scholarly journals Smoking and periodontal disease severity, probing pocket depth and bleeding on probing

2021 ◽  
Vol 6 (2) ◽  
pp. 72
Author(s):  
AbhishekSingh Nayyar ◽  
JSuresh Babu ◽  
C Swarnalatha ◽  
Ritu Mathur ◽  
TayfNaif Radhi Alshammari ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Disease Severity ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Probing Pocket Depth

scholarly journals CORRELATION BETWEEN PERIODONTAL DISEASE INDICES AND LUNG CANCER IN GREEK ADULTS: A CASE — CONTROL STUDY

2016 ◽  
Vol 38 (1) ◽  
pp. 49-53 ◽  
Author(s):  
N A Chrysanthakopoulos
Keyword(s):  
Lung Cancer ◽  
Periodontal Disease ◽  
Case Control Study ◽  
Case Control ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Attachment Loss ◽  
Probing Pocket Depth ◽  
Control Study

Aim: The aim of the present case — control study was to examine the possible associations between periodontal disease indices and the risk of lung cancer development in a sample of Greek out-patients referred to a medical and a dental private practice. Materials and Methods: A total of 200 individuals were interviewed and underwent an oral clinical examination, and 64 of them were suffered from several histological types of lung cancer. The estimation of the possible associations between lung cancer as a dependent variable and periodontal disease indices as independent ones was carried out by using a multiple regression analysis model. Results: Probing pocket depth (odds ratio (OR) = 2.72, 95% confidence interval (CI) 1.05–7.06), clinical attachment loss (OR = 3.51, 95% CI 1.30–9.47) bleeding on probing (OR = 1.93, 95% CI 0.98–3.81) were significantly associated with the risk of developing lung cancer. Smoking (OR = 2.49, 95% CI 1.20–5.17) was significantly associated with the mentioned risk, whereas it was consisted as a confounder regarding the estimated associations between moderate/severe clinical attachment loss and presence of bleeding on probing with the risk of developing lung cancer. Conclusion: Probing pocket depth as an index for periodontal disease severity was statistically significantly associated with the risk of developing lung cancer.

scholarly journals Application of Lactoferrin andα1-Antitrypsin in Gingival Retention Fluid to Diagnosis of Periodontal Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Ryosuke Koshi ◽  
Kazuhiko Kotani ◽  
Mariko Ohtsu ◽  
Naoto Yoshinuma ◽  
Naoyuki Sugano
Keyword(s):  
Clinical Practice ◽  
Periodontal Disease ◽  
Area Under The Curve ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Periodontal Status ◽  
Positive Correlation ◽  
Probing Pocket Depth ◽  
The Relationship

Objectives.Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin andα1-antitrypsin were both inflammation-related molecules. The present study investigated the relationship between the periodontal status and the two biomarkers in gingival retention fluid (GRF).Patients and Methods. In 63 subjects with periodontitis, the GRF was sampled from maxillary anterior gingiva using a microbrush for 30 seconds. The lactoferrin andα1-antitrypsin levels in GRF were measured by an enzyme-link solvent immunoassay. Periodontal status was evaluated by probing pocket depth (PD) and bleeding on probing (BOP).Results. There was a higher level of these biomarkers in saliva (median (ng/mL), lactoferrin: 3611.9,α1-antitrypsin: 4573.3) than in GRF (lactoferrin: 61.0,α1-antitrypsin: 54.7). There was a mild-to-moderate but significantly positive correlation in lactoferrin orα1-antitrypsin between GRF and saliva. There was a positively mild-to-moderate accuracy (area under the curve: 0.60–0.81) of lactoferrin orα1-antitrypsin in GRF or in saliva to distinguish the severity of periodontal status. The cutoff level (ng/mL) of lactoferrin in GRF for detecting ≥30% of PD ≥ 4 mm (moderate periodontitis) was 68.6 and for detecting ≥20% of BOP (clinically active periodontitis) was 61.2. The cutoff level (ng/mL) ofα1-antitrypsin in GRF for detecting ≥30% of PD ≥ 4 mm was 54.5 and for detecting ≥20% of BOP was 35.3.Conclusions.The data can promote an application of the measurements of lactoferrin andα1-antitrypsin in GRF to clinical practice on periodontal disease.

scholarly journals Association between chronic periodontitis and herpes viruses: A review of the literature.

