PERIODONTITIS AND MYOCARDIAL INFARCTION RISK: A CASE-CONTROL STUDY

Objectives: This study aimed to assess the association of periodontitis and Myocardial Infarction (MI) and contributes as a potential risk factor for its incidence. Methodology: This multi-centre, case-control study enrolled 125 participants. Case group comprising of Acute Myocardial Infarction (AMI) = 55, control group consisting of non – AMI = 70. Both groups were assessed for presence of periodontitis along with specific risk factors that were recorded in a modified proforma comprising of questions pertaining to demographics, oral hygiene practices and oral eating habits. Chi-square test was used to assess association and p-value was considered significant at ≤0.05. Results: Periodontitis was found to be prevalent in 71% of Myocardial Infarction (MI) patients with an OR 4.125 (95% CI, 1.934 - 8.797) as compared to 37% in Control (non-Myocardial Infarct). Increasing age, male gender, illiteracy, unemployment/retirement, low socio-economic status, being overweight, no dental visits, and smoking (both duration & frequency) were found to be statistically significantly associated with occurrence of periodontitis and myocardial infarction in the study. Conclusion: Periodontitis was found to be prevalent among the MI patients suggesting a causal link between these two conditions that can be reduced by adopting a healthy lifestyle, refraining from smoking, good oral hygiene and visiting a dentist for regular check-up.

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Vitiligo associated hypoacusis: a case control study

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20160958 ◽

2016 ◽

Vol 2 (2) ◽

pp. 77

Author(s):

Abhishek Maheshwari ◽

Rajlaxmi Panigrahi ◽

Shruti Mahajan

Keyword(s):

Head And Neck ◽

Pure Tone ◽

Case Control Study ◽

Hearing Threshold ◽

Pure Tone Audiometry ◽

Case Control ◽

Control Group ◽

P Value ◽

Case Group ◽

Control Study

Background: Vitiligo is a progressive depigmenting cutaneous disorder, resulting from the loss of melanocytes. In the inner ear, melanocytes are believed to play an important role in development and normal functioning of stria vascularis. Acoustic abnormalities in vitiligo patients remain obscured for long durations. This study was carried out to determine the prevalence of subclinical sensorineural hearing loss in vitiligo patients, if any, in comparison with controls and to detect any relevant demographic or clinical finding characteristic of hypoacusis in vitiligo patients.Methods: A prospective case control study was undertaken in 50 vitiligo patients (case group), who were compared with another 50 age and sex matched healthy volunteers (control group). All cases underwent detailed dermatological and ENT examination and were subjected to tests like pure tone audiometry, transient evoked otoacoustic emission (TEOAE).Results: A statistically significant (p value = 0.039), higher average pure tone hearing threshold (APT-HT) was noted in vitiligo patients in comparison with the control group. Vitiligo originating at the head and neck was strongly associated with hypoacusis (54.55%, 6 of 11 cases). TEOAE reproducibility % was reduced to 42.6% in the vitiligo group.Conclusion: Vitiligo is associated with subclinical sensorineural hypoacusis. Vitiligo with its primary site in head and neck region and co-exixting leucotrichia shows a strong association with asymptomatic sensorineural hypoacusis in such patients. Pure tone audiometery and TEOAE can be effectively used to assess and follow up vitiligo patients for asymptomatic subclinical sensorineural hypoacusis.

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Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Neonatology ◽

10.1159/000512020 ◽

2020 ◽

pp. 1-7

Author(s):

Tobias Hengartner ◽

Mark Adams ◽

Riccardo E. Pfister ◽

Diane Snyers ◽

Jane McDougall ◽

...

Keyword(s):

Retinopathy Of Prematurity ◽

Odds Ratio ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Same Sex ◽

Live Births ◽

Adjusted Logistic Regression ◽

Control Study

Aim: The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. Methods: This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of <28 weeks, who developed higher stage ROP (≥stage 2, n = 178). Each case infant was matched to another of the same sex who did not develop ROP (n = 178, control group). Results: When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. Conclusions: Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

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The role of leukotriene modifying agent treatment in neuropsychiatric events of elderly asthma patients: a nested case control study

Asthma Research and Practice ◽

10.1186/s40733-021-00070-4 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Sang Oh Kang ◽

