scholarly journals The impact of genetic polymorphism in pain mechanisms

2021 ◽  
Author(s):  
Júlia Campos Fabri ◽  
Maria Julia Filgueiras Granato ◽  
Maria Clara Lopes Rezende ◽  
Maria Luiza Franco de Oliveira ◽  
Leandro de Souza Cruz
Keyword(s):  
Genetic Polymorphism ◽  
Pain Perception ◽  
Resting Membrane Potential ◽  
Genetic Profile ◽  
Pain Mechanisms ◽  
Oprm1 Gene ◽  
Nociceptive Pathway ◽  
The Individual ◽  
The Impact

Background:Variations in genes codifying target structures in the nociceptive pathway can result in pain attenuation or increase.Objective:Investigate the genetic polymorphism influence in the individual pain threshold. Methods: Search on PubMed with the terms “genetic”, “pain” and its synonyms published in the last 10 years. Results:The subjective and individual mechanisms of pain aren’t completely understood, but genetic susceptibility is one of the hypothesis to explain these differences.The KCNK18 gene influences the synaptic transmission by producing potassium channel protein that equalizes resting membrane potential, calcineurin activated and inhibited by arachidonic acid. This gene was found more frequently in migraine individuals. The COMT gene increase the sensibility to pain by met-enkephalins reduction and/or catecholamine elevation. Its activity’s reduced in fibromyalgia patients. However, the OPRM1 gene, an opioid receptor, was found in individuals with a higher pain threshold.Furthermore, studies with human cell culture shows the analgesic role of the gene A118G, by its greater binding affinity for β-endorphin.It is associated with more effective endorphinergic endogenous pain inhibition. Conclusion:Researches indicates a striking participation of genetic polymorphism in pain mechanisms. The knowledge about genetic variables on pain perception can contribute to the development of individualized analgesic protocols and therapeutic strategies, accordantly to the patient genetic profile. This evolution becomes fundamental in a population that tend to the indiscriminate use of analgesics.

The Role of Threat and Economic Uncertainty in Support for Scottish Independence

2014 ◽  
Vol 23 (1) ◽  
pp. 103-124 ◽  
Author(s):  
Daniel Kopasker
Keyword(s):  
Economic Consequences ◽  
Perceived Threat ◽  
Constitutional Change ◽  
Lack Of Information ◽  
Economic Expectations ◽  
Scottish Independence ◽  
The Individual ◽  
The Impact ◽  
Levels Of Support

Existing research has consistently shown that perceptions of the potential economic consequences of Scottish independence are vital to levels of support for constitutional change. This paper attempts to investigate the mechanism by which expectations of the economic consequences of independence are formed. A hypothesised causal micro-level mechanism is tested that relates constitutional preferences to the existing skill investments of the individual. Evidence is presented that larger skill investments are associated with a greater likelihood of perceiving economic threats from independence. Additionally, greater perceived threat results in lower support for independence. The impact of uncertainty on both positive and negative economic expectations is also examined. While uncertainty has little effect on negative expectations, it significantly reduces the likelihood of those with positive expectations supporting independence. Overall, it appears that a general economy-wide threat is most significant, and it is conjectured that this stems a lack of information on macroeconomic governance credentials.

scholarly journals Factors affecting the organizational performance of manufacturing firms

2017 ◽  
Vol 9 ◽  
pp. 184797901771262 ◽  
Author(s):  
Ahmad Adnan Al-Tit
Keyword(s):  
Organizational Performance ◽  
Measurement Instrument ◽  
Manufacturing Firms ◽  
Factors Affecting ◽  
Mediating Role ◽  
Values And Beliefs ◽  
The Individual ◽  
The Impact ◽  
The Relationship

Numerous studies have been conducted to explore the individual effects of organizational culture (OC) and supply chain management (SCM) practices on organizational performance (OP) in different settings. The aim of this study is to investigate the impact of OC and SCM on OP. The sample of the study consisted of 93 manufacturing firms in Jordan. Data were collected from employees and managers from different divisions using a reliable and valid measurement instrument. The findings confirm that both OC and SCM practices significantly predict OP. The current study is significant in reliably testing the relationship between SCM practices and OP; however, it is necessary to consider cultural assumptions, values and beliefs as the impact of OC on OP is greater than the impact of SCM practices. Based on the results, future studies should consider the moderating and mediating role of OC on the relationship between SCM practices and OP.