2020 ◽  
Vol 9 (3) ◽  
pp. 234-244
Author(s):  
Héctor Oñate ◽  
◽  
Alejandra Bravo ◽  
Carolina Arancibia ◽  
Paola Bustos ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Insertion Loss ◽  
Chronic Periodontitis ◽  
Data Matrix ◽  
Pocket Depth ◽  
Bleeding On Probing ◽  
Barr Virus ◽  
Probing Pocket Depth ◽  
Epstein Barr ◽  
Simplex Virus

Objective: This research aims to analyze the available spe-cialized literature concerning the association between Herpesviruses [Cytomegalovirus (CMV), Epstein Barr virus (EBV), Herpes Simplex virus (HSV)] and chronic periodontitis to clarify the possible role of these microorganisms in the progression and severity of the disease. Materials and Methods: A search for scientific articles was carried out in March 2019 in the main metasearch engines: PubMed /MEDLINE, SciELO, EBSCO, and the Trip search engine, to select articles according to the exclusion and inclusion criteria. The analysis of the articles was carried out through a data matrix expressed in frequency tables using descriptive statistics with measures of central tendency, dispersion, and correlation. Results: The results of this study show that the presence of CMV, EBV, and HSV in patients with chronic periodontitis is related to an increase in clinical parameters such as probing pocket depth (PD), clinical insertion loss (CIL) and bleeding on probing (BOP), in 96%, 60% and 40% of the studies, respectively, for HCMV; 96.55% (PD), 51.72% (CIL), and 48.28% (BOP) for EBV, and 80% (PD), 90% (CIL), and 60% (BOP) for HSV. The average prevalence of EBV, HCMV, and HSV was 46.3%, 35.4%, and 40.1%, respectively. Conclusions: EBV, CMV, and HSV could be associated with the progression and severity of periodontal disease as they are related to a greater probing depth, greater clinical insertion loss, and greater bleeding on probing. EBV presented a higher prevalence in the reviewed literature. More clinical studies are needed to verify a direct relationship between EBV, HSV, CMV, and periodontal disease, to confirm the trends observed in this work.

scholarly journals Exploring the Role of Interleukin-6 Receptor Inhibitor Tocilizumab in Patients with Active Rheumatoid Arthritis and Periodontal Disease

2021 ◽  
Vol 10 (4) ◽  
pp. 878
Author(s):  
Codrina Ancuța ◽  
Rodica Chirieac ◽  
Eugen Ancuța ◽  
Oana Țănculescu ◽  
Sorina Mihaela Solomon ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Periodontal Disease ◽  
Interleukin 6 ◽  
Gingival Index ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Bleeding On Probing ◽  
Periodontal Status ◽  
Probing Pocket Depth ◽  
Receptor Inhibitor

Background: The aim of our study was to explore the influence of weekly subcutaneous administration of interleukin-6 (IL-6) receptor inhibitor tocilizumab (TCZ) on periodontal status in a local longitudinal study of patients with rheumatoid arthritis (RA) and periodontal disease (PD). Methods: We performed a 6-month prospective study in 51 patients with chronic periodontitis and moderate-to-severe RA starting TCZ in accordance with local recommendations. Extensive rheumatologic (clinical activity, inflammatory, serological biomarkers) and periodontal (visible plaque index, gingival index, bleeding on probing, probing pocket depth, clinical attachment loss) assessments were done. Changes in RA activity and periodontal status were reassessed after 3 and 6 months. Results: We demonstrated significant correlations between periodontal status, disease activity, and serologic biomarkers (p < 0.05). Tocilizumab significantly improved the gingival index scores and decreased the number of sites with bleeding on probing after only 3 months (p < 0.05), while the probing pocket depth significantly decreased after 6 months; overall, clinical attachment loss presented only slight changes without any statistical significance as well as teeth count and plaque levels (p > 0.05). Conclusion: IL-6 inhibition is able to improve periodontal outcomes in patients with RA and concomitant PD, which is essentially related to a dramatic decrease in serum inflammatory mediators.