Kyung Hyun Min ◽

Hyun Jeong Kim ◽

Tae Hyeok Kim ◽

Woorim Kim ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Boxed Warning ◽

Control Group ◽

Case Group ◽

Newly Diagnosed ◽

Crude Odds Ratio ◽

Asthma Patients ◽

Nested Case Control ◽

Control Study

Abstract Background In March 2020, the US Food and Drug Administration decided that the dangers related to neuropsychiatric events (NPEs) of montelukast, one of the leukotriene modifying agents (LTMAs), should be communicated through ‘boxed warning’. In case of NPEs, the prevalence has been the highest in elderly people. Because the characteristics of the elderly such as old age itself can act as risk factors. Therefore, an investigation on safety of LTMAs related to NPEs in elderly using LTMAs is needed. Method A nested case-control study using an elderly sample cohort from the Korean National Health Insurance Service database was used. The asthma cohort included asthma patients newly diagnosed between 2003 and 2013. Within the asthma cohort, the case group was defined as patients who were diagnosed with NPEs. Among patients who had never been diagnosed with NPEs, the control group was selected by matching 1:1 by propensity score. Patients who were prescribed LTMAs for 1 year prior to index date were defined as the exposure group. The logistic regression model was used to measure the effect of LTMAs on NPEs. Results We identified 141,165 patients with newly diagnosed asthma, and selected 31,992 patients per each case and control group. Exposure to LTMAs significantly increased the risk of overall NPEs about in comparison with the absence of exposure (crude odds ratio [OR] 1.58, 95% CI 1.50–1.68). After adjusting for confounding factors, the overall NPEs risk increased (adjusted OR, 1.67, 95% CI 1.58–1.78). Conclusion This study suggests that elderly asthma patients prescribed LTMAs had a higher risk of NPEs than patients who were not treated with LTMAs. Therefore, clinicians should be aware of the potential risks of LTMAs.

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Analisis Faktor Fetus dan Tali Pusat terhadap Risiko Asphyxia Perinatal di Surakarta

Jurnal Ilmu Keperawatan Anak ◽

10.32584/jika.v3i1.521 ◽

2020 ◽

Vol 3 (1) ◽

pp. 16

Author(s):

Siti Lestari ◽

Dyah Dwi Astuti ◽

Fachriza Malika Ramadhani

Keyword(s):

Risk Factors ◽

Case Control Study ◽

Perinatal Asphyxia ◽

Case Control ◽

Control Group ◽

Case Group ◽

Retrospective Case ◽

Chi Square ◽

Fetal Position ◽

Control Study

Asfiksia perinatal merujuk pada kekurangan oksigen selama persalinan, sehingga berpotensi menyebabkan kematian dan kecacatan. WHO memperkirakan 4 juta anak terlahir dengan asfiksia setiap tahun, dimana 1 juta di antaranya meninggal dan 1 juta anak bertahan hidup dengan gejala sisa neurologis yang parah. Penelitian ini bertujuan untuk menganalisis faktor risiko fetal dan tali pusat pada asfiksia neonatal.Penelitian dilakukan di lakukan di RS Dr Moewardi Surakarta dengan pendekatan quantitative retrospective case control study. Data diambil dari rekam medis antara tahun 2013-2018. Penelitan ini melibatkan 264 neonatal yang terdiri dari 88 kelompok kasus dan 176 kelompok control. Kelompok kasus adalah bayi dengan diagnosa asfiksia yang dilakukan analisis terhadap faktor risiko fetal, sedangkan bayi yang tidak mengalami asfiksia dijadikan kelompok kontrol. Hasil analisis statistik uji Chi-Square dan Fisher Exact ditemukan bahwa kelahiran prematur (OR 2,07 CI 95% P 0,02), persalinan dengan tindakan (OR 3,61 CI 95% P 0,00), berat bayi (OR 2,85 CI 95% P 0,00), posisi janin (OR 2,37 CI 95% P 0,05), tali pusat ( QR 3,071 CI 95% P 0,01) berisiko terhadap insiden asfiksia perinatal. Air ketuban yang bercampur meconium (OR 1,51 CI 95% P 0,16) tidak memiliki risiko dengan Asfiksia perinatal. Kesimpulan: Risiko terhadap insiden asfiksia perinatal meliputi kelahiran prematur, persalinan dengan tindakan, berat bayi, posisi janin, dan tali pusat.Perinatal asphyxia refers to a lack of oxygen during labor, which has the potential to cause death and disability. WHO estimates 4 million children born with asphyxia each year, in which 1 million dies and 1 million survive with severe neurological sequelae. This study aims to analyze fetal and umbilical risk factors in neonatal asphyxia.This research is a quantitative retrospective case-control study, which was conducted at The Dr. Moewardi hospital, Surakarta. Data was taken from medical records from 2013-2018. The case group was patients diagnosed asphyxia, while those who did not experience asphyxia were treated as a control group. A total of 264 samples, consisting of 88 case group respondents and 176 control group respondents. Statistical analysis Chi- Square and Fisher Exact found that preterm birth (OR 2.07 CI 95% P 0.02), labor with instrument or complication (OR 3.61 CI 95% P 0.00), infant weight (OR 2.85 CI 95% P 0, 00), fetal position (OR 2.37 CI 95% P 0.05), umbilical cord (QR 3.071 CI 95% P 0.01) are at risk for the incidence of perinatal Asphyxia. The amniotic fluid mixed with meconium (OR 1.51 CI 95% P 0.16) has no risk with perinatal asphyxia.The risk factors of incidences of perinatal asphyxia were preterm birth, labor with instrument or complication, baby weight, fetal position and umbilical cord.

