scholarly journals Haematological profile of healthy adult blood donors in Mwanza, Tanzania

2018 ◽  
Vol 20 (3) ◽  
Author(s):  
Ally Faya ◽  
Mwesige Charles ◽  
Larry Fred Sembajwe ◽  
Haruna I. Dika
Keyword(s):  
Haemoglobin Level ◽  
Reference Values ◽  
Blood Donors ◽  
Healthy Adult ◽  
Local Population ◽  
Cross Sectional Study ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Normal Ranges ◽  
Haematological Profile

Background: While it is customary to apply the same haematological reference ranges, variations exist between populations. This study was conducted to determine hematologic profiles among a local population of north-western Tanzania.Methods:  This was a cross sectional study, which enrolled healthy adult blood donors in Mwanza, Tanzania. Collected blood samples were put in EDTA-coated tubes and haematological indices were determined using Auto Hematology-Analyzer. Results are summarized in medians plus 95% interquartile ranges and compared using either Mann–Whitney U or Kruskal–Wallis tests depending on appropriateness.Results:  A total of 163 (143 males and 20 females) adult healthy blood donors (median age= 31 years) were enrolled.  We found a median haemoglobin level of 15.1 g/dL [10.5-23.8], erythrocytes of 5.3x106/µL [4.1-8.3 x106], haematocrit of 44.0 % [32.4-71.4], total leucocytes of 4300 cells/μL [1700-8500], lymphocytes 1700/μL [800-3000], neutrophils 2100/μL [300-5300]; mid-sized cells (monocytes, eosinophils and basophils) of 400/μL [100-1400] and platelets of 194x103/μL [55.2-379.0 x103].  We observed significantly higher haemoglobin level (P = 0.017) as well as erythrocytes (P = 0.012) and haematocrit (p = 0.006) among males than females.   Conclusion: The percentile range (2.5%-97.5%) which can be used to determine the higher and lower values of haematological profile normal ranges for most indices differ from Western adopted reference values.  Therefore, we recommend a large study to establish local normal hematologic reference values.

A descriptive cross-sectional study of Platelets count in apparently healthy Eritrean blood donors attending the National Blood Transfusion Center, Asmara, Eritrea

2020 ◽  
Vol 3 (1) ◽  
pp. 14-17
Author(s):  
Faris Mohamed Awad Abdon ◽  
◽  
Elias Teages Adgoy ◽  
Nahom Yacob Berhane ◽  
Senet Awolker Ibrahim ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Blood Donors ◽  
Cross Sectional Study ◽  
Blood Bank ◽  
Reference Ranges ◽  
Sectional Study ◽  
Cross Sectional ◽  
Normal Ranges ◽  
The Difference ◽  
Apparently Healthy

Background: Platelets are an important constituent of blood. Safety measures of blood transfusion are important for optimum health environment. To the knowledge of the researchers, there is no study that was conducted concerning Platelets count in apparently healthy Eritrean blood donors. Therefore, this study will help in establishing the reference ranges of Platelets count in them. Objectives: To measure the serum platelets levels and mean platelets volume in apparently healthy Eritrean blood donors attending the national blood bank of Eritrea. Study design: Descriptive crosssectional study. Materials and methods: 610 Blood donors were incorporated in the study. 4 ml of venous blood was collected into K3EDTA tubes (Becton Dickinson, Plymouth, UK) from all of the participants of the study. Blood samples collected into the (EDTA)-tubes were examined for Platelets count and mean platelet volume. Results: The overall mean of platelets count was 267.145 ± (65.915) ×109 /L, The median and mode of values were both 266.3 thousands/mm3. The mean platelet count for the females was 296.122 thousands /mm3, and for males was 252.477 ×109 /L, and the statistic difference between them was significant. The statistic mean of MPV for males was 8.763 fl, and for females was 8.717, and the difference between the two means also considered insignificant. Conclusion: This descriptive cross sectional study was performed in the National Blood bank in Asmara where platelets levels and mean platelets volume were measured for 610 healthy blood donors. The results were found to be within reference normal ranges. The difference between the males and females results was statistically significant

