115.59 ± 17.80) (P < 0.005), while no significant changes were observed in the control group (P > 0.05). Conclusion: Ear acupressure can reduce anxiety and stress (cortisol) levels in breast cancer patients undergoing radiotherapy before mastectomy.

scholarly journals PERBEDAAN INDEKS PLAK SEBELUM DAN SESUDAH PENGUNYAHAN BUAH APEL

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Preazy Agung C. Penda ◽  
Stefana H. M. Kaligis ◽  
Juliatri .
Keyword(s):  
Oral Hygiene ◽  
Sampling Method ◽  
T Test ◽  
Plaque Index ◽  
P Value ◽  
Significant Difference ◽  
West Papua ◽  
Before And After ◽  
Plaque Control ◽  
Papua Barat

Abstract: Teeth and mouth are important parts in human body. In order to perform its function properly, dental and oral hygiene need to be considered. Dental and oral hygiene can be observed from the formation of plaque. The effort to prevent plaque formation is called plaque control. Plaque control can be done naturally by masticating fibrous foods, inter alia apple. This study aimed to determine whether there were any difference in plaque index between before and after masticating an apple. Samples were collected by using total sampling method. There were 44 samples, obtained from 72 students of Senior High School Sorong, West Papua. The results showed that the average of plaque index before and after masticating an apple was 2.1 and 1.2. The paired sample t-test showed a P value of 0.000. Conclusion: There was a significant difference in plaque index before and after masticating an apple.Keywords: plaque index, masticating, appleAbstrak: Gigi dan mulut merupakan bagian penting dalam tubuh manusia.Agar dapat menjalankan fugsinya dengan baik, kesehatan gigi dan mulut perlu diperhatikan.Tingkat kebersihan gigi dan mulut dapat dilihat dari pembentukan plak.Upaya pencegahan timbulnya plak disebut dengan kontrol plak.Kontrol plak dapat dilakukan secara alamiah yaitu dengan mengunyah makanan berserat, salah satunya adalah buah apel. Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan indeks plak sebelum dan sesudah pengunyahan buah apel. Metode yang digunakan dalam penelitian ini ialah metode Pra eksperimental dengan rancangan pretest and posttest one group only yang dilakukan pada siswa kelas XI SMA Negeri 1 Sorong Papua Barat. Metode pengambilan sampel yang digunakan ialah total sampling dengan jumlah responden 44 dari 72 siswa. Hasil penelitian menunjukkan rerata indeks plak sebelum pengunyahan buah apel ialah 2,1 dan rerata indeks plak sesudah pengunyahan buah apel ialah 1,2. Analisis data menggunakan uji paired t-test menunjukkan P = 0,000. Simpulan: Terdapat perbedaan yang signifikan antara indeks plak sebelum dengan sesudah pengunyahan buah apel.Kata kunci: indeks plak, pengunyahan, buah apel

scholarly journals The Effectiveness Chewing gum versus Cryotherapy on Salivary Volume among Patient with Head and Neck Cancer undergoing Radiotherapy

Jurnal NERS ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 91
Author(s):  
Dwi Uswatun Sholikhah ◽  
I Ketut Sudiana ◽  
Ninuk Dian Kurniawati
Keyword(s):  
Head And Neck ◽  
Cancer Patients ◽  
Repeated Measure ◽  
Chewing Gum ◽  
P Value ◽  
Negative Effects ◽  
Significant Difference ◽  
Volume Increment ◽  
Before And After ◽  
Quasi Experimental

