scholarly journals Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10-23: a bibliometric study

2021 ◽  
Vol 10 (35) ◽  
pp. 78-78
Author(s):  
Peter Christian Endler
Keyword(s):  
Basic Research ◽  
Initial Study ◽  
Experimental Models ◽  
Research Community ◽  
Model Systems ◽  
Personal Contact ◽  
Important Criterion ◽  
Sources Of Information ◽  
Fundamental Research

Introduction: Repeatability of experiments is an important criterion of modern research and a major challenge for homeopathic basic research. There is a lack of a recent overview about basic research studies in high homeopathic potencies that have been subjected to laboratory-internal, multicenter or independent repetition trials. Methods: We considered biochemical, immunological, botanical, cell biological and zoological studies on high potencies, i.e. beyond a dilution of 10-23. Main sources of information were reviews, personal contact with members of the homeopathic basic research community, and the MEDLINE and HOMBREX databases. Studies were extracted from the publications and grouped into models. Studies were further sorted according to repetition type (laboratory-internal, multicenter, or independent) and results achieved. Results: A total of 107 studies have been found. From these, 30 were initial studies. In the attempt to reproduce one of these initial studies, 53 follow up studies yielded comparable effects (35 laboratory-internal, 8 multicenter, 10 independent repetitions), eight studies showed a consistent, yet different result from the initial study (2 laboratory-internal, 2 multicenter, 4 independent repetitions), and 16 studies yielded zero effects (5 laboratory-internal, 2 multicenter, 9 independent repetitions). When all repetitive studies are considered, 69% reported effects comparable to that of the initial study, 10% different effects, and 21% zero effects. Independently performed repetition studies reported 44% comparable effects, 17% different effects, and 39% zero effects. Conclusions: We identified 24 experimental models in basic research on high homeopathic potencies, which were repeatedly investigated. 22 models were reproduced with comparable results, 6 models with different results, and repetition showed no results for 15 models. Independent reproductions with either comparable or different results were found for seven models. We encourage further repetition trials of published studies, in order to learn more about the model systems used and in order to test their repeatability

Factors and Trends in the Development of Institutional and Organizational Leadership in the Leading Scientific and Technical Sectors and Basic Research

2020 ◽  
Vol 9 (1) ◽  
pp. 20-26
Author(s):  
I. Korneeva
Keyword(s):  
Organizational Leadership ◽  
Effective Leadership ◽  
Science And Technology ◽  
Basic Research ◽  
Important Task ◽  
Study Analysis ◽  
Sources Of Information ◽  
Institutional Leadership ◽  
Number Of Factors ◽  
Fundamental Research

The article is devoted to the development of institutional and organizational leadership in the leading scientific and technical sectors and fundamental research. The paper presents the characteristics of the categories “organizational leadership” and “institutional leadership”, the features of effective leadership. Methodological tools of the study: analysis of statistical sources of information. As the study showed, the formation and development of leading positions are influenced by a number of factors. Their analysis is carried out, tendencies of development of leadership in the leading scientific and technical sectors and fundamental researches are revealed. It is concluded that an important task is the choice of the country’s development in the field of science and technology. The author considers the ways in which it is possible to develop institutional and organizational leadership in the leading scientific and technical sectors and fundamental research.

scholarly journals The Influence of Friends on Teen Vaping: A Mixed-Methods Approach

2021 ◽  
Vol 18 (13) ◽  
pp. 6784
Author(s):  
Allison L. Groom ◽  
Thanh-Huyen T. Vu ◽  
Robyn L. Landry ◽  
Anshula Kesh ◽  
Joy L. Hart ◽  
...  
Keyword(s):  
Social Media ◽  
Peer Influence ◽  
Urban Areas ◽  
Online Survey ◽  
Strong Association ◽  
Self Esteem ◽  
Demographic Variables ◽  
Common Source ◽  
Sources Of Information

