The role of overweight and obesity on severe Covid-19: the evidence and possible mechanisms of action

2020 ◽  
Vol 1 (1) ◽  
pp. 1-5
Author(s):  
Rafael Rangel-Aldao
Keyword(s):  
Mechanical Ventilation ◽  
Risk Factor ◽  
Causal Relationship ◽  
Molecular Mechanisms ◽  
Fat Metabolism ◽  
Mechanisms Of Action ◽  
Overweight And Obesity ◽  
Relationship Of

This commentary addresses three fundamental questions, 1) How solid is the evidence regarding obesity as a risk factor to Covid-19, in particular to the most serious form of the disease requiring hospitalization and mechanical ventilation? 2) What cellular and/or molecular mechanisms could explain a possible enhancement of the disease by obesity? 3) Given a probable and causal relationship of overweight and obesity with severe Covid-19, the question then arises on whether it may be possible to use as therapy well know drugs that work on fat metabolism?

scholarly journals Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders

2009 ◽  
Vol 43 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Elin Swedenborg ◽  
Joëlle Rüegg ◽  
Sari Mäkelä ◽  
Ingemar Pongratz
Keyword(s):  
Endocrine Disruption ◽  
Metabolic Disorders ◽  
Molecular Mechanisms ◽  
Fat Metabolism ◽  
Mechanisms Of Action ◽  
Mediating Effects ◽  
Aryl Hydrocarbon ◽  
Metabolic Functions ◽  
Considerable Concern

Endocrine disruption refers to the ability of chemicals to interfere with hormonal systems, and has raised considerable concern in recent years. Endocrine disruptive chemicals (EDCs) pose a documented risk to wildlife and have the potential to negatively influence human health. This review focuses on the molecular mechanisms of endocrine disruption and the possible involvement of EDCs in metabolic disorders. The first part describes the role of aryl hydrocarbon receptor (AhR) and nuclear receptors (NRs) in mediating effects of EDCs, in particular, how cross-talk between AhR and NR pathways can lead to endocrine disruption. The second part deals with how these receptors are involved in metabolic functions and how their targeting by EDCs can lead to disturbances in glucose and fat metabolism. The article illustrates that, although there is accumulating data on molecular mechanisms of EDC action as well as on EDC involvement in metabolic disorders, there is still a great demand for data that can unite the mechanistic and the toxicological/epidemiological observations.

The impact of Traditional Chinese Medicine on mitophagy in disease models

2021 ◽  
Vol 27 ◽  
Author(s):  
Li-Ping Yu ◽  
Ting-Ting Shi ◽  
Yan-Qin Li ◽  
Jian-Kang Mu ◽  
Ya-Qin Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Molecular Mechanisms ◽  
Human Diseases ◽  
Regulatory Mechanisms ◽  
Disease Models ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

: Mitophagy plays an important role in maintaining mitochondrial quality and cell homeostasis through the degradation of damaged, aged, and dysfunctional mitochondria and misfolded proteins. Many human diseases, particularly neurodegenerative diseases, are related to disorders of mitochondrial phagocytosis. Exploring the regulatory mechanisms of mitophagy is of great significance for revealing the molecular mechanisms underlying the related diseases. Herein, we summarize the major mechanisms of mitophagy, the relationship of mitophagy with human diseases, and the role of traditional Chinese medicine (TCM) in mitophagy. These discussions enhance our knowledge of mitophagy and its potential therapeutic targets using TCM.

Predicting human adiposity – sometimes – with food insecurity: Broaden the model for better accuracy

2017 ◽  
Vol 40 ◽  
Author(s):  
Sarah E. Hill ◽  
Randi P. Proffitt Leyva ◽  
Danielle J. DelPriore
Keyword(s):  
Risk Factor ◽  
Food Insecurity ◽  
Overweight And Obesity ◽  
High Income ◽  
Potential Contribution ◽  
Adult Women ◽  
Insurance Hypothesis ◽  
Target Article

AbstractThe target article explores the role of food insecurity as a contemporary risk factor for human overweight and obesity. The authors provide conditional support for the insurance hypothesis among adult women from high-income countries. We consider the potential contribution of additional factors in producing variation in adiposity patterns between species and across human contexts.

scholarly journals Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

PPAR Research ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-12 ◽  
Author(s):  
Anne Bugge ◽  
Susanne Mandrup
Keyword(s):  
Energy Homeostasis ◽  
Target Gene ◽  
Molecular Mechanisms ◽  
Fat Metabolism ◽  
Special Focus ◽  
Peroxisome Proliferator ◽  
Subtype Specificity ◽  
Genome Wide ◽  
Peroxisome Proliferator Activated Receptors

The peroxisome proliferator-activated receptors (PPARs) are central regulators of fat metabolism, energy homeostasis, proliferation, and inflammation. The three PPAR subtypes, PPAR, /, and activate overlapping but also very different target gene programs. This review summarizes the insights into PPAR subtype-specific transactivation provided by genome-wide studies and discusses the recent advances in the understanding of the molecular mechanisms underlying PPAR subtype specificity with special focus on the regulatory role of AF-1.

