scholarly journals Relationship of anti-fertility effects of Andrographis paniculata and hormonal assay in female rats

1970 ◽  
pp. 10-14 ◽  
Author(s):  
S Sakila ◽  
N Begum ◽  
S Kawsar ◽  
ZA Begum ◽  
MS Zola
Keyword(s):  
Medical Science ◽  
Water Extract ◽  
Andrographis Paniculata ◽  
Female Rats ◽  
Male Rats ◽  
Control Group ◽  
Exposure Group ◽  
Medical College ◽  
Group I

Aims: This study was aimed to find out anti-fertility effects of Andrographis paniculata (AP) plant. Study design & Methodology: A prospective case control animal study with 85 female and 30 male rats (Total 115 rats) was done in the Department of Pharmacology of Dhaka Medical College and Bangladesh Medical College, Dhaka, Bangladesh from July 2002 to December 2003. The total 85 female rats were grouped into case study or exposure group (N=60 female rats) exposed to water extract of AP & control or non exposure group (N=25 female rats, 30 male rats also considered as control group) Exposure group (water extract) of female were again subdivided in 3 groups according to duration of (A.P) exposure (N=20 in each group) e.g. 4 weeks, 6 weeks and 8 weeks. Mating schedules were done after the completion of scheduled duration of exposure with A.P (Dose was 1 gm/kg). Results: In group I percentage of infertility was 33.33% in 4 weeks exposure, 50% in 6 weeks exposure & 100% in 8 weeks exposure respectively. In control group (Group II) percentage of infertility was 0%. In case study group of female rats the value of FSH was 1.20 1U/L (4 weeks), 1.12 1U/L (6 weeks), 1.00 1U/L (8 weeks), LH 0.78 1U/L (4 weeks), 0.70 1U/L (6 weeks), 0.64 1U/L (8 weeks), Estrogen 45.30 pg/ml (4 weeks), 44.80 pg/ml (6 weeks), 44.20 pg/ml (8 weeks) and Progesterone 4.84 nmol/L (4 weeks), 4.72 nmol/L (6 weeks) and 3.80 nmol/L (8 weeks). In non exposure group the value of FSH was 1.23 1U/L, LH 0.80 1U/L, Estrogen 47.05 pg/L and Progesterone 5.50 nmol/L. In exposure group all the values were lesser than the normal hormonal value. Conclusion: This study suggests that due to lower level of hormone, female rats have promising percentage of infertility with AP. Further study is needed with rat as well as clinical trial with human being. Key Words: Andrographis paniculata, Antifertility effects doi: 10.3329/bjms.v8i1.3183 Bangladesh Journal of Medical Science Vol.8 No. 1-2; 2009 10-14

scholarly journals Effects of Solanum torvum fruit water extract on hyperlipidemia and sex hormones in high-fat fed male rats

2017 ◽  
Vol 7 (5) ◽  
pp. 401-405 ◽  
Author(s):  
Supaporn Wannasiri ◽  
Sunee Chansakaow ◽  
Seewaboon Sireeratawong
Keyword(s):  
Sex Hormones ◽  
Water Extract ◽  
Male Rats ◽  
High Fat ◽  
Solanum Torvum

A Study of the Effect of Forcipomyia Taiwana Repellents Made of Plant Extracts

2013 ◽  
Vol 365-366 ◽  
pp. 1221-1224
Author(s):  
Ching Wen Lou ◽  
Ming Chun Sie ◽  
Chao Tsang Lu ◽  
Huey Liang Kuo ◽  
Jia Horng Lin
Keyword(s):  
Immune System ◽  
Plant Extracts ◽  
Water Extract ◽  
Repellent Effect ◽  
Sensitive Skin ◽  
Tube Test ◽  
Intense Pruritus ◽  
Influence Of Water ◽  
Long Time ◽  
The Difference

The bite of Forcipomyia taiwana (F. taiwana) causes intense pruritus and swelling in sensitive skin. Most commercially available F. taiwana repellents are made of N, N-diethyl-3-methylbenzamide synthetic repellents [; however, using them for a long time influences skins, and the nervous and immune system. This study uses the water extracted Cinnamomum osmophloeum Kaneh and Cymbopogon excavates for the Y-tube test, determining the repellent effect of these two extracts and the influence of water extract time on the difference in their repellent effect.

scholarly journals THE EFFECTIVENESS OF CORIANDER (Coriandrum sativum L.) EXTRACTS ON REDUCING THE BLOOD SUGAR LEVELS OF ALLOXAN INDUCED WISTAR MALE RATS (Rattus norvegicus L.)

2020 ◽  
Vol 6 (1) ◽  
pp. 36-44
Author(s):  
Kalvin Dersing
Keyword(s):  
Blood Sugar ◽  
Rattus Norvegicus ◽  
Water Extract ◽  
Coriandrum Sativum ◽  
Male Rats ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Wistar Strain ◽  
Sugar Levels

AbstractBackground : Diabetes mellitus is the most common metabolic syndrome in the whole world with an incidence of 1-8%. This disease arises when insufficient insulin is produced or insulin cannot function properly.The ability of coriander juice water extract is expected to reduce blood glucose levels because the action is similar to insulin and can stimulate insulin release. Purpose : Knowing effectiveness coriander extract (Coriandrum sativum L.)to decline blood sugar levels in male white rats (Rattus norvegicus L.) wistar strain induced by alloxan. Method : This is a pure experimental study (true-experiment) using a pre and post test design with control group design using subjects namely white rats (Rattus norvegicus L.) male Wistar strain aged 10-12 weeks with a weight of 150-200 grams. By looking at changes in blood sugar levels during administration of alloxan and administration of coriander extract. Results : There were significant changes in some groups induced alloxan (p <0.05), but the effect of coriander extract was not very significant (p> 0.05). Conclusion : Coriander extract can control blood sugar levels to be stable or normal, but it takes longer and more research.  Keywords : coriander extract, blood sugar levels, alloxan

