scholarly journals E-SELECTIN AS A BIOMARKER IN FEMALE PATIENTS WITH Β-THALASSEMIA IN AL-NAJAF PROVENCE, IRAQ

2020 ◽  
Vol 28 (29) ◽  
pp. 66-73
Author(s):  
Intisar Razzaq Sharba ◽  
Arshad Noori Al-Dujaili
Keyword(s):  
Inflammatory Process ◽  
Normal Weight ◽  
Control Group ◽  
World Population ◽  
Control Groups ◽  
Healthy Control ◽  
Entire World ◽  
The Relationship ◽  
Weight Groups ◽  
Inflammation Cytokines

E-selectin, as identified (CD62E), is expressed on endothelial cells after stimulation with inflammation cytokines. β-Thalassemia diseases (βT) and early diagnosis are of utmost significance in the entire world population. This study was performed in the Thalassemia Center of the Al-Zahraa Educational Hospital in Al-Najaf Province, Iraq, on sixty-nine with β-thalassemia (54 βT major and 15 βT Intermedia) aged 8-40 years who transfused blood. Compared to 20 healthy volunteers as a control group. In both βT patients and healthy groups were assessed serum E-selectin levels. It was investigated the relationship with RBC, Hb, PCV, WBC, PLT, BMI, splenic status, iron, and ferritin levels. The results revealed a significant (P<0.05) decreased values of HB, RBC, P.C.V, and BMI. In contrast, values of WBC, PLT, Iron, and Ferritin were significantly increased in βT patients as compared to the healthy control groups. A significant (P<0.05) increase in serum E- Selectin level in βT patients (20.55±0.47) ng/ml to compare with the healthy group (9.16±0.50) ng/ml. Furthermore, it was a significant decrease in groups of βT major (19.87±0.42) ng/ml more than in βT intermedia (23±1.42) ng/ml. E-Selectin revealed a significant increase (P<0.05) in progress age and associated with splenectomies and underweight groups compared to splenectomies and the normal weight groups, respectively. Also, E-Selectin levels significantly positively correlated with WBC, PLT value, iron, and Ferritin levels. However, it was no significant with RBC, PCV, Hb. As a conclusion from this study, E- Selectin is an important biomarker in β-thalassemia patients can be identified as the complications associated with iron overload, inflammatory process, and endothelial dysfunction in βT disease.

CLEC4E as a New Tumor Marker for Early Diagnosis of GIT Tumors

2021 ◽  
pp. 3167-3172
Author(s):  
Rasha Hasan Jasim ◽  
Hadeer Haider Abdualameer
Keyword(s):  
Early Diagnosis ◽  
Tumor Marker ◽  
Patient Group ◽  
Study Groups ◽  
The Other ◽  
Control Group ◽  
Control Groups ◽  
Healthy Control ◽  
The Relationship ◽  
Sera Samples

During the period from the beginning of December 2018 to the end of May 2019, 108 resident of Babylon were included to participate in the current study, were divided into two main groups: 81 patients with GIT diseases, their age ranged from 12-80 years; and the controls group (27 individuals) with the age 17-71 years old. Furthermore, the patient group was divided into two subgroups, the first involved 51 patients with GIT tumors and the other with non-tumoral diseases of GIT (30 individuals suffered non tumoral GIT illness were enrolled as a pathological control group). CLEC4L, Serotonin were evaluated in the sera samples of the study groups. The current study revealed statistical significant increase in the levels of serotonin while it showed significant decrease in the levels of CLEC4L in the sera testers of patients with malignant GIT tumors when compared to benign GIT tumors, pathological GIT control, and healthy control groups. The present study showed that the relationship between CLEC4E with serotonin became negative. Serotonin showed the (88%) sensitivity among the assessed criteria followed by CLEC4L (76%).

Self-monitoring in patients with schizophrenia

2004 ◽  
Vol 34 (8) ◽  
pp. 1561-1569 ◽  
Author(s):  
GÜNTHER KNOBLICH ◽  
FRANK STOTTMEISTER ◽  
TILO KIRCHER
Keyword(s):  
Hand Movements ◽  
Control Group ◽  
Formal Thought Disorder ◽  
Self Monitoring ◽  
The Core ◽  
Matched Healthy Control ◽  
Healthy Control ◽  
Dsm Iv ◽  
Core Symptoms ◽  
The Relationship

