Utilizzo del protossido di azoto nella riduzione del dolore e dell’ansia da procedura in Pediatria

2021 ◽  
Vol 24 (4) ◽  
pp. 92-100
Author(s):  
Alessandra Di Cesare Merlone ◽  
Roberta Martinelli ◽  
Ornella Molteni ◽  
Angelo Selicorni
Keyword(s):  
Nitrous Oxide ◽  
Side Effects ◽  
Personal Data ◽  
First Aid ◽  
Procedural Pain ◽  
Post Procedure ◽  
Special Procedure ◽  
Sedative Effects ◽  
And Control ◽  
Trained Nurse

<b>Background -</b> To prevent and control the procedural pain includes an adequate analgesia and the reduction of the anxiety/distress related to the procedure itself. A useful tool that combines the analgesic and sedative effects is nitrous oxide combined in different percentages with oxygen. <br> <b>Objective -</b> The goal of this study is to evaluate the efficiency of the nitrous oxide in the management of procedural pain and distress in a paediatric environment, also considering the possibility that a pre-made solution of nitrous oxide and oxygen 50/50 could be given independently of the inmate by a properly trained nurse. <br> <b>Methods -</b> An observational study at the Paediatric First Aid Department in Sant’Anna Hospital (Como, Italy) was performed by creating a special procedure that was applied to children older than 1 year old that needed to undergo low to mild painful procedures between July 6th 2017 and December 31st 2019. The blend was dosed by a demand valve. For each procedure a form was filled in with personal data, side effects, parameters and an evaluation of the pre-procedure and post-procedure pain. All the staff then took a satisfaction questionnaire.<br> <b>Results -</b> The study corroborates that preblended nitrous oxide 50/50 is safe and efficient, and also guarantees analgesic and anxiolytic effects for a vast case of mildly painful procedures. The little use of other drugs and the absence of opioids in the treatment is likely the main reason for the absence of major side effects. <br> <b>Conclusions -</b> The collected data suggest that a 50/50 blend of nitrous oxide and oxygen is still used considering its efficiency and manageability in the procedural sedation and also confirm that using the same concentrations and avoiding combination with opioids is safe and available to properly formed nurses.

Nitrous oxide analgesia for bone marrow aspiration and biopsy – A randomized, controlled and patient blinded study

2015 ◽  
Vol 7 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Anna-Maria Kuivalainen ◽  
Freja Ebeling ◽  
Eira Poikonen ◽  
Per H. Rosenberg
Keyword(s):  
Bone Marrow ◽  
Nitrous Oxide ◽  
Cognitive Function ◽  
Side Effects ◽  
Bone Marrow Aspiration ◽  
Bone Marrow Examination ◽  
Procedural Pain ◽  
Randomized Controlled ◽  
Pain Scores ◽  
Blinded Study

