Nasal response in patients with diisocyanate asthma

Background: To date, no studies have assessed nasal and bronchial response to diisocyanates during specific inhalation challenges (SIC). Objectives: This study was performed to assess nasal response during SIC with diisocyanates (nasal and oral breathing) in patients with suspected occupational asthma due to these agents. Methods: Fourteen patients with suspected clinical history of diisocyanate-induced asthma were challenged with diisocynates in a 7m3 chamber. Nasal response testing during challenges was assessed by acoustic rhinometry, peak nasal inspiratory flow (PNIF), and visual analog scale (VAS), alongside bronchial responses. Results: Eleven patients had a significant asthmatic response to diisocyanates. None reported clear work-related nasal symptoms. In patients with positive bronchial response to diisocyanates, nasal mean minimal cross-sectional area (MCA) decreased by 26.9%, nasal volume at 5 cm decreased by 33.5%, and PNIF decreased by 28.3%, all from baseline. A positive nasal response was elicited in 45%, 54%, and 45% of patients, respectively. A significant increase in VAS was observed in 4 patients. Three patients with negative bronchial response had a negative nasal response. Conclusion: SIC revealed an objective nasal response in around 50% of patients with occupational asthma due to diisocyanates, in spite of the fact that none of them reported work-related nasal symptoms. The clinical significance of this finding is a poor association between nasal symptoms at work and an objective nasal response during positive SIC with diisocyanates.

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Seroprevalence of varicella antibodies in adults without clinical history of disease

Cadernos de Saúde Pública ◽

10.1590/0102-311x00149119 ◽

2020 ◽

Vol 36 (1) ◽

Author(s):

Konrad Silva Büchele ◽

Danusa Ferreira Correa ◽

Mari Tuyama ◽

Alberto dos Santos de Lemos ◽

Marcellus Dias da Costa ◽

...

Keyword(s):

Travel Medicine ◽

Clinical History ◽

Cross Sectional Study ◽

Older Individuals ◽

Cross Sectional ◽

Varicella Zoster ◽

History Of Disease ◽

Protective Antibodies ◽

High Positive Predictive Value ◽

History Of

Abstract: Varicella in adults and immunocompromised patients can be severe. The clinical diagnosis of varicella has high accuracy and the history of disease has a high positive predictive value for protection. A significant portion of adults, however, cannot remember if they have had varicella, especially older individuals. We conducted a cross-sectional study to determine the seroprevalence of varicella protective antibodies titers in adults with no clinical history of disease, attended at a Reference Center for Special Immunobiologicals and Travel Medicine in Rio de Janeiro (Brazil). Titration of immunoglobulin G (IgG) antibodies to varicella-zoster was determined by chemiluminescence immunoassay. Among 140 adults without history of varicella, 92% had protective antibody titers. We concluded that seroprevalence of varicella-zoster protection was very high in adults with negative history of disease and the use of serology before vaccination reduced significantly unnecessary vaccine and immunoglobulin use.

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The pathology of the ulnar nerve in acromegaly

Acta Endocrinologica ◽

10.1530/eje-08-0327 ◽

2008 ◽

Vol 159 (4) ◽

pp. 369-373 ◽

Cited By ~ 18

Author(s):

Alberto Tagliafico ◽

Eugenia Resmini ◽

Raffaella Nizzo ◽

Lorenzo E Derchi ◽

Francesco Minuto ◽

...

Keyword(s):

Ulnar Nerve ◽

Clinical History ◽

Cubital Tunnel Syndrome ◽

Cubital Tunnel ◽

Control Group ◽

Cross Sectional ◽

Sensory Disturbances ◽

History Of ◽

Tunnel Syndrome ◽

Written Informed Consent

ContextAcromegalic patients may complain of sensory disturbances in their hands. Cubital tunnel syndrome, the ulnar nerve neuropathy at the cubital tunnel (UCT), in acromegalic patients has never been reported.ObjectiveTo describe and assess the prevalence of UCT in acromegalic patients and the effects of 1 year of therapy on UCT.PatientsWe examined prospectively 37 acromegalic patients with no history of polyneuropathy, acute trauma at the elbow, no diabetes or hypothyroidism with clinical examination, nerve conduction studies (NCS), and high-resolution ultrasound (US). A control group was made by 50 volunteers. The local ethics committee approved the study and written informed consent was obtained from all subjects involved in the study.InterventionClinical history, physical examination, NCS, and US were used to diagnose UCT at the beginning of the study and after 1 year.ResultsIn 8 of 37 patients, a diagnosis of UCT was made at the beginning of the study reflecting a prevalence of 21%. After 1 year, 5 of 8 (62.5%) patients reported clinical and NCS improvements and evident US reduction of nerve cross-sectional area (CSA; 16.7±2.9 mm2 vs 12.2±3.1 mm2; P<0.001). In 3 of 8 (37.5%) patients, the UCT was unchanged. Ulnar nerve CSA was significantly increased in acromegalic patients with UCT (16.7±2.9 mm2 vs 11.1±2.3 mm2; P<0.047).ConclusionUlnar neuropathy could occur in acromegalic patients and can improve in 62% of cases with disease control. Due to the different management and therapeutic approach, it would be important to make differential diagnosis between cubital and carpal tunnel syndrome in acromegaly.

