Physicochemical Properties and Antimicrobial Potential of Green Synthesized Cerium Oxide (CeO2) Nanoparticles from Pomegranate Peel Extract

2021 ◽  
Vol 14 (1) ◽  
pp. 71-78
Keyword(s):  
Antimicrobial Activity ◽  
Biomedical Applications ◽  
Punica Granatum ◽  
Ceo2 Nanoparticles ◽  
X Ray Diffraction ◽  
Fruit Peel ◽  
Pomegranate Peel ◽  
X Ray ◽  
Pomegranate Peel Extract ◽  
Peel Extract

Abstract: Green synthesis of CeO2 Nanoparticles (NPs) with small size and high stability paved the approach to recover and protect the environment by decreasing the use of toxic chemicals and eliminating biological risks in biomedical applications. Peel-mediated synthesis of CeO2 NPs is gaining more importance owing to its easiness and eco-friendliness. In this study, biosynthesis of CeO2 NPs using the fruit peel extract of punica granatum is reported. The synthesized CeO2 NPs are characterized by Powder X-ray Diffraction (PXRD), UV-Diffused Reflection Spectroscopy (UV-DRS), Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-Ray Analysis (EDAX) and antimicrobial activity. The CeO2 NPs show more lethal activity towards gram +ve bacteria than towards gram –ve bacteria. Keywords: Biosynthesis, Optical properties, Antimicrobial activity.

An aqueous pomegranate peel extract (Punica granatum) protect against Elastase-induced pulmonary emphysema in Sprague Dawley rats model

2021 ◽  
Vol 57 ◽  
Author(s):  
Zioud Fatma ◽  
Martín-Barrasa Jose Luis ◽  
Espinosa De Los Monteros Y Zaya Antonio ◽  
Santana Reyes Laura ◽  
Herráez Thomas Pherraez ◽  
...  
Keyword(s):  
Pulmonary Emphysema ◽  
Punica Granatum ◽  
Sprague Dawley ◽  
Pomegranate Peel ◽  
Sprague Dawley Rats ◽  
Pomegranate Peel Extract ◽  
Peel Extract

scholarly journals Krim ekstrak kulit delima merah (Punica granatum) menghambat peningkatan jumlah melanin sama efektifnya dengan krim hidrokuinon pada kulit marmut (Cavia porcellus) betina yang dipapar sinar UVB

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Eva R. Siahaan ◽  
Wimpie Pangkahila ◽  
A A G P Wiraguna
Keyword(s):  
Guinea Pigs ◽  
Punica Granatum ◽  
Control Group ◽  
Cavia Porcellus ◽  
Pomegranate Peel ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Pomegranate Peel Extract ◽  
Peel Extract

