scholarly journals Synthesis of past isotope hydrology investigations in the area of Ljubljana, Slovenia

Geologija ◽  
2020 ◽  
Vol 63 (2) ◽  
pp. 251-270
Author(s):  
Klara Nagode ◽  
Tjaša Kanduč ◽  
Sonja Lojen ◽  
Branka Bračič Železnik ◽  
Brigita Jamnik ◽  
...  
Keyword(s):  
Surface Water ◽  
Stable Isotope ◽  
Large Scale ◽  
Numerical Data ◽  
Domestic Water ◽  
Sava River ◽  
The Impact ◽  
Ljubljansko Barje ◽  
The Sava River

Water isotope investigations are a powerful tool in water resources research as well as in understanding the impact that humans have on the water cycle. This paper reviews past hydrological investigations of the Ljubljansko polje and Ljubljansko barje aquifers that supply drinking water to the City of Ljubljana, with an emphasis on hydrogen, oxygen and carbon stable isotope ratios. Information about the methods used and results obtained are summarised, and the knowledge gaps identified. Overall, we identified 102 records published between 1976 and 2019. Among them, 41 reported stable isotope data of groundwater, surface water and precipitation and were further analysed. Isotope investigations of the Ljubljansko barje began in 1976, while groundwater and surface water investigations of the Ljubljansko polje and along the Sava River began as late as 1997. Isotope investigations of carbon started even later in 2003 in the Ljubljansko polje and in 2010 in the Ljubljansko barje. These investigations were performed predominantly in the frame of short-term groundwater research projects at five main wellfields and sites along the Sava River. Almost no large-scale, long-term stable isotope studies have been conducted. The exceptions include groundwater monitoring by the Union Brewery in Ljubljana (2003- 2014) and precipitation in Ljubljana since 1981. Since 2011, more detailed surveys of the Ljubljansko barje were performed, and in 2018, the first extensive investigation started at wellfields and objects that form part of the domestic water supply system. Given the number of available studies, we felt that publishing all the numerical data and appropriate metadata would allow for a better understanding of the short and long-term dynamics of water circulation in the urban environment. In the future, systematic long-term approaches, including the appropriate use of isotopic techniques, are needed.

A Perspective On The Impact of COVID-19 Pandemic in Basic Science Research and its Future implications

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Yam Nath Paudel ◽  
Efthalia Angelopoulou ◽  
Bhupendra Raj Giri ◽  
Christina Piperi ◽  
Iekhsan Othman ◽  
...  
Keyword(s):  
Basic Science ◽  
Large Scale ◽  
Preventive Measure ◽  
Science Research ◽  
Research Institutes ◽  
Basic Science Research ◽  
Long Term Consequences ◽  
Long Term Impact ◽  
The Impact

: COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed a lock-down as a preventive measure to lower the spread of COVID-19 infection. As a result of lock-down most of the universities and research institutes has witnessed a long pause in basic science research ever. Much has been talked about the long-term impact of COVID-19 in economy, tourism, public health, small and large-scale business of several kind. However, the long-term implication of these research lab shutdown and its impact in the basic science research has not been much focused. Herein, we provide a perspective that portrays a common problem of all the basic science researchers throughout the globe and its long-term consequences.

scholarly journals Anti-meningococcal B vaccination in Italian adolescents: a cost-effective health opportunity

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
D Panatto ◽  
P Landa ◽  
D Amicizia ◽  
P L Lai ◽  
E Lecini ◽  
...  
Keyword(s):  
Large Scale ◽  
Public Health Problem ◽  
Vaccination Strategy ◽  
Cost Effective ◽  
Dose Schedule ◽  
Developed Countries ◽  
Invasive Disease ◽  
International Setting ◽  
The Impact

Abstract Background Invasive disease due to Neisseria meningitidis (Nm) is a serious public health problem even in developed countries, owing to its high lethality rate (8-15%) and the invalidating sequelae suffered by many (up to 60%) survivors. As the microorganism is transmitted via the airborne route, the only available weapon in the fight against Nm invasive disease is vaccination. Our aim was to carry out an HTA to evaluate the costs and benefits of anti-meningococcal B (MenB) vaccination with Trumenba® in adolescents in Italy, while also considering the impact of this new vaccination strategy on organizational and ethics aspects. Methods A lifetime Markov model was developed. MenB vaccination with the two-dose schedule of Trumenba® in adolescents was compared with 'non-vaccination'. Two perspectives were considered: the National Health Service (NHS) and society. Three disease phases were defined: acute, post-acute and long-term. Epidemiological, economic and health utilities data were taken from Italian and international literature. The analysis was conducted by means of Microsoft Excel 2010®. Results Our study indicated that vaccinating adolescents (11th year of life) with Trumenba® was cost-effective with an ICER = € 7,912/QALY from the NHS perspective and € 7,758/QALY from the perspective of society. Vaccinating adolescents reduces the number of cases of disease due to meningococcus B in one of the periods of highest incidence of the disease, resulting in significant economic and health savings. Conclusions This is the first study to evaluate the overall impact of free MenB vaccination in adolescents both in Italy and in the international setting. Although cases of invasive disease due to meningococcus B are few, if the overall impact of the disease is adequately considered, it becomes clear that including anti-meningococcal B vaccination into the immunization program for adolescents is strongly recommended from the health and economic standpoints. Key messages Free, large-scale MenB vaccination is key to strengthening the global fight against invasive meningococcal disease. Anti-meningococcal B vaccination in adolescents is a cost-effective health opportunity.

scholarly journals Impact of climate change on groundwater point discharge: backflooding of karstic springs (Loiret, France)

2011 ◽  
Vol 8 (2) ◽  
pp. 2235-2262
Author(s):  
E. Joigneaux ◽  
P. Albéric ◽  
H. Pauwels ◽  
C. Pagé ◽  
L. Terray ◽  
...  
Keyword(s):  
Climate Change ◽  
Surface Water ◽  
Groundwater Quality ◽  
Atmospheric Circulation ◽  
Large Scale ◽  
Weather Type ◽  
Future Climate Change ◽  
Impact Of Climate Change ◽  
The Impact ◽  
Large Scale Atmospheric Circulation

Abstract. Under certain hydrological conditions it is possible for spring flow in karst systems to be reversed. When this occurs, the resulting invasion by surface water, i.e. the backflooding, represents a serious threat to groundwater quality because the surface water could well be contaminated. Here we examine the possible impact of future climate change on the occurrences of backflooding in a specific karst system, having first established the occurrence of such events in the selected study area over the past 40 yr. It would appear that backflooding has been more frequent since the 1980s, and that it is apparently linked to river flow variability on the pluri-annual scale. The avenue that we adopt here for studying recent and future variations of these events is based on a downscaling algorithm relating large-scale atmospheric circulation to local precipitation spatial patterns. The large-scale atmospheric circulation is viewed as a set of quasi-stationary and recurrent states, called weather types, and its variability as the transition between them. Based on a set of climate model projections, simulated changes in weather-type occurrence for the end of the century suggests that backflooding events can be expected to decrease in 2075–2099. If such is the case, then the potential risk for groundwater quality in the area will be greatly reduced compared to the current situation. Finally, our results also show the potential interest of the weather-type based downscaling approach for examining the impact of climate change on hydrological systems.

Numerical Modelling of a District Scale Groundwater Heat Pump Operation: Case Study from Colchester, UK

2021 ◽  
Author(s):  
Taha Sezer ◽  
Abubakar Kawuwa Sani ◽  
Rao Martand Singh ◽  
David P. Boon
Keyword(s):  
Large Scale ◽  
District Level ◽  
Thermal Plume ◽  
Injection Wells ◽  
Term Operation ◽  
Heating And Cooling ◽  
Groundwater Heat Pump ◽  
The Impact

<p>Groundwater heat pumps (GWHP) are an environmentally friendly and highly efficient low carbon heating technology that can benefit from low-temperature groundwater sources lying in the shallow depths to provide heating and cooling to buildings. However, the utilisation of groundwater for heating and cooling, especially in large scale (district level), can create a thermal plume around injection wells. If a plume reaches the production well this may result in a decrease in the system performance or even failure in the long-term operation. This research aims to investigate the impact of GWHP usage in district-level heating by using a numerical approach and considering a GWHP system being constructed in Colchester, UK as a case study, which will be the largest GWHP system in the UK. Transient 3D simulations have been performed pre-construction to investigate the long-term effect of injecting water at 5°C, into a chalk bedrock aquifer. Modelling suggests a thermal plume develops but does not reach the production wells after 10 years of operation. The model result can be attributed to the low hydraulic gradient, assumed lack of interconnecting fractures, and large (>500m) spacing between the production and injection wells. Model validation may be possible after a period operational monitoring.</p>

scholarly journals The study of the interactions between Sava River and Zagreb aquifer system (Croatia) using water stable isotopes

2019 ◽  
Vol 98 ◽  
pp. 12017
Author(s):  
Jelena Parlov ◽  
Zoran Kovač ◽  
Jadranka Barešić
Keyword(s):  
Stable Isotopes ◽  
Surface Water ◽  
Spatial Variability ◽  
River Water ◽  
Aquifer System ◽  
Protection Zones ◽  
Sava River ◽  
Water Fractions ◽  
Definition Of ◽  
The Sava River

Water stable isotopes were used to investigate hydrological pathways and interactions between surface water and groundwater in the Zagreb aquifer system (Croatia). δ2H and δ18O values indicate a spatial variability of the influence of individual groundwater sources inside the aquifer – local precipitation and the Sava River water. Fractions of surface water in groundwater strongly depend on fluctuations of the river water level and less on the distance from the Sava River. These data extend our understanding of groundwater flow in the Zagreb aquifer system, interactions between Sava River water, local precipitation and groundwater. The results of the research allow more precise monitoring plans and definition of the sanitary protection zones of the well fields in the future.

scholarly journals Nonlinear Creep Model of Deep Gangue Backfilling Material and Time-Dependent Characteristics of Roof Deformation in Backfilling Mining

Geofluids ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Peng Huang ◽  
Jixiong Zhang ◽  
Qi Zhang ◽  
Ntigurirwa Jean Damascene ◽  
Yuming Guo
Keyword(s):  
Large Scale ◽  
High Stress ◽  
Viscoelastic Model ◽  
Creep Model ◽  
Mine Pressure ◽  
Nonlinear Creep ◽  
Viscoelastic Foundation ◽  
The Impact ◽  
Roof Deformation

With the gradual increase in mining depth of coal resource exploitation, deep backfilling mining has effectively solved the impact of strong deep mine pressure and strong mining disturbances. However, after deep backfilling mining, the backfilling material is subjected to high stress for a long time, and its viscoelasticity has a significant impact on the roof control effect. This paper uses a large-scale bulk confinement test device to analyze the viscoelastic properties of gangue, establishes a high-precision fractional viscoelastic creep model, and identifies the gangue parameters. The established fractional viscoelastic model was used as the foundation model of the beam, and the roof model based on the fractional viscoelastic foundation was solved. The top deformation characteristics of elastic foundation and fractional foundation were compared and analyzed, and the time effect, viscoelastic effect, and order effect of the fractional order viscoelastic foundation beam were discussed. The results show that the viscosity of gangue increased under the action of deep high stress. As time increased, the roof deformation also increased. In order to more effectively control the long-term deformation of the roof, the viscosity coefficient of the backfilling material should be greater than 20 MPa. This research provides relevant guidance for the requirements of backfilling materials for deep backfilling mining and the prediction of long-term dynamic deformation of the roof in underground excavations.

Replicative Senescence-Associated Gene Expression Changes In Human MSPCs Independent of Genomic Variations

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4775-4775
Author(s):  
Katharina Schallmoser ◽  
Christina Bartmann ◽  
Eva Rohde ◽  
Simone Bork ◽  
Christian Guelly ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Culture ◽  
Bone Marrow ◽  
Large Scale ◽  
Replicative Senescence ◽  
Genomic Stability ◽  
The State ◽  
Efficient Treatment ◽  
The Impact

Abstract Abstract 4775 Background: Based on promising experimental studies with mesenchymal stem and progenitor cells (MSPCs) multiple clinical trials have been initiated. In previous studies we have observed genomic stability of MSPCs after efficient short-term expansion in a humanized GMP compliant system with pooled human platelet lysate (pHPL) replacing fetal bovine serum (FBS) as the cell culture supplement (Schallmoser K. and Strunk D., Journal of Visualized Experiments (32) DOI: 10.3791/1523, 2009). Notably, depending on culture protocols, an extensive propagation with highly variable cell culture duration may be necessary to yield enough MSPCs for therapy. The decline in proliferation rates of MSPCs in the course of the different long-term expansion procedures may indicate a propensity for replicative senescence which may hamper long term functionality in vivo. We have therefore initiated a molecular profiling of senescence-associated regulated genes to determine the state of senescence before MSPC transplantation. Methods: Human bone marrow-derived MSPCs were cultured following a highly efficient two-passage protocol (primary culture of unseparated bone marrow and subsequent large scale expansion; Schallmoser K. et al., Tissue Engineering 14:185-196, 2008) compared to conventional serial passaging in three different growth conditions with regularly more then four passages to obtain comparable final cell numbers. Culture media were either supplemented with FBS in different concentrations or pHPL. Gene expression changes were tested by microarray analysis and selected targets were reanalyzed by quantitative real-time PCR. The genomic stability of MSPCs after long-term culture was determined by array comparative genomic hybridization (CGH). Results: Despite high proliferation rate large scale expanded MSPCs showed genomic stability in array CGH. Long-term MSPC growth induced similar gene expression changes in MSPCs irrespective of isolation and expansion conditions. In particular, genes involved in cell differentiation, apoptosis and cell death were up-regulated, whereas genes involved in mitosis and proliferation were down-regulated. Furthermore, overlapping senescence-associated gene expression changes were found in all MSPC preparations. The genomic copy number variations detected in MSPCs of early and late passages in all culture conditions did not coincide with differentially expressed genes. Conclusion: Our data indicate that MSPC expansion can induce gene expression changes independent of isolation and FBS-supplemented as well as FBS-free expansion conditions. A panel of genes will be presented that might offer a practicable approach to assess MSPC quality with regard to the state of replicative senescence in advance of therapeutic application. Determining the impact of senescence acquired during cell expansion on the therapeutic potential of MSCPs for both immune modulation and organ regeneration may help to develop more efficient treatment strategies. Disclosures: No relevant conflicts of interest to declare.

The Impact of Compressor Exit Conditions on Fuel Injector Flows

2012 ◽  
Vol 134 (11) ◽  
Author(s):  
C. L. Ford ◽  
J. F. Carrotte ◽  
A. D. Walker
Keyword(s):  
Flow Field ◽  
Large Scale ◽  
Numerical Data ◽  
Flow Fields ◽  
Main Reaction ◽  
Fuel Injector ◽  
Lean Burn ◽  
Field Development ◽  
Inlet Conditions ◽  
The Impact

This paper examines the effect of compressor generated inlet conditions on the air flow uniformity through lean burn fuel injectors. Any resulting nonuniformity in the injector flow field can impact on local fuel air ratios and hence emissions performance. The geometry considered is typical of the lean burn systems currently being proposed for future, low emission aero engines. Initially, Reynolds-averaged Navier-Stokes (RANS) computational fluid dynamics (CFD) predictions were used to examine the flow field development between compressor exit and the inlet to the fuel injector. This enabled the main flow field features in this region to be characterized along with identification of the various stream-tubes captured by the fuel injector passages. The predictions indicate the resulting flow fields entering the injector passages are not uniform. This is particularly evident in the annular passages furthest away from the injector centerline which pass the majority of the flow which subsequently forms the main reaction zone within the flame tube. Detailed experimental measurements were also undertaken on a fully annular facility incorporating an axial compressor and lean burn combustion system. The measurements were obtained at near atmospheric pressure/temperatures and under nonreacting conditions. Time-resolved and time-averaged data were obtained at various locations and included measurements of the flow field issuing from the various fuel injector passages. In this way any nonuniformity in these flow fields could be quantified. In conjunction with the numerical data, the sources of nonuniformities in the injector exit plane were identified. For example, a large scale bulk variation (+/−10%) of the injector flow field was attributed to the development of the flow field upstream of the injector, compared with localized variations (+/−5%) that were generated by the injector swirl vane wakes. Using this data the potential effects on fuel injector emissions performance can be assessed.

scholarly journals The impact of environmental conditions on water salinity in the area of the city of Inowrocław (north-central Poland)

2017 ◽  
Vol 13 (1) ◽  
pp. 5-15 ◽  
Author(s):  
Piotr Hulisz ◽  
Arkadiusz Krawiec ◽  
Sylwia Pindral ◽  
Łukasz Mendyk ◽  
Kamila Pawlikowska
Keyword(s):  
Surface Water ◽  
Groundwater Resources ◽  
Geological Structure ◽  
Anthropogenic Factors ◽  
Limit Values ◽  
Surface Water And Groundwater ◽  
Zechstein Salt ◽  
The Impact ◽  
The City

AbstractThe article presents the influence of natural and anthropogenic factors on the chemical and physical properties of surface water and groundwater in the area of the city of Inowrocław. It has been shown that the properties of the waters were most strongly affected by the specific geological structure (the city is located within the Zechstein salt dome) as well as the long-term influence of a salt mine and soda plant. The composition of most analysed samples was dominated by Ca2+, Na+and Cl−ions. In places of heavy industrial activity, some water parameters were several time higher than permissible limit values according to Polish standards. It is concluded that, due to the threat to the city’s drinking groundwater resources and fertile soils, the surface water and groundwater in the area in question require permanent monitoring.

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