ANTIBACTERIAL AND ANTIFUNGAL POTENTIAL OF EXTRACTS OF Anacardium occidentale

Anacardium occidentale is a native plant from Brazilian Northeast popularly known as cashew tree, having great socioeconomic importance for this region, due to the great popularity of its fruit and its medicinal properties, the example antimicrobial activity. The present study had as objective to make a bibliographical survey about the antimicrobial activity of A. occidentale against strains of bacteria and fungi. We used the databases Scielo, PubMed, Lilacs and Periódicos Capes, in which 110 articles were analyzed and only 48 were selected. From the data obtained in the literature, it was observed that the bark of the stem, leaves, flowers and the own fruit of A. occidentale present antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi of the genus Candida. Thus, A. occidentale presents as a potential species for the research and development of possible herbal medicines to combat bacterial and fungal infections.

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Antimicrobial Activity of Apple Cider Vinegar

Mapana Journal of Sciences ◽

10.12723/mjs.41.2 ◽

2017 ◽

Vol 16 (2) ◽

pp. 11-15 ◽

Cited By ~ 1

Author(s):

Asma Saqib

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Agents ◽

Medicinal Purpose ◽

Diverse Range ◽

Antifungal Activities ◽

Apple Cider ◽

Antibacterial And Antifungal Activities ◽

Medicinal Properties ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal

In recent years, there has been a growing interest in researching and developing new antimicrobial agents from various sources to combat microbial resistance. Apple cider vinegar, otherwise known as cider vinegar or ACV, is a type of vinegar made from cider or apple must and has a pale to medium amber color. Unpasteurized or organic ACV contains mother of vinegar. It has been used for medicinal purpose for thousands of years for its various medicinal properties. The antimicrobial activity of cider vinegar has been recognized but not investigated. It can be used as alternative to commercial antimicrobial agents. The present study aims at finding the antibacterial and antifungal activities of various dilutions of ACV against diverse range of bacteria and fungi to generate data for which little investigation exist.

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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL PYRAZOLO[3,4-b]PYRIDINES AND THEIR SPIRO-HETEROCYCLIC DERIVATIVES

JOURNAL OF ADVANCES IN CHEMISTRY ◽

10.24297/jac.v10i7.6802 ◽

2014 ◽

Vol 10 (7) ◽

pp. 2901-2915 ◽

Cited By ~ 4

Author(s):

Shawkat A. Abdelmohsen ◽

Talaat I El Emary

Keyword(s):

Antimicrobial Activity ◽

Aromatic Aldehydes ◽

Antibacterial And Antifungal Activity ◽

Pyrimidine Derivatives ◽

Spiro Derivatives ◽

Heterocyclic Derivatives ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal ◽

New Compounds ◽

Hydrazone Derivative

The present work describes the synthesis of a novel series of heterocyclic moieties derived from 5-acetylpyrazolo[3,4-b]pyridine (1). The formation of chalcones (2a-d) was utilized to synthesize pyrazoline, isoxazoline and pyrimidine derivatives (3-10). Thiosemicarbazone and semicarbazone (11, 17) were utilized to synthesize other new triazolethiones, thiadiazole and selenadiazole derivatives (11-19). Some new spiro derivatives (22-25) were synthesized by the reaction of chalcone (21) of 1 and isatine with hydrazines, hydroxyl amines and thiourea. Also, The reaction of 1 with cyanoacetyl hydrazine gave the hydrazide-hydrazone derivative 26, which was allowed to react with aromatic aldehydes and α-cyanocinnamonitrile to afford coumarine and substituted pyridine derivatives (28, 29). The structures of all the new compounds have been established on the basis of their analytical and spectral data. Twenty two of the synthesized compounds were also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi and most are found to possess promising antimicrobial activity when compared with Chloramphenicol and Clotrimazole

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Antimicrobial Activity ofLippiaSpecies from the Brazilian Semiarid Region Traditionally Used as Antiseptic and Anti-Infective Agents

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/614501 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 4

Author(s):

Cristiana da Purificação Pinto ◽

Velize Dias Rodrigues ◽

Fernanda da Purificação Pinto ◽

Renata da Purificação Pinto ◽

Ana Paula Trovatti Uetanabaro ◽

...