Role of lipoprotein(a) and its autoantibodies in polyvascular atherosclerotic disease

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
N Tmoyan ◽  
O Afanasieva ◽  
M Ezhov ◽  
U Chubykina ◽  
E Klesareva ◽  
...  
Keyword(s):  
Risk Factor ◽  
Independent Risk Factor ◽  
Lower Limbs ◽  
Public Institution ◽  
Funding Source ◽  
Lipoprotein A ◽  
National Medical ◽  
Vascular Beds ◽  
Relationship Of

Abstract Background Lipoprotein(a) [Lp(a)] is an independent risk factor of cardiovascular disease. The role of Lp(a) and its autoantibodies in the development of atherosclerosis, depending on the severity of lesion, is uncertain. Purpose To define the relationship of Lp(a) level and autoantibodies to Lp(a) with atherosclerosis of different vascular beds. Methods The study included 1288 patients older than 18 years with instrumental examination of three vascular beds (coronary, carotid and lower limbs arteries). Patients were divided according to the number of affected vascular beds (stenosis ≥50%): 0 (n=339), 1 (n=470), 2 (n=315), 3 (n=164). Levels of lipids, Lp(a) and autoantibodies to Lp(a) were measured in serum of all patients. Results Lp(a) concentration steadily increased and the level of IgM autoantibodies decreased with the number of affected vascular beds (Figure). There was no any association between IgG autoantibodies to Lp(a) and stenotic atherosclerosis. In logistic regression analysis adjusted for age, sex, hypertension, diabetes mellitus, smoking, elevated Lp(a) level was an independent predictor of stenotic atherosclerosis and it was associated with severity of lesions (table). Conclusions Lipoprotein(a) is an independent risk factor of stenotic atherosclerosis and its concentration increases with the number of affected vascular beds, while IgM autoantibodies to Lp(a) possess cardioprotective properties. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): National Medical Research Center of Cardiology of Ministry of Health of the Russian Federation

Subjectivity in incentive schemes, cognitive orientations and counterproductive knowledge behavior: an experimental study

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Lufi Yuwana Mursita ◽  
Luciana Spica Almilia
Keyword(s):  
Causal Relationship ◽  
Undergraduate Students ◽  
Content Type ◽  
Incentive Schemes ◽  
Cognitive Orientation ◽  
Cognitive Orientations ◽  
The Right ◽  
Relationship Of ◽  
The Relationship

Purpose This study aims to examine the causal relationship of subjective incentive schemes on counterproductive knowledge behavior. Besides, this study also identifies the moderating role of cognitive orientation on the relationship between those two variables. Design/methodology/approach This study used a 2 × 2 between-subjects laboratory experiment with accounting undergraduate students as the subjects. Findings Subjective-based incentive schemes reduce the tendency for counterproductive knowledge behavior. Also, the collectivist cognitive orientation negatively influences the behavior. However, cognitive orientation does not act as a moderator in the causal relationship of incentive schemes and counterproductive knowledge behavior. Originality/value To the best of the authors’ knowledge, this study is the first that investigates and finds the effect of inclusion of subjectivity in incentive schemes and the level of individual’s collectivism on the reluctance to share knowledge in the workplace. This study has also strived to reduce an overlapping between the concept of knowledge sharing and counterproductive knowledge behavior by applying the right basic concept during the experiment.

scholarly journals Adipokines and Osteoarthritis: Novel Molecules Involved in the Pathogenesis and Progression of Disease

Arthritis ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Javier Conde ◽  
Morena Scotece ◽  
Rodolfo Gómez ◽  
Veronica Lopez ◽  
Juan Jesus Gómez-Reino ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Risk Factor ◽  
White Adipose Tissue ◽  
Molecular Mechanisms ◽  
Mechanical Load ◽  
Critical Role ◽  
Fat Cells ◽  
Mechanical Effects ◽  
Progression Of Disease

Obesity has been considered a risk factor for osteoarthritis and it is usually accepted that obesity contributes to the development and progression of osteoarthritis by increasing mechanical load of the joints. Nevertheless, recent advances in the physiology of white adipose tissue evidenced that fat cells produce a plethora of factors, called adipokines, which have a critical role in the development of ostearthritis, besides to mechanical effects. In this paper, we review the role of adipokines and highlight the cellular and molecular mechanisms at play in osteoarthritis elicited by adipokines. We also emphasize how defining the role of adipokines has broadned our understanding of the diversity of factors involved in the genesis and progression of osteoarthritis in the hope of modifying it to prevent and treat diseases.