AbstractBackground and aims Bone marrow aspiration and/or biopsy (BMAB), performed under local anaesthesia in adults, is a common and often painful procedure. Anxiety is known to intensify pain during the procedure. Nitrous oxide (N2O), known for its sedative and analgesic benefit in various short medical procedures and labour pain, could be advantageous also for pain relief during bone marrow examination. N2O acts rapidly and is eliminated in a couple of minutes once the inhalation is stopped, and occasional side effects (e.g. dizziness and nausea) are mild. The aim of this study was to compare the analgesic effects of inhaled 50% mixture of nitrous oxide and oxygen to 50% oxygen during bone marrow examination.MethodsIn this randomized, controlled, patient and observer blinded study patients received either 50% mixture of nitrous oxide and oxygen or 50% mixture of oxygen in air during bone marrow examination, in addition to local analgesia. Both patient groups comprised 35 adult patients. Pre-procedural anxiety and procedural pain were rated on the Numeral Rating Scale (NRS 0‒10). Cognitive function was measured before and 30 min after the procedure. Possible side effects were recorded. A telephone interview was performed 24 h later.ResultsThere were no statistically significant differences in pain scores of the procedural steps (median NRS ranging 3.0‒4.0) between the study groups. High pain scores of 8‒10 comprised 0% vs. 8.6% of the scores during infiltration, 2.9% vs. 5.7% during puncture, 11.4% vs. 14.3% during aspiration and 2.9% vs. 2.9% during biopsy in N2O and 50% O2 groups, respectively (NS). Pre-procedural anxiety (median NRS 3.5 in both groups), measured in the outpatient clinic just prior to procedure, correlated with pain intensity during bone marrow aspiration (P = 0.045). There were no significant differences between side effects. During the BMAB four patients (3 in N2O group, 1 in 50% O2 group) reported dizziness and one patient in the N2O group reported nausea. Gas inhalation did not affect the cognitive function of the participants. In both groups the majority (>80%) of the patients was satisfied with the inhalation technique. During the 24 h interview, most of the participants were pain free and they did not report any serious adverse effects.ConclusionsIn spite of similar moderate to strong procedural pain in both groups and no benefit of N2O, most patients were satisfied with the inhalational techniques. We assume that the bedside presence of an anaesthesiologist and the distraction caused by the inhalational arrangements introduced positive context-sensitive therapeutic effect independent of the gas used. Pre-procedural anxiety predicted pain associated with bone marrow aspiration.ImplicationsInhaled 50% nitrous oxide was not an effective analgesic during bone marrow examination in our unselected outpatient population. Further studies should concentrate on its use with patients predicted to be at increased risk of suffering intense pain during the procedure, such as very anxious patients or those who have a painful history of previous bone marrow examinations.

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

2016 ◽  
Vol 1 (1) ◽  
pp. 22
Author(s):  
Nazli Zainuddin ◽  
Nurul Azira Mohd Shah ◽  
Rosdan Salim
Keyword(s):  
Allergic Rhinitis ◽  
Side Effects ◽  
Coconut Oil ◽  
Test Group ◽  
Nasal Symptom ◽  
Control Group ◽  
Virgin Coconut Oil ◽  
Control Groups ◽  
Significant Difference ◽  
And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Effect of aromatherapy massage with orange essential oil on postoperative pain after cesarean section: a randomized controlled trial

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Seyedmohammad Mirhosseini ◽  
Ali Abbasi ◽  
Nastaran Norouzi ◽  
Fatemeh Mobaraki ◽  
Mohammad Hasan Basirinezhad ◽  
...  
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Cesarean Section ◽  
Statistical Tests ◽  
Intervention Group ◽  
Nursing Intervention ◽  
Anxiety Score ◽  
Control Group ◽  
And Control ◽  
Orange Essential Oil

Abstract Objectives Many women in recent years have been willing to undergo puncture surgery for childbirth, which, like other surgeries, has physical and psychological side effects such as incision, infertility, chronic pain, and anxiety. Therefore, it is important to reduce and improve these side effects. The aim of this study was to determine the effect of foot massage with orange essential oil on pain and anxiety in women undergoing cesarean section. Methods This randomized clinical trial study was conducted in 2019 on 80 women referred to Bahar Shahroud Hospital after cesarean section surgery. The samples were divided into two groups by intervention (foot massage with orange essential oil) and control (foot massage without orange essential oil). The Spielberger scale was used to determine anxiety scores after cesarean section. In the intervention group, the feet were massaged with orange essential oil, and in the control group, the orange essential oil massage was performed without oil. Anxiety before, immediately after, and 60 min after the intervention was measured and evaluated in both groups. Data analysis was performed using descriptive and inferential statistics. Significant levels were considered for all statistical tests (p<0.05). Results The anxiety score before the intervention in the two groups of intervention and control was 57.12 ± 3.12 and 57.07 ± 3.54, respectively, which were not significantly different, but immediately after the intervention, the anxiety scores in both groups decreased significantly so that there was a further decrease in the intervention group (52.10 ± 4.75 and 56.02 ± 3.77), 1 h after the intervention, the anxiety score in the intervention group decreased compared to the previous stage and increased in the control group (50.40 ± 3.74 and 56.85 ± 4.27). Conclusions Foot massage with orange essential oil can probably be effective as a proper nursing intervention in reducing anxiety after cesarean section surgery.