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Risk factors related to childbirth in El Salvador

ALERTA Revista Científica del Instituto Nacional de Salud ◽

10.5377/alerta.v2i2.7922 ◽

2019 ◽

Vol 2 (2) ◽

pp. 144-152

Author(s):

Fátima Larisa Chavarría Rodríguez

Keyword(s):

Public Health ◽

Risk Factors ◽

Preterm Birth ◽

El Salvador ◽

Multiple Pregnancy ◽

Public Health Problem ◽

Clinical History ◽

Cross Sectional ◽

History Of ◽

Prevalence Ratios

Introduction. Preterm birth is a public health problem, considered a high risk factor for morbidity, disability and neonatal mortality. Objective. Characterize risk factors related to preterm birth in El Salvador. Methodology. Analytical cross-sectional study of risk factors related to preterm birth, in women who received childbirth care in the national public health system, during 2017. Data was obtained from the Perinatal Information System. 44 891 cases were analyzed. Qualitative variables were analyzed through absolute values and frequencies, and the quantitative variables, through absolute values, frequency and central tendency measures, using the Statistical Package for the Social Science (SPSS) version 24 program. The analysis of relation of variables, was performed with the Epidat version 3.1 program, through the calculation of prevalence ratios (PR) and the calculation of Odds Ratio (OR), both analysis with a 95% confidence interval and a value of p <0.05. Results. 9.5% of the deliveries attended were preterm. The risk analysis through the calculation of prevalence ratios showed that women with a multiple pregnancy were 14 times more likely to have a preterm birth. Preterm birth was 4.7 times more frequent in women with a clinical history of diabetes mellitus and 2.4 times more frequent, with a history of high blood pressure. Conclusions. Women who have a multiple pregnancy and pregnant women with a clinical history of chronic diseases, and an obstetric history of preeclampsia, are more likely to have a preterm birth. Likewise, obesity and inadequate age for pregnancy, mainly women over 35 years, are also related to preterm birth.

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Analysis of the Behaviour of Immunoglobulin G Antibodies in Children and Adults Convalescing From Severe Acute Respiratory Syndrome-Coronavirus-2 Infection

Frontiers in Pediatrics ◽

10.3389/fped.2021.671831 ◽

2021 ◽

Vol 9 ◽

Author(s):

Horacio Márquez-González ◽

Briceida López-Martínez ◽

Israel Parra-Ortega ◽

Daniela de la Rosa-Zamboni ◽

Marcela Salazar-García ◽

...

Keyword(s):

Clinical History ◽

Paediatric Population ◽

Adult Patients ◽

Igg Antibodies ◽

Sample Collection ◽

Rt Pcr ◽

Cross Sectional ◽

Duration Of Symptoms ◽

Paediatric Hospital ◽

History Of

The pandemic caused by SARS CoV-2 (COVID-19) has affected millions of people since 2020. There are clinical differences and in mortality between the adult and paediatric population. Recently, the immune response through the development of antibodies has gained relevance due to the risk of reinfection and vaccines' development.Objective: Was to compare the association of clinical history and the clinical presentation of the disease with the development of IgG antibodies against SARS-CoV-2 in paediatric and adult patients with a history of positive reverse transcriptase-polymerase chain reaction (RT-PCR) results.Methods: Cross-sectional observational study carried out in a Paediatric Hospital in Mexico City included patients under 18 years of age and health personnel with positive RT-PCR for COVID-19 comparing antibody expression. The development of specific IgG antibodies was measured, the presence of comorbidities, duration, and severity of symptoms was determined.Results: Sixty-one subjects (20 < 18 years and 41 > 18 years) were analysed. The median sample collection was 3 weeks. There were no differences in the expression of specific antibodies; no differences were shown according to the symptoms' severity. A positive correlation (r = 0.77) was demonstrated between the duration of symptoms and antibody levels.Conclusions: In conclusion, there is a clear association between the duration of the symptoms associated with SARS-CoV-2 infection and the IgG units generated in paediatric and adult patients convalescing from COVID-19.

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Evaluation of elderly patients with hearing impairment.