Fetal echocardiography: reference values for the Chinese population

2017 ◽  
Vol 45 (2) ◽  
Author(s):  
Xiaoyan Gu ◽  
Yihua He ◽  
Ye Zhang ◽  
Lin Sun ◽  
Ying Zhao ◽  
...  
Keyword(s):  
Reference Values ◽  
Fetal Echocardiography ◽  
Ductus Arteriosus ◽  
Cross Sectional Study ◽  
Quadratic Model ◽  
Reference Ranges ◽  
Single Center ◽  
Cross Sectional ◽  
Normal Reference ◽  
Inner Diameter

AbstractObjective:Global racial variability in human development can lead to differences in size of fetal cardiac structures during gestation. Our objective is to establish normal reference ranges of fetal cardiac dimensions between 20 and 34 weeks from fetal echocardiograms recorded at a single center in China.Methods:A prospective cross-sectional study was undertaken on single pregnancies with normal fetuses of varying gestational ages (GAs). A total of 4396 normal fetuses were divided into 15 groups from 20 to 34 weeks according to the GA. Measurements included the inner diameter of the fetal cardiac chambers and arteries, the aortic arch isthmus (AI), the descending aorta (DAO), the ductus arteriosus (DA), and the foramen ovale (FO). Measurements were statistically analyzed and regression analysis was applied to assess for correlation with GA.Results:Normal reference values of fetal cardiovascular dimensions between 20 and 34 weeks were obtained from 4396 subjects at a single center in China. Measurements of fetal cardiac structures increase with advancing GA. It seems there is no difference in r values among linear, cubic, and quadratic model analyses (P > 0.05). However, the r values for the exponential models appear to be smaller than those of the other three models (P < 0.05). Ratios of the diameters of fetal cardiac structures were calculated in order to identify for differential changes in the growth of structures.Conclusions:The presented data derived from 4396 normal fetuses provide the reference values of fetal echocardiography in China, which provide guidance to fetal echocardiography examinations.

scholarly journals SYPHILIS;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Ahsan Ashfaq ◽  
KAUSAR ABBAS SALDERA ◽  
AYESHA EJAZ ◽  
NOOR-UN NISA MEMON ◽  
HINA RASHID ◽  
...  
Keyword(s):  
Blood Donors ◽  
Viral Infections ◽  
Local Population ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Serum Neopterin ◽  
Neopterin Level

Objectives: To assess serum Neopterin levels in blood donors of local population and to study its relationship with transfusion transmitted infections (TTIs) including syphilis. Study Design: Descriptive cross-sectional study. Place and Duration of Study: This study was carried out in the Department of Physiology LNMC in collaboration with Basic Medical Sciences Institute, (BMSI), and Jinnah Post Graduate Medical Centre (J.P.M.C.) Karachi, from Jan to July 2015.”Methods: Total 174 blood donors were included in the study through random sampling technique. They were screen through the standard procedures used for screening at the JPMC blood bank for WHO recommended diseases. Neopterin was estimated using ELISA. Data analysis was performed using SPSS version 21. Chi square and ANOVA were applied at a confidence level of 95%.”Results: Neopterin level in the sera of syphilis positive blood donors was 5.86 ± 0.78 nmol/l which was within normal range below the cutoff value of 10 nmol/l. Neopterin content in the serum of blood donors who were negative for transfusion transmitted infections was 6.23± 2.19 nmol/l as compared to blood donors testing positive for transfusion transmitted viral infections showing high Neopterin level of 15.10 ± 4.93 nmol/l. (P value 0.001).”Conclusion: Neopterin levels were found to be within normal limits in blood donors testing positive for syphilis However in  blood donors with transfusion transmitted viral infections  serum neopterin levels were elevated.

scholarly journals Percentiles and Reference Values for Accelerometric Gait Assessment in Women Aged 50–80 Years

2020 ◽  
Vol 10 (11) ◽  
pp. 832
Author(s):  
Raquel Leirós-Rodríguez ◽  
Jesús García-Liñeira ◽  
Anxela Soto-Rodríguez ◽  
Jose L. García-Soidán
Keyword(s):  
Life Expectancy ◽  
Reference Values ◽  
Postural Stability ◽  
Healthy Adult ◽  
Cross Sectional Study ◽  
Adult Women ◽  
Sectional Study ◽  
Risk Of Falling ◽  
Cross Sectional ◽  
Gait Assessment