Introduction: Hyposalivation is a common problem experienced by head and neck (H&N) cancer patients undergoing radiotherapy. Hyposalivation can cause negative effects on the physical aspects of making oral mucositis, pain during eating and talking as well as psychological effects that cause feeling of discomfort sadness and, ultimately, depression. Many nonpharmacological interventions can be done for hyposalivation that occur in patients, among which are chewing gum and cryotherapy because they are easy to do, easy to access, inexpensive and have minimal side effects. However, the effectiveness of these interventions is not yet clear. Hence, this study is aimed to determine the effectiveness of chewing gum versus cryotherapy to increase salivary volume in H&N cancer patients undergoing radiotherapy.Methods: A quasi-experimental time series group design to determine the most effective time to influence the increase in salivary volume. This research was conducted on 36 respondents H&N cancer undergoing radiotherapy with four times measurement are pretest-posttest on the 3rd, 5th, and 7th day of intervention between February and March 2020. Subjects were chosen using consecutive sampling. Chewing gum group will chew gum six (6) pieces/day and cryotherapy group will suck on ice cubes five (5) minutes before and after radiotherapy. The spitting method was used to collect saliva and the data were analyzed using General Linear Model-Repeated Measure (GLMRM).Results: Chewing gum is more effective to increase salivary volume than cryotherapy. The GLMRM within subjects at four (4) times measurement showed a significant difference between chewing gum and cryotherapy group with p value <0.05 on the 7th day. Subjects in the chewing gum group had better salivary volume increment than cryotherapy group.Conclusion: This study showed that chewing gum is more effective to increase salivary volume on patient H&N cancer undergoing radiotherapy because chewing gum has higher salivary volume increment than cryotherapy groups

scholarly journals SIMVASTATIN GENERIK

2018 ◽  
Vol 20 (2) ◽  
pp. 107
Author(s):  
DAP. Rasmika Dewi ◽  
DG. Diah Dharma Santhi ◽  
DM Sukrama ◽  
AA. Raka Karsana
Keyword(s):  
Statistical Analysis ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
P Value ◽  
Low Density ◽  
Serum Samples ◽  
Significant Difference ◽  
Before And After

This study aims to know and determine the lipid profile in patients with hyperlipidemia who consumed Generic Simvastatin comparedwith its patent product contained in the Formularium at Sanglah Hospital. The observations made, were the measurement of the totalcholesterol and low-density lipoprotein (LDL) before and after the drug administration. A total of 30 subjects who met the inclusioncriteria, were divided into two (2) groups, each group consist of 15 persons, the first group was given 20 mg generic Simvastatin(1 tablet daily) for 15 days and Group II given 20 mg patent Simvastatin (1 tablet daily) for 15 day. After 15 days, their blood sampleswere taken and examined for total cholesterol and LDL. Once the data were collected, statistical analysis was done by using the normalitytest, homogeneity and t. Statistical analysis using p-value less than or equal to 0.05 was the limit of significance. The statistical analysisshowed that the data was normally distributed and homogeneous (p≥0.05). The T-test showed that there were significant differencesin the levels of total cholesterol and LDL serum samples before and after the administration of generic simvastatin and patents the(sig.=0.000). However, there was no significant difference in decreased levels of totall cholesterol samples between the generic Simvastatinand patent (sig=0.365 with α=0.05 level). Besides this, there was also no significant difference in the decreased levels of LDL betweengeneric Simvastatin and the patent one (sig=0.372 with α=0.05 level).

scholarly journals Effects of Vitamin D Supplementation on Female Vitamin D Deficient Teenagers: A Randomized Clinical Trial

2020 ◽  
Author(s):  
Salma Ahi ◽  
Fatemeh Gholami ◽  
Naser Hatami ◽  
Fatemeh Golabi
Keyword(s):  
Clinical Trial ◽  
Body Mass Index ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Randomized Clinical Trial ◽  
Body Mass ◽  
Anthropometric Indices ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Before And After

