Lower Serum Levels of Antibodies against Tetanus Toxin in Patients with Hypothyroidism

Abstract Objectives To investigate whether the perioperatively combined application of dexamethasone and furosemide could alleviate the inflammation in patients undergoing percutaneous nephrolithotomy (PCNL). Patients and methods 147 patients undergoing PCNL between November 2018 and October 2019 were enrolled in the study. 77 patients accepted a single dose of dexamethasone and furosemide administration (EXP group, n = 77), and 70 patients did not (CON group, n = 70). Demographic and perioperative data, inflammatory markers including interleukin-6 (IL-6) and procalcitonin (PCT), and clinical outcomes were compared between the two groups. Results Compared with the CON group, the incidence rate of urosepsis of the EXP group were significantly lower (11.69% vs. 24.29%, p = 0.046). 3 patients developed severe urosepsis in the EXP group, while 5 patients developed severe urosepsis in the CON group. Compared with those in the CON group, the patients with postoperative urosepsis in the EXP group showed lower serum levels of IL-6 at postoperative hour two (p = 0.045) and at postoperative day one (p = 0.031) and lower serum levels of PCT at postoperative day one (p = 0.015). There was a better clinical outcome of a shorter postoperative hospital stay (p = 0.015) in patients with postoperative urosepsis in the EXP group than in those in the CON group. Conclusion The perioperatively combined application of dexamethasone and furosemide was beneficial for alleviating postoperative inflammatory reaction and caused a better clinical outcome of a shorter postoperative hospital stay.

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Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker

Multiple Sclerosis Journal ◽

10.1177/1352458516667564 ◽

2016 ◽

Vol 23 (7) ◽

pp. 937-945 ◽

Cited By ~ 6

Author(s):

Teresa Órpez-Zafra ◽

Jose Pavía ◽

Isaac Hurtado-Guerrero ◽

Maria J Pinto-Medel ◽

Jose Luis Rodriguez Bada ◽

...

Keyword(s):

Multiple Sclerosis ◽

Serum Levels ◽

Cross Sectional Study ◽

First Year ◽

Diagnostic Biomarker ◽

Lower Serum ◽

Cross Sectional ◽

Treatment Naïve ◽

Β Receptor ◽

Multiple Sclerosis Patients

Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in untreated multiple sclerosis (MS) than in healthy controls (HCs). Objective: To assess sIFNAR2 levels in a new cohort of MS patients and HCs, as well as in patients with clinically isolated syndrome (CIS) and with other inflammatory neurological disorders (OIND) and to assess its ability as a diagnostic biomarker. Methods: The cross-sectional study included 148 MS (84 treatment naive and 64 treated), 87 CIS, 42 OIND, and 96 HCs. Longitudinal study included 94 MS pretreatment and after 1 year of therapy with IFN-β, glatiramer acetate (GA), or natalizumab. sIFNAR2 serum levels were measured by a quantitative ELISA developed and validated in our laboratory. Results: Naive MS and CIS patients showed significantly lower sIFNAR2 levels than HCs and OIND patients. The sensitivity and specificity to discriminate between MS and OIND, for a sIFNAR2 cutoff value of 122.02 ng/mL, were 70.1%, and 79.4%, respectively. sIFNAR2 increased significantly in IFN-β-treated patients during the first year of therapy in contrast to GA- and natalizumab-treated patients who showed non-significant changes. Conclusion: The results suggest that sIFNAR2 could be a potential diagnostic biomarker for MS.