Abstract: As the outer organ of the body, skin becomes the main target of environmental influences, particularly the UVB rays. Based on analysis of phytochemicals, red pomegranate peel extract contains antioxidants such as flavonoids, phenols, tannins, and vitamin C which are able to prevent increased skin melanin by inhibiting the actions of tyrosinase. This study was aimed to prove that application of 8% red pomegranate peel extract (Punica granatum) cream could prevent the increase of skin melanin in female guinea pigs (Cavia porcellus) exposed to UVB as well as to prove that the 8% red pomegranate peel extract cream was as effective as 4% hydroquinone cream in preventing increased skin melanin. This was a true experimental study using post test only control group design. Subjects were divided into three groups, with 10 guinea pigs each group. Group 1, the control group, was treated with UVB exposure and basic cream. Group 2 was treated with UVB exposure and 4% hydroquinone cream. Group 3 was treated with UVB and 8% red pomegranate peel extract cream. A total of 390 mJ/cm UVB dosage was given for 2 weeks. Histopahtologic slides were stained with Masson-Fontana. The amount of melanin area colored in black was evaluated by the percentage of pixel areas of melanin compared with pixel areas of all epidermal tissues. The results showed that the highest amount of melanin was in group 1 (18.13±4.76%), followed by group 3 (1.876±0.73%), and group 2 as the lowest (0.67±0.291%). There was a significant difference between control group and group 2 as s well as group 3 (P <0.05). There was no significant difference between group 2 and group 3 (P >0.05). Conclusion: Application of 8% red pomegranate peel extract (Punica granatum) cream could prevent the increase of skin melanin in guinea pigs (Cavia porcellus) exposed to UVB. The 8% red pomegranate peel extract cream was as effective as 4% hydroquinone cream in preventing increased skin melanin.Keywords: red pomegranate peel extract, melanin, skin, UVBAbstrak: Sebagai organ terluar dari tubuh, kulit menjadi target utama dari pengaruh lingkungan, terutama oleh sinar UVB. Berdasarkan analisis fitokimia, ekstrak kulit delima merah memiliki kandungan antioksidan seperti flavonoid fenol, tanin, dan vitamin C yang mampu mencegah peningkatan jumlah melanin dengan cara menghambat kerja enzim tirosinase. Penelitian ini bertujuan untuk membuktikan efek pemberian krim ekstrak kulit delima merah (Punica granatum) 8% dalam menghambat peningkatan jumlah melanin pada kulit marmut (Cavia porcellus) betina yang dipapar sinar UVB dan krim ekstrak kulit delima merah (Punica granatum) 8% memiliki efektivitas yang sama dengan krim hidrokuinon 4% dalam menghambat peningkatan jumlah melanin tersebut. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Subyek penelitian dibagi menjadi tiga kelompok, masing-masing berjumlah 10 ekor marmut betina. Kelompok 1 (kontrol) diberikan pajanan sinar UVB dan krim dasar; kelompok 2 diberikan paparan sinar UVB dan krim hidrokuinon 4%; dan kelompok 3diberikan pajanan sinar UVB dan krim ekstrak kulit delima merah 8%. Dosis total UVB 390 mJ/cm2 yang diberikan selama 2 minggu. Sediaan histopatologik jaringan kulit menggunakan pewarnaan Masson-Fontana. Jumlah melanin dihitung dengan persentase pixel luas area melanin dibandingkan pixel seluruh jaringan epidermis. Hasil penelitian menunjukkan bahwa jumlah melanin paling tinggi terdapat pada kelompok 1 (18,13±4,76%), diikuti kelompok 3 (1,876±0,73%), dan paling rendah pada kelompok 2 (0,67±0,291%). Terdapat perbedaan bermakna antara kelompok 1 dengan kelompok 2 dan 3 (P <0,05) sedangkan antara kelompok 2 dan 3 tidak berbeda bermakna dalam mencegah peningkatan jumlah melanin (P >0,05). Simpulan: Krim ekstrak kulit delima merah (Punica granatum) 8% dapat menghambat peningkatan jumlah melanin pada kulit marmut (Cavia porcellus) betina. Krim ekstrak kulit delima merah (Punica granatum) 8% sama efektif dengan krim hidrokuinon 4% dalam menghambat peningkatan jumlah melanin pada kulit marmut.Kata kunci: kulit delima merah, melanin, kulit, UVB, marmut betina.

scholarly journals Pengaruh Polivinilpirolidon sebagai Polimer Mukoadhesif terhadap Sifat Fisik Patch Ekstrak Kulit Buah Delima (Punica granatum L.)