Background. The present study investigated whether a failure of self-monitoring contributes to core syndromes of schizophrenia.Method. Three groups of patients with a DSM-IV diagnosis of schizophrenia (n=27), with either prominent paranoid hallucinatory or disorganization syndrome, or without these symptoms, and a matched healthy control group (n=23) drew circles on a writing pad connected to a PC monitor. Subjects were instructed to continuously monitor the relationship between their hand movements and their visual consequences. They were asked to detect gain changes in the mapping. Self-monitoring ability and the ability to automatically correct movements were assessed.Results. Patients with either paranoid-hallucinatory syndrome or formal thought disorder were selectively impaired in their ability to detect a mismatch between a self-generated movement and its consequences, but not impaired in their ability to automatically compensate for the gain change.Conclusions. These results support the claim that a failure of self-monitoring may underlie the core symptoms of schizophrenia.

scholarly journals Investigation on Glucose and levels of Zn and Cu in Sera of Iraqi Males addicted on Methamphetamine or Tramadol

2021 ◽  
Vol 3 (2) ◽  
pp. 52-63
Author(s):  
Rulla Sabah ◽  
Ahmed saad abbas Fatin F.Al-Kazazz ◽  
Salam A.H Al-Ameri
Keyword(s):  
Chronic Disease ◽  
Normal Weight ◽  
Control Group ◽  
Healthy Group ◽  
Significant Difference ◽  
Zn And Cu In ◽  
Healthy Control ◽  
Group A ◽  
Age Range ◽  
Heavy Smokers

Addiction is the most critical form of Addiction. It is a chronic disease with a potential for fatality if not treated. In this work, 180 samples of male individuals were collected in this study. They classified into three groups, groups:  G1 who were healthy control; G2 who was addicted to methamphetamine (meth); G3 who was addicted to tramadol (Tra). Each group consists of 60 heavy smokers Iraqi male individuals in the age range of 18-43 years. The results showed a highly significant increase (p<0.0001) in the level of Glucose of the two addicted groups in comparison with the healthy group. A highly significant decrease (p<0.0001) could be seen in the level of Zn of the two addicted groups G2, G3 compared to the control group, while the level of Cu of the two addicted groups were highly significant increased (p<0.0001). Also, the results showed a highly significant difference (p<0.0001) in BMI for the studied groups, G2, G3 in comparison with the control group. All addictive individuals under this study were at normal weight depending on their BMI.  

scholarly journals Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

2020 ◽  
Author(s):  
Yuan-jing Leng ◽  
Hai-bin Zhou ◽  
Jiang-ling Fu ◽  
Wen-juan Wang
Keyword(s):  
Healthy Subjects ◽  
Characteristic Curve ◽  
Urinary Stone ◽  
Urinary Stones ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Control ◽  
The Mean ◽  
The Difference ◽  
The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

scholarly journals Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

2020 ◽  
Author(s):  
Mahmut Atum ◽  
Gürsoy Alagöz
Keyword(s):  
Retinal Artery Occlusion ◽  
Artery Occlusion ◽  
Control Group ◽  
Retrospective Case ◽  
Control Subjects ◽  
Gender And Age ◽  
Significant Difference ◽  
Healthy Control ◽  
Retinal Artery ◽  
The Relationship

Purpose: This study aimed to compare the neutrophil-to-lymphocyte (NLR) and plateletto- lymphocyte (PLR) ratios in patients with retinal artery occlusion (RAO) with those from a healthy control population and to identify the relationship between them. Methods: Forty-six patients with RAO and fifty-one healthy control subjects were included in this retrospective case-control study. RAO was diagnosed following an ophthalmic examination and fluorescein angiography (FA). Blood neutrophil, lymphocyte, and platelet counts were recorded for each of the 97 subjects, from which NLR and PLR values were calculated. Results: There were 46 patients (28 male [M], 18 female [F]) in the RAO group and 51 patients (27 M, 24 F) in the control group. No significant differences were found between patients with RAO and the control subjects in terms of gender and age (P > 0.05). Patients with RAO had significantly increased NLR values (2.85 ± 1.70) than the control subjects (1.63 ± 0.59, P < 0.001). The mean PLR in patients with RAO was 123.69 ± 64.98, while that in control subjects was 103.08 ± 36.95; there was no significant difference between the two groups (P = 0.055). A logistic regression analysis revealed that NLRs were 3.8 times higher in patients with RAO than in control subjects (odds ratio = 3.880; 95% confidence interval = 1.94 to 7.74; P < 0.001). Conclusion: NLRs were significantly increased in patients with RAO compared to the control subjects.

scholarly journals The expression and significance of inflammatory cytokines and MMP-9 in the tears of the infected eye and contralateral uninfected eye in patients with fungal keratitis

2021 ◽  
Author(s):  
Shuang Zhang ◽  
Hui-Min Wu ◽  
Xiang-Ni Cao ◽  
Xian-Qi Zhang ◽  
Gui-ping Gao
Keyword(s):  
Tear Film ◽  
Fungal Keratitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Controls ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Healthy Control ◽  
The Relationship ◽  
Tear Film Function