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The Relationship between Serum Levels of Vitamin C, Uric Acid and Antioxidant Condition with Coronary Artery Diseases: a Case-Control Study

10.21203/rs.2.15439/v1 ◽

2019 ◽

Author(s):

Aida Torkzaban ◽

Seyed Amir Mansour Alavi Naeini ◽

Akbar Hassanzadeh ◽

Mehrdad Namdari

Keyword(s):

Uric Acid ◽

Vitamin C ◽

Case Control Study ◽

Demographic Data ◽

Systolic Pressure ◽

Case Control ◽

Control Group ◽

Case Group ◽

Significant Difference ◽

Control Study

Abstract Background Coronary hearth diseases are among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are an effective factor in progress of atherosclerosis. Some studies have also reported different malondialdehyde and total antioxidant capacity among the atherosclerosis patients.Methods In this case-control study, 44 atherosclerosis patients referring to Shahid Madani treatment-education center were considered as the case group; while 44 healthy peoples were placed in the control group. Demographic data and anthropometric indices were measured. Food frequency questionnaire and international physical activity questionnaires were also completed. After 12 hours of fasting, 10 ml blood was sampled from the participants. Uric acid, vitamin C, TAC and MDA were also measured. The data were finally analyzed by SPSS Ver 22 software.Results A significant difference was observed between the two groups in terms of uric acid (P<0.001) and vitamin C (P<0.03). However, mean MDA and TAC showed no significant difference between the two groups. The two groups’ difference in terms of vitamin A, E and beta carotene, zinc and selenium intake was not significant. A significant difference was however detected between the two groups in terms of vitamin C (P<0.047). A significant relationship was also observed between the systolic pressure and CHD (P<0.028).Conclusion Results of this study indicated that the uric acid and vitamin C levels of atherosclerosis patients had significant increase and decrease in comparison with the healthy subjects, respectively. Mean TAC and antioxidant levels of their diets (except for vitamin C) showed no significant difference. Systolic blood pressure of the patients was significantly higher than the controls.

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Mental and personality disorders in infertile women with polycystic ovary: a case-control study

African Health Sciences ◽

10.4314/ahs.v20i3.28 ◽

2020 ◽

Vol 20 (3) ◽

pp. 1241-1249

Author(s):

Mostafa Ahmadi ◽

Mahbobeh Faramarzi ◽

Zahra Basirat ◽

Farzan Kheirkhah ◽

Mohammad Chehrazi ◽

...

Keyword(s):

Personality Disorders ◽

Polycystic Ovarian Syndrome ◽

Case Control Study ◽

Case Control ◽

Control Group ◽

Case Group ◽

Infertile Women ◽

The Mean ◽

Ovarian Syndrome ◽

Control Study

Background: Polycystic Ovarian Syndrome (PCOS) is one of the most common causes of infertility in women. Objective: The current study investigated mental and personality disorders in infertile women with and without PCOS. Methods: This case-control study evaluated 400 infertile women who referred to the Infertility Center in Babol city (North of Iran). Participants were categorized into the case group (201 PCOS) and the control group (199 without PCOS). All of the participants completed the Millon Clinical Multi-axial Inventory-III (MCMI-III). Results: The mean scores for clinical personality patterns were significantly higher for six personality disorders (schiz- oid, avoidant, antisocial, depressive, sadistic, and negativistic) and for three classes of severe personality disorder patterns (schizotypal, borderline, and paranoid) in infertile women with PCOS than in women without PCOS. The mean scores for eight clinical disorders (somatoform, manic disorder, dysthymia, alcohol-dependence, drug-dependence, post-trauma stress disorder, major depression, and delusion disorder) were also higher in infertile women with PCOS than in women without PCOS. Conclusion: The scores of many mental and personality disorders are higher in infertile women with PCOS than in women without PCOS. Thus, clinicians should prioritize recognizing and treating psychological problems of infertile women with PCOS. Keywords: Polycystic ovarian syndrome; infertility; personality disorders.