Vaping is popular among adolescents. Previous research has explored sources of information and influence on youth vaping, including marketing, ads, family, peers, social media, and the internet. This research endeavors to expand understanding of peer influence. Our hypothesis is that friends’ influence on teen vapers’ first electronic nicotine delivery systems (ENDS) use varies by demographic variables and awareness of ENDS advertising. In August–October 2017, youth (n = 3174) aged 13–18 completed an online survey to quantify ENDS behaviors and attitudes and were invited to participate in follow-up online research in November-December 2017 to probe qualitative context around perceptions and motivations (n = 76). This analysis focused on the ENDS users, defined as having ever tried any ENDS product, from the survey (n = 1549) and the follow-up research (n = 39). Among survey respondents, friends were the most common source of vapers’ first ENDS product (60%). Most survey respondents tried their first ENDS product while “hanging out with friends” (54%). Among follow-up research participants, the theme of socializing was also prominent. ENDS advertising and marketing through social media had a strong association with friend networks; in fact, the odds of friends as source of the first vaping experience were 2 times higher for those who had seen ENDS ads on social media compared with other types of media. The influence of friends is particularly evident among non-Hispanic Whites, Hispanics/Latinos, those living in urban areas, those living in high-income households, those with higher self-esteem, and those who experiment with vaping. These findings support the premise that peer influence is a primary social influencer and reinforcer for vaping. Being included in a popular activity appears to be a strong driving force.

scholarly journals GT-Repeat Polymorphism in the HO-1 Gene Promoter Is Associated with Risk of Liver Cancer: A Follow-Up Study from Arseniasis-Endemic Areas in Taiwan

2021 ◽  
Vol 10 (7) ◽  
pp. 1489
Author(s):  
Meei-Maan Wu ◽  
Fang-I Hsieh ◽  
Ling-I Hsu ◽  
Te-Chang Lee ◽  
Hung-Yi Chiou ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Risk ◽  
Cox Regression ◽  
Therapeutic Potential ◽  
Gene Promoter ◽  
Experimental Models ◽  
Heme Oxygenase 1 ◽  
Cox Regression Analysis ◽  
S Alleles

The induction of heme oxygenase-1 (HO-1) has been shown to have therapeutic potential in experimental models of hepatitis and liver fibrosis, which are closely related to liver cancer. In humans, HO-1 induction is transcriptionally modulated by the length of a GT-repeat [(GT)n] in the promoter region. We aimed to investigate the effect of HO-1 (GT)n variants on liver cancer in a human population. We determined the HO-1 genotype in 1153 study subjects and examined their association with liver cancer risk during a 15.9-year follow-up. Allelic polymorphisms were classified as short [S, <27 (GT)n] or long [L, ≥27 (GT)n]. Newly developed cancer cases were identified through linkage to the National Cancer Registry of Taiwan. Multivariate Cox regression analysis was used to evaluate the effect of the HO-1 (GT)n variants. Alpha-fetoprotein (AFP) and cirrhosis history were also examined. The S/S genotype was found to be significantly associated with liver cancer risk, compared to the L/S and L/L genotypes. The S/S genotype group also had a higher percentage of subjects with abnormal AFP levels than other groups. There were significant percentages of cirrhosis among groups who carried S-alleles. Our findings indicate that short (GT)n variants in the HO-1 gene may confer susceptibility to rather than protection from liver cirrhosis/cancer.

[P-036]: Prodromal cognitive signs of dementia in 85 year-olds - validity of four sources of information in a three year follow-up

2005 ◽  
Vol 1 ◽  
pp. S19-S19
Author(s):  
Simona Sacuiu ◽  
Magnus Sjögren ◽  
Boo Johansson ◽  
Ingmar Skoog
Keyword(s):  
Sources Of Information

scholarly journals Long-term Follow-up of Craniofacial Alterations in Juvenile Idiopathic Arthritis

2009 ◽  
Vol 79 (6) ◽  
pp. 1057-1062 ◽  
Author(s):  
Marinka Twilt ◽  
Alcuin J. M. Schulten ◽  
Birte Prahl-Andersen ◽  
Lisette W. A. van Suijlekom-Smit
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Temporomandibular Joint ◽  
Initial Study ◽  
Study Cohort ◽  
Craniofacial Skeleton ◽  
Lateral Cephalograms ◽  
Long Term Follow Up ◽  
Angular Measurements

Abstract Objective: To investigate changes in the craniofacial skeleton in relation to the changes in condylar alterations that occur during long-term follow-up in patients with juvenile idiopathic arthritis. Materials and Methods: Temporomandibular joint (TMJ) involvement is defined as a condylar alteration that is observed on the orthopantomogram. Lateral cephalograms were used to determine linear and angular measurements. Results: Seventy of 97 patients from the initial study cohort were included, with a mean follow-up of 68 months. The overall prevalence of condylar alterations and posterior rotation of the mandible decreased; however, the prevalence of retrognathia remained the same. Patients showed improvement in the degree of retrognathia and posterior rotation (40% ANB, 51% OP-SN, and 44% GO-GN-SN). Improvement in the degree of retrognathia was seen more often in patients with improved condylar alterations than in patients with persistent alterations and in those without alterations (50%, 33%, and 28%, respectively). The degree of posterior rotation improved almost equally in patients without TMJ involvement and in patients with improved condylar alterations (57% and 50% by OP-SN, and 67% and 38% GO-GN-SN, respectively) and did not improve in patients with stable persistent alterations. Conclusion: Both condylar and craniofacial alterations can improve in patients with juvenile idiopathic arthritis.

