scholarly journals IMMUNOLOGICAL FEATURES IN CHILDREN WITH HEMORRHAGIC VASCULITIS

2021 ◽  
Vol 0 (1) ◽  
pp. 85-95
Author(s):  
Darya B. Nizheharodava ◽  
◽  
Galina M. Batsian ◽  
Mariya Yu. Yurkevich ◽  
Marina M. Zafranskaya ◽  
...  
Keyword(s):  
Chronic Infection ◽  
Age Groups ◽  
Antineutrophil Cytoplasmic Antibodies ◽  
Disease Course ◽  
High Ability ◽  
Functional Changes ◽  
Functional Features ◽  
Cellular And Humoral Immunity ◽  
Further Development ◽  
Activation Capacity

Currently the incidence of hemorrhagic vasculitis in children is characterized by an increase in all age groups what may be associated with environmental problems, chronic infection as well as food and drugs allergy. To date there are no biomarkers predicting the further development of hemorrhagic exanthema at the onset of the disease and followed its outcome. The quantitative and functional features of cellular and humoral immunity in children with hemorrhagic vasculitis of various origins accompanied by hemorrhagic exanthema at the onset of the disease are presented in this article. The reduction of γδТ-cells number in the peripheral blood correlated with levels of specific antineutrophil cytoplasmic antibodies and IgG EBNA-1 antibodies against a high ability of γδТ-cells to activation were established in children with systemic (immunocomplex) vasculitis. At the contrast, the background of a normal γδT-lymphocytes’ content was associated with the decrease in γδТ-cells activation capacity in children with hemorrhagic vasculitis of infectious-allergic genesis. Thus, quantitative and functional changes in γδТ-lymphocytes can be a potential labor biomarker for early diagnosis of systemic or infectious-allergic hemorrhagic vasculitis in children what may be used for the further disease course prediction.

scholarly journals Parosteal Osteosarcoma with Pancreatic Metastasis and Multiple Relapses: A Case Report and Review of the Literature

2021 ◽  
pp. 983-988
Author(s):  
Daniel Cirotski ◽  
Jyoti Panicker
Keyword(s):  
Age Groups ◽  
Bone Cancer ◽  
Pancreatic Metastasis ◽  
Low Grade ◽  
Parosteal Osteosarcoma ◽  
Disease Course ◽  
Review Of The Literature ◽  
Histologic Subtype ◽  
Primary Bone ◽  
Multiple Relapses

Osteosarcoma is the most common primary bone cancer in all age groups. Metastasis mostly occurs with high-grade tumors disseminating to the lungs and other bones. Spread to the pancreas is rare and undocumented in the low-grade subtypes. Additionally, it is uncommon for the disease course of low-grade subtypes to involve multiple relapses. We present a 35-year-old woman with parosteal osteosarcoma who has experienced an atypical metastasis to the pancreas as well as multiple local and pulmonary relapses. The lesion was identified incidentally on routine imaging, and the patient underwent resection. We compare our case to the other reports of pancreatic metastasis in the literature. Despite being especially rare, clinicians ought to be aware of pancreatic metastasis of osteosarcoma. Furthermore, despite parosteal osteosarcoma’s less aggressive disease course, it can uncommonly lead to multiple relapses. We present a rare case exemplifying these phenomena in the prognostically favorable histologic subtype of parosteal osteosarcoma.

The effects of Fasciola hepatica on Lymnaea truncatula

Parasitology ◽  
1972 ◽  
Vol 65 (2) ◽  
pp. 359-369 ◽  
Author(s):  
J. K. M. Hodasi
Keyword(s):  
Rapid Growth ◽  
Egg Production ◽  
Fasciola Hepatica ◽  
Age Groups ◽  
Sharp Decline ◽  
General Belief ◽  
Functional Changes ◽  
Complete Cessation ◽  
Lymnaea Truncatula ◽  
Accelerated Growth