Practitioner Review: Continuity and Change: The Fair Work Act in Aviation

2011 ◽  
Vol 53 (3) ◽  
pp. 392-401 ◽  
Author(s):  
Sue Bussell ◽  
John Farrow
Keyword(s):  
Industrial Relations ◽  
Safety Net ◽  
Aviation Industry ◽  
Continuity And Change ◽  
National Debate ◽  
New Development ◽  
Key Issues ◽  
The Individual ◽  
The Impact

This article begins by discussing the specific industrial relations challenges of the highly competitive aviation industry. It then reflects on the outcome of the recent intense national debate over industrial relations, exploring the consequences of that debate for practice and policy, and discusses some key issues that remain in play. Although the Fair Work Act 2009 may have come about as a reaction to what many perceive as the ‘excesses’ of Work Choices, the new Act does not so much ‘wind back the clock’ as represent a significant new development in Australia’s long and unique industrial relations history. This article will discuss the impact of the changes, to date, made by the Fair Work Act on one organization, including the expansion of the ‘safety net’, and how the new compromise between the role of the ‘collective’ and the role of the ‘individual’ struck by the Act has the potential to fundamentally change the nature and structure of bargaining. We offer these comments as practitioners who have worked under successive industrial relations regimes since the early 1980s.

The Evolution of the Role of U.S. School Nurses in Adolescent Mental Health at the Individual, Community, and Systems Level: An Integrative Review

2022 ◽  
pp. 105984052110681
Author(s):  
Ashwini R. Hoskote ◽  
Emily Croce ◽  
Karen E. Johnson
Keyword(s):  
Mental Health ◽  
Adolescent Mental Health ◽  
School Nurse ◽  
School Nurses ◽  
Integrative Review ◽  
School Nursing ◽  
Individual Level ◽  
The Individual ◽  
The Impact

School nurses are crucial to addressing adolescent mental health, yet evidence concerning their evolving role has not been synthesized to understand interventions across levels of practice (i.e., individual, community, systems). We conducted an integrative review of school nurse roles in mental health in the U.S. related to depressive symptoms, anxiety, and stress. Only 18 articles were identified, published from 1970 to 2019, and primarily described school nurses practicing interventions at the individual level, yet it was unclear whether they were always evidence-based. Although mental health concerns have increased over the years, the dearth of rigorous studies made it difficult to determine the impact of school nurse interventions on student mental health outcomes and school nurses continue to feel unprepared and under supported in this area. More research is needed to establish best practices and systems to support school nursing practice in addressing mental health at all levels of practice.

scholarly journals Chemo-mechanical Diffusion Waves Orchestrate Collective Dynamics of Immune Cell Podosomes

2021 ◽  
Author(s):  
Ze Gong ◽  
Koen van den Dries ◽  
Alessandra Cambi ◽  
Vivek Shenoy
Keyword(s):  
Actin Polymerization ◽  
Immune Cell ◽  
Wave Dynamics ◽  
Diffusion Waves ◽  
Mechanical Diffusion ◽  
Mechanical Waves ◽  
The Individual ◽  
The Impact ◽  
Cell Mechanosensing

