Determining Safe Levels of Mycotoxins

1984 ◽  
Vol 47 (7) ◽  
pp. 570-575 ◽  
Author(s):  
PAT B. HAMILTON
Keyword(s):  
Data Base ◽  
Field Data ◽  
Laboratory Data ◽  
Epidemiological Studies ◽  
Animal Experimentation ◽  
Laboratory Studies ◽  
Safe Level ◽  
Subjective Evaluations ◽  
Increasing Risk

The establishing of safe levels of mycotoxins to date has been a legal rather than scientific exercise. This has resulted in levels which have varied in response to economic and political pressures. The data base for rationally determining safe levels is very small. This has resulted in subjective evaluations of the worth of different studies in attempts to deduce safe levels from experiments designed to demonstrate effects, and in assumed safe levels which vary from field experiences. Using physiological parameters other than growth as criteria of safety, known deleterious interactions of mycotoxins with other factors, and statistical corrections for inadequate numbers of animals tested, permit better agreement between safe levels determined from laboratory data and from field data. However, the number of animals required makes impractical the laboratory determination of truly safe levels. Well-conceived and executed epidemiological studies coupled with laboratory studies designed to elaborate underlying principles appear to be the best approach to determining safe levels of mycotoxins. Until safe levels are based on sound animal experimentation, the prudent person would assume there is no truly safe level and that increasing levels of mycotoxins carry increasing risk.

Porcellio spinicornis Say (Isopoda) demography. II. A comparison between field and laboratory data

1976 ◽  
Vol 54 (6) ◽  
pp. 825-842 ◽  
Author(s):  
Donald J. McQueen
Keyword(s):  
Field Data ◽  
Laboratory Data ◽  
Field Population ◽  
Laboratory Studies ◽  
The Third ◽  
Terrestrial Isopod ◽  
Independent Laboratory ◽  
Demographic Study ◽  
June July ◽  
Rates Of Growth

Field data from a demographic study of the terrestrial isopod Porcellio spinicornis Say were analyzed and compared with laboratory data reported by McQueen and Carnio. On the study area, which covered 482.8 m2, it was observed that reproduction began when average temperatures were > 13 °C, and that about 86% of the individuals produced one brood and about 30% produced two broods. During 1972, 25 654 offspring were produced and during 1973, 27 664 offspring resulted from reproduction, which took place during May, June, July, and August. By October of both years, these animals attained sizes ranging from 10 to 30 mg and exhibited 42 to 47% survivorship. During the next summer, females grew to between 30 and 50 mg and males to between 20 and 40 mg, and survivorship ranged from 15% in May to 2% in August. During the third summer, females attained sizes ranging from 80 to 100 mg and males from 40 to 70 mg. Survivorship during this period ranged from 1% in May to 0% in August. All rates of growth, reproduction, and survival, as well as reproductive periodicity, agreed with independent laboratory studies conducted under controlled conditions. During the 3 years studied the field population remained relatively constant and appeared to be limited by temperature conditions.

Laboratory data base for isomer-specific determination of polychlorinated biphenyls

1984 ◽  
Vol 56 (8) ◽  
pp. 1303-1308 ◽  
Author(s):  
Ted R. Schwartz ◽  
Randolph D. Campbell ◽  
David L. Stalling ◽  
Robert L. Little ◽  
Jimmie D. Petty ◽  
...  
Keyword(s):  
Polychlorinated Biphenyls ◽  
Data Base ◽  
Laboratory Data ◽  
Specific Determination

Using field data to evaluate the complex bridge piers scour methods

2016 ◽  
Vol 43 (3) ◽  
pp. 218-225 ◽  
Author(s):  
M.H. Jannaty ◽  
A. Eghbalzadeh ◽  
S.A. Hosseini
Keyword(s):  
Field Data ◽  
Complex Geometry ◽  
Bridge Piers ◽  
Scour Depth ◽  
Laboratory Studies ◽  
Sediment Characteristics ◽  
Pier Scour ◽  
Recorded Data

Scour is a phenomenon that causes riverbed erosion. Many laboratory studies have been conducted to identify the complex geometry of the scour mechanism and to predict its depth, and various methods have been proposed. In this study, the performance of these methods in estimating scour depth was evaluated using field data. For this purpose, scour data on the Adinan Bridge, which was destroyed as a result of the scour phenomenon and consequently rebuilt, was collected. The bridge was built with complex piers. The flow and sediment characteristics for the bridge site were determined using field measurement. Then, the pier scour was calculated using the empirical formula and the calculated values were compared with the recorded data. The results showed the inefficiency of these methods in accurately estimating the scour depth. However, the role of the components of a composite pier has not been reflected properly in the determination of scour in these methods.