The Professional Medical Journal ◽

10.29309/tpmj/2020.27.10.4071 ◽

2020 ◽

Vol 27 (10) ◽

pp. 2154-2158

Author(s):

Syed Ali Naqi ◽

Syed Maisam Ali ◽

Arslan Akhtar ◽

Tabassum Aziz ◽

Tahira Sajid ◽

...

Keyword(s):

Hearing Impairment ◽

Past History ◽

Clinical History ◽

The Elderly ◽

Cross Sectional Study ◽

Variable Degree ◽

Cross Sectional ◽

Detailed Clinical History ◽

History Of ◽

Study Setting

Hearing is decreased in later age is due to aging and is normally seen in most of the elderly people all over the world. Objectives: To ascertain the degree of hearing in elders in relation to age, pattern and extent of hearing weakness in old age so that interventional strategies can be planned to improve their wellbeing. Study Design: Cross Sectional Study. Setting: ENT Outdoor Clinic of Akbar Niazi Teaching Hospital of Islamabad Medical and Dental College, Bhara Kahu, Islamabad. Period: December 2017 to October 2018. Material & Methods: 200 patients were part of the study with age > 50 years and no past history of drug therapy. Data was gathered by detailed clinical history, clinical examination and audiometric findings. Result: 57% patients were found with normal hearing and 43% had variable degree of hearing deterioration. Highest number of hearing weakness was found in 9th decade. Most of hearing deterioration was found in both the ears and that of sensorineural in type. Conclusion: Sensorineural type of hearing impairment is very frequently occurring problem seen in the latter part of life in our community. The frequency and severity of decreased hearing is directly proportional to age.

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Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children’s Pilot Study

PLoS ONE ◽

10.1371/journal.pone.0257721 ◽

2021 ◽

Vol 16 (9) ◽

pp. e0257721

Author(s):

Mayako Saito-Abe ◽

Kiwako Yamamoto-Hanada ◽

Kensuke Shoji ◽

Miori Sato ◽

Makoto Irahara ◽

...

Keyword(s):

Pilot Study ◽

Pediatric Population ◽

Clinical History ◽

Allergic Diseases ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Antibody Positivity ◽

History Of ◽

The Relationship

Background The relationship between allergic individuals and their responsiveness to routine vaccines has rarely been investigated. This study examined whether the seroprevalence of measles antibody differed between children with and without allergic diseases in the general pediatric population. Methods The cross-sectional study was performed within a prospective general birth cohort (a pilot study of the Japan Environment & Children’s Pilot Study [JECS]) of children aged 8 years. The clinical history of allergic diseases, measles, and the concentration of measles immunoglobulin G titers in serum enzyme immunoassay were examined. Fisher’s exact tests were used to assess the relationships between the allergic characteristics of the children and their measles antibody positivity rates. Results This study included 162 children. Any allergic disease was reported in 75 (46.3%). The measles antibody positivity rate was 94.7% among children with any allergic diseases and 92.0% among children without allergic diseases. Our results revealed no differences in measles antibody seropositivity between children with allergies and controls. Conclusions Children with allergies mount and maintain a comparable immune response to the measles vaccine.

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Determinan Kejadian Dermatitis Kontak Pada Pekerja Bengkel di Kota Kendari

Jurnal Keperawatan Muhammadiyah ◽

10.30651/jkm.v4i2.2762 ◽

2019 ◽

Vol 4 (2) ◽

Author(s):

La Ode Alifariki ◽

Adius Kusnan ◽

Saida Saida

Keyword(s):

Contact Dermatitis ◽

Occupational Disease ◽

Cross Sectional Study ◽

Personal Hygiene ◽

Cross Sectional ◽

Informal Workers ◽

Work Related ◽

Study Results ◽

History Of ◽

Allergic Contact

One of the problems in occupational health is occupational diseases. Occupational disease is a disease caused by a job or work environment. Occupational disease that often occurs is contact dermatitis. Contact dermatitis is dermatitis caused by material or substance that sticks to the skin. The study results of the Indonesian Ministry of Health in 2016 for informal workers were 44.2%. Allergic contact dermatitis. Likewise, in 2017 the 2017 Profile of Worker Health Problems in Indonesia obtained 50.5% of work related to work, one of which was skin disorders of 5.3%. This study aims to determine the factors associated with the incidence of contact dermatitis in motorbike workshop workers in Kendari City 2018. This study was quantitative with cross sectional study design. The populations in this study were all The mechanics of motorcycle workshop in Kendari city in 2016, amounting to 459 people. The samples in this study were 58 people. The Results showed that, there was a relationship between long contact and symptoms of contact dermatitis with ρ value = 0.000, there was no relationship between a history of skin disease and symptoms of contact dermatitis with ρ value = 0.174, there was relationship between personal hygiene and symptoms of contact dermatitis with ρ value = 0.026, and there was a relationship between the use of PPE and symptoms of contact dermatitis with ρ value 0,003

