scholarly journals OPTIMASI FORMULA TABLET BUKAL MUKOADHESIVE GLIBENKLAMID MENGGUNAKAN MATRIKS CMC NA SERTA ASAM OLEAT SEBAGAI ENHANCHER

2021 ◽  
Vol 4 (1) ◽  
pp. 38-43
Author(s):  
ASA FALAHI ◽  
DEWI RASHATI
Keyword(s):  
Oleic Acid ◽  
Physical Properties ◽  
Hardness Test ◽  
Oral Tablet ◽  
Mucoadhesive Polymers ◽  
Buccal Tablet ◽  
Mucoadhesive Tablets ◽  
Test Requirements ◽  
Buccal Tablets ◽  
Tablet Hardness

Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclamide mucoadhesive buccal tablet is formulated using a variety of mucoadhesive polymers, namely CMC Na and oleic acid as enhancers. The manufacture of four mucoadhesive buccal tablet formulas used the direct compression method. The results of the weight uniformity test showed that they did not meet the NP requirements specified, all formulas had an NP of more than 15. The tablet hardness test also showed results that did not meet the test requirements. However, the results of the physical properties of the brittleness, pH and swelling index showed the results that met the test requirements. In this research, the optimum variation of CMC Na polymer and oleic acid as enhancers to physical properties (hardness, brittleness, pH, swelling ability) and the release of glibenclamide mucoadhesive tablets were CMC Na of 37.5 mg and oleic acid of 3.5. ml.

Mucoadhesive Delivery Systems. I. Evaluation of Mucoadhesive Polymers for Buccal Tablet Formulation

2004 ◽  
Vol 30 (9) ◽  
pp. 985-993 ◽  
Author(s):  
Noha Adel Nafee ◽  
Fatma Ahmed Ismail ◽  
Nabila Ahmed Boraie ◽  
Lobna Mohamed Mortada
Keyword(s):  
Delivery Systems ◽  
Tablet Formulation ◽  
Mucoadhesive Polymers ◽  
Buccal Tablet

scholarly journals FORMUALTION AND DEVELOPMENT OF MUCOADHESIVE SUSTAINED RELEASE BUCCAL TABLETS AND PATCHES OF 5-FLUOROURACIL USING DIFFERENT POLYMERS

2018 ◽  
Vol 11 (5) ◽  
pp. 174
Author(s):  
Nitin Gawai ◽  
Zahid Zaheer
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Research Work ◽  
Sodium Deoxycholate ◽  
Content Uniformity ◽  
Design Expert ◽  
Buccal Tablet ◽  
Buccal Tablets

 Objective: The present research study was undertaken to formulate mucoadhesive sustained release buccal tablets and patches of 5-fluorouracil (5-FU).Method: For the research experiment work design expert software version 10, stat-ease, Inc. has been used. A 32 full factorial design was selected for the formulation of the buccal tablet as well as buccal patches. In this research work, formulated tablets and patches using different polymers such as carbopol 974p, polyvinylpyrrolidone-K 30, sodium deoxycholate, microcrystalline cellulose, and polyvinyl alcohol. An after formulation of batches formulated products studied for characterization, namely, Fourier transform infrared (FTIR) and differential scanning calorimeter (DSC). Evaluation parameters studied such as weight uniformity, thickness, hardness, friability, and content uniformity also carried out. For drug release purpose from the formulation of buccal tablet and patches in vitro drug released performed. In vivo drug releases study also carried out using Rabbit for drug reaction point of view.Results: Design expert showed the significant results on independent and dependent variables. The R-Squared 0.9943 for drug release and 0.9985 for swelling index is in reasonable agreement with the formulations. FTIR and DSC indicating compatibility of the drug and polymers in the tablet formulation and patch formulations at the molecular level. The drug release of buccal tablet showed 75.10–99.34% and buccal patches showed 58.41–81.43%. These formulations showed good results when compared to the conventional tablet.Conclusion: Formulation of mucoadhesive sustained release buccal tablets and patches of 5-FU successfully done using different polymers, which would definitely help in increasing bioavailability of the drug.

