scholarly journals Vital signs of Cavia porcellus (Guinea pig) diagnosed with malignant hyperthermia using sevoflurane gas

2021 ◽  
Vol 48 (5) ◽  
pp. 69-76
Author(s):  
M. Gilmar Mendoza-OrdoÑez ◽  
R. Oscar Rebaza ◽  
P.C Rufino Paucar-Chanca ◽  
V. Nicasio Valencia ◽  
D. Olusegun D. Oshibanjo
Keyword(s):  
Body Temperature ◽  
Malignant Hyperthermia ◽  
Vital Signs ◽  
Clinical Syndrome ◽  
The Body ◽  
Cavia Porcellus ◽  
Anesthetic Agents ◽  
Muscle Squelettique ◽  
Inhalational Anesthetic ◽  
Dramatic Rise

Malignant hyperthermia (MH) is a life-threatening clinical syndrome of hypermetabolism involving the skeletal muscle. It is triggered in susceptible individuals primarily by volatile inhalational anesthetic agents and the muscle relaxant succinylcholine. MH affects humans, certain pig breeds, dogs, horses, and probably other animals. The classic signs of MH include A dramatic rise in body temperature, rigid or painful muscles, especially in the jaw, flushed skin, sweating, an abnormally rapid or irregular heartbeat, rapid breathing or uncomfortable breathing, brown or cola-colored urine, very low blood pressure (shock), confusion and muscle weakness or swelling after the event. The syndrome is likely to be fatal if untreated. This study therefore assessed the effects of sevoflurane gas on the vital signs of Cavia porcellus with malignant hyperthermia. For the determination of malignant hyperthermia, 50, 15 day-old weaned kits of Peru breed were placed in an anesthesia chamber for 5 minutes and subjected to a mixture of air with 3% sevoflurane gas. Only 6% of them reacted positively, while most of them, 94%, were negative. The average body temperature of the positive kits was 38.9ºC, oscillating between 38.7 and 39.1 ° C, while the negative ones averaged 37.9 ° C. The positive kits had an average of 142.3 breaths per minute compared to the negative ones, which was determined to be 83.7. The number of heart beats per minute in the kits with a positive reaction to sevoflurane averaged 205 and the negative ones 119.5. Muscle tremors were observed throughout the body during exposure of the positive kits to sevoflurane gas. It is concluded that for every 16 guinea pigs, 1 will react to the sevoflurane gas exposure positive due to the result obtained from the vital sign. Only the positive ones presented muscle tremors.     L'hyperthermie maligne (HM) est un syndrome clinique d'hypermétabolisme mettant en jeu le pronostic vital impliquant le muscle squelettique. Elle est déclenchée chez les individus sensibles principalement par des agents anesthésiques volatils par inhalation et le relaxant musculaire succinylcholine. MH affecte les humains, certaines races de porcs, les chiens, les chevaux et probablement d'autres animaux. Les signes classiques de MH comprennent une augmentation spectaculaire de la température corporelle, des muscles rigides ou douloureux, en particulier dans la mâchoire, une peau rougeoyante, une transpiration, un rythme cardiaque anormalement rapide ou irrégulier, une respiration rapide ou une respiration inconfortable, une urine brune ou de couleur cola, très faible tension artérielle (choc), confusion et faiblesse ou gonflement musculaire après l'événement. Le syndrome estsusceptible d'être fatal s'il n'est pas traité. Cette étude a donc évalué les effets du gaz sévoflurane sur les signes vitaux de Cavia porcellus avec hyperthermie maligne. Pour la détermination de l'hyperthermie maligne, 50 chatons sevrés de 15 jours de race Pérou ont été placés dans une chambre d'anesthésie pendant 5 minutes et soumis à un mélange d'air avec 3% de sévoflurane. Seuls 6 % d'entre eux ont réagi positivement, alors que la plupart d'entre eux, 94 %, ont été négatifs. La température corporelle moyenne des kits positifs était de 38,9 ° C, oscillant entre 38,7 et 39,1 ° C, tandis que les kits négatifs étaient en moyenne de 37,9 ° C. Les kits positifs avaient une moyenne de 142,3 respirations par minute par rapport aux négatifs, ce qui a été déterminé à être 83,7. Le nombre de battements cardiaques par minute dans les kits avec une réaction positive au sévoflurane était en moyenne de 205 et ceux négatifs de 119,5. Des tremblements musculaires ont été observés dans tout le corps pendant l'exposition des kits positifs au sévoflurane. Il est conclu que pour 16 cobayes, 1 réagira positivement à l'exposition au gaz sévoflurane en raison du résultat obtenu à partir du signe vital. Seuls les positifs présentaient des tremblements musculaires.