scholarly journals Experimental Models to Study COVID-19 Effect in Stem Cells

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 91
Author(s):  
Rishi Man Chugh ◽  
Payel Bhanja ◽  
Andrew Norris ◽  
Subhrajit Saha
Keyword(s):  
Stem Cells ◽  
Ex Vivo ◽  
Drug Efficacy ◽  
Cell Loss ◽  
Experimental Models ◽  
Model Systems ◽  
Virus Infectivity ◽  
Ex Vivo Model ◽  
Global Pandemic ◽  
The Impact

The new strain of coronavirus (severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2)) emerged in 2019 and hence is often referred to as coronavirus disease 2019 (COVID-19). This disease causes hypoxic respiratory failure and acute respiratory distress syndrome (ARDS), and is considered as the cause of a global pandemic. Very limited reports in addition to ex vivo model systems are available to understand the mechanism of action of this virus, which can be used for testing of any drug efficacy against virus infectivity. COVID-19 induces tissue stem cell loss, resulting inhibition of epithelial repair followed by inflammatory fibrotic consequences. Development of clinically relevant models is important to examine the impact of the COVID-19 virus in tissue stem cells among different organs. In this review, we discuss ex vivo experimental models available to study the effect of COVID-19 on tissue stem cells.

Assessment of public perception regarding wastewater reuse

2005 ◽  
Vol 5 (1) ◽  
pp. 59-65 ◽  
Author(s):  
K.G. Robinson ◽  
C.H. Robinson ◽  
S.A. Hawkins
Keyword(s):  
Public Perception ◽  
Wastewater Reuse ◽  
Primary Sources ◽  
Personal Contact ◽  
Sources Of Information ◽  
Population Demographics ◽  
Southeast United States ◽  
Demographic Groups ◽  
Lawn Irrigation ◽  
Or Applications

A descriptive-correlational study was recently conducted in a four county metropolitan area in the southeast United States (US) as part of a collaborative effort between nursing and environmental engineering researchers. The purpose of the study was to assess attitudes, knowledge and information sources concerning wastewater reuse and evaluate the results with respect to population demographics. The study indicated that both men and women unfavorably view the use of wastewater for possible consumption (released into potable surface or groundwater supplies) or applications involving close, personal contact (laundry). Women were especially concerned about pumping wastewater into the groundwater for subsequent potable use. Both genders felt that wastewater reuse for applications not involving close personal contact (such as firefighting, car washing, lawn irrigation and agricultural uses) was acceptable. General knowledge concerning wastewater reuse was mixed. Those with lower incomes, less education, and 65 years of age or older had significantly less knowledge of this issue than younger, more educated, higher income individuals. Primary sources of information for most demographic groups included newspaper and television, although the Internet was identified as a frequent source for selected groups.

Identifying and Assessing the Implementation of Human Rights Decisions

2020 ◽  
Vol 12 (1) ◽  
pp. 125-148
Author(s):  
Alice Donald ◽  
Debra Long ◽  
Anne-Katrin Speck
Keyword(s):  
Human Rights ◽  
Status Quo ◽  
Good Faith ◽  
Civil Society Organizations ◽  
Evidence Based ◽  
Sources Of Information ◽  
European Regions ◽  
The Status ◽  
Public Record

Abstract Assessing the extent to which states have implemented the decisions of supranational human rights bodies is a challenging task. It requires supranational bodies—be they judicial, quasi-judicial or political—to create an evidence-based public record of the status quo of implementation at any point in time and determine whether the measures taken do, in fact, satisfy the requirements of the decision. This, in turn, relies upon states engaging in good faith, victims having a voice, and civil society organizations seizing the opportunity to influence the follow-up process. Using empirical data from interviews in selected states in the African, Inter-American and European regions, and within regional and United Nations bodies, this article argues that in no human rights ‘system’ are all these expectations met, in part because follow-up work is inadequately resourced. It argues that supranational bodies should proactively seek out diverse sources of information and adopt more transparent and responsive working methods so as to enable ‘real time’ participation by all interested parties. The article concludes with recommendations for supranational bodies, and state and non-state actors.

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