2020 ◽  
Vol 1 (2) ◽  
pp. 85
Author(s):  
Rahmat A Hi Wahid
Keyword(s):  
Active Substance ◽  
Contact Time ◽  
Punica Granatum ◽  
Dosage Forms ◽  
Pomegranate Peel ◽  
Mucoadhesive Polymer ◽  
Evaluation Test ◽  
Pomegranate Peel Extract ◽  
Punica Granatum L ◽  
Peel Extract

ABSTRAKBuah delima (Punica granatum L.) secara empiris digunakan untuk mengobati masalah gigi dan mulut seperti sariawan. Pengembangan obat sariawan berbasis herbal dengan bentuk sediaan patch dilakukan untuk mempertahankan waktu kontak antara zat aktif dengan bagian sariawan. Polivinilpirolidon (PVP) digunakan sebagai polimer karena sifatnya mukoadhesif sehingga mampu berikatan pada mukosa mulut. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan PVP sebagai polimer mukoadhesif terhadap karakteristik fisik sediaan patch yang mengandung ekstrak kulit buah delima (EKBD). EKBD diperoleh dengan metode maserasi. Konsentrasi EKBD yang digunakan adalah 5% dan 10%. Sedangkan konsentrasi polimer PVP yang digunakan yaitu 30,29%, 33,04, 48,75%, dan 65,5%. Patch selanjutnya akan di evaluasi fisik yang meliputi keseragaman bobot dan dimensi ketebalan, pH permukaan, swelling, daya lekat, dan waktu lekat. Hasil menunjukkan bahwa patch yang mengandung ekstrak 10% dengan tambahan polimer konsentrasi 30,29% memiliki sifat yang cukup elastis disbanding dengan konsentrasi 48,75% dan 65,5%. Sedangkan uji evaluasi fisik menghasilkan keseragaman bobot dan dimensi yang seragam, pH 6,63, rata-rata indeks swelling 40,69% ± 16, dan rata-rata daya dan waktu lekat 13,50 ± 11,6. Dengan demikian dapat disimpulkan bahwa konsentrasi PVP terbukti berpengaruh pada sifat fisik patch yang dihasilkan. Kata kunci : Polivinilpirolidon; Ekstrak Kulit Buah Delima; Patch.ABSTRACTPomegranate (Punica granatum L.) is empirically used to treat dental and mouth problems such as reccurent aphthous stomatitis (RAS). The development of RAS  therapy based on herbal with patches dosage forms is carried out to maintain the contact time between the active substance and the RAS. Polyvinylpyrrolidone (PVP) is used as a polymer because it is mucoadhesive, so it can bind to the oral mucosa. Aimed to determine the effect of the use of PVP as a mucoadhesive polymer on the physical characteristics of patches preparations containing pomegranate peel extract (PPE). PPE was obtained by maceration method. The PPE concentration used were 5% and 10%. PVP concentration used were 30.29%, 33.04%, 48.75%, and 65.5%. The patches properties such as uniformity of thickness, pH, swelling index, tensile and mucoadhesive strength. The results showed that patches containing 10% extract and PVP concentration of 30.29% had sufficient elastic properties compared to both concentration. While the physical evaluation test obtained uniform weights and dimensions that are uniform, pH 6.63, the average swelling index is 40.69% ± 16, and the tensile and mucoadhesive strength is 13.50 ± 11.6. Altogether, the concentration of PVP is proven to affect the physical properties of the resulting patch.Key word : Polyvinylpyrrolidone; Pomegranate Peel Extract; Patch. 

Effect of Pomegranate Peel Extract onCandida albicansGrowth and Biofilm Formation

2018 ◽  
Vol 17 (3) ◽  
pp. 120-128
Author(s):  
H. Merzouk ◽  
B. Bedja ◽  
B. Benmeziane ◽  
N. Touati ◽  
M. Chibane
Keyword(s):  
Candida Albicans ◽  
Biofilm Formation ◽  
Qualitative Assessment ◽  
Diffusion Method ◽  
Total Phenolic ◽  
Fruit Peel ◽  
Pomegranate Peel ◽  
Total Polyphenols ◽  
Pomegranate Peel Extract ◽  
Peel Extract