Among the functional changes observed in L. truncatula infected with F. hepatica were those of growth, reproduction and mortality. For the first 3 weeks after infection there was no difference between the growth of infected and uninfected groups of snails. Thereafter there was a temporary accelerated growth which occurred between the fourth and seventh weeks after infection. The onset of this period of rapid growth in the different age groups of infected snails coincided with the time of migration of the rediae into the hepatopancreas. Of more significance was the influence of infection on the reproduction of the snail. There was a sharp decline in oviposition 2–3 weeks after infection, followed by a complete cessation of egg production at the end of the fifth week. Once oviposition ceased, it was not resumed and there was no self-cure. Contrary to general belief, infected groups of L. truncatula have been found to live longer than the uninfected controls. With isolated snails, however, there was a tendency for the uninfected snails to live longer than the infected ones. The possible interpretation of the discrepancies between isolated and mass cultured snails are discussed. The hepatopancreas and the gonad (ovotestis) were the two structures directly affected by the infection. Establishment of the rediae in the hepatopancreas invariably resulted in parasitic castration.

scholarly journals CAN STATURE, ABDOMINAL PERIMETER AND BMI INDEX PREDICT POSSIBLE CARDIOMETABOLIC RISKS IN FUTURE OBESITY?

2020 ◽  
Vol 33 (2) ◽  
Author(s):  
Ricardo Wallace das Chagas LUCAS ◽  
Paulo Afonso Nunes NASSIF ◽  
Fernando Issamu TABUSHI ◽  
Denise Serpa Bopp NASSIF ◽  
Bruno Luiz ARIEDE ◽  
...  
Keyword(s):  
Age Groups ◽  
Abdominal Circumference ◽  
Fat Percentage ◽  
Height Measurement ◽  
Men And Women ◽  
Functional Changes ◽  
Abdominal Perimeter ◽  
Cardiometabolic Risks ◽  
The Aesthetic ◽  
The Individual

ABSTRACT Background: Obesity changes the anatomy of the patient. In addition to the aesthetic change, the high percentage of fat determines evident functional changes. Anthropometric normality in measuring abdominal circumference and height can serve as a basis for measuring cardiometabolic risks of obesity. Aim: To verify if it is possible to determine parameters of normality between waist and height in people with normal BMI and fat percentages, to serve as a basis for assessing risks for obesity comorbidities. Methods: A sample of 454 individuals with BMI and percentages of fat considered within the normal range was extracted. It was divided into age groups for both men and women between 18 and 25; 26 to 35; 36 to 45; 46 to 55; 56 to 65. A total of 249 men and 205 women were included. Results: Regarding the percentage of height as a measure of the abdominal perimeter, the total female sample had an average of 44.2±1.1% and the male 45.3%+1.5. For women, this percentage determined the equation of the waist-height ratio represented by X=(age+217) / 5.875, and for men X=(age+190.89) / 5.2222. “X” represents the percentage of the height measurement so that the individual falls into the category of adequate percentage of fat and BMI. Conclusion: Between the stature of adult men and women with normal fat percentage and BMI, there is a common numerical relationship, with is on average 44% for women and 45% for men.

scholarly journals Physiological adaptation of modern Ukrainian preschoolers

2013 ◽  
Vol 7 (4) ◽  
pp. 4-9
Author(s):  
Olha Fedortsiv ◽  
Nataliia Luchyshyn
Keyword(s):  
Cardiovascular System ◽  
Developmental Disorders ◽  
Age Groups ◽  
Individual Development ◽  
Physiological Adaptation ◽  
Rate Pressure Product ◽  
Noninvasive Methods ◽  
Functional Changes ◽  
Physical Burden ◽  
System Functioning

Introduction: High demands of modern social environment to the child’s individual development are connected with their health decline and wide variation of individual capabilities. Because of such inconsistency decreased functional abilities are being observed in preschoolers. It leads mainly to health problems and developmental disorders. Body adaptive properties are considered to be the integral indicator of health. Researches find high prevalence of the lack of adaptation among children of different age groups which might lead to low quality of life.Aim of the study: The aim of the research was to estimate preschooler’s cardiovascular system functioning and the adaptation abilities based on the examples of children from Tarnopol, Ukraine.Material and methods: 170 healthy preschoolers were among the participants of the research. Anthropometry and the assessment of some hemodynamic parameters were performed to draw conclusions about the level of their cardiovascular capacity.Results: Only 54.7% of the examined children reflect the satisfactory level of cardiovascular system adaptation. The deviations mainly result from high BMI, Rate Pressure Product and abnormal reaction of the autonomic nervous system after a squatting test.Conclusions: Simple noninvasive methods (functional changes index, pulse rate and blood pressure and the indicator of arteries’ pressure) help to identify children with reduced circulatory response to stress and physical burden.