Keyword(s):

Antimicrobial Activity ◽

Fungal Infections ◽

Active Species ◽

Semiarid Region ◽

Antimicrobial Drugs ◽

Promising Alternative ◽

Popular Medicine ◽

Antibacterial And Antifungal Activities ◽

Methanolic Extracts ◽

Antibacterial And Antifungal

Lippia origanoidesKunth,Lippia alnifoliaSchauer, andLippia thymoidesMartius and Schauer are shrubs used in the traditional Brazilian medicine as antiseptics, as well as in the treatment of infectious diseases. This study was designed to investigate the antibacterial and antifungal activities of the methanolic extracts of these species, as new potential sources of antimicrobial drugs. The antimicrobial activity of methanolic extracts was investigated against resistant yeasts and bacteria by agar disk diffusion. Then, the MIC determination of the most active species and its fractions in hexane, dichloromethane, ethyl acetate, and water was performed. By the agar diffusion assay, all species were active against at least two microorganisms, giving evidence to support their use in the popular medicine.L. origanoidesleaves exhibited the widest antimicrobial action, inhibiting the growth of two Gram-positive bacteria and two yeasts; this activity was also confirmed by the MIC evaluation. The fractionation ofL. origanoidescrude extracts improved the activity in spectrum and intensity. The results obtained in this study indicate thatL. origanoidesmay be a promising alternative in the treatment of bacterial and fungal infections and in the seeking of new antimicrobial drugs.

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Synthesis, antibacterial, and antifungal activities of new pyrimidinone derivatives

Heterocyclic Communications ◽

10.1515/hc-2015-0066 ◽

2015 ◽

Vol 21 (4) ◽

pp. 191-194 ◽

Cited By ~ 5

Author(s):

Oussama Cherif ◽

Fatma Masmoudi ◽

Fatma Allouche ◽

Fakher Chabchoub ◽

Mohamed Trigui

Keyword(s):

Antimicrobial Activity ◽

Broad Spectrum ◽

Pathogenic Fungi ◽

Gram Negative Bacteria ◽

Efficient Synthesis ◽

Gram Negative ◽

Antifungal Activities ◽

Antibacterial And Antifungal Activities ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal

AbstractAn efficient synthesis of new pyrrolopyrimidinones 3a-d and isoxazolopyrimidinones 4a-c from the respective aminocyanopyrroles 1a-d and aminocyanoisoxazoles 2a-c is presented. The synthesized compounds were screened for antimicrobial activity against a panel of bacteria and fungi. Compound 4c exhibits remarkable activity against a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi.

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Antifungical and immunomodulatory activities from Caesalpinia pulcherrima extracts

Scientific Electronic Archives ◽

10.36560/14920211454 ◽

2021 ◽

Vol 14 (9) ◽

Author(s):

Ricardo Sérgio da Silva ◽

Dayane Kelly Dias do Nascimento Santos ◽

Georon Ferreira de Sousa ◽

Marcela de Araújo Sobral ◽

Paulo Henrique Oliveira de Miranda ◽

...

Keyword(s):

Ethyl Acetate ◽

Fungal Infections ◽

Folk Medicine ◽

Biological Properties ◽

In Vitro Tests ◽

Organic Extracts ◽

Medicinal Properties ◽

Cytokine Stimulation ◽

Antibacterial And Antifungal

Caesalpinia pulcherrima is a species widely used in folk medicine for various diseases such as fever, infections and mouth ulcers. In addition, scientific studies have reported medicinal properties such as antitumor, antiviral, antibacterial and antifungal. Therefore, the objective of this work was to evaluate if organic extracts obtained from leaves of C. pulcherrima have medicinal properties. Three organic extracts were obtained (hexane, ethyl acetate and ethanol) from the leaves collected from the Soxhlet equipment. The characterization was made by GC-MS and UPLC-MS and biological properties as antioxidant (AAT, DPPH, ABTS and lipid peroxidation radicals), antimicrobial, cytotoxicity and immunostimulant (using splenocytes of mice Balb/c) were investigated. Results showed several classes of secondary metabolites, but the ethyl acetate showed more phenols and flavonoids than the other extracts. Extracts showed good results in antioxidant tests, especially the ethyl acetate, but did not show antibacterial activity. The fungal evaluation showed high antifungal properties, especially the hexanic and the ethyl acetate against Candida tropicalis, Aspergillus terreu, Candida krusei and Cryptococcus neoformans strains. Cytotoxicity evaluation showed that under 25 μg/mL are the safety doses that can be used for in vitro tests, besides that, extracts were able to induce cytokine stimulation. These results show that the ethyl acetate extract was the best formulation found in this study to be used against fungal infections, for antioxidant proposes and for promote immunostimulation.