Background: The identification of factors that alter postural stability is fundamental in the design of interventions to maintain independence and mobility. This is especially important for women because of their longer life expectancy and higher incidence of falls than in men. We constructed the percentile box charts and determined the values of reference for the accelerometric assessment of the gait in women. Methods: We used a cross-sectional study with 1096 healthy adult women, who were asked to walk a distance of 20 m three times. Results: In all of the variables, a reduction in the magnitude of accelerations was detected as the age of the group advanced. The box charts show the amplitude of the interquartile ranges, which increases as the age of the participants advances. In addition, the interquartile ranges were greater in the variables that refer to the maximum values of the accelerations. Conclusions: The values obtained can be used to assess changes in gait due to aging, trauma and orthopaedic alterations that may alter postural stability and neurodegenerative processes that increase the risk of falling.

Normal Reference Values of Fetal Atrioventricular (AV) and Ventriculoatrial (VA) Time Intervals and VA:AV Ratio Assessed by Pulse Wave Doppler

2021 ◽  
Vol 104 (5) ◽  
pp. 781-786
Keyword(s):  
Reference Values ◽  
Pulse Wave ◽  
Rank Correlation ◽  
Reference Value ◽  
Cross Sectional Study ◽  
Time Interval ◽  
Reference Ranges ◽  
Time Intervals ◽  
Cross Sectional ◽  
Normal Reference

Objective: To identify the normal reference ranges of the atrioventricular (AV) time interval, ventriculoatrial (VA) time interval, and VA:AV ratio in fetuses between 18 and 37 weeks of gestational age (GA) and to establish the relationship between AV and VA time intervals and VA:AV ratio with GA and fetal heart rate (FHR). Materials and Methods: A prospective cross-sectional study was conducted at Rajavithi Hospital between December 2019 and June 2020. AV and VA time intervals and VA:AV ratio were obtained by pulse wave Doppler over inflow and outflow tract of left ventricle. The correlation of the measurement values with GA and FHR were analyzed by Spearman’s rank correlation. Results: Three hundred seventy pregnant women were enrolled in the present study with 343 participants included in the analysis. The average values of AV and VA time intervals and VA:AV ratio, along with their 5th, 10th, 50th, 90th, and 95th percentiles were calculated from the measurement values. A correlation between each measurement value and GA was demonstrated to be linear [AV time intervals = 91.74+1×GA(weeks) (R²=0.516, p<0.001); VA time intervals = 2.58E2+1.39×GA(weeks) (R²=0.151, p<0.001); and VA:AV ratio = 2.74–8.99E–3×GA(weeks) (R²=0.063, p<0.001)]. A correlation between each measurement value and FHR was also linear [AV time intervals = 1.79E2–0.41×FHR (R²=0.181, p<0.001); VA time intervals = 6.21E2–2.23×FHR (R²=0.811, p<0.001); and VA:AV ratio = 3.9–9.64E-3×FHR (R²=0.150, p<0.001)]. Conclusion: Both AV and VA time intervals are positively correlated with GA but VA:AV ratio is negatively correlated with GA. All measurement values have negative correlation with FHR. The normal reference values of AV, VA time intervals, and VA:AV ratio from the present study may be useful for diagnosis of fetal arrhythmia. Keywords: normal reference value, atrioventricular time intervals, ventriculoatrial time intervals, VA:AV ratio

Red blood cell counts and indices in the elderly German population

2018 ◽  
Vol 42 (4) ◽  
pp. 131-139 ◽  
Author(s):  
Gabriele Röhrig ◽  
Ingrid Becker ◽  
Kai Gutensohn ◽  
Thomas Nebe
Keyword(s):  
Blood Cell ◽  
Reference Values ◽  
Objective Assessment ◽  
Cross Sectional Study ◽  
Mean Corpuscular Hemoglobin ◽  
Reference Ranges ◽  
Inclusion Criteria ◽  
Corpuscular Hemoglobin ◽  
Cross Sectional ◽  
Cell Counts