Functional maturation of tactile sensory fibers in the kitten

1984 ◽  
Vol 52 (1) ◽  
pp. 74-85 ◽  
Author(s):  
D. G. Ferrington ◽  
M. O. Hora ◽  
M. J. Rowe
Keyword(s):  
Age Groups ◽  
Postnatal Period ◽  
High Frequencies ◽  
Functional Changes ◽  
Functional Maturation ◽  
Tactile Stimuli ◽  
Adult Cats ◽  
Skin Indentation ◽  
Sensory Fibers ◽  
Cutaneous Vibration

The maturation of tactile coding capacities was investigated in sensory fibers supplying the forelimb footpads in anesthetized kittens. Fibers were isolated by microdissection from the median or ulnar nerves of neonatal kittens (1st to 5th postnatal day) and kittens in the age categories 10-15, 25-30, 55-63, and 83-90 days. The use of quantitative, reproducible tactile stimuli, in particular, cutaneous vibration, and objective analytical procedures enabled response parameters to be quantified and compared at different ages with those of adult fibers. While three classes of myelinated tactile sensory fibers are associated with the footpads in adult cats, one of them slowly adapting (SA) and two, the rapidly adapting (RA) and pacinian corpuscle (PC) classes, showing pure dynamic sensitivity, this breakdown into three classes is not apparent until 10-15 days after birth. In all age groups, the SA fibers displayed responses that were graded depending on the magnitude of the skin indentation. However, in younger kittens (less than 25-30 days) plateau levels of response were sometimes attained over a narrow range (0.5 mm) of indentation. From 10-15 days, when RA fibers are identifiable, their sensitivity, as measured by absolute and 1:1 thresholds to cutaneous vibration, was independent of age at low vibration frequencies, less than or equal to 80 Hz. However, at high frequencies, e.g., 200 Hz, their thresholds appeared to decrease during the 1st postnatal month with a resulting expansion in their bandwidth of vibratory sensitivity. At their best frequency, around 30 Hz, RA fibers appear mature by 10-15 days in their capacity for encoding vibratory frequency information. The PC class of tactile afferents displayed the most striking functional changes with age. Their vibratory bandwidths, at 50-micron amplitude, expand from an upper limit of about 200-300 Hz in the neonate to mature values of about 800-1,000 Hz over a 2-mo postnatal period.(ABSTRACT TRUNCATED AT 400 WORDS)

scholarly journals Aortae of Young Rats with Metabolic Syndrome Exhibit Enhanced Vasoconstrictor Activity Than Older Rats

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
R H Ali ◽  
N M B Gamil ◽  
A M Abdelrahman ◽  
M A Ahmed ◽  
G K Megahed ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Young Adult ◽  
Fasting Blood Glucose ◽  
Age Groups ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Functional Changes ◽  
Vasoconstrictor Response ◽  
Nitrite Content

Abstract Background Metabolic syndrome (MetS) causes pathological remodeling of the heart and adjacent vessels. The functional changes in the big vessels in different age groups had not been fully delineated. Aim of the work The present study was planned to investigate aortic vasodilator and vasoconstrictor reactivity in young, adult and old female rats with MetS. Design: The experimental study was performed on 90 female albino rats randomized into 6 groups: young, adult and old rats with MetS and their respective control groups. Methods MetS was induced by feeding rats 41% fructose -containing diet and giving fructose solution (5 g fructose in 4 ml distilled water/day) by gavage in two sessions (2 ml/session). On the 8th week, all rats were sacrificed and were subjected to determination of body weight (BW), body mass index (BMI), absolute and relative visceral fat weight (VF), fasting blood glucose (FBG), plasma insulin (PI), homeostasis model of insulin resistance (HOMA-IR) and plasma lipid profile. All rats’ aortae were subjected to study of vascular reactivity to Potassium chloride (KCL), phenylephrine (PE) and acetyl choline (A.Ch) as well as estimation of nitrite content. Results On the 8th week of the study, all MetS groups developed criteria of metabolic syndrome as evidenced by the significant increase in final BW, BMI, absolute and relative VF weights, FBG, PI and HOMA-IR compared to their control group values. Also, MetS rat groups exhibited evident dyslipidemia in the form of significant increase in plasma levels of triglycerides, total cholesterol and significant decrease in HDL-cholesterol compared to their control group values. Aortae of young and adult MetS rat groups showed significant increase in their vasoconstrictor response to KCl and PE and decrease in A.Ch/KCL% and A.Ch/PE % compared to their controls, while old MetS rat group showed significantly increased vasoconstrictor response only to KCL compared to their controls. When compared to each other, young age MetS group had significantly higher vasoconstrictor response to PE compared to old MetS group despite comparable nitrite content. Conclusion Met.S causes functional vascular changes in all age groups with unexpectedly enhanced vasoconstrictor response in the young group compared to old.