Stress-induced malignant hyperthermia in a head-injured patient

1988 ◽  
Vol 68 (2) ◽  
pp. 297-299 ◽  
Author(s):  
Tony Feuerman ◽  
George F. Gade ◽  
Robert Reynolds
Keyword(s):  
Head Injury ◽  
Body Temperature ◽  
Malignant Hyperthermia ◽  
Injured Patient ◽  
Drug Induced ◽  
Content Type ◽  
Anesthetic Agents ◽  
Head Injured ◽  
Inhalational Anesthetic ◽  
Fine Print

✓ Susceptibility to malignant hyperthermia is a rare inherited myopathy. Hypermetabolic crises accompanied by a rise in body temperature to as high as 44°C are the hallmark of malignant hyperthermia episodes. These are triggered by inhalational anesthetic agents or depolarizing muscle-relaxant drugs. A similar condition exists in pigs; however, in addition to drug-induced attacks, episodes of malignant hyperthermia occur in these animals as a result of stress. It has been proposed that stress-induced malignant hyperthermia occurs in man. The present paper presents a case of stress-induced malignant hyperthermia in a 21-year-old man in whom the inciting stress was a head injury.

scholarly journals Measurement of Heart Rate, and Body Temperature Based on Android Platform

2020 ◽  
Vol 2 (1) ◽  
pp. 26-33
Author(s):  
Musyahadah Arum Pertiwi ◽  
I Dewa Gede Hari Wisana ◽  
Triwiyanto Triwiyanto ◽  
Sasivimon Sukaphat
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Temperature Sensor ◽  
Liquid Crystal Display ◽  
Vital Signs ◽  
Health Condition ◽  
The Body ◽  
Digital Data ◽  
Mental Condition ◽  
Measurement Results

Heart rate and body temperature can be used to determine the vital signs of humans. Heart rate and body temperature are two important parameters used by paramedics to determine the physical health condition and mental condition of a person. Because if your heart rate or body temperature is not normal then you need to make further efforts to avoid things that are not desirable. The purpose of this study is to design a heart rate and body temperature. In this study, the heart rate is detected using a finger sensor which placed on the finger. This sensor detects the heart rate pulses through infrared absorption of blood hemoglobin, and measure the body temperature using a DS18B20 temperature sensor which is placed axially. DS18B20 sensor works by converting temperature into digital data. The measurement results will be displayed on liquid crystal display (LCD) 2 x 16 and the data will be sent to android mobile phone via Bluetooth.  After the comparision beetwen the desain and the standart, the error is 0.46% for beats per minutes (BPM) parameters and 0.31 degrees Celsius for temperature parameters.

scholarly journals Analysis and Discussion Concerning Death

2021 ◽  
Vol 2 (Issue 4) ◽  
pp. 1-8
Author(s):  
Joshua Juma Mugane
Keyword(s):  
Blood Pressure ◽  
Body Temperature ◽  
Pressure Pulse ◽  
Vital Signs ◽  
The Body ◽  
Human Beings ◽  
Chronic Pulmonary Obstructive Disease ◽  
Supernatural Power ◽  
The Dead ◽  
Unpleasant Smell

The analysis and discussion concerning death as intended by the Researcher depicts that death is an irreversible condition or state encountered by beings (all living creatures), due to a total dysfunction of the body organs. Such an irreversible condition is an enemy of human beings, which supersedes humanity, causing unexpected changes in life. It came as a punishment of abusing the supernatural power and finally it became a fact of not living forever. By the use of different literatures, Interviews and Documents, the research explored diverse concerns of death and drew its conclusion. Some of those concerns are “how is death detected? What are the causatives of death? Does death have its remedy? Where are dead people? Why do we bury the dead? And what is next after death?” The findings reveal that Doctors prove death by assessing and measuring the vital signs such as Blood Pressure, Pulse Rate, Respiratory Rate and Body Temperature. Moreover, the causatives of death include chronic pulmonary obstructive disease, ischemia, stroke, dehydration, infections and pain as well as old age. Those who encounter death are laid in the graves because God commanded it to be so and they produce unpleasant smell and stink. The remedy of it depends on the supernatural power that is believed to have ability of restoring the lost lives at consummation. That’s why Christians believe that on the second coming of Jesus Christ, all the dead shall rise. Hence, human beings have to be kin enough in lifetime, so that they may prolong a bit their lifespan through observance of health principles and guidelines.