Physical properties of nanocomposite polylactic acid films prepared with oleic acid modified titanium dioxide

2018 ◽  
Vol 17 ◽  
pp. 30-38 ◽  
Author(s):  
Naerin Baek ◽  
Young T. Kim ◽  
Joe E. Marcy ◽  
Susan E. Duncan ◽  
Sean F. O’Keefe
Keyword(s):  
Titanium Dioxide ◽  
Oleic Acid ◽  
Physical Properties ◽  
Polylactic Acid

Peanut Oil Stability and Physical Properties Across a Range of Industrially Relevant Oleic Acid/Linoleic Acid Ratios

2016 ◽  
Vol 43 (1) ◽  
pp. 1-11 ◽  
Author(s):  
J.P. Davis ◽  
K.M. Price ◽  
L.L. Dean ◽  
D.S. Sweigart ◽  
J.M. Cottonaro ◽  
...  
Keyword(s):  
Refractive Index ◽  
Oleic Acid ◽  
Linoleic Acid ◽  
Physical Properties ◽  
Shelf Life ◽  
Stability Index ◽  
Oil Stability ◽  
Oil Viscosity ◽  
High Oleic ◽  
Oil Blends

ABSTRACT High oleic cultivars are becoming increasing prevalent in the peanut industry due to their increased shelf life compared to conventional cultivars. High oleic peanuts are typically defined as having oleic acid/linoleic acid (O/L) ratios ≥ 9, whereas most traditional varieties have O/L ratios near 1.5-2.0. In practice, this ratio can vary substantially among commercial material; accordingly, the goal of this study was to gain an understanding of the shelf life and physical properties of 16 model oil blends with O/L ratios systematically prepared from 1.3 to 38.1. Across these samples, % oleic acid, % linoleic acid, refractive index, density and dynamic viscosity were all highly (R2 > 0.99) linearly correlated. Increasing concentrations of oleic acid and corresponding decreases in linoleic acid were associated with decreasing oil density, decreasing refractive index, and increasing viscosity. Oxidative stability index (OSI), an established method for predicting relative oil shelf life, increased more than 7X from an O/L of 1.3 to 33.8 and this response was well described by a 2nd order polynomial. Oil stability was also assessed by storing oil blends at 24 C with 50% R.H. for 24 wk and periodically sampling these oils to measure peroxide value (PV) and describe oil flavor via sensory analysis. Excellent correlations were observed among O/L chemistry and off-flavor (oxidized/cardboard/rancid) development during storage, PV development during storage, and OSI. While viscosity was greatest for high oleic samples when comparing fresh oils, after storage under abusive conditions oil viscosity increased exponentially with decreasing O/L ratio due to oxidation/polymerization reactions. Overall, these data and observations will aid processors in selection of high O/L peanuts for various food applications and better determine final product shelf life.

scholarly journals Particle Engineering of Chitosan and Kaolin Composite as a Novel Tablet Excipient by Nanoparticles Formation and Co-Processing

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1844
Author(s):  
Chonwipa Yarangsee ◽  
Phanphen Wattanaarsakit ◽  
Jakkapan Sirithunyalug ◽  
Phuriwat Leesawat
Keyword(s):  
Physical Properties ◽  
Spray Drying ◽  
Chitosan Nanoparticles ◽  
Direct Compression ◽  
Spray Dryer ◽  
Particle Engineering ◽  
Successful Development ◽  
Feed Formulation ◽  
The Individual ◽  
Tablet Hardness

Chitosan is not a common excipient for direct compression due to poor flowability and inadequate compressibility. Co-processing of chitosan and kaolin is a challenging method to overcome the limitations of the individual excipients. The purpose of the present study was to develop co-processed chitosan–kaolin by the spray drying technique (rotary atomizer spray dryer) and to characterize the excipient properties. The formation of chitosan nanoparticles was the major factor for desirable tablet hardness. The ratio of chitosan/tripolyphosphate of 10:1 and 20:1 had a significant effect on hardness. The successful development of co-processed chitosan–kaolin as a novel tablet excipient was obtained from a feed formulation composed of chitosan and kaolin at a ratio of 55:45 and the optimum chitosan/tripolyphosphate ratio of 20:1. Co-processing altered the physical properties of co-processed chitosan–kaolin in such a way that it enhanced the flowability and tableting performance compared to the physical mixture.

scholarly journals OPTIMASI KONSENTRASI POLIVINIL PIROLIDON (PVP) SEBAGAI BAHAN PENGIKAT TEHADAP SIFAT FISIK TABLET EKSTRAK ETANOL RIMPANG BANGLE (Zingiber cassumunar Roxb)

2018 ◽  
pp. 45
Author(s):  
Ida ayu Sintha Devi
Keyword(s):  
Physical Properties ◽  
Bitter Taste ◽  
Ethanol Extract ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Organoleptic Test ◽  
Size Uniformity ◽  
The Right ◽  
Test Requirements ◽  
Zingiber Cassumunar