Abstract Background Data on peripheral blood cell values in older subjects are rare. While hemoglobin (Hb) values are supposed to change with rising age, little is known about reference values for other erythrocytic blood cell counts. This cross-sectional study was initiated to analyze hematologic laboratory parameters among subjects aged ≥60 years. Methods This was a retrospective cross-sectional study of outpatient laboratory data between January 1st and December 31st, 2015 originating from a German countrywide laboratory group; inclusion criteria: age ≥60 years, normal C-reactive protein (CRP), transferrin saturation, reticulocytes, lactate dehydrogenase, haptoglobin and soluble transferrin receptor; exclusion criteria: glomerular filtration rate (GFR)<60 mL/min, lack of inclusion criteria; primary objective: assessment of the mean Hb value; secondary objective: assessment of mean values of red blood cell (RBC) counts. Results Of 30,611 subjects ≥60 years, 4641 met the inclusion criteria and were thus considered hematologically healthy; the following age groups were formed: 60–69 years (2094), 70–79 years (2171), 80–89 years (360), >90 years (16); median values for male/female subjects were: Hb 15.2/14.0 g/dL, RBC 5.0/4.6/μL, mean cellular volume (MCV) 89/89/fl, mean corpuscular hemoglobin (MCH) 31/30 pg/RBC, mean corpuscular hemoglobin concentration (MCHC) 34/34 g/dL, hematocrit (hct) 44/41%. Statistical evaluation revealed a slight but significant decrease in values over age decades for all parameters except for MCH. However, all values remained within the recommended German Society of Hematology and Oncology (DGHO) reference ranges. Hb values remained above the recommended World Health Organization (WHO) cut-offs for definition of anemia. Conclusions The results confirm the WHO reference values and are in accordance with the recommended DGHO reference values and previous results of other study cohorts outside Germany. There seems to be no need for establishing age-specific RBC or erythrocytic reference ranges for subjects >60 years.

scholarly journals Defining normal ranges and centiles for heart and respiratory rates in infants and children: a cross-sectional study of patients attending an Australian tertiary hospital paediatric emergency department

2015 ◽  
Vol 100 (8) ◽  
pp. 733-737 ◽  
Author(s):  
Fenton O'Leary ◽  
Andrew Hayen ◽  
Francis Lockie ◽  
Jennifer Peat
Keyword(s):  
Emergency Department ◽  
Respiratory Rate ◽  
Life Support ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Reference Ranges ◽  
Sectional Study ◽  
Cross Sectional ◽  
Normal Ranges ◽  
Quantile Regression Analysis

ObjectiveKey components in the assessment of a child in the emergency department (ED) are their heart and respiratory rates. In order to interpret these signs, practitioners must know what is normal for a particular age. The aim of this paper is to develop age-specific centiles for these parameters and to compare centiles with the previously published work of Fleming and Bonafide, and the Advanced Paediatric Life Support (APLS) reference ranges.DesignA retrospective cross-sectional study.SettingThe ED of the Children's Hospital at Westmead, Australia.PatientsAfebrile, Triage Category 5 (low priority) patients aged 0–15 years attending the ED.InterventionsCentiles were developed using quantile regression analysis, with cubic B-splines to model the centiles.Main outcome measuresCentile charts were compared with previous studies by concurrently plotting the estimates.Results668 616 records were retrieved for ED attendances from 1995 to 2011, and 111 696 heart and respiratory rates were extracted for inclusion in the analysis. Graphical comparison demonstrates that with heart rate, our 50th centile agrees with the results of Bonafide, is considerably higher than the Fleming centiles and fits well between the APLS reference ranges. With respiratory rate, our 50th centile was considerably lower than the comparison centiles in infants, becomes higher with increasing age and crosses the lower APLS range in infants and upper range in teenagers.ConclusionsClinicians should consider adopting these centiles when assessing acutely unwell children. APLS should review their normal values for respiratory rate in infants and teenagers.