scholarly journals An Overview of Long Non-Coding (lnc)RNAs in Neuroblastoma

2021 ◽  
Vol 22 (8) ◽  
pp. 4234
Author(s):  
Francesca Baldini ◽  
Matilde Calderoni ◽  
Laura Vergani ◽  
Paola Modesto ◽  
Tullio Florio ◽  
...  
Keyword(s):  
Recent Progress ◽  
Molecular Mechanisms ◽  
Mechanisms Of Action ◽  
Biological Functions ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Definitive Therapy ◽  
Sporadic Cases ◽  
Non Coding Rnas

Neuroblastoma (NB) is a heterogeneous developmental tumor occurring in childhood, which arises from the embryonic sympathoadrenal cells of the neural crest. Although the recent progress that has been done on this tumor, the mechanisms involved in NB are still partially unknown. Despite some genetic aberrations having been identified, the sporadic cases represent the majority. Due to its wide heterogeneity in clinical behavior and etiology, NB represents a challenge in terms of prevention and treatment. Since a definitive therapy is lacking so far, there is an urgent necessity to unveil the molecular mechanisms behind NB onset and progression to develop new therapeutic approaches. Long non-coding RNAs (lncRNAs) are a group of RNAs longer than 200 nucleotides. Whether lncRNAs are destined to become a protein or not, they exert multiple biological functions such as regulating gene expression and functions. In recent decades, different research has highlighted the possible role of lncRNAs in the pathogenesis of many diseases, including cancer. Moreover, lncRNAs may represent potential markers or targets for diagnosis and treatment of diseases. This mini-review aimed to briefly summarize the most recent findings on the involvement of some lncRNAs in NB disease by focusing on their mechanisms of action and possible role in unveiling NB onset and progression.

scholarly journals Unraveling the Relationship of Asthma and COVID-19

2021 ◽  
Vol 11 (12) ◽  
pp. 1374
Author(s):  
Agamemnon Bakakos ◽  
Petros Bakakos ◽  
Nikoletta Rovina
Keyword(s):  
Molecular Mechanisms ◽  
Viral Infections ◽  
Asthma Severity ◽  
Current Evidence ◽  
Asthma Exacerbations ◽  
Inflammatory Phenotypes ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

Viral infections are one of the main causes of asthma exacerbations. During the COVID-19 era, concerns regarding the relationship of SARS-CoV2 with asthma have been raised. The concerns are both for COVID severity and asthma exacerbations. Many studies on COVID-19 epidemiology and comorbidities have assessed whether asthma represents a risk factor for SARS-CoV2 infection and/or more severe course of the disease. This review covers the current evidence on the prevalence of asthma in COVID-19 and its association with susceptibility to and severity of SARS-CoV2 infection. It will examine the possible role of underlying asthma severity in COVID-19 related outcomes as well as the molecular mechanisms involved in the co-existence of these entities. The possible role of asthma inflammatory phenotypes will also be evaluated. Finally, the impact of asthma comorbidities and the implications of asthma medication on COVID-19 will be addressed.

scholarly journals Femoroacetabular Impingement: A Natural History

2020 ◽  
Vol 26 (3) ◽  
pp. 182-192
Author(s):  
A. P. Sereda
Keyword(s):  
Risk Factor ◽  
Natural History ◽  
Causal Relationship ◽  
Femoroacetabular Impingement ◽  
Anatomical Variations ◽  
Review Article ◽  
Natural Course ◽  
Surgical Correction ◽  
Relationship Of

This review article is devoted to the natural course of hip femoroacetabular impingement (FAI). The evolution of the understanding and views of surgeons on primary (idiopathic) arthrosis are considered. It is noted that nowadays, the primary arthrosis in fact almost always arises from anatomical variations. Among those are cam- and pincer-deformities, leading to impingement. In most of the major works, a reliable causal relationship of cam-FAI with arthrosis has been proven. Moreover, cam-FAI also carries the risk of impending arthroplasty. The association of pincer-FAI with arthrosis has been controversial. The course of FAI arthrosis, most likely, is not as aggressive as, for example, dysplastic arthrosis, and less often requires arthroplastics. Since cam-FAI is a reliable risk factor for arthrosis and arthroplasty, it could be assumed that timely surgical correction of FAI would stop or slow down arthrosis and avoid arthroplasty. However, at present, this assumption has not been proven, therefore, there is no reason to assert that surgery for FAI in any way affects its natural history in the form of severe arthrosis following by arthroplasty.

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