Zingiber cassumunar Roxb contains active compounds such as cassumumin AC, cassummarin AC, phenylbutanoid, and (E) -4- (3,4-dimethoxyphenyl) but-3-en-1-ol which has activities as anti-inflammatory, antioxidant and anti-allergenic agents so that they are potentially used as anti-allergies. Zingiber cassumunar Roxb is made into tablet because it has several advantages, which are easy to consume, practical, the right amount, cover the bitter taste and the distinctive smell and its stability is maintained in storage. This study aims to produce Zingiber cassumunar Roxb tablets that have good physical properties by using PVP as a binder. Zingiber cassumunar Roxb extract was made by maceration using 70% ethanol solvent, the tablet was formulated using wet granulation method. Zingiber cassumunar Roxb ethanol extract tablet was formulated in 3 formulas with variations in the PVP FI content of 1%, FII 2.75%, and FIII 4.5%. The resulting granules were tested for physical properties including moisture test, particle size distribution, flow time, stationary angle, bulk density, and compressibility, while the tablets produced were tested for physical properties including organoleptic test, uniformity of size, uniformity of weight, friability, and disintegration time. The results showed that the optimum concentration obtained was at FIII with 4.5% PVP concentration that complied the organoleptic test requirements, uniformity of size, weight uniformity, and fragility of tablets.

Chemical and Physical Properties of Sri Lankan Medium Seeded Groundnuts (Arachis hypogaea L) Genotypes

2017 ◽  
Vol 4 (1) ◽  
Author(s):  
RAA RANATHUNGA ◽  
YPJ AMARASINGHE ◽  
GTN GUNASEKARA
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Oleic Acid ◽  
Fatty Acid ◽  
Linoleic Acid ◽  
Physical Properties ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Behenic Acid ◽  
Composition Analysis

Physical properties of commonly grown Sri Lanka groundnuts cultivars and promising accession varied considerably and numbers of kernels, pod beak, reticulation, testa colour, and shell out percentage have differences among groundnuts. However, they showed more similarities for most of the characters. Moisture (5.4-8.4%), crude protein (18.7-28.5%), lipid (43.4-53.0%), ash (4.4-5.8%), carbohydrates (9.3-18.2%) and energy level (565.7-618.2kcal) contents varied considerably. Quality and flavor of edible groundnuts and its products are affected by fatty acid composition of oil. Lipids were mainly composed of mono and polyunsaturated fatty acids (>78% of the total lipids). Fatty acid composition analysis indicated that oleic acid (C18:1) was the main constituent of monounsaturated lipids in all seed samples. With the exception of ANKG1, linoleic acid (C18:2) was the major polyunsaturated fatty acid. The saturated fatty acids (Palmatic, Stearic acid and behenic acid) in different cultivars ranged between 10.2 to 15.6%, 2.5 to 6.3% and 1.1 to 5.3%, respectively. Differences among cultivars for oleic acid exhibited significance which ranged between 38.2 to 47.4%. Similarly, cultivars differed statistically for linoleic acid which showed a range of 23.1 to 38.7%. Oleic to linoleic acid ratio was differed and all the released varieties were below the minimum standard level of 1.6, whereas ICGV 86590 and ICGV 00073 showed higher O/L ratio of 1.94 and 1.75 respectively.

scholarly journals Drug Complexation and Formulation of a Buccal Tablet

1970 ◽  
Vol 45 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Rajashree Hirlekar ◽  
Vilasrao Kadam
Keyword(s):  
Scanning Calorimetry ◽  
Beta Cyclodextrin ◽  
Cyclodextrin Complexation ◽  
Kneading Method ◽  
Buccal Tablet ◽  
First Pass Metabolism ◽  
First Pass ◽  
Buccal Tablets ◽  
Key Words Carvedilol ◽  
Pass Metabolism

In the present work use of Beta-Cyclodextrin for inclusion of Carvedilol, an antihypertensive drug with poor solubility and high first pass metabolism was studied, in order to improve its dissolution rate. The complex prepared by kneading method was characterized by Differential Scanning Calorimetry, Fourier Transformation Infra Red Spectroscopy and X-Ray Diffractometry along with the plain drug and physical mixture. The drug so complexed was incorporated into a buccal dosage form to by pass first pass metabolism to improve its bioavailability. The buccal tablets containing complex showed reasonable mucoadhesive strength. The dissolution and permeability across pig buccal mucosa were improved in case of tablets containing the complex as compared to plain drug tablet. Key words: Carvedilol; Beta-Cyclodextrin; Complexation; Dissolution; Characterization; Permeation. DOI: 10.3329/bjsir.v45i2.5709Bangladesh J. Sci. Ind. Res. 45(2), 123-128, 2010

scholarly journals Peanut Oil Stability and Physical Properties Across a Range of Industrially Relevant Oleic Acid/Linoleic Acid Ratios

2016 ◽  
Author(s):  
Jack P. Davis ◽  
Kristin Price ◽  
Lisa L. Dean ◽  
Daniel S. Sweigart ◽  
Jane Cottonaro ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Linoleic Acid ◽  
Physical Properties ◽  
Oil Stability ◽  
Peanut Oil
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