Abstract Background: Vitamin D deficiency is one of the most prevalent disorders worldwide. Considering the magnitude of growth in adolescence, the aim of this study was to ascertain the prevalence of vitamin D deficiency and discover the association between anthropometric indices and vitamin D levels and the effect of vitamin D treatment on anthropometric indices in adolescent girls. Method: we performed this randomized clinical trial study (approved by Iranian Registry of Clinical Trials with code of IRCT20200615047785N2) conducting 313 high school girl students in a random cluster sampling from Jahrom city schools. Blood samples were collected from participants to determine the serum level (OH) D25. We divided vitamin D deficient patients into two groups: control who received placebo (n=150) and intervention group (n=150) who were prescribed one tablet of 50,000 units of vitamin D per week for eight weeks. Anthropometric indices of participants were measured before and after the intervention. Datas were analyzed by SPSS software version 19.Results: The prevalence of vitamin D deficiency was 95%. Body mass index had no significant difference before the intervention in both groups (P = 0.76). After intervention in the case group, body mass index increased significantly (P = 0.01), but there was no significant difference in the control group after treatment (P = 0.42). There was no significant difference in waist circumference, height and weight before and after the intervention in both groups (P > 0.05). There was also a weak but significant correlation between height, weight, and baseline 25OHD levels of participants.Conclusion: The results of this study showed that there is a reverse and significant relationship between height and weight index with 25OHD. Further monitoring and prolonged studies with extended follow ups might improve the anthropometric parameters after treatment.

scholarly journals The effect of aromatherapy using Lavender (Lavandula angustifolia Miller) and Citrus aurantium L. extracts to treat anxiety of patients undergoing laparoscopic cholecystectomy: A randomized clinical trial in Iran

2018 ◽  
Vol 5 (3) ◽  
pp. 2096-2110 ◽  
Author(s):  
Jamshid Eslami ◽  
Abed Ebrahimi ◽  
Ayda Hosseinkhani ◽  
Zaher Khazaei ◽  
Isan Darvishi
Keyword(s):  
Clinical Trial ◽  
Laparoscopic Cholecystectomy ◽  
Randomized Clinical Trial ◽  
Control Group ◽  
Citrus Aurantium ◽  
Patient Anxiety ◽  
Lavandula Angustifolia ◽  
Chi Square ◽  
Significant Difference ◽  
Before And After

Introduction: Nowadays, complementary medicine such as aromatherapy has an important application in medicine, particularly in treating anxiety. The objective of the present study was to compare the effects of aromatherapy using lavender (Lavandula angustifolia Miller) and Citrus aurantium L. extracts on the anxiety level of patients undergoing laparoscopic cholecystectomy at Shiraz University of Medical Sciences Training Hospital in Iran. Methods: This Randomized Clinical Trial (RCT) was carried out in 2017 on a total of 90 patients undergoing laparoscopic cholecystectomy using aromatherapy. The subjects were randomly assigned to 3 groups based on the inclusion and exclusion criteria using sampling methods based on the goals. Two groups received either aromatherapy with Lavandula angustifolia Miller extract, aromatherapy with Citrus aurantium L. extract. The third group (control) received a placebo (odorless oil). The aromatherapy was performed on all subjects for 20 minutes. Patient anxiety was assessed using a Spielberg questionnaire before and after applying the aromatherapy intervention. The data obtained were analyzed by SPSS software via Chi-square test, one-tailed variance analysis, Tukey, t-tests, and Kruskal-Wallis test. Results: State and trait anxiety decreased for the aromatherapy groups, compared to control group, after applying the aromatherapy (P<0.001); moreover, there was an increased severity of anxiety in the control group (P<0.05). Indeed, the effects of aromatherapy with Lavandula angustifolia Miller and Citrus aurantium L. extracts were observed and confirmed; both extracts significantly decreased the severity of anxiety in the trial groups as compared to the control group (P<0.001). Moreover, the effect of aromatherapy with both of the aforementioned extracts was similar to each other. Conclusion: There was no significant difference between the lavender (Lavandula angustifolia Miller) and Citrus aurantium L. extracts in aromatherapy; therefore, either extract may be applied and useful in the clinic to alleviate preoperative anxiety. 

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