Abstract Background: We investigated bilateral tear cytokine levels including interleukin (IL)-1β, IL-10, IL-17, tumor necrosis factor (TNF)-α and Matrix metalloproteinase-9 (MMP-9) in patients with fungal keratitis(FK). Meanwhile, we evaluated the relationship between the changes of tear cytokines with corneal perception and pain in infected eyes, and the relationship between tear cytokines and tear film function in contralateral uninfected eyes .Methods : A total of 60(20 FK, 20 contralateral, 20 healthy controls) tear samples were collected prospectively and analyzed by enzyme linked immunosorbent assay(ELISA). Approximately 50 to 60 ul of tear samples in each case were collected. Meanwhile ,we analyzed the changes of visual analogue scale(VAS), tear breakup time (TBUT), Schirmer I test (SIT) and corneal perception compared with healthy controls. Results :The concentrations of IL-1β, IL-10 and IL-17 increased in bilateral eyes compared with healthy controls(P<0.05). The tear concentrations of MMP-9 , TNF-α only significantly increased in affected eyes (P <0.05). Patients with FK showed significant reduction in corneal perception of infected eyes compared with controls(P<0.05). Corneal perception of the normal eyes in FK patients was slightly lower than that of control group, but there was not statistical difference (P>0.05).TBUT and SIT of contralateral uninfected eyes were significantly lower than that of control group(P<0.05), which were significantly correlated with levels of IL-1β, IL-17(P<0.05). SIT were also negatively correlated with MMP-9(P<0.05), while the levels of IL-1β, IL-10, IL-17, TNF-α and MMP-9 in the tears of the healthy control group had no significant correlation with TBUT and SIT indicators(P>0.05).The corneal perception and VAS score of the affected FK eyes showed correlation with IL-1β, IL-17 and TNF-α(P<0.05).In addition, concentration of IL-10 inversely was correlated with VAS (P<0.05). Conclusion: Proinflammatory tear cytokines are elevated in bilateral eyes with unilateral FK as associated with tear film function ,pain and corneal sensitivity.

Rhythm of 24-h Intraocular and Perfusion Pressure in Patients With Ocular Hypertension

2020 ◽  
Author(s):  
Ran Xia ◽  
Na Shu ◽  
Huixian Cui ◽  
JORGE AGUSTÍN TRUJILLO PERDOMO ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Perfusion Pressure ◽  
Open Angle Glaucoma ◽  
Healthy Control Group ◽  
Control Group ◽  
Ocular Perfusion Pressure ◽  
Control Groups ◽  
Ocular Perfusion ◽  
Healthy Control ◽  
Maximum Minimum

Abstract AIMThe aim of the present study was to characterize the rhythm of 24-h intraocular pressure (IOP) and ocular perfusion pressure (OPP) in patients with ocular hypertension (OHTN), in order to provide a reference for the clinical diagnosis and treatment of OHTN. METHODSAccording to the diagnostic criteria, 107 patients with OHTN were included, and an age- and sex-matched healthy control group (71 patients) was selected. The IOP and blood pressure (BP) of the OHTN and the healthy control groups were recorded every 2 h over a 24-h period. BP was measured using a digital automatic BP monitor, and IOP was measured using a non-contact tonometer. RESULTSThe maximum, minimum and mean IOP were significantly higher in subjects with OHTN than in the healthy control group (P<0.05), and the maximum, minimum and mean MOPP were significantly lower in the OHTN group than in the healthy control group (P<0.05). The minimum and mean SOPP and DOPP values of the OHTN group were lower than those of the healthy control group (P<0.05), and the IOP, MOPP, SOPP and DOPP diurnal and nocturnal fluctuation values were significantly greater in the OHTN group than in the healthy control group (P<0.05). The peak and trough IOP times of the two groups coincided, which tended to be low during the day and higher at night. The peak and trough MOPP and SOPP times of the two groups also coincided, and were primarily higher during the day and lower at night. The 24-h DOPP in the healthy control group was generally higher during the daytime and lower at night, with peak values between 19:00-23:00 h, and trough values between 3:00-7:00 h. No obvious day-to-night fluctuations were observed in the OHTN group. CONCLUSIONThe OPP of patients with OHTN is lower, and the 24-h OPP fluctuates more than that of healthy control subjects. This may be an important blood flow factor for the progression to primary open angle glaucoma in patients with OHTN.

scholarly journals THE PREVALENCE OF CELIAC DISEASE AMONG PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER