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Association between alcohol and drug use and arrest for driving under the influence after crash involvement in a rural area of Norway: a case–control study

BMJ Open ◽

10.1136/bmjopen-2018-023563 ◽

2019 ◽

Vol 9 (1) ◽

pp. e023563 ◽

Cited By ~ 1

Author(s):

Ragnhild Elén Gjulem Jamt ◽

Hallvard Gjerde ◽

Giovanni Romeo ◽

Stig Tore Bogstrand

Keyword(s):

Rural Area ◽

Case Control Study ◽

Case Control ◽

Driving Under The Influence ◽

Control Group ◽

Case Group ◽

Psychoactive Substances ◽

Traffic Crashes ◽

Alcohol And Drugs ◽

Control Study

ObjectivesThe rate of deaths caused by road traffic crashes is particularly high in rural areas. It has been hypothesised that one factor that may contribute is differences in patterns of alcohol use. The aim was to compare the prevalence of psychoactive substances among crash-involved drivers arrested for suspicion of driving under the influence (DUI) who are tested for alcohol and drugs and recent random drivers in a rural area. Furthermore, we investigated the association between traffic crashes and driving after using alcohol, illicit or medicinal drugs either alone or in combination.MethodsA case–control study was carried out in which the case group consisted of crash-involved drivers arrested for suspicion of DUI from 2000 to 2015. This group was compared with a control group of randomly selected drivers recruited to a roadside survey in normal traffic from 2014 to 2015. The case group consisted of 612 individuals (542 men and 70 women) and the control group of 3027 individuals (2099 men and 927 women). Drug and alcohol screening was performed on blood samples from the cases and samples of oral fluid from the controls.ResultsThe proportion of psychoactive substances was 81.7% among cases and 1.6% among the controls. The prevalence of combinations of psychoactive substances was 18% among the cases and 0.3% among the controls. The multivariate regression model analysis identified significant drug interactions.ConclusionThe prevalence of alcohol and drugs was high among the crash-involved drivers arrested for suspicion of DUI by the police. In contrast to earlier published research combinations of different psychoactive substances did not increase the OR for traffic crash involvement more than the single drug with highest OR. The statistical methodology presented in this study should be allied in future studies with greater statistical power to confirm these findings.

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Associations of Genetic Variation in Glyceraldehyde 3-Phosphate Dehydrogenase Gene with Noise-Induced Hearing Loss in a Chinese Population: A Case-Control Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17082899 ◽

2020 ◽

Vol 17 (8) ◽

pp. 2899 ◽

Cited By ~ 1

Author(s):

Liu Wan ◽

Boshen Wang ◽

Juan Zhang ◽

Baoli Zhu ◽

Yuepu Pu

Keyword(s):

Hearing Loss ◽

Genetic Variation ◽

Chinese Population ◽

Case Control Study ◽

Quantitative Polymerase Chain Reaction ◽

Case Control ◽

Control Group ◽

Case Group ◽

Noise Induced Hearing Loss ◽

Control Study

Objective: The purpose of this paper was to clarify the association between genetic variation in the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene and the risk of noise-induced hearing loss (NIHL). Methods: A case-control study (633 cases and 625 controls) was conducted in this study. Logistic regression was used to analyze the relationships between environmental and individual factors and NIHL. Gene expression levels were compared among each GAPDH rs6489721 genotype and between the case and control groups based on real-time fluorescence quantitative Polymerase Chain Reaction (PCR). Results: The T allele of GADPH rs6489721 was significantly associated with NIHL (odds ratio (OR) = 1.262, 95% confidence interval (CI) (1.066, 1.493), p = 0.006) and showed strong associations in the codominant and dominant models (TT vs. CC: OR = 1.586, 95% CI (1.131, 2.225), p = 0.008; TT vs. TC/CC: OR = 1.391, 95% CI (1.073, 1.804), p = 0.013). The expression level of the TT genotype was significantly higher than that of the CC genotype (p = 0.012), and the expression of the case group was also higher than that of the control group (p = 0.013). Conclusions: The homozygous risk allele (TT) of rs6489721 was associated with an enhanced GAPDH expression, resulting in the development of NIHL in a Chinese population.