scholarly journals Impact on Antibiotic Resistance, Therapeutic Success, and Control of Side Effects in Therapeutic Drug Monitoring (TDM) of Daptomycin: A Scoping Review

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 263
Author(s):  
Carolina Osorio ◽  
Laura Garzón ◽  
Diego Jaimes ◽  
Edwin Silva ◽  
Rosa-Helena Bustos
Keyword(s):  
Side Effects ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Bacterial Resistance ◽  
Plasma Concentrations ◽  
Resistant Bacteria ◽  
Therapeutic Drug ◽  
Therapeutic Success ◽  
Favorable Clinical Outcome ◽  
And Control

Antimicrobial resistance (AR) is a problem that threatens the search for adequate safe and effective antibiotic therapy against multi-resistant bacteria like methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococci (VRE) and Clostridium difficile, among others. Daptomycin is the treatment of choice for some infections caused by Gram-positive bacteria, indicated most of the time in patients with special clinical conditions where its high pharmacokinetic variability (PK) does not allow adequate plasma concentrations to be reached. The objective of this review is to describe the data available about the type of therapeutic drug monitoring (TDM) method used and described so far in hospitalized patients with daptomycin and to describe its impact on therapeutic success, suppression of bacterial resistance, and control of side effects. The need to create worldwide strategies for the appropriate use of antibiotics is clear, and one of these is the performance of therapeutic drug monitoring (TDM). TDM helps to achieve a dose adjustment and obtain a favorable clinical outcome for patients by measuring plasma concentrations of an administered drug, making a rational interpretation guided by a predefined concentration range, and, thus, adjusting dosages individually.

scholarly journals Is There a Predisposition towards the Use of New Technologies within the Traffic Field of Emerging Countries? The Case of the Dominican Republic

Electronics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1208
Author(s):  
Francisco Alonso ◽  
Mireia Faus ◽  
Cristina Esteban ◽  
Sergio A. Useche
Keyword(s):  
Dominican Republic ◽  
Road Safety ◽  
New Technologies ◽  
Technological Development ◽  
Personal Data ◽  
Emerging Countries ◽  
Level Of Knowledge ◽  
One Year ◽  
The One ◽  
And Control

Technological devices are becoming more and more integrated in the management and control of traffic in big cities. The population perceives the benefits provided by these systems, and, therefore, citizens usually have a favorable opinion of them. However, emerging countries, which have fewer available infrastructures, could present a certain lack of trust. The objective of this work is to detect the level of knowledge and predisposition towards the use of new technologies in the transportation field of the Dominican Republic. For this study, the National Survey on Mobility was administered to a sample of Dominican citizens, proportional to the ONE census and to sex, age and province. The knowledge of ITS topics, as well as the use of mobile applications for mobility, are scarce; however, there was a significant increase that can be observed in only one year. Moreover, technology is, in general, positively assessed for what concerns the improvement of the traffic field, even though there is a lack of predisposition to provide one’s personal data, which is necessary for these devices. The process of technological development in the country must be backed up by laws that protect the citizens’ privacy. Thus, technologies that can improve road safety, mobility and sustainability can be implemented in the country.

scholarly journals REFORMS IN THE COMMUNICATIONS MONITORING SYSTEM AS A PRECONDITION FOR EFFECTIVE HUMAN RIGHTS PROTECTION

2019 ◽  
Vol 31 (5) ◽  
pp. 1509-1514
Author(s):  
Biljana Karovska-Andonovska ◽  
Zoran Jovanovski
Keyword(s):  
Monitoring System ◽  
A Priori ◽  
Personal Data ◽  
The Other ◽  
Right To Privacy ◽  
Human Rights Protection ◽  
Personal Data Protection ◽  
The Right To Privacy ◽  
The Right ◽  
And Control