scholarly journals FPGA Based Health Monitoring System

2020 ◽  
Vol 8 (5) ◽  
pp. 5573-5575
Keyword(s):  
Heart Rate ◽  
Body Temperature ◽  
Monitoring System ◽  
Health Monitoring ◽  
Wearable Sensors ◽  
Vital Signs ◽  
The Body ◽  
Health Report ◽  
Reduced Physical Activity ◽  
Healthcare Monitoring

In present days, Health issues are occurring more frequently. Because of climatic changes, industrialization and technical advancement which led to reduced physical activity. Saving lives requires monitoring the health conditions of people who have chronic diseases or heart related problems. Decrease in morbidity from disease and extend lives can be achieved by earlier detection of problems. When we reach a certain age we have to keep monitoring the three vital signs of the body to extend our lives. In this paper, we are designing a healthcare monitoring system which can either monitor or measure three vital signs i.e. heart rate, respiratory rate and body temperature of human body. The developed system uses wearable sensors to measure body temperature, heart rate and breathing rate. In order to minimize human involvement and respond at an appropriate time a health monitoring designed FGPA system will take the data from the sensors and analyze the date. It will give the health report, health status and alerts the concerned whenrequired.

scholarly journals An effect of physical exercise-induced fatigue on the vital sign parameters: A preliminary study

2019 ◽  
Vol 15 (2) ◽  
pp. 173-177
Author(s):  
Zulkifli Ahmad ◽  
Mohd Najeb Jamaludin ◽  
Kamaruzaman Soeed
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Body Temperature ◽  
Physical Exercise ◽  
Vital Sign ◽  
Vital Signs ◽  
Health Condition ◽  
The Body ◽  
Physical Movement ◽  
Exercise Induced

Vital sign monitoring is an important body measurement to identify health condition and diagnose any disease and illness. In sports, physical exercise will contribute to the changes of the physiological systems, specifically for the vital signs. Therefore, the objective of this study was to determine the effect of physical fatigue exercise on the vital sign parameters. This is significant for the fitness identification and prediction of each individual when performing an exercise. Five male subjects with no history of injuries and random BMI were selected from students of biomedical engineering, Universiti Teknologi Malaysia. Based on the relationship between physical movement and physiology, the parameters considered were heart rate, blood pressure, and body temperature. Subjects were required to run on the treadmill at an initial speed of 4 km/h with an increase of 1 km/h at every 2 minutes interval. The effect of exercise was marked according to the fatigue protocol where the subject was induced to the maximum condition of performance. All parameters were measured twice, for pre and post exercise-induced protocol. The analysis of relationship of each parameter between pre and post fatigue was p<0.05. The results revealed that the heart rate and gap between blood pressure’s systolic and diastolic were greater for all categories except underweight, where the systolic blood pressure dropped to below 100mmHg at the end of exercise. Also, the body temperature was slightly declined to balance the thermoregulatory system with sweating. Hence, the vigorous physical movement could contribute to the active physiological system based on body metabolism. Heart rate and blood pressure presented significant effects from the fatiguing exercise whereas the body temperature did not indicate any distinguishable impact. The results presented might act as the basis of reference for physical exercise by monitoring the vital sign parameters.

scholarly journals The impact of vital signs on the death of patients with new coronavirus pneumonia: A systematic review and meta-analysis

2020 ◽  
Author(s):  
Meixia Du ◽  
Jie Zhao ◽  
Xiaochun Yin ◽  
Nadi Zhang ◽  
Guisen Zheng
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Heart Rate ◽  
Body Temperature ◽  
Respiratory Rate ◽  
Meta Analysis ◽  
Vital Signs ◽  
The Body ◽  
Survival Group ◽  
The Impact