Some Methodology for Appraising Contaminants in Aquatic Systems

1975 ◽  
Vol 32 (10) ◽  
pp. 1852-1859 ◽  
Author(s):  
L. L. Eberhardt
Keyword(s):  
Body Size ◽  
Kinetic Models ◽  
Field Data ◽  
Laboratory Data ◽  
Aquatic Systems ◽  
Commercial Fisheries ◽  
Small Fish ◽  
Aquatic Biota ◽  
Laboratory Studies ◽  
Mercury In Fish

Kinetic models for uptake and retention of various contaminants by aquatic biota are recommended as a useful means of summarizing and intercomparing laboratory studies, and as essential tools in analyzing field data. Some simple models are fitted to laboratory data on the uptake and retention of DDT and dieldrin by fish. The well-known relation between metabolic rate and body size is used to appraise data and concentrations of DDT, PCBs, and mercury in fish taken from lakes and oceans. Evidence suggests that uptake and retention experiments performed on small fish give very different results from those expected on individuals important in sports or commercial fisheries.

Determination of Cerebral Death in the Pediatric Intensive Care Unit

PEDIATRICS ◽  
1986 ◽  
Vol 78 (1) ◽  
pp. 107-112
Author(s):  
Beth Drake ◽  
Stephen Ashwal ◽  
Sanford Schneider
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Death ◽  
Pediatric Patients ◽  
Life Support ◽  
Clinical Course ◽  
Laboratory Data ◽  
Pediatric Intensive Care ◽  
Laboratory Studies

The clinical course, laboratory data, outcome, and autopsy findings in 61 pediatric patients with suspected brain death were reviewed. In 58% of patients, the initial EEG was isoelectric, and cerebral blood flow was absent. In six of nine children, the initial EEG, which showed activity, became isoelectric by 72 hours. In no child without demonstrable cerebral flow did flow resume in later studies. In four of five children who had initial EEG activity despite absent cerebral flow, an isoelectric EEG developed on repeated study. The average time from initial insult until clinically suspected brain death was 29.5 hours and 61.5 hours until brain death was confirmed. The time from confirmation of brain death until discontinuation of life support systems was 32 hours in the majority of patients. Our current protocol for evaluating pediatric patients with suspected brain death is reviewed with emphasis on the clinical examination, laboratory studies, and use of serial EEGs and radionuclide cerebral blood flow determinations.

Role of laboratory studies in diagnostics of rare diseases. «Hair cellular leukemia»

2021 ◽  
pp. 66-69
Author(s):  
Tatyana Vladimirovna Krugova
Keyword(s):  
Laboratory Data ◽  
Laboratory Research ◽  
Laboratory Studies ◽  
Medical Decisions ◽  
High Quality ◽  
High Quality Medical Care ◽  
Choice Of Therapy ◽  
Quality Medical Care

Automation of laboratory production, formalization of processes and a phased quality control system ensure sufficient reliability of laboratory data, which is of great importance for the provision of high-quality medical care. For many people, laboratory research remains the invisible side of medicine. Nevertheless, 60–70 % of all medical decisions are made based on the results of clinical and laboratory studies, from the diagnosis to the choice of therapy and the determination of the prognosis.

Mekanisme Dan Proteksi Jaminan Nasabah Pada Gadai Informal

Liquidity ◽  
2017 ◽  
Vol 6 (2) ◽  
pp. 103-109
Author(s):  
Yuri Nanda Larasati ◽  
Jafril Khalil
Keyword(s):  
Qualitative Research ◽  
Research Methods ◽  
Financial Services ◽  
Field Data ◽  
Qualitative Research Methods ◽  
Research Field ◽  
Consumer Society ◽  
Library Research ◽  
The Cost

Regulation of the financial services authority (OJK) No. 31/POJK.05/2016 on Venture had arranged that the financial services agency on the basis of the law of pledge is in coaching and supervision OJK. Yet the existence of laws – invitation to Governing Enterprise pawn shops causing business activities conducted by the above parties are not yet regulated. The condition is feared could cause harm to the consumer society. The purpose of this research is to know the procedures, mechanisms, protection of goods and guarantee the consumer on an informal pledge financing, methods of determination of the cost of maintenance of the goods and the goods of the execution mechanism of the pledge as well as protection for the collateral items are viewed from the side of the consumer by looking at laws-invitations and Sharia. To find out whether the pledge have gotten permission from OJK. This research uses qualitative research methods with the study of library research, field data and simulations. The approach used in this study is the empirical juridical approach. Elaboration upon the results is discussed further in this article.

scholarly journals Determination of amino acids in human biological fluids by high-performance liquid chromatography: critical review

Amino Acids ◽  
2021 ◽  
Author(s):  
Grażyna Gałęzowska ◽  
Joanna Ratajczyk ◽  
Lidia Wolska
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
High Performance ◽  
Hplc Analysis ◽  
Limit Of Detection ◽  
Biological Fluids ◽  
Analytical Techniques ◽  
Epidemiological Studies ◽  
Preparation Conditions