The reforms in the communications monitoring system as part of the wider reform of the security services in the Republic of Macedonia, resulted with creation of a package of several laws whose adoption was supposed to provide the legislative basis for a system that would really work in accordance with the goals for which it was established. The communications monitoring system should provide a balanced protection of the right to security, on the one hand, and the right to privacy, on the other. Only on that way a priori primacy of the right to security over the right to privacy will it be disabled. Hence, the reforms in communications monitoring system are a precondition for the effective protection, primarily for the right to privacy and the secrecy of communications, but also for the right to personal data protection, the inviolability of the home as well as for the right to presumption of innocence. It is a complex and delicate matter where opening of a real debate through which the present deficiencies will be perceived in order to create an appropriate legal solutions was very important. However, the new Law on Interception of Communications as the most important in this area, retained a certain part of the provisions that were debatable in the previous legal solutions. The provisions regarding the model for interception of communications, which stipulates the establishment of a separate agency that mediates between the operators and the authorized bodies for interception of communications, were questionable as well. Also, new measures for monitoring communications in the interest of security and defense, as well as the provisions which regulate the disposition and delivery of metadata for security and defense, are also debatable. On the other side, the reform laws made an evident progress in a positive sense through the provisions for oversight and control over the interception of communications. With these changes, certain debatable elements have been overcome, especially those that have hindered it so far, and in some cases completely paralyzed the oversight and control over the monitoring of communications. In this paper we analyzed the debatable elements in the reform package of laws on interception of communications as well as some positive aspects contained in the provisions of the reform laws.

‘Personal data literacies’: A critical literacies approach to enhancing understandings of personal digital data

2018 ◽  
Vol 21 (2) ◽  
pp. 419-437 ◽  
Author(s):  
Luci Pangrazio ◽  
Neil Selwyn
Keyword(s):  
Digital Literacy ◽  
Data Science ◽  
Personal Data ◽  
Digital Data ◽  
Data Generation ◽  
Critical Literacies ◽  
And Control ◽  
Future Education ◽  
Socially Situated ◽  
Crucial Part

The capacity to understand and control one’s personal data is now a crucial part of living in contemporary society. In this sense, traditional concerns over supporting the development of ‘digital literacy’ are now being usurped by concerns over citizens’ ‘data literacies’. In contrast to recent data safety and data science approaches, this article argues for a more critical form of ‘personal data literacies’ where digital data are understood as socially situated and context dependent. Drawing on the critical literacies tradition, the article outlines a range of salient socio-technical understandings of personal data generation and processing. Specifically, the article proposes a framework of ‘Personal Data Literacies’ that distinguishes five significant domains: (1) Data Identification, (2) Data Understandings, (3) Data Reflexivity, (4) Data Uses, and (5) Data Tactics. The article concludes by outlining the implications of this framework for future education and research around the area of individuals’ understandings of personal data.

THE APPLICATION OF STATISTICAL METHODS IN EVALUATING THE RESULTS OF CLINICAL FINDINGS OF THE DRUG BOVHUALONIDASE AZOXIMER IN CATS WITH UROLOGICAL DISEASES

2020 ◽  
pp. 212-218
Author(s):  
А. V. Nazarova ◽  
◽  
B. S. Semenov ◽  
Т. Sh. Kuznetsova ◽  
◽  
...  
Keyword(s):  
Relative Risk ◽  
Side Effects ◽  
Risk Reduction ◽  
Absolute Risk ◽  
Control Group ◽  
Control Groups ◽  
Saint Petersburg ◽  
Number Of Patients ◽  
And Control ◽  
Experimental Group