Background: Assessing the impact of vital signs (blood pressure, body temperature, heart rate, respiratory rate, and oxygen saturation) on the death of patients with new coronavirus pneumonia would provide a simple and convenient method for the monitoring of subsequent illness, and therefore, in some degree reduce treatment costs and increase the cure rate clinically. Methods: Six databases were retrieved. The software R 3.6.2 was used for meta-analysis of the included literature. Results: 12 studies were included, which comprise 8996 patients affected with COVID-19 infection. The meta-analysis study found that blood pressure (MAP, SBP and DBP), heart rate, respiration rate and SpO2 are the risk factors for disease progression in patients with COVID-19. Among them, the increase in MAP and the decrease in SpO2 have the greatest impact on the death of patients with COVID-19 [MAP: MD = 5.66, 95% CI (0.34, 10.98), SpO2: MD = -5.87, 95% CI (-9.17, -2.57), P = 0.0005]. However, comparing the body temperature of the death group and the survival group found that the body temperature was not statistically significant between the two groups [body temperature: MD = 0.21, 95% CI (-0.01, 0.43), P = 0.0661]. Conclusion: The increase in MAP, heart rate and respiratory rate, as well as the decrease in SBP, DBP and SpO2 are all independent risk factors for death in patients with COVID-19. These factors are simple and easy to monitor, and individualized treatment can be given to patients in time, reducing the mortality rate and improving treatment efficiency.

scholarly journals Effect of heat stress on vital signs in high-yield dairy cows

2010 ◽  
Vol 64 (1-2) ◽  
pp. 53-63 ◽  
Author(s):  
Ivan Vujanac ◽  
Danijela Kirovski ◽  
Jovan Bojkovski ◽  
Radisa Prodanovic ◽  
Bozidar Savic ◽  
...  
Keyword(s):  
Heat Stress ◽  
Body Temperature ◽  
Dairy Cows ◽  
Vital Signs ◽  
The Body ◽  
Heat Index ◽  
High Yield ◽  
Physiological Indicators ◽  
High Degree ◽  
Respiratory Movements

The objective of this work was to examine the influence of outer temperature on values of the vital signs (temperature, pulse, respiration) in high-yield dairy cows in early stages of lactation, as well as to establish, on the grounds of the degree of correlation between the values for the vital signs and the temperature humidity index (THI), possibilities for using the examined physiological parameters of the organism as an indicator of heat stress. The experiment covered 10 high-yield dairy cows in the first phase of lactation. The investigations were carried out in the course of July and the first half of August. During the course of the experiment, the average THI was determined daily. An average daily THI higher than 70 indicated that the animal had been exposed to heat stress on that day. Vital signs were measured on twelve occasions during the period of investigation (June 30, July 4, July 7, July 10, July 14, July 17, July 21, July 24, July 29, August 5, August 11, and August 14). It was established on the grounds of the THI values that the examined animals were exposed to heat stress on June 30, July 4, July 7, July 14, July 17, July 21, July 29, August 5, and August 14, while there was no heat stress on July 10, July 24, and August 11. The average body temperature during all the periods of examination, with the exception of July 24, was above the upper physiological limit. A high degree of correlation was established between body temperature and the heat index (r = +0. 509; p = 0.05). The number of respiratory movements per minute was above the physiological values during the entire period of investigation. There was a high degree of correlation between the number of respiratory movements and THI (r = + 0.625; p<0.05). The average pulse values and number of contractions of the rumen did not vary significantly during the period of investigation. No significant correlation was established between the pulse and THI values, or between motoric activities of the rumen and THI. The results obtained in this work demonstrate that, in high-yield dairy cows exposed to moderate heat stress, the body temperature and the number of respiratory movements are above physiologically permitted values. On these grounds, it can be concluded that these two parameters of the vital signs can be used as physiological indicators of heat stress. .

scholarly journals SUHU TUBUH: HOMEOSTASIS DAN EFEK TERHADAP KINERJA TUBUH MANUSIA

2013 ◽  
Vol 1 (2) ◽  
Author(s):  
Yondry Kukus ◽  
Wenny Supit ◽  
Fransiska Lintong
Keyword(s):  
Body Temperature ◽  
Vital Signs ◽  
Heat Energy ◽  
The Body ◽  
Whole Body ◽  
Sweat Glands ◽  
Body Temperatures ◽  
Connective Tissues ◽  
Ambient Temperatures ◽  
Key Words Core Temperature