Immune cells, such as macrophages and dendritic cells, can utilize podosomes, actin-rich protrusions, to generate forces, migrate, and patrol for foreign antigens. In these cells, individual podosomes exhibit periodic protrusion and retraction cycles (vertical oscillations) to probe their microenvironment, while multiple podosomes arranged in clusters demonstrate coordinated wave-like spatiotemporal dynamics. However, the mechanisms governing both the individual vertical oscillations and the coordinated oscillation waves in clusters remain unclear. By integrating actin polymerization, myosin contractility, actin diffusion, and mechanosensitive signaling, we develop a chemo-mechanical model for both the oscillatory growth of individual podosomes and wave-like dynamics in clusters. Our model reveals that podosomes show oscillatory growth when the actin polymerization-associated protrusion and the signaling-associated myosin contraction occur at similar rates, while the diffusion of actin monomers within the cluster drives mesoscale coordination of individual podosome oscillations in an apparent wave-like fashion. Our model predicts the influence of different pharmacological treatments targeting myosin activity, actin polymerization, and mechanosensitive pathways, as well as the impact of the microenvironment stiffness on the wavelengths, frequencies, and speeds of the chemo-mechanical waves. Overall, our integrated theoretical and experimental approach reveals how collective wave dynamics arise due to the coupling between chemo-mechanical signaling and actin diffusion, shedding light on the role of podosomes in immune cell mechanosensing within the context of wound healing and cancer immunotherapy.

The Role of the Individual in ICT Standardisation

2015 ◽  
pp. 244-261
Author(s):  
Kai Jakobs
Keyword(s):  
Literature Review ◽  
Social Shaping Of Technology ◽  
The Social ◽  
Social Shaping ◽  
Technical Factors ◽  
Standards Development ◽  
The Individual ◽  
The Impact

This chapter discusses the influence individuals have in the ICT standards development process. The chapter draws upon ideas underlying the theory of the Social Shaping of Technology (SST). Looking through the SST lens, a number of non-technical factors that influence ICT standards development are identified. A literature review on the role of the individual in ICT standards setting and a case study of the IEEE 802.11 Working Group (WG) show that in a standards body's WG, the backgrounds, skills, attitudes, and behaviour of the individual WG members are crucially important factors. Yet, the case study also shows that in most cases employees tend to represent the ideas and goals of their respective employer. The chapter observes that the non-technical factors are ignored all too often in the literature. It argues that a better understanding of the impact and interplay of these factors, specifically including the skills and attitudes of the WG members, will have significant implications both theoretical and managerial.

An Exploratory Analysis of the Role of Emotions in E-Learning

2010 ◽  
pp. 563-571 ◽  
Author(s):  
M. A. Rentroia-Bonito ◽  
J. Jorge ◽  
C. Ghaoui
Keyword(s):  
Learning Processes ◽  
Learning Support ◽  
Face To Face ◽  
Learning Contexts ◽  
The People ◽  
E Learning ◽  
Individual Learning Processes ◽  
The Individual ◽  
The Impact

Technology-rich environments are assuming a key role in the individual learning processes. Still, one of the major IT challenges identified in the education field is to establish e-learning as a credible and viable complement to face-to-face education. This represents a paradigm shift in the way of learning, which is driving changes at individual, process, institutional, and societal levels. However, despite last-decade advances in the application of usability principles in system design, there is still a need to better understand the people-technology fit in learning contexts. Current results, gaps, and issues define the challenges that dictate new requirements. Among these new requirements, minimizing the impact of the distance factor on communication and learning effectiveness calls for alternatives approaches. Due to the importance of communication among instructor and students in learning, the scope of this work focuses on exploring the role of emotions within the user and learning-support technology fit.

«Quanta» Language Consciousness and Problems in the Functioning of the Communicative Norms

2019 ◽  
Vol 8 (1) ◽  
pp. 26-30
Author(s):  
Татьяна Черкашина ◽  
Tatiana Cherkashina ◽  
Н. Новикова ◽  
N. Novikova ◽  
О. Трубина ◽  
...  
Keyword(s):  
Cognitive Abilities ◽  
Point Of View ◽  
Cultural Phenomenon ◽  
Globalizing World ◽  
The World ◽  
The Subject ◽  
The Individual ◽  
The Impact ◽  
The Relationship