Association of ALDH2 Genotypes with Periodontitis Progression

2009 ◽  
Vol 89 (2) ◽  
pp. 138-142 ◽  
Author(s):  
N. Nishida ◽  
M. Tanaka ◽  
S. Sekine ◽  
T. Takeshita ◽  
K. Nakayama ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Periodontal Disease ◽  
Disease Progression ◽  
Odds Ratio ◽  
Alcohol Sensitivity ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Significant Odds Ratio ◽  
Progression Risk ◽  
Prospective Association

The progression of periodontitis may be affected by ALDH2 genotypes with respect to the oxidation of acetaldehyde to acetate, which leads to the accumulation of acetaldehyde in plasma and potential toxic effects. We examined the prospective association of ALDH2 genotypes in terms of alcohol sensitivity between alcohol consumption and periodontal disease progression. In 2003, 224 of 256 (87.5%) individuals examined at baseline (1999) completed probing pocket depth measurements for the evaluation of periodontitis progression. Missing data on self-reported questionnaires and blood samples were excluded; therefore, 183 samples were analyzed. Individuals who consumed ≥ 33.0 g/day of alcohol exhibited high periodontal disease progression risk (OR = 3.54). ALDH2 *1/*2 individuals who consumed ≥ 33 g/day of alcohol displayed a significant odds ratio (OR = 4.28) of periodontitis progression risk, in contrast to ALDH2 *1/*1 individuals. These results suggested that alcohol consumption as well as alcohol sensitivity may be a risk factor for periodontitis progression.

scholarly journals A COMPARATIVE STUDY TO ASSES THE EFFICACY OF NANOBIO FUSION GEL AS AN ADJUNCT TO SCALING AND POLISHING IN CHRONIC PERIODONTITIS. - A CLINICAL STUDY

2020 ◽  
pp. 1-3
Author(s):  
Patil A. Veena ◽  
Ansari T. Sobia ◽  
Agarwal Priyanka ◽  
Ayesha Ayesha ◽  
Sultana Shahnaaz
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Antimicrobial Agents ◽  
Test Group ◽  
Controlled Clinical Trial ◽  
Pocket Depth ◽  
Antioxidant Power ◽  
Probing Pocket Depth ◽  
Significant Difference ◽  
And Control

Introduction: Various chemical agents such as nonsteroidal, anti-inflammatory drugs and antimicrobial agents has gained popularity in treatment of periodontal disease but simultaneously lead to condition such as drug resistance and drug allergy. Hence , the topical application of herbal agents such as propolis, aloevera, green tea extracts, Neem reduces the potency and effectiveness to prevent progression of periodontal disease. NanoBioFusion(NBF)gel contains the natural antioxidant power of propolis,vit C,vit E which allows the ultrafine antioxidant to surpase the moist intraoral environment to enter the cells and rejuvenate,revitalize,support,protect and optimize gum and soft oral tissue.Hence the present study is aimed to evaluate the clinical effect of locally delivered NBF gel as an adjunctive therapy to scaling and polishing in the treatment of Periodontitis. Materials and Methods: Chronic Periodontitis patients with 40 sites and probing pocket depth (PD) between 5 and 7 mm were selected in a randomized controlled clinical trial. SRP was performed in both control and test group followed by NBF gel application in 40 sites. The plaque index, gingival index and probing Pocket depth,were recorded at baseline, 6 weeks, and 3 months.The statistical analysis with paired t‑test was used to compare the test and control sites. Results: From baseline to a period of 3 months, a statistically significant difference was seen between both groups for Pocket probing depth and from baseline to 6 weeks the mean GI and PI score have a statistically significant result was obtained(P=0.01& 0.00). Conclusions: Locally delivered NBF gel exhibited a significant improvement compared with SRP alone in chronic periodontitis.