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Smoking Functions as a Negative Regulator of IGF1 and Impairs Adipokine Network in Patients with Rheumatoid Arthritis

Mediators of Inflammation ◽

10.1155/2016/3082820 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 11

Author(s):

Malin C. Erlandsson ◽

Roberto Doria Medina ◽

Sofia Töyrä Silfverswärd ◽

Maria I. Bokarewa

Keyword(s):

Rheumatoid Arthritis ◽

Cigarette Smoking ◽

Serum Levels ◽

Negative Regulator ◽

Lower Serum ◽

Bivariate Correlation ◽

Novel Association ◽

Long Term Prognosis ◽

Never Smokers

Objectives.Smoking is pathogenic for rheumatoid arthritis (RA) being tightly connected to the genetic and serological risk factors for this disease. This study aims to understand connections between cigarette smoking and serum levels of IGF1 and adipokines in RA.Methods.Serum levels of IGF1 and adipokines leptin, adiponectin, resistin, and visfatin were measured in two independent cohorts of RA patients from Gothenburg (n=350) and Leiden (n=193). An association of these parameters with smoking was tested in a direct comparison and proved by bivariate correlation analysis. The obtained associations were further tested in multivariate regression models where the confounders (age, gender, disease duration, and BMI) were controlled.Results.The smokers had significantly lower serum levels of IGF1, adiponectin, and leptin compared to never smokers. In regression analysis, smoking and low leptin, but not adiponectin, were associated and predicted low IGF1. Additionally, high disease activity and high BMI increased the probability of low leptin.Conclusions.The study indicates cigarette smoking as an important cause of a relative IGF1 and leptin deficiency in RA patients. This novel association between smoking and hypoleptinemia may be of importance for long-term prognosis of RA and for prediction of comorbidities.

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Nearly Lethal Resuscitated Suicide Attempters Have No Low Serum Levels of Cholesterol and Triglycerides

Psychological Reports ◽

10.2466/pr0.106.3.785-790 ◽

2010 ◽

Vol 106 (3) ◽

pp. 785-790 ◽

Cited By ~ 17

Author(s):

Maurizio Pompili ◽

David Lester ◽

Marco Innamorati ◽

Paolo Girardi ◽

Roberto Tatarelli

Keyword(s):

Suicide Attempt ◽

Mood Disorders ◽

Serum Cholesterol ◽

Suicide Risk ◽

Suicide Attempts ◽

Serum Levels ◽

Small Sample ◽

Major Depressive ◽

Lower Serum ◽

Lower Serum Cholesterol

To verify the hypothesis that suicide attempts are associated with lower serum cholesterol and triglyceride levels of patients with mood disorders, 26 patients with mood disorders (bipolar disorder and major depressive disorder) were admitted after a medically serious suicide attempt to the emergency department and then hospitalized in the psychiatric unit of the Sant'Andrea Hospital (Rome, Italy). Controls were 87 patients who had not made a recent suicide attempt. Attempters and nonattempters did not differ in the levels of serum cholesterol or triglycerides. Indeed, attempters had nonsignificantly higher serum levels of cholesterol and lower serum levels of triglycerides. The use of biologic indicators such as levels of serum cholesterol and triglycerides in the prediction of suicide risk in mood disorders was not fully supported from this small sample.

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Lower serum levels of vitamin D in adults with urinary tract infection

Infection ◽

10.1007/s15010-021-01750-2 ◽

2022 ◽

Author(s):

Lingling Liu ◽

Kehang Xie ◽

Mengmeng Yin ◽

Xiaoqiu Chen ◽

Binhuan Chen ◽

...

Keyword(s):

Vitamin D ◽

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Serum Levels ◽

Lower Serum

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Lower Serum Levels of Th2-Related Chemokine CCL22 in Women Patients with Multiple Sclerosis: A Comparison Between Patients and Healthy Women

Inflammation ◽

10.1007/s10753-013-9775-z ◽

2013 ◽

Vol 37 (2) ◽

pp. 604-610 ◽

Cited By ~ 11

Author(s):

A. Jafarzadeh ◽

H. A. Ebrahimi ◽

S. Bagherzadeh ◽

F. Zarkesh ◽

F. Iranmanesh ◽

...

Keyword(s):

Multiple Sclerosis ◽

Serum Levels ◽

Women Patients ◽

Lower Serum ◽

Healthy Women

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Fat-soluble vitamins A and E and health disparities in a cohort of pregnant women at delivery

Journal of Nutritional Science ◽

10.1017/jns.2018.5 ◽

2018 ◽

Vol 7 ◽

Cited By ~ 2

Author(s):

Corrine Hanson ◽

Marina Verdi Schumacher ◽

Elizabeth Lyden ◽

Dejun Su ◽

Jeremy Furtado ◽

...