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Green synthesis of chitosan capped silver nanoparticles and their antimicrobial activity

MRS Advances ◽

10.1557/adv.2018.368 ◽

2018 ◽

Vol 3 (42-43) ◽

pp. 2505-2517 ◽

Cited By ~ 6

Author(s):

Zondi Nate ◽

Makwena Justice Moloto ◽

Pierre Kalenga Mubiayi ◽

Precious Nokwethemba Sibiya

Keyword(s):

Antimicrobial Activity ◽

Silver Nanoparticles ◽

Spherical Particles ◽

Cubic Phase ◽

Face Centered Cubic ◽

Surface Binding ◽

Polymeric Compound ◽

Antibacterial And Antifungal Activities ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal

AbstractChitosan is a polymeric compound with functional groups which enable surface binding to nanoparticles and antibacterial activity. The antimicrobial activity was studied using silver nanoparticles with varied concentrations of chitosan. The nanoparticles were synthesized through a simple and environmentally friendly method at room temperature. Spherical particles with average sizes between 2 and 6 nm were obtained and their crystallinity showed a face-centered cubic phase. The evidence of chitosan presence on the nanoparticle surface was confirmed by the characteristic diffraction peak of chitosan and by FTIR spectra where the bonding of amine group could be depicted. The chitosan-capped silver nanoparticles showed good antibacterial and antifungal activities with MIC values between 0.20 and 1.5 mg.mL-1 compared to those obtained from most of references (up to 6.25 mg.mL-1) on the selected gram-positive (Staphylococcus aureus, Enterococcus faecalis), gram-negative (Klebsiella pneumoniae, Pseudomonas aeruginosa ) bacteria and fungi (Candida albicans, Cryptococcus neoformans).

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Ethnobotany, ecology, pharmacology, and chemistry of Anredera cordifolia (Basellaceae): a review

Rodriguésia ◽

10.1590/2175-7860202071060 ◽

2020 ◽

Vol 71 ◽

Author(s):

Thainara Marcotto Alba ◽

Carla Maria Garlet de Pelegrin ◽

Andréa Michel Sobottka

Keyword(s):

Staphylococcus Aureus ◽

Invasive Plant ◽

Fungal Infections ◽

Chemical Constituents ◽

Pharmacological Properties ◽

Native Plant ◽

Nutritional Properties ◽

Healing Of Wounds ◽

Medicinal Properties ◽

Botanical Classification

Abstract The potential of a plant with medicinal and nutritional properties, Anredera cordifolia, is reviewed. Its common names include “Bertalha” and “folha gorda” and it is popularly used for wound healing and against fungal infections and other types of infection. Its pharmacological properties have been widely investigated and acknowledged, especially with regard to its antibacterial activity, which improves the healing of wounds infected by Staphylococcus aureus, and to its antifungal activity against Candida albicans. It is an unconventional food plant, with leaves and aerial tubers used as food prepared in varied ways. It is also considered an invasive plant in several countries and thus classified as a weed. Its characteristics of a Brazilian native plant, with proven medicinal properties and unconventional use as food, underlie our study on its ecology and botanical classification, as well as the pharmacological assays and screening of chemical constituents.

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Synthesis, Characterization and Antimicrobial Activity of Methylquinolino[3,2-b][1,5]benzodiazepine and Methylquinolino[3,2-b][1,5]benzoxazepine and its Various Metal Complexes

E-Journal of Chemistry ◽

10.1155/2007/639828 ◽

2007 ◽

Vol 4 (1) ◽

pp. 32-38 ◽

Cited By ~ 2

Author(s):

B. Basavaraju ◽

H. S. Bhojya Naik ◽

M. C. Prabhakara

Keyword(s):

Antimicrobial Activity ◽

Metal Complexes ◽

Antimicrobial Agents ◽

Spectral Studies ◽

Antibacterial And Antifungal Activity ◽

H Nmr ◽

Uv Visible ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal ◽

Metal Ligand

2-Chloro-6-methylquinoline-3-carbaldehyde was condensed witho-Phenylenediammine and 2-aminophenol in presence of potassium iodide. The resulting Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methylquinolino[3,2-b][1,5]benzoxazepine(MQBO) were characterized by elemental analysis and spectral studies. The metal chelatesvizPd(II), Rh(III) and Ru(III) of ligands were prepared and characterized by metal-ligand (M:L) ratio, UV-Visible, IR,1H NMR spectroscopes and magnetic properties. The antibacterial and antifungal activity of MQBD, MQBO and its metal complexes were screened against various bacteria and fungi. The results show that all these samples are good antimicrobial agents.