scholarly journals Validating gingival surface temperature as an alternative tool in the diagnosis of periodontal disease activity: An observational clinical trial

2019 ◽  
Vol 13 (2) ◽  
pp. 123-127
Author(s):  
Sumanth Gunupati ◽  
Hasya Sappiti ◽  
Sreenivas Nagarakanti ◽  
BV Ramesh Reddy ◽  
Vijay Kumar Chava
Keyword(s):  
Pilot Study ◽  
Periodontal Disease ◽  
Surface Temperature ◽  
Disease Activity ◽  
Diagnostic Tool ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Cross Sectional ◽  
Probing Pocket Depth ◽  
Pilot Clinical Study

Background. Elevated temperature has been recognized as an inflammatory sign. It is the only indication that can be both objectively and quantitatively evaluated and is considered as a potential indicator of periodontal disease. Assessing gingival surface temperature (GST) could be a diagnostic parameter to determine periodontal health. This pilot clinical study aimed to validate gingival surface temperature (GST) as a clinical diagnostic tool to measure periodontal disease activity by correlating with the periodontal inflamed surface area (PISA). Methods. A cross-sectional mono-center pilot study was conducted with a convenient sample of 50 participants with a mean age of 34.14±13.7 years. Clinical parameters such as probing pocket depth (PPD) clinical attachment loss (CAL) and bleeding on probing (BOP) were measured. GST was recorded with a single lead of the bedside patient monitor and correlated with PISA. Results. The results showed a positive correlation between PISA and GST (P=0.46). Conclusion. This study showed a rise in GST of inflamed sites, but the results did not support the hypothesis that increased GST is an indicator of periodontal disease. As this is a pilot study, further studies with more larger sample sizes need to be undertaken to confirm its use as a diagnostic tool in clinical trials.

scholarly journals Folate-receptor 1 level in periodontal disease: a pilot study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Duygu Alkan ◽  
Berrak Guven ◽  
Cigdem Coskun Turer ◽  
Umut Balli ◽  
Murat Can
Keyword(s):  
Periodontal Disease ◽  
Gingival Crevicular Fluid ◽  
Folate Receptor ◽  
Serum Folate ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Serum Samples ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Significant Difference

Abstract Background The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status. Methods The study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent assay. Results The values of FOLR1 in GCF were higher in gingivitis and periodontitis groups than among patient in control group (p < 0.016). Serum FOLR1 levels showed no significant difference between the groups. A significant correlation was observed between FOLR1 levels of GCF and BOP (p < 0.05). Conclusions Our preliminary data suggest that FOLR1 is not useful in monitoring the periodontal disease. Further studies are necessary to clarify the role, regulation and function of folate and it’s receptors in the pathogenesis of periodontal disease.

scholarly journals Evaluation of statins (Simvastatin and lovastatin) in reducing periodontal parameters in patients with chronic periodontitis

2018 ◽  
Vol 6 (5) ◽  
Author(s):  
Ali Banihashem Rad ◽  
Majid Reza Mokhtari ◽  
Ershad Aghasizadeh ◽  
Mojtaba Bakhshande Far ◽  
Ahmad Banihashem ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Mevalonate Pathway ◽  
Blood Cholesterol ◽  
Lipid Lowering ◽  
Control Group ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Periodontal Index ◽  
Experimental Group