Rapidly progressive course of very late onset multiple sclerosis presenting with Parkinsonism: case report

2010 ◽  
Vol 17 (2) ◽  
pp. 245-249 ◽  
Author(s):  
T Schultheiss ◽  
H Reichmann ◽  
T Ziemssen
Keyword(s):  
Multiple Sclerosis ◽  
Potential Benefit ◽  
Late Onset ◽  
Age Groups ◽  
Treatment Strategies ◽  
Disease Course ◽  
Spastic Paraplegia ◽  
Diagnostic Challenge ◽  
Progressive Course ◽  
Neuroprotective Therapies

Multiple sclerosis mainly affects young adolescents, making late-onset multiple sclerosis a rarity and diagnostic challenge, particularly for cases after age 80 years. We present an 82-year-old patient with multiple sclerosis with very late onset. As well as spastic paraplegia, additional Parkinsonism secondary to demyelination in the basal ganglia was observed in this case. In most publications, spinal cord lesions were more common in late-onset multiple sclerosis which, in contrast, could not be found in our case. Despite different treatment strategies, rapid clinical deterioration and death after about 2 years of disease course occurred. Further discrimination in late-onset multiple sclerosis (50–70 years) and multiple sclerosis with very late onset (above 70 years) might be considered. Future trials to elucidate potential benefit of immunosuppressive (and neuroprotective) therapies in these age groups are mandatory.

scholarly journals Stimulus transformation into motor action: dynamic graph analysis reveals a posterior-to-anterior shift in brain network communication of older subjects

2020 ◽  
Author(s):  
Nils Rosjat ◽  
Bin A. Wang ◽  
Liqing Liu ◽  
Gereon R. Fink ◽  
Silvia Daun
Keyword(s):  
Age Groups ◽  
Brain Network ◽  
Hemispheric Lateralization ◽  
Dynamic Graph ◽  
Movement Initiation ◽  
Motor Action ◽  
Low Frequencies ◽  
Functional Changes ◽  
Age Related ◽  
Older Subjects

AbstractCognitive performance slows down with increasing age. This includes cognitive processes that are essential for the performance of a motor act, such as the slowing down in response to an external stimulus. The objective of this study was to identify aging-associated functional changes in the brain networks that are involved in the transformation of external stimuli into motor action. To investigate this topic, we employed dynamic graphs based on phase-locking of Electroencephalography signals recorded from healthy younger and older subjects while performing a simple visually-cued finger-tapping task. The network analysis yielded specific age-related network structures varying in time in the low frequencies (2-7 Hz), which are closely connected to stimulus processing, movement initiation and execution in both age groups. The networks in older subjects, however, contained several additional, particularly interhemispheric, connections and showed an overall increased coupling density. Cluster analyses revealed reduced variability of the subnetworks in older subjects, particularly during movement preparation. In younger subjects, occipital, parietal, sensorimotor and central regions were - temporally arranged in this order - heavily involved in hub nodes. Whereas in older subjects, a hub in frontal regions preceded the noticeably delayed occurrence of sensorimotor hubs, indicating different neural information processing in older subjects.All observed changes in brain network organization, which are based on neural synchronization in the low frequencies, provide a possible neural mechanism underlying previous fMRI data, which report an overactivation, especially in the prefrontal and pre-motor areas, associated with a loss of hemispheric lateralization in older subjects.