AbstractThe quantitation and qualification of amino acids are most commonly used in clinical and epidemiological studies, and provide an excellent way of monitoring compounds in human fluids which have not been monitored previously, to prevent some diseases. Because of this, it is not surprising that scientific interest in evaluating these compounds has resurfaced in recent years and has precipitated the development of a multitude of new analytical techniques. This review considers recent developments in HPLC analytics on the basis of publications from the last few years. It helps to update and systematize knowledge in this area. Particular attention is paid to the progress of analytical methods, pointing out the advantages and drawbacks of the various techniques used for the preparation, separation and determination of amino acids. Depending on the type of sample, the preparation conditions for HPLC analysis change. For this reason, the review has focused on three types of samples, namely urine, blood and cerebrospinal fluid. Despite time-consuming sample preparation before HPLC analysis, an additional derivatization technique should be used, depending on the detection technique used. There are proposals for columns that are specially modified for amino acid separation without derivatization, but the limit of detection of the substance is less beneficial. In view of the fact that amino acid analyses have been performed for years and new solutions may generate increased costs, it may turn out that older proposals are much more advantageous.

scholarly journals E-cigarette Use and Respiratory Disorder: An Integrative Review of Converging Evidence from Epidemiological and Laboratory Studies

2020 ◽  
pp. 1901815
Author(s):  
Thomas A. Wills ◽  
Samir S. Soneji ◽  
Kelvin Choi ◽  
Ilona Jaspers ◽  
Elizabeth K. Tam
Keyword(s):  
Electronic Cigarettes ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Chronic Obstructive ◽  
Human Populations ◽  
Respiratory Disorder ◽  
Biological Processes ◽  
Cigarette Use ◽  
Laboratory Studies ◽  
Consistency Strength

BackgroundUse of electronic cigarettes (e-cigarettes) is prevalent among adolescents and young adults but there has been limited knowledge about health consequences in human populations. We conduct a systematic review and meta-analysis of results on respiratory disorder from studies of general-population samples and consider the mapping of these results to findings about biological processes linked to e-cigarettes in controlled laboratory studies.MethodWe conduct a literature search and meta-analysis of epidemiological studies on the association of e-cigarette use with asthma and with chronic obstructive pulmonary disease (COPD). We then discuss findings from laboratory studies about effects of e-cigarettes on four biological processes: cytotoxicity, oxidative stress/inflammation, susceptibility to infection, and genetic expression.ResultsEpidemiological studies, both cross-sectional and longitudinal, show a significant association of e-cigarette use with asthma and COPD, controlling for cigarette smoking and other covariates. For asthma (n=15 studies), the pooled adjusted odds ratio (AOR) was 1.39 (CI 1.28–1.51); for COPD (n=9 studies) the AOR was 1.49 (CI 1.36–1.65). Laboratory studies consistently show an effect of e-cigarettes on biological processes related to respiratory harm and susceptibility to illness, with e-cigarette conditions differing significantly from clean-air controls though sometimes less than for cigarettes.ConclusionsThe evidence from epidemiological studies meets established criteria for consistency, strength of effect, temporality, and in some cases a dose-response gradient. Biological plausibility is indicated by evidence from multiple laboratory studies. We conclude that e-cigarette use has consequences for asthma and COPD, which is of significant concern for respirology and public health.

Positive Association Between the Lys198 Asn Polymorphism in the Endothelin-1 and Blood Pressure in Obese Japanese Subjects: Ohasama Study

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 714-714
Author(s):  
Tomohiro Katsuya ◽  
Takayoshi Ohkubo ◽  
Yuxiao Fu ◽  
Ichiro Tsuji ◽  
Kenichi Nagai ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Level ◽  
Positive Association ◽  
Epidemiological Studies ◽  
Buffy Coat ◽  
Baseline Characteristic ◽  
Endothelin 1 ◽  
Overweight People ◽  
Obese Subjects

P117 A recent report by Tiret et al. (Hypertension 33, 1999) revealed that a G/T polymorphism with an amino acid substitution (Lys to Asn) at codon 198 in the exon 5 of endothelin 1 gene (ET1) is associated with blood pressure in overweight people using two epidemiological studies, ECTIM and Glasgow Heart Scan Study. They suggested that G/T polymorphism strongly interacted with body mass index (BMI) in the determination of blood pressure levels. To examine the interaction among G/T polymorphism of ET1, BMI and blood pressure, we carried out an association study using a general population. Subjects (n=1,446) were recruited from Ohasama population, which is a cohort in a rural community of northern Japan. The research protocol was approved by the Institutional Review Board of the Tohoku University. DNA was extracted from the buffy coat of the participants using QIAamp DNA Blood Kit (Qiagen Inc.). G/T polymorphism of ET1 was determined by TaqMan PCR method, which is a powerful tool for semiautomatic genotype determination in a large number of samples. The frequency of T198 allele in Japanese (26%) was significantly higher than that in Caucasians (23%). The baseline characteristic (age, BMI, SBP, DBP, antihypertensive treatment) of all subjects was not significantly different according to the genotype of G/T polymorphism. In the obese subjects (≥25kg/m2), however, SBP and DBP were significantly associated with G/T polymorphism. Blood pressure level in the subjects carrying T198 allele was 2.6 mmHg in systolic (p<0.02) and 2.3 mmHg in diastolic (p<0.005) higher than that in those with GG genotype in overweight people. That the same result was obtained from different races suggested that the T198 allele of ET1 is involved in the determination of blood pressure levels in obese subjects.

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