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The Association between Hyperhomocysteinemia and Thoracoabdominal Aortic Aneurysms in Chinese Population

BioMed Research International ◽

10.1155/2020/4691026 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Jianqing Deng ◽

Jie Liu ◽

Long Cao ◽

Qun Wang ◽

Hongpeng Zhang ◽

...

Keyword(s):

Logistic Regression ◽

Confidence Interval ◽

Regression Models ◽

Case Control Study ◽

Case Control ◽

Aortic Aneurysms ◽

Control Group ◽

Case Group ◽

Logistic Regression Models ◽

Control Study

Objective. To shed light on the association between hyperhomocysteinemia (HHcy) and thoracoabdominal aortic aneurysms (TAAAs). Methods. From July 2013 to March 2017, we conducted a matched case–control study involving individuals who presented to the Chinese People’s Liberation Army General Hospital and underwent thoracoabdominal magnetic resonance angiography or computed tomography angiography. A total of 73 patients with TAAAs were enrolled in the case group, and 219 sex-matched subjects without TAAAs were included in the control group. We then examined the relationship between HHcy and TAAAs by logistic regression models and subgroup as well as interaction analyses. Results. Serum total homocysteine (tHcy) concentrations and the proportion of HHcy were significantly higher in the patients with TAAAs than in those without TAAAs (P<0.001). Furthermore, the multivariate logistic regression models indicated that participants with HHcy had a 2.14-fold higher risk of TAAAs than those with a normal serum tHcy level (adjusted odds ratio (OR), 2.14; 95% confidence interval, 1.00–4.56). Similarly, each 1 μmol/L increase in the serum tHcy concentration was associated with a 4% higher risk of TAAAs (adjusted OR, 1.04; 95% confidence interval, 1.00–1.07). Subgroup analyses indicated that HHcy tended to be associated with a greater risk of TAAAs in all stratified subgroups (adjusted ORs>1). Furthermore, the interaction analyses revealed no interactive role in the association between HHcy and TAAAs. Conclusions. The present case–control study suggests that HHcy is an independent risk factor for TAAAs. Larger prospective cohort studies are warranted to validate these findings.

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Is Entamoeba Gingivalis a Risk Factor for Periodontal Diseases? A Case-Control Study

10.26810/perioj.2019.a3 ◽

2019 ◽

Vol 3 (1) ◽

pp. 18-28 ◽

Cited By ~ 1

Author(s):

Sandy Shabaan Hassan ◽

Gihane Gharib Madkour ◽

Ramy Wahba Henin ◽

Selvia Wahib Fayek Gad ◽

Amany Ahmed Abd El-Aal

Keyword(s):

Oral Hygiene ◽

Case Control Study ◽

Periodontal Diseases ◽

Case Control ◽

Control Group ◽

Healthy Control ◽

Hematoxylin And Eosin ◽

Group 3 ◽

Group 2 ◽

Control Study

Background: Entamoeba gingivalis was the first commensal parasite detected in the oral cavity of humans, and a high incidence has been reported in patients with poor oral hygiene. The current study aimed to investigate the association of Entamoeba gingivalis with gingivitis and periodontitis among Egyptian subjects. Methods: A total of 120 plaque samples were collected for this case-control study and were divided as follows: 40 plaque samples from gingivitis patients (group 1), 40 from stage II grade A and B periodontitis patients (group 2), and 40 samples from healthy volunteers (group 3). Diagnosis of parasitic stages relied on direct microscopic detection using permanent stains, trichrome stain, and hematoxylin and eosin (H&E) stain, in addition to ocular micrometry to confirm the diagnosis. Results: The occurrence of Entamoeba gingivalis within the gingivitis group was significantly higher (40%) than that observed in the control group (22.5%), whereas the occurrence within the periodontitis group was 15%. Samples from diseased subjects, regardless of immune status, were found to be moderately to severely affected with numerous parasitic nests, in contrast to a moderate near mild occurrence that was recorded in the healthy control group. Moreover, Entamoeba gingivalis occurrence was significantly higher (77.4%) in subjects with bad oral hygiene. Conclusion: The results of the present study suggest a potential role for the neglected oral parasitic Entamoeba gingivalis, especially the intensively multiplying forms, in the pathogenesis of periodontal diseases. This certainly needs further elucidation on a larger scale to explore the basis behind such multiplication, which may be related to genetic variation or may be pathophysiological in origin.

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