The article considers the conceptualization of the world from the point of view of its methodological paradigm assessment in the context of the globalizing world. A retrospective analysis of the relationship between language and human speech activity is given. The authors explain the role of language as a socio-cultural phenomenon in the formation of worldview systems that develop in the consciousness with the help of minimal units of human experience in their ideal meaningful representation in special concepts, which allows the individual to think within the boundaries of a certain linguistic picture of the world. Analyzes the problems of the functioning of communicative norms with regard to the hierarchy of the spiritual representations of the world. The article attempts to consider the impact of the “blurring” of the information boundaries of the globalizing world on the cognitive abilities of the individual in the nomination, qualification of the subject, phenomenon, process.

scholarly journals Translation and the Individual Talent: Ambiguity in the Qurʾanic Text and the Role of the Translator

2021 ◽  
Author(s):  
Raed A. Qassas
Keyword(s):  
Frame Of Reference ◽  
Sacred Text ◽  
Translation Process ◽  
New Horizons ◽  
The Individual ◽  
The Impact ◽  
Point Of Departure ◽  
Individual Talent

This article examines the impact of traditional Tafsīr, the exegesis of the Qur’an, on the translation of the Qurʾanic text into English. Caught between the authority of tradition and the sensitivity of translating a sacred text, many translators refrain from practicing interpretation as an integral part of the translation process, whereas others defiantly dismiss the authority of tradition en masse. The significance of the study lies in undermining over-reliance on explanatory texts yields semantically dogmatic interpretations recurrently manifest in the various English renditions of the Qurʾan. The article questions what is called the etic translation that involves translation from the perspective of one who remains an outsider and does not participate in the interpretation. The finding of the study lead to the conclusion that many translations of the Qurʾan disregard possible interpretations because of rehashing interpretations handed down from traditional exegeses. The article also argues that translators have an active, interpretative role in the translation of the Qurʾan. Compatibility with tradition does not mean being constricted exclusively by Tafsīr. Tradition is a frame of reference, a point of departure for new horizons of interpretation where interpretation is viewed as an augmentation to tradition, not sedition.

scholarly journals Peran Perempuan Dalam Pemeliharaan Rumah Tradisional di Kampung Tarung, Sumba Barat, NTT

HUMANIS ◽  
2019 ◽  
pp. 151
Author(s):  
Sarah Ulina Kariny ◽  
Ni Luh Arjani ◽  
Industri Ginting Suka
Keyword(s):  
Local Knowledge ◽  
Field Data ◽  
Role Theory ◽  
Participant Observation ◽  
Female Figures ◽  
Role Of Women ◽  
Village Women ◽  
The Individual ◽  
The Impact

Local knowledge of Kampung Tarung community is maintained to preserve the traditional house. Most of the local knowledge is practiced by women because it relates to its domestic role. So the role of women has an impact on the preservation of traditional homes. The formulation of problem in this research include (1) How is the role of Kampung Tarung women in traditional house maintenance? (2) What forms of local knowledge do women have in Kampung Tarung? and (3) How is the impact of local knowledge owned by Kampung Tarung women towards the preservation of traditional house ?. The purpose of this research is to (1) identify and explain the role of Tarung Village women in traditional house maintenance; (2) describes the local knowledge forms owned by the Kampung Tarung women; and (3) disclose and analyze the impact of local knowledge of Kampung Tarung women on the preservation of traditional houses. Descriptive qualitative research methods with participant observation techniques, interviews, literature studies, and analysis of field data findings. The role of women in the maintenance of traditional houses in Kampung Tarung can be described by applying the role theory and the theory of ecofeminism. The role, according to Soekanto, is the dynamic aspect of status, so that if a person exercises his rights and obligations in accordance with his position he can be said to run a role. Meanwhile, ecofeminism as proposed Megawangi, see the individual comprehensively as a being that is bound and interact with the environment. This study also uses the concept of women's roles, local knowledge, and traditional houses. The results of the study show the importance of the role of women in the maintenance of traditional houses related to their daily domestic activities, the role is based on local knowledge possessed by women as the most effective way of maintaining traditional houses. Forms of local knowledge that are presently maintained, can not be separated from female figures and forms of local knowledge are taught to the children so that the next generation retains the kelur of the traditional house of Kampung Tarung.

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