Effectiveness of Garlic Water Extract Gel (Allium sativum. L) Against Necrotic Factor Alfa Tumors and Mouth Ulcer Diameter in Wistar White Male Rats

2020 ◽  
Vol 6 (1) ◽  
pp. 27-34
Author(s):  
Dian Anggraeni ◽  
Kamaluddin Kamaluddin ◽  
Theodorus Theodorus
Keyword(s):  
Treatment Group ◽  
Allium Sativum ◽  
Water Extract ◽  
Oral Ulcer ◽  
Male Rats ◽  
Gingival Tissue ◽  
Epithelial Tissue ◽  
Test Results ◽  
Oral Ulcers ◽  
One Way Anova

Oral ulcers are pathological conditions that are characterized by loss of epithelial tissue, causing inflammation. During inflammation, the inflammatory mediator is TNF will increase. Therefore, drugs are needed to suppress TNF-levels to suppress inflammation. One of the herbal ingredients that can suppress inflammation is garlic. In vivo laboratory experimental research with pre-post systems. The samples used were 36 male Wistar white rats divided into 6 groups (6 individuals / groups), namely the group without drug treatment (as pre-treatment data), negative control group namely HPMC gel base, positive control given benzydamin, group treatment I was given a garlic water extract gel 20%, treatment group II was given a garlic water extract gel 40%, treatment group III were given a garlic water extract gel 80%. The drug is given topically 2 times a day for 4 days. Making oral ulcers is done by placing filter paper that has been soaked in a 50% acetic acid solution in the labial area of the mandibular gingival tissue. Measurement of oral ulcers was performed on the 1st day after the manufacture of oral ulcers and the 5th day. On the 5th day all the mice were sacrificed to be taken gingival tissue and TNF-levels were measured. using ELISA. Data analysis using SPSS version 24 and One Way Anova test with 5% specification followed by Post Hoc Test using LSD test and Games Howell. Analysis using One Way Anova showed that there were significant differences in TNF-levels and the diameter of the oral ulcer (p <0.05) between groups which indicated that the garlic water extract gel applied in the area of the oral ulcer affected TNF levels. and the diameter of the oral ulcer. LSD test results showed that 80% effective garlic water extract gel significantly reduced TNF levels. (p <0.05). Games Howell test results showed that 20%, 40% and 80% garlic water extract gel had the same effectiveness as benzydamin in decreasing the diameter of oral ulcer. Garlic water extract gel (Allium sativum. L) concentration was 80% more effective than benzydamin for decreasing TNF levels Garlic water extract gel (Allium sativum. L) concentrations of 20%, 40% and 80% are as effective as benzydamin in reducing the diameter of oral ulcers in male wistar strain rats.

scholarly journals The Antidiabetic and Antilipidemic Activity of Aqueous Extract of Urtica dioica L. on Type2 Diabetic Model Rats

1970 ◽  
Vol 17 ◽  
pp. 1-6 ◽  
Author(s):  
M Das ◽  
BP Sarma ◽  
AKA Khan ◽  
M Mosihuzzaman ◽  
N Nahar ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Water Extract ◽  
Treated Group ◽  
Serum Glucose ◽  
Urtica Dioica ◽  
Male Rats ◽  
Diabetic Model ◽  
Type 2 Diabetic

Context: To evaluate the anti-diabetic activity of Urtica dioica L. in type 2 diabetic model rats.Objectives: The aim of this study is to explore the effect of water extract of U. dioica on glycemic status, body weight and lipidemic status in type2 diabetic model ratsMaterials and Methods: The mature and fresh leaves of U. dioica was collected from the mountain range of Assam in India and the leaves extract was used at a dose of 1.25 g-kg body weight. Type2 diabetes was induced by a single intraperitoneal injection of STZ to 48 hours old pups of Long Evans. Experiments for semi-chronic effects were done with continuous feeding of aqueous extract for 14 days at a dose of 1.25 g-kg body weight type 2 diabetic male rats. Serum glucose was estimated by GOD-POD method, serum triglyceride and cholesterol by enzymatic-colorimetric methods.  Results: Water extract showed significant effect on lowering fasting serum glucose levels in type 2 diabetic model rats on 14th day (14.05 ± 3.4 mmol/l in control vs 8.3 ± 1.4 mmol/l in treated group, p = 0.04). There was significant increase in the body weight of treated group in comparison to the control group (175 ± 8 g in control vs in 168 ± 9 g in treated group on 0 day, p = ns; 193 ± 26 g in control vs in 185 ± 25 g in treated group on 14th day, p=0.002]. Beneficial effect was observed in lipid although the change was not statistically significant.Conclusion:  The results obtained in this study suggests that U. dioica has hypoglycemic and hypo-lipidemic activity in type 2 diabetic model rats. This may be due to the histological and functional improvement of b-cells with the consequence of improved insulinemic status.Key words: hypoglycemic; hypolipidemic; Urtica dioica; diabetes mellitusDOI: 10.3329/jbs.v17i0.7092J. bio-sci. 17: 1-6, 2009

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