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ISOLATION, SCREENING AND CHARACTERIZATION OF ANTIBIOTIC PRODUCING ACTINOMYCETES FROM KAPULUPPADA PLASTIC WASTE DUMPING YARD, VISAKHAPATNAM

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2016v8i11.10110 ◽

2016 ◽

Vol 8 (11) ◽

pp. 221

Author(s):

Midhun Kumar Duddu ◽

Girijasankar Guntuku

Keyword(s):

Antimicrobial Activity ◽

Antagonistic Activity ◽

Plastic Waste ◽

Diffusion Method ◽

Crude Extracts ◽

Antifungal Antibiotics ◽

Test Organisms ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal ◽

Physiological And Biochemical

Objective: To isolate, screen and characterize antibiotic producing actinomycetes from Kapuluppada plastic waste dumping yard, Visakhapatnam.Methods: A total of 12 soil samples were collected, serially diluted and spread on starch casein agar supplemented with Rifampicin and Cycloheximide for inhibition of bacteria and fungi, respectively. Cross-streak method was used to check the antagonistic activity of isolated actinomycetes against bacteria and fungi. Crude extracts from submerged state fermentation were used for the production of antimicrobial compounds. Agar well diffusion method was used for antimicrobial activity of crude extracts against test organisms. The isolates were characterized by morphological, physiological and biochemical methods.Results: A total of 110 actinomycete isolates were isolated from plastic waste dumping yard. All isolates had shown antimicrobial activity against one or more tested bacteria/fungi. The crude extract of the isolates PD66 (12.2 mm), PD85 (11.5 mm) were most active against methicillin-resistant Staphylococcus aureus, PD4 (14.1 mm), PD66 (15.6 mm) were active against Pseudomonas aeruginosa, whereas the extracts of PD10 (19.2 mm), PD47 (19.8 mm), PD106 (19.1 mm) were active against Candida albicans, PD10 (14.6 mm), PD82 (15.7 mm) active against Saccharomyces cereviciae. The isolates had shown varying morphological, physiological and biochemical characteristics.Conclusion: The actinomycetes isolated from Kapuluppada plastic waste dumping yard were found to be most promising microorganisms for the production of antibacterial and antifungal antibiotics.

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Novel (+)-Neoisopulegol-Based O-Benzyl Derivatives as Antimicrobial Agents

International Journal of Molecular Sciences ◽

10.3390/ijms22115626 ◽

2021 ◽

Vol 22 (11) ◽

pp. 5626

Author(s):

Tam Minh Le ◽

Thu Huynh ◽

Fatima Zahra Bamou ◽

András Szekeres ◽

Ferenc Fülöp ◽

...

Keyword(s):

Antimicrobial Activity ◽

Antimicrobial Agents ◽

Substituent Effects ◽

Moderate Activity ◽

Gram Negative Bacteria ◽

Gram Positive Bacteria ◽

Urgent Task ◽

Bacteria And Fungi ◽

Antibacterial And Antifungal ◽

Derivatives Of

Discovery of novel antibacterial agents with new structures, which combat pathogens is an urgent task. In this study, a new library of (+)-neoisopulegol-based O-benzyl derivatives of aminodiols and aminotriols was designed and synthesized, and their antimicrobial activity against different bacterial and fungal strains were evaluated. The results showed that this new series of synthetic O-benzyl compounds exhibit potent antimicrobial activity. Di-O-benzyl derivatives showed high activity against Gram-positive bacteria and fungi, but moderate activity against Gram-negative bacteria. Therefore, these compounds may serve a good basis for antibacterial and antifungal drug discovery. Structure–activity relationships were also studied from the aspects of stereochemistry of the O-benzyl group on cyclohexane ring and the substituent effects on the ring system.

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