Role of C-reactive protein, serum ferritin, albumin, and lactate dehydrogenase in hospitalized coronavirus disease-19 infected patients - A study in tertiary care coronavirus disease-19 center in Eastern India

Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS.

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Prognostic Biomarkers For Mortality In Severe COVID-19 Patients : The Worth of C-reactive Protein, Serum Ferritin and D-dimer

International Journal of Medical Science ◽

10.14445/23939117/ijms-v8i8p103 ◽

2021 ◽

Vol 8 (8) ◽

pp. 15-18

Author(s):

Kripasindhu Gantait ◽

Arindam Bhattacharjee ◽

Rabi Lochan Maji ◽

Akshaya Elango

Keyword(s):

Serum Ferritin ◽

Prognostic Biomarkers ◽

C Reactive Protein ◽

Reactive Protein ◽

Protein Serum ◽

D Dimer

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Association of Various Biomarkers and Liver Enzymes with Severity of COVID-19

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd10-3/002 ◽

2021 ◽

Keyword(s):

Lactate Dehydrogenase ◽

Serum Ferritin ◽

Liver Enzymes ◽

Medical Profession ◽

Serum Markers ◽

Gamma Glutamyl Transferase ◽

C Reactive Protein ◽

Reactive Protein ◽

Group B ◽

Glutamyl Transferase

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing novel coronavirus (COVID-19) outbreak has an impact on the liver enzymes. The study aimed to determine the serum markers and liver enzymes and their association in COVID-19 patients admitted to hospital. Methods: It was a retrospective, observational study conducted at the Gastroenterology Department of Lahore General Hospital, from April 2020-July 2020. Total 495 patients were divided into two groups. Group A (318) comprised of patients with moderate symptoms and group B (177) with severe symptoms. Records were obtained from the hospital laboratory in which Lactate dehydrogenase (LDH), Aspartate aminotransferase, (AST), Alanine aminotransferase (ALT), Gamma glutamyl transferase (GGT) and Alkaline phosphatase (ALP) were assessed using an automated biochemistry analyzer. Serum C-reactive protein test was performed by the immunoturbidimetric assays. Serum Ferritin was determined using the ELISA technique. Results: The mean age of moderate cases was 48.57±16.84 years and of severe cases were 62.51±9.76 years. In both moderate and severe cases, males [200(63%), 98(55.36%)] were more affected than females [118(37.10%), 79(44.63%)]. Furthermore, 79(16%) of severe cases were associated with medical profession. The levels of CRP, Ferritin and LDH were increased significantly in severe COVID-19 cases (p<0.05) compared to moderate ones. On the other hand, liver enzymes ALT, AST, GGT and ALP were non-significantly raised in severe cases compared to moderate cases (p> 0.05). Conclusion: Serum ferritin, C-reactive protein and lactate dehydrogenase acts as prognostic biochemical parameters based on severity. In addition, levels of liver enzymes were also raised indicating liver derangement; however, the results were not significant. Keywords: Ferritin; C-Reactive Protein; Lactate Dehydrogenase; Gama Glutamyl Transferase; Covid-19.

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The effect of remdesivir on selective biomarkers and its value in predicting the clinical outcome in patients with COVID-19

Asian Journal of Medical Sciences ◽

10.3126/ajms.v12i12.39164 ◽

2021 ◽

Vol 12 (12) ◽

pp. 3-8

Author(s):

Sanjana Rai ◽

Dyna Jones ◽

Chinnappa Anjanappa Jayashankar ◽

Venkata Bharat Kumar Pinnelli ◽

Eashwer Manpreeth ◽

...

Keyword(s):

Lactate Dehydrogenase ◽

Clinical Outcome ◽

Serum Ferritin ◽

Inflammatory Markers ◽

Complete Blood Count ◽

Group Versus ◽

C Reactive Protein ◽

Reactive Protein ◽

Significant Difference ◽

D Dimer

Background: To the best of our knowledge, there have been no studies to evaluate the effect of remdesivir on inflammatory markers. Aims and Objectives: To study the effect of Remdesivir on Selective biomarkers namely C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), Serum Ferritin and D-dimer and their value in predicting the clinical outcome in patients with COVID -19 infection. Materials and Methods: This is a retrospective observational study including 102 laboratory-confirmed COVID-19 patients of moderate and severe category who were subjected to complete blood count, liver function test, BUN, creatinine, C-reactive protein, lactate dehydrogenase, D-dimer, serum ferritin, ECG, and chest X-ray. The association was analyzed using independent sample t-test or Mann–Whitney U-test. Patients were divided into two groups. Both received corticosteroids and anticoagulants. Group A also received remdesivir. Results: Of the 102 patients, 90.2% of the patients in the non-remdesivir group and 94.1% in the remdesivir group were discharged. The mortality rate was 9.8% in the non-remdesivir group versus 5.9% in the remdesivir group (P=0.71). There was no statistically significant difference in the decrease of the inflammatory markers overtime in both the groups, irrespective of whether they received remdesivir or not. Conclusion: High values of the inflammatory markers were seen at the time of admission. A 5 days course of remdesivir failed to demonstrate a statistically significant difference in the decrease in the levels of the inflammatory markers. However, we have observed a possible clinical benefit of remdesivir among patients with moderate and severe COVID-19 disease, as there was a trend toward better clinical outcomes. Further studies are needed to evaluate this therapeutic strategy.

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