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Health and safety issues among construction workers in Bangladesh

International Journal of Occupational Safety and Health ◽

10.3126/ijosh.v9i1.25162 ◽

2019 ◽

Vol 9 (1) ◽

pp. 13-18

Author(s):

Firoz Ahmed Mamin ◽

Ganesh Dey ◽

Shazal Kumar Das

Keyword(s):

Health And Safety ◽

Cross Sectional Study ◽

Construction Workers ◽

Safety Equipment ◽

Cross Sectional ◽

Safety Issues ◽

Work Related ◽

History Of ◽

Set Up ◽

Health And Safety Issues

Background: Bangladesh is a rapidly developing country. Lots of infrastructures are set up every year. A large number of people are working in the construction industry. Work related injuries and deaths of construction workers are common. The aim of this study was to find the health and safety awareness of informal construction workers. Methodology: This study was a cross sectional study by using a preset questionnaire among the construction workers in Bangladesh. Results: Participants of this study had lower income and education. About 87% of participants did not receive any health and safety training and did not wear safety equipment when they were working. About 57% of the participants had a history of injury. This study also found that the main reasons for the non-use of safety equipment were lack of safety equipment, motivation and training. Conclusion: Construction workers are not adequately aware about health and safety issues that relate to them.

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A Cross-Sectional Evaluation of Illness Perception About Asthma Among Asthma Patients at a Referral Tertiary Care Public Chest Hospital in Delhi, India

International Journal of User-Driven Healthcare ◽

10.4018/ijudh.2012070104 ◽

2012 ◽

Vol 2 (3) ◽

pp. 32-43

Author(s):

Sushil Shendge ◽

Barnali Deka ◽

Anita Kotwani

Keyword(s):

Inhaled Corticosteroids ◽

Tertiary Care ◽

Illness Perception ◽

Clinical History ◽

Self Management ◽

Cross Sectional ◽

The Public ◽

Co Morbidity ◽

Asthma Patients ◽

History Of

Adult patients visiting emergency room (March 2009-December 2009) of the public chest hospital for asthma exacerbation completed interviewer-administered questionnaires on sociodemographics, clinical history, disease beliefs, use of inhaled corticosteroids (ICS), and self-management of asthma after stabilization of their condition. Overall 87% patients believed that they had asthma when they are having symptoms, which is called as no symptoms, no asthma belief. No association was found between no symptoms, no asthma belief with gender, income, family history of asthma, and co-morbidity. Younger patients in the age group 18-29 years had four to five-fold greater odds and patients with education above 10th grade had three to four-fold greater odds of having the no symptoms, no asthma belief or the acute episodic belief. Acute episodic belief was negatively associated with beliefs about always having asthma, asthma being a serious condition, having lung inflammation, or the importance of using ICS, and was positively associated with expecting to be cured. All patients irrespective of their belief of acute or chronic nature of asthma had poor adherence to the treatment and other self-management behaviors.

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Work-Related Asthma in Automobile Spray Painters: Two Case Reports

Archives of Industrial Hygiene and Toxicology ◽

10.2478/10004-1254-59-2008-1858 ◽

2008 ◽

Vol 59 (2) ◽

pp. 117-125 ◽

Cited By ~ 1

Author(s):

Jordan Minov ◽

Jovanka Karadžinska-Bislimovska ◽

Kristin Vasilevska ◽

Snežana Risteska-Kuc ◽

Sašo Stoleski

Keyword(s):

Occupational Asthma ◽

Diagnostic Procedure ◽

Case Reports ◽

Bronchial Hyperresponsiveness ◽

Diurnal Variations ◽

The Other ◽

Respiratory Impairment ◽

Work Related ◽

Increased Risk ◽

History Of

Work-Related Asthma in Automobile Spray Painters: Two Case ReportsThis report describes two patients who had developed asthma after working as automobile painters with isocyanate-based aerosol paint for two years or over. In both patients asthma was confirmed using the standard diagnostic procedure. One of the subjects was atopic. One was ex-smoker and the other had never smoked. Neither had a family history of asthma. The symptoms occurred after workplace exposure lasting two years in one patient and three in the other. As both reported work-relatedness of the symptoms, they underwent serial peak expiratory flow rate (PEFR) measurement and bronchoprovocation testing. Significant work-related changes in PEFR diurnal variations and in non-specific bronchial hyperresponsiveness (NSBH) were observed in one patient, suggesting allergic occupational asthma (OA), while the other patient was diagnosed work-exacerbated asthma (WEA). Our data confirm that spray painting is an occupation with increased risk of respiratory impairment and asthma.

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