2015 ◽  
Vol 52 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Sedat IŞIKAY ◽  
Nurgül IŞIKAY ◽  
Halil KOCAMAZ
Keyword(s):  
Celiac Disease ◽  
Familial Mediterranean Fever ◽  
Tissue Transglutaminase ◽  
Control Group ◽  
Marsh Type ◽  
Significant Difference ◽  
Healthy Control ◽  
Mediterranean Fever ◽  
Relationship Of ◽  
The Relationship

Background Familial Mediterranean Fever and celiac disease are both related to auto-inflammation and/or auto-immunity and they share some common clinical features such as abdominal pain, diarrhea, bloating and flatulence. Objectives We aimed to determine the association of these two diseases, if present. Methods Totally 112 patients diagnosed with Familial Mediterranean Fever and 32 cases as healthy control were included in the study. All participants were examined for the evidence of celiac disease, with serum tissue transglutaminase IgA levels (tTG IgA). Results Totally 144 cases, 112 with Familial Mediterranean Fever and 32 healthy control cases were included in the study. tTG IgA positivity was determined in three cases with Familial Mediterranean Fever and in one case in control group. In that aspect there was no significant difference regarding the tTG IgA positivity between groups (P=0.81). Duodenum biopsy was performed to the tTG IgA positive cases and revealed Marsh Type 3b in two Familial Mediterranean Fever cases and Marsh Type 3c in the other one while the biopsy results were of the only tTG IgA positive case in control group was Marsh Type 3b. In HLA evaluation of the celiac cases; HLA DQ2 was present in two celiac cases of the Familial Mediterranean Fever group and in the only celiac case of the control group while HLA DQ8 was present in one celiac case of the Familial Mediterranean Fever group. Conclusions We did not determine an association of Familial Mediterranean Fever with celiac disease. Larger studies with subgroup analysis are warranted to determine the relationship of these two diseases.

Plasma kisspeptin and ghrelin levels in puberty variant cases

2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Erdal Kurnaz ◽  
Yaşar Şen ◽  
Süleyman Aydın
Keyword(s):  
Serum Levels ◽  
Control Group ◽  
Control Groups ◽  
Premature Thelarche ◽  
Premature Adrenarche ◽  
Significant Difference ◽  
And Gender ◽  
And Control ◽  
Relationship Of ◽  
The Relationship

AbstractBackground:The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders.Methods:A PT group aged 1–8 years (n = 40), a PA group aged 1–9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study. Kisspeptin and ghrelin levels were measured with ELISA methods from blood samples drawn while fasting in the morning.Results:When the PT group was compared with the controls, the plasma kisspeptin levels of the cases were significantly higher than the control group (165.47 ± 15.45 pmol/L, 96.82 ± 12.33 pmol/L, p = 0.005, respectively). Kisspeptin levels in the PA group did not show a difference with the control group (121.36 ± 17.99 pmol/L, 95.52 ± 11.54 pmol/L, p = 0.249, respectively). No significant difference could be found when GAH levels in the PT and PA groups were compared with controls. No significant correlation was found between kisspeptin and GAH levels in the PT and PA groups.Conclusions:Our results indicate that kisspeptin plays an important role in the PT, but GAH is not associated with puberty disorders.

scholarly journals An investigation into the relationship between anaerobic work capacity, percentage body fat and the grade of asthma in asthmatics and a healthy control group

1991 ◽  
Vol 47 (2) ◽  
pp. 28-33
Author(s):  
M. Burger ◽  
M. Geyer ◽  
W. Regel ◽  
G. M. Smit ◽  
E. Terblanche ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Body Fat ◽  
Anaerobic Exercise ◽  
Healthy Control Group ◽  
Control Group ◽  
Healthy Children ◽  
Working Capacity ◽  
Percentage Body Fat ◽  
Healthy Control ◽  
The Relationship

The goal of this study was to compare the anaerobic working capacity of asthmatic children to that of a healthy control group and to ascertain the relationship between the degree of asthma, anaerobic exercise and percentage body fat. A total of 41 children, 21 asthmatics and 20 healthy children (13-18 years) were tested. Three variables - percentage body fat, pulmonary function and fitness - were measured. It was found that there is very little difference between the asthmatic and the healthy child, with regard to anthropometric measurements, fitness and anaerobic working capacity. A poor correlation was found between percentage body fat, pulmonary function and anaerobic working capacity. The results further showed that there is a slight correlation between the percentage body fat and anaerobic working capacity. This tendency can only be confirmed with a larger random sample of children.The researchers conclude that asthmatics, irrespective of the degree of asthma, are not restricted as far as anaerobic activities are concerned. They can  therefore lead a normal healthy life and, as far as anaerobic exercise is  concerned, can compete on equal terms with healthy children.

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