CONCENTRATION OF THE SERUM TGF-BETA1 IN HEALTHY ADULT PEOPLE

2014 ◽  
pp. 90-93
Author(s):  
Van Tuan Nguyen ◽  
Tam Vo ◽  
Bui Bao Hoang
Keyword(s):  
Transforming Growth Factor ◽  
Healthy Adult ◽  
Age Groups ◽  
Elevated Serum ◽  
Cross Sectional Study ◽  
Healthy People ◽  
Sectional Study ◽  
Transforming Growth Factor Beta1 ◽  
Cross Sectional ◽  
And Gender

Elevated serum Transforming growth factor-beta1 (TGF-beta1) levels have been linked to tissue fibrosis including chronic kidney disease. Objectives: (1) Investigate serum TGF-beta1 levels in healthy adult people and (2) Examined the relation between serum TGF-beta1 level and gender, age, body mass index (BMI). Method: A cross-sectional study. TGF-beta1 were quantified by ELISA. Results: Levels of serum TGF-beta1 in healthy people were 13,45 ± 7,17 ng/mL mL (0,59 - 33,10 ng/mL). There are no difference of serum TGF-beta1 levels between men and women, between the age groups (<40 years, 40 to < 60 years and ≥ 60 years), between BMI groups < 23 and BMI group ≥ 23. Key words: TGF-beta1, healthy people

scholarly journals Reference values and factors associated with hand grip strength among older adults living in southeastern Poland

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Agnieszka Wiśniowska-Szurlej ◽  
Agnieszka Ćwirlej-Sozańska ◽  
Justyna Kilian ◽  
Natalia Wołoszyn ◽  
Bernard Sozański ◽  
...  
Keyword(s):  
Older Adults ◽  
Older People ◽  
Reference Values ◽  
Handgrip Strength ◽  
Age Groups ◽  
Cross Sectional Study ◽  
Normative Values ◽  
Dominant Hand ◽  
Cross Sectional ◽  
Factors Associated

AbstractHandgrip strength (HGS) is used as a biomarker for the state of health of older people, but the number of research publications containing the normative values of HGS in older adult populations is limited. The aim of the study was to define reference values and factors associated with HGS in older adults living in southeastern Poland. A cross-sectional study including 405 participants aged 65 and older was conducted. Handgrip strength for the dominant hand was assessed by the average of three trials using a JAMAR dynamometer. The sample was categorized into the following age groups: 65–69 years, 70–74 years, 75–79 years, 80–84 years, 85 and over. The average HGS was 19.98 kg (16.91 kg for women and 26.19 kg for men). There was a decrease in handgrip strength across the age range in both sexes. The average handgrip strength of the older people was 17.97 kg (14.47 kg for women and 25.66 kg for men) for those aged 80–85 and 16.68 kg (13.51 kg for women and 21.77 kg for men) in the group over 85 years old. In both sexes, marital status was an independent factor associated with reduced handgrip strength. In conclusion, this study described, for the first time, handgrip strength values for the southeastern Polish population aged ≥ 65 years according to age and gender.

scholarly journals Seroprevalence of hepatitis E virus in risk populations and blood donors in a referral hospital in the south of Brazil

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marisa Boff Costa ◽  
Michele Soares Gomes Gouvêa ◽  
Samira Chuffi ◽  
Gustavo Hirata Dellavia ◽  
Felipe Ornel ◽  
...  
Keyword(s):  
Low Income ◽  
Hepatitis E Virus ◽  
Blood Donors ◽  
Total Sample ◽  
Hepatitis E ◽  
Cross Sectional Study ◽  
Elisa Test ◽  
Confirmatory Test ◽  
Cross Sectional ◽  
Populations At Risk

AbstractThe prevalence of anti-hepatitis E virus (HEV) antibodies has a high heterogeneity worldwide. South American data are still scarce. The aim of this study was to evaluate the prevalence of HEV in populations at risk in comparison to blood donors (BD). A cross-sectional study was carried out in adults of different risk populations including crack users (CK), residents in a low income area (LIA), cirrhotic (CIR) and liver transplant patients (LT) compared with BD. The WANTAI HEV ELISA test was used and real-time PCR (in-house for screening and ALTONA as confirmatory test) for HEV RNA screening. A total of 400 participants were included. Anti-HEV IgG was positive in 19.5% of the total sample, reaching the highest rate in the CIR group, 22.5%, followed by CK, LT, and LIA (20%, 18.7%, and 17.5%, respectively). The prevalence found in BD individuals was of 18.7% (p = NS). Anti-HEV IgM was positive in only 1.5% of the sample (6/400). No blood or stools samples were positive for HEV RNA. The seroprevalence reported is among the highest rates ever found in Brazil. Considering the intense diagnostic investigation, data show that HEV circulation is more common that might be expected in our country.

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