scholarly journals Indicators of dental incidence in older populations

2021 ◽  
Vol 25 (1) ◽  
pp. 23-28
Author(s):  
Anastasia S. Kozhokar ◽  
Sergey V. Kuznetsov ◽  
Arina S. Podkhvatilina ◽  
Andrey E. Bratus ◽  
Yuriy O. Paramonov ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Periodontal Diseases ◽  
Age Groups ◽  
Older Age ◽  
World Health ◽  
Special Treatment ◽  
Oral Diseases ◽  
Functional Changes ◽  
Dental Examination ◽  
Dental Diseases

BACKGROUND: The study of dental problems characteristic of geriatric patients is becoming increasingly relevant. As a person ages, the entire dental system undergoes physiological and functional changes. To eliminate the adverse effects of oral diseases, prolong the period of remission, preventive measures, constant monitoring of the level of hygiene, dispensary supervision of elderly and senile persons are necessary. AIM: This study aimed to determine the prevalence and intensity of dental diseases in the following older age groups: young elderly (6574 years old), old elderly (7584 years old), and very old elderly (85 years old and older). MATERIALS AND METHODS: A dental examination of 183 patients was carried out using a modified card for assessing the state of the dental status, according to guidelines of the World Health Organization. RESULTS: Analysis of dental morbidity in the older age group showed that the most common dental diseases in this group were extractions of lossened teeth caused by caries and periodontal diseases. Following a comprehensive dental examination of elderly patients and people with senility, the intensity of KPU and OHI-S was 19.760.52 and 2.710.12, respec-tively, and this indicates the poor hygienic state of the oral cavity of this population. CONCLUSION: Data support the untimeliness and inadequacy of dental care in elderly patients and people with senility. This necessitates the development of special treatment and prophylactic programs for this population, aimed at reducing dental morbidity.

scholarly journals Design of the designershoes with the use of innovative technologies

2020 ◽  
Vol 80 (4) ◽  
pp. 115-121
Author(s):  
J. Mazina ◽  
◽  
L. Shokorova ◽  
I. Chechevatkin ◽  
Keyword(s):  
Experimental Models ◽  
Age Group ◽  
Technical Data ◽  
Innovative Technologies ◽  
Wide Range ◽  
Rational Understanding ◽  
Functional Features ◽  
Smart Things ◽  
Constituent Elements ◽  
Further Development

The article discusses methods for creating smart things, using the example of the use of innovative technologies in the field of materials for clothing and footwear. The factors of form formation are substantiated by the example of the preferences of an individual customer who forms its image through accessories and shoes. The author considers the factors of shaping, based on the special functional features of shoes in connection with ergonomic factors. The designer is able to foresee the factor of transformability in modern footwear, changes in functional qualities, appearance, and design features of new footwear. As a result, on the basis of these transformations, to get a new emotional image and a new form. The shape of the shoe becomes a factor for transformations at the request of the customer. The article discusses the functional tasks of this shoe, plastic characteristics, technical and design tasks. As research methods, the article proposes variants of experimental models with possible stages of transformation, presents preliminary technical data, conducts a comparative analysis with innovative footwear samples of famous world designers, and makes assumptions about the development of this model in the future. An experimental method was used during the study. A shoe shape was developed, which took into account the preferences of the age group of 12-16 years old, relying on this category of consumers, we were able to go beyond the rational understanding of shoes as a functional form and gave it the meaning of a fantastic image, which allowed us to consider the form in the semantic and artistic context dictated by this age group of consumers. In addition, investing in this model the concept of "smart shoes", we considered not only the ability of modification and transformation by rearranging replaceable parts, the possibility of designing and reincarnating from one form to another, combining the constituent elements of the shoe into one whole, but also the development of the creative potential of the consumer, who at its own discretion can rebuild the structure and, in fact, as a designer itself, form a new model. The article makes assumptions about its further development in various fields of activity. For example, medicine, sports, art, etc. Considering the introduction of new materials, we relied on discoveries in the field of nanotechnology and considered among the possible features of this model the change in color on the basis, the reaction of materials to light, temperature, etc. The project is aimed at creating such shoes that will be developed for a wide range of consumers thanks to the wide range of possibilities contained in the design of the form and the features of modern materials.

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