In the present work, we studied the potential antioxidant capacity and antibiofilm of pomegranate peel extract of two cultivars againstCandida albicansstrains. First, both pomegranate peel extracts were evaluated to determine their total phenolic and tannin contents. Their antioxidant activity was investigated using hydrogen peroxide scavenging assay. Acid fruit peel extract showed the most significant levels of total polyphenols (513.78 ± 1.552 mg GAE/g DE) and possessed the strongest antioxidant ability (96.32%). Next, the possible effect of the extracts onCandida albicansstrains was studied using agar diffusion method and subjected to various extracts concentrations. The zone sizes of growth inhibition showed clearly that these extracts had a good antifungal activity againstCandida albicansspecies in the following order: CA1 > CA3 > CA2 with minimum inhibitory concentrations (MICs) in the range 0.97–1.94 mg/ml. Images obtained by scanning electron microscopy allowed for a qualitative assessment of the biofilm reduction.

scholarly journals Pomegranate (Punica granatum) Peel Extract as a Green Corrosion Inhibitor for Mild Steel in Hydrochloric Acid Solution

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Habib Ashassi-Sorkhabi ◽  
Shoja Mirzaee ◽  
Taghi Rostamikia ◽  
Robabeh Bagheri
Keyword(s):  
Hydrochloric Acid ◽  
Mild Steel ◽  
Corrosion Inhibitor ◽  
Chemical Compounds ◽  
Punica Granatum ◽  
Pomegranate Peel ◽  
Inhibition Performance ◽  
Pomegranate Peel Extract ◽  
Peel Extract ◽  
Hcl Solution

The inhibition effect of pomegranate peel extract (PPE) on the corrosion of mild steel in hydrochloric acid (HCl) solution was investigated. The polarization, mass loss, and electrochemical impendence techniques were used to evaluate the corrosion inhibition performance of the pomegranate peel extract. The results revealed that PPE acts as a corrosion inhibitor in HCl solution. The inhibition efficiency increased with the increase of extract concentration. The inhibition action was attributed to the adsorption of the chemical compounds present in the extract solution, on mild steel surface.

Punica granatum (pomegranate) peel extract exerts potent antitumor and anti-metastasis activity in thyroid cancer

RSC Advances ◽  
2016 ◽  
Vol 6 (87) ◽  
pp. 84523-84535 ◽  
Author(s):  
Yujue Li ◽  
Tinghong Ye ◽  
Fangfang Yang ◽  
Mingxing Hu ◽  
Libo Liang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Punica Granatum ◽  
Pomegranate Peel ◽  
The Past ◽  
The World ◽  
Pomegranate Peel Extract ◽  
Peel Extract

The incidence of thyroid carcinoma has obviously been rising throughout the world during the past ten years.

scholarly journals Extraction of tannins from Punica granatum peel for pharmacological activities

2020 ◽  
Vol 8 (1) ◽  
pp. 144-147
Author(s):  
Sayed Muhammad Amin Sadat ◽  
Anisa Omari
Keyword(s):  
Biological Activities ◽  
Punica Granatum ◽  
Health Food ◽  
Fruit Peel ◽  
Pomegranate Peel ◽  
Pharmacological Activities ◽  
High Antioxidant Activity ◽  
Anti Inflammatory ◽  
Pomegranate Peel Extract ◽  
Punica Granatum L

Punica granatum L. (Pomegranate) is utilized in the treatment of parasitic contamination, loose bowels and ulcers. Extracts of the various parts of P. granum is reported to have anti-inflammatory, antioxidant and anticarcinogenic activities. Tannins are a group of polyphenolic compounds that are widely present in plant regions and possess various biological activities including antimicrobial, anti-parasitic, anti-viral, antioxidant, anti-inflammatory, immunomodulatory activities. This study focused on extraction of tannins from Punica granatum peel which can be further analyzed for its pharmacological activities. The results of this study revealed the abundance of tannins in the pomegranate peel extract. Tannins from pomegranate peel might contribute to the high antioxidant activity of this fruit peel and it is a valuable natural antioxidant source applicable in the health food industry.

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