Abstract: Body temperature is defined as one of the vital signs that indicates the health status of a person. Compared with other primates, man has a greater ability to tolerate hot temperatures due to his many sweat glands, and that his skin is covered mostly by fine hair. In our bodies, heat energy is produced by muscles (mostly), sweat glands, fats, bones, connective tissues, and nerves. Heat energy is distributed to the whole body by blood circulation, but the temperatures are not the same in all parts of the body. There is a difference (around 40C) between core and surface body temperatures. The thermoregulator system has to obtain two suitable gradients: 1) between core and surface body temperatures, and 2) between surface and ambient temperatures. The gradient between core and surface body temperatures is the most important one to maintain optimum body function. Understanding from physics the aspect of body temperature and its influence on homeostatis mechanism, gives some valuable contribution to applied clinical sciences. Key words: core temperature, skin temperature, energy.     Abstrak: Suhu tubuh didefinisikan sebagai salah satu tanda vital yang menggambarkan status kesehatan seseorang. Dibandingkan dengan primata lainnya, manusia mempunyai kemampuan yang lebih besar untuk mentolerer suhu tinggi oleh karena banyaknya kelenjar keringat, dan kulitnya hanya ditumbuhi oleh rambut halus. Di dalam tubuh energi panas dihasilkan oleh jaringan aktif terutama dalam otot, kemudian juga dalam alat keringat, lemak, tulang, jaringan ikat, serta saraf. Energi panas yang dihasilkan didistribusikan ke seluruh tubuh melalui sirkulasi darah, namun suhu bagian-bagian tubuh tidak merata. Terdapat perbedaan yang cukup besar (sekitar 4°C) antara suhu inti dan suhu permukaan tubuh.6,7 Sistem termo-regulator tubuh harus dapat mencapai dua gradien suhu yang sesuai, yaitu: 1) antara suhu inti dengan suhu per-mukaan, 2) antara suhu permukaan dengan suhu lingkungan. Dari keduanya, gradien suhu inti dengan suhu permukaan adalah yang terpenting untuk kelangsungan fungsi tubuh yang optimal. Pemahaman tentang besaran suhu dan pengaruhnya terhadap mekanisme homeostatis tubuh melalui pendekatan hukum-hukum fisika setidaknya memberi kontribusi yang berarti pada bidang ilmu klinis terapan. Kata kunci: suhu inti, suhu kulit, energi.

Antipyretic Plants: An Updated Review

2020 ◽  
Vol 16 (1) ◽  
pp. 4-12
Author(s):  
Vandana Garg ◽  
Rohit Dutt
Keyword(s):  
Side Effects ◽  
Body Temperature ◽  
Medicinal Plants ◽  
Inflammatory Mediators ◽  
Review Paper ◽  
The Body ◽  
Hypothalamic Area ◽  
Antipyretic Activity ◽  
Disease States ◽  
Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

A Litreary Review of Vishama Jwara and its principle of treatment

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr.Saurabh Parauha ◽  
Hullur M. A. ◽  
Prashanth A. S.
Keyword(s):  
High Temperature ◽  
Body Temperature ◽  
The State ◽  
The Body ◽  
Cardinal Symptoms

In Ayurveda, Jwara is not merely the concept of raised body temperature, but as is said in Charaka Samhita, 'Deha- Indriya- Manah- Santap' is the cardinal symptoms of Jwara. This can be defined as the state where the body, mind as well as sense oragans suffer due to the high temperature. Vishamajwara is a type of fever, which is described in all Ayurvedic texts. Charaka mentioned Vishamajwara and Chakrapani have commented on Vishamajwara as Bhutanubanda, Susruta affirmed that Aagantuchhanubhandohi praysho Vishamajware. Madhavakara has also recognised Vishamajwara as Bhutabhishangajanya (infected by microorganism). Vishamajwara is irregular (inconsistent) in it's Arambha (nature of onset commitment), Kriya (action production of symptoms) and Kala (time of appearance) and possesses Anushanga (persistence for long periods). The treatment of this disease depends upon Vegavastha and Avegavastha of Jwara. Various Shodhana and Shamana procedures are mentioned in classics to treat Visham Jwara.

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