Keyword(s):

Public Health ◽

Health Disparities ◽

Food Security ◽

Health Insurance ◽

Vitamin E ◽

Vitamin A ◽

Serum Levels ◽

Food Desert ◽

Health Concern ◽

Lower Serum

AbstractThe objective of the present study was to evaluate intakes and serum levels of vitamin A, vitamin E, and related compounds in a cohort of maternal–infant pairs in the Midwestern USA in relation to measures of health disparities. Concentrations of carotenoids and tocopherols in maternal serum were measured using HPLC and measures of socio-economic status, including food security and food desert residence, were obtained in 180 mothers upon admission to a Midwestern Academic Medical Center labour and delivery unit. The Kruskal–Wallis and independent-samples t tests were used to compare measures between groups; logistic regression models were used to adjust for relevant confounders. P < 0·05 was considered statistically significant. The odds of vitamin A insufficiency/deficiency were 2·17 times higher for non-whites when compared with whites (95 % CI 1·16, 4·05; P = 0·01) after adjustment for relevant confounders. Similarly, the odds of being vitamin E deficient were 3·52 times higher for non-whites (95 % CI 1·51, 8·10; P = 0·003). Those with public health insurance had lower serum lutein concentrations compared with those with private health insurance (P = 0·05), and living in a food desert was associated with lower serum concentrations of β-carotene (P = 0·02), after adjustment for confounders. Subjects with low/marginal food security had higher serum levels of lutein and β-cryptoxanthin compared with those with high food security (P = 0·004 and 0·02 for lutein and β-cryptoxanthin). Diet quality may be a public health concern in economically disadvantaged populations of industrialised societies leading to nutritional disadvantages as well.

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Lower serum levels of selenium, copper, and zinc are related to neuromotor impairments in children with konzo

Journal of the Neurological Sciences ◽

10.1016/j.jns.2015.01.007 ◽

2015 ◽

Vol 349 (1-2) ◽

pp. 149-153 ◽

Cited By ~ 20

Author(s):

G.M.-M. Bumoko ◽

N.H. Sadiki ◽

A. Rwatambuga ◽

K.P. Kayembe ◽

D.L. Okitundu ◽

...

Keyword(s):

Serum Levels ◽

Lower Serum ◽

Copper And Zinc

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The combined supplementation of omega-3 fatty acids and probiotics decreased the levels of serum polyamines in experimental colitis

Food and Health ◽

10.3153/fh21029 ◽

2021 ◽

Vol 7 (4) ◽

pp. 279-285

Author(s):

Havvanur Yoldaş İlktaç ◽

Nihal Büyükuslu ◽

Cüneyd Parlayan

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

High Performance ◽

Experimental Colitis ◽

Serum Levels ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Lower Serum ◽

Omega 3 Fatty Acid ◽

Combined Supplementation

Polyamines play an important role in the maintenance of intestinal permeability. Therefore we aimed to determine the effects of probiotics and omega 3 fatty acids on serum polyamine levels in colitis. Fifty BALB/c mice were randomly grouped as normal, colitis with no treatment applied, colitis treated by probiotics (VSL#3), colitis treated by omega-3, and colitis treated by both probiotics and omega-3. Experimental colitis was induced by injection of 200 mg/kg 2,4-Dinitrobenzenesulfonic acid (DNBS). The probiotic and the omega-3 fatty acid supplements were applied daily by oral gavage. Serum polyamine levels were measured with high performance liquid chromatography (HPLC). In each group, the levels of serum polyamines are the highest in spermidine and the least in spermine. Bowel inflammation in experimentally induced colitis mice resulted in lower serum polyamine concentrations. In probiotic and omega 3 fatty acid supplemented group significant decreases were observed for spermine and spermidine (p<0.001), while no significant changes were obtained for putrescine. Combined supplementation of probiotics and omega-3 fatty acids for 10 days in colitis mice significantly decreased the serum levels of spermine and spermidine.

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