Introduction and objective: Chronic periodontitis is the most common form of periodontal disease. Progression of the disease is due to high levels of pro-inflammatory cytokines. Statins are a class of lipid-lowering drugs that used for cardiovascular disease and stroke. Statins has potential anti-inflammatory effect by blocking intermediate metabolites of the mevalonate pathway. The aim of this study was to evaluate the influence of Lovastatin and Simvastatin in improve the parameters of chronic periodontitis in the population of Khorasan Razavi province. Methods and materials: 40 subjects with chronic periodontitis were selected and informed consent was obtained from participants. Participants were divided into control and experimental groups and we scaling for patients of both groups, then control group without high blood cholesterol and treatment of patients was done without statin drugs and in case groups, patients with blood cholesterol higher than 240 mg/dl with Lovastatin 20 mg/day during 3 month treated. Periodontal indices; such as probing pocket depth (PPD), GI, PI, CAL and bleeding on probing in patients with chronic periodontitis were measured by the examiner before and after treatment in the control group and the experimental group. Also this index were measured 3 months after treatment in both groups by the same person examiner as Blind and dataes were analyzed by statistical software. Results: In this study, Mean ± SD of age was 7.93 ± 43.8 in the control group and the experimental group was 7.72 ± 47.8 and of the 40 patients in the study, 18 were males and 22 were females. Our study showed that the index of GI, CAL, BOP and probing depth were significantly different between the two groups after the intervention (P less than 0.05) and only after the intervention PI index was not significantly different between the two groups (P>0.05). Conclusion: Our findings showed that statins may improve periodontal index in patient with periodontal disease. This is probably because that statins increase bone regeneration and reduced inflammatory parameters such as CRP, MMP-9, TNF-α and the intermediate products.

scholarly journals Serum Immunoglobulin Levels in Type 2 Diabetes Patients with Chronic Periodontitis

2010 ◽  
Vol 11 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Fatin Awartani
Keyword(s):  
Glycemic Control ◽  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Serum Immunoglobulin ◽  
Diabetic Patients ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Group 2 ◽  
Immunoglobulin Levels

Abstract Aim The association between diabetes and periodontal disease has been well documented. Periodontitis is associated with alterations in immune responses in both diabetic and nondiabetic subjects. While diabetes is considered to be a risk factor for periodontal disease progression, few studies have demonstrated an association between the level of glycemic control and periodontal disease. Although poor glycemic control is significantly associated with poor periodontal health, few studies have been performed in Saudi Arabia to evaluate the immune responses in poor and better glycemic control and its effect on periodontal tissue. The aim of this study is to assess serum immunoglobulin levels (IgA, IgG, IgM) in type 2 diabetic (poor control and better control) and nondiabetic subjects with chronic periodontitis. Methods and Materials A total of 105 female patients were included in the study and they were divided into three groups, with 35 patients in each group. Group 1 was comprised of cases of diabetes exhibiting better control (HbA1c≤9%) and Group 2 was comprised of cases of diabetes exhibiting poorer control (HbA1c>9%). The third group was comprised of nondiabetic subjects with chronic periodontitis. In this study, clinical examination included plaque index, bleeding on probing, probing pocket depth, and attachment level (measured in all three groups). Serum immunoglobulin (IgA, IgG, IgM) levels were estimated and compared to the levels estimated for diabetic controls. Results Mean plaque index, bleeding index, and probing pocket depth showed no significant differences among the three groups. However, mean clinical attachment loss was significantly higher for Group 2 as compared to Groups 1 and 3. IgA and IgG levels were found to be significantly higher in Group 2 (poorly controlled diabetes) as compared to Group 1 (better control) and Group 3 (control group). There is a positive correlation between CAL and IgA and IgG, whereas there is a negative correlation between CAL and IgM. Conclusion The present study indicates that poor glycemic control may be associated with the increase in IgA and IgG serum antibodies. Elevated antibody levels may explain why poorly controlled diabetes exacerbates periodontal disease. Clinical Significance These findings demonstrate the importance of the immune system as well as good glycemic control, especially in patients diagnosed with periodontitis. The changes observed in immune response may be the cause or the effect of periodontal disease in diabetic patients. The increased incidence of periodontitis in diabetic patients suggests that the alteration in immune response may contribute to the pathogenesis of periodontitis in patients with poorly controlled diabetes. Citation Awartani F. Serum Immunoglobulin Levels in Type 2 Diabetes Patients with Chronic Periodontitis. J Contemp Dent Pract [Internet]. 2010 May; 11(3):001-008. Available from: http:// www.thejcdp.com/journal/view/volume11-issue3- awartani.

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