In the period from November 2018 to August 2020, we conducted a randomized blind placebo-controlled confirmatory clinical trial in parallel groups on the basis of network of veterinary clinics in Saint Petersburg and Saint Petersburg state university of veterinary medicine. The purpose of the study: to evaluate the effectiveness of Bovhualonidaze azoximer(BA) in patients subjected to surgical intervention on the urethra and bladder, to prevent postoperative complications and relapses of the underlying disease. The frequency of complications was taken as an indicator of effectiveness. 80 cats were evaluated according to the criteria for inclusion in the study, after evaluation and randomization, 53 patients (24 and 29 cats in the experimental and control groups, respectively) who had indications for surgery on the urethra and/or bladder were included in the study. After the withdrawal of some patients, 38 cats were analyzed (17 and 23 cats in the experimental and control groups, respectively). Animals in the experimental group received BA drugs in addition to conventional therapy, and animals in the control group received placebo. The rate of complications in the experimental group was 11.8 %, in the control group-61.9 %. The relative risk was 19.0 %, and the relative risk reduction was 80.9 %. The chance of developing complications in the animals of the experimental group is 12.2 times lower than in animals of the control group.. Absolute risk reduction — 50.1 %, and the number of patients to be treated — 2 patients. The confidence interval for the risk of side effects of BA drugs in cats was 0.0-10.1 %. Based on the results of our clinical study, we proved that the use of BA drugs is effective for preventing complications during surgical interventions on the urethra and bladder, and the risk of side effects when using BA drugs in cats is insignificant

Theft Preventive Measures for Interconnected Personal Computer Devices as Proactive Physical Security of Data

2021 ◽  
pp. 337-352
Author(s):  
Ekaterina Pshehotskaya ◽  
Oleg Mikhalsky
Keyword(s):  
User Behavior ◽  
Personal Data ◽  
Data Access ◽  
Security And Privacy ◽  
Portable Devices ◽  
Physical Security ◽  
Security Risks ◽  
Portable Computer ◽  
Relative Risks ◽  
And Control

This article is concerned with the arising problems and implications of physical security and privacy of personal and control data on portable computer devices, especially smartphones. The authors consider various classifications of portable computer devices, isolate smartphones as a most common device, and study types of user behavior regarding the involved security risks of unauthorized access to the data stored both locally and remotely with accent of physical data access via device theft. Based on provided categorization the researchers discuss the factors and criteria suitable to generalize user patterns and evaluate the corresponding vulnerability level against specified statistics. The considered statistical criteria can be formulated as a mathematical model of relative risks and implemented as a service or an application to be used for improving user awareness on current threats to his personal data and respective interconnected personal portable devices.

scholarly journals Pain and anxiety experiences of South African adult burn injury patients during physiotherapy management

2010 ◽  
Vol 66 (1) ◽  
Author(s):  
L.D. Morris ◽  
Q.A. Louw
Keyword(s):  
Pain Management ◽  
Side Effects ◽  
South African ◽  
Functional Outcomes ◽  
Burn Injury ◽  
Current Situation ◽  
Procedural Pain ◽  
Short Report ◽  
Burn Unit ◽  
Effective Adjunct

A dequate management of procedural pain during physiotherapy management plays an important role in building a trusting relationship betweenthe burn victim and the physiotherapist, and in ensuring desirable functional outcomes. However, the burn pain management regimens currently utilized inburn units, primarily consist of traditional pharmacologic analgesics which areassociated with numerous side-effects and alone are often reported as inadequateto alleviate procedural pain, warranting safer and effective adjunct therapies.Prior to the introduction and implementation of adjunct therapies into a developing world, it is imperative that the current situation in a burn unit, in terms of whether or not the pain management regimens in place are adequate, is first assessed, due to cost concerns. The following short report exemplifies the pain and anxiety experiences of a small number of burn injury patients during physiotherapy at the Tygerberg Hospital adult burn unit, South A frica.  It was hypothesized that the results of this study would underpin whether adult burn injury patients in a developing countryrequire adjunct therapies during physiotherapy management to supplement traditional pharmacologic analgesics inmanaging their